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한국인 정신분열병 환자의 지연성 운동장애와 $CYP2D6^*4$ 및 $CYP2D6^*10$ 다형성들의 연합에 대한 고찰
우성일,강동우,서한길,김봉조,이인상,정근화,박소영,정치영,이환철,정경천,손진욱,Woo, Sung-Il,Kang, Dong-Woo,Seo, Han-Gil,Kim, Bong-Jo,Lee, In-Sang,Jeong, Geun-Hoa,Park, So-Young,Jung, Chi-Yeong,Lee, Hwan-Cheol,Jeong, Kyeong-Cheon,Sohn, 대한생물정신의학회 2000 생물정신의학 Vol.7 No.2
P450 CYP2D6 enzyme(=debrisoquine hydroxylase) is known to metabolize many neuroleptics and some genetic polymorphisms in the CYP2D6 gene were reported to be associated with tardive dyskinesia(TD). We investigeted the association of two genetic polymorphisms in the CYP2D6 gene, $CYP2D6^*4$ and $CYP2D6^*10$, with TD in Korean schizophrenic subjects. Subjects consisted of 71 Korean schizophrenics and TD was evaluated using the Abnormal Involuntary Movement Scale (AIMS). There were no statistically significant differences in the demographic variables of age, male to female percentage and the current antipsychotic(CPZ equivalent) dose between the group with TD and the group without TD. But the duration of antipsychotic drug exposure was significantly higher in the group without TD(p=0.000, by independent t-test). The mean AIMS score in the group with TD was $11.2{\pm}6.6$(S.D.). Genotypings for the presence of $CYP2D6^*4$ and $CYP2D6^*10$ were done using PCR amplifications and endonuclease digestions. There were no statistically significant genotypic and alleleic associations between TD and $CYP2D6^*4$(by chisquare tests), and between TD and $CYP2D6^*10$(by chi-square tests). These results indicate that the $CYP2D6^*4$ and $CYP2D6^*10$ polymorphisms have no significant roles in the causation of TD.
정치영(Jeong Chi Yeong) 한국지역지리학회 2003 한국지역지리학회지 Vol.9 No.2
본고는 萬夏氷이 저술한 『千一錄』을 통해 18세기 말 우리 나라 농업의 지역적 특성을 살펴보는 것을 목적으로 하였다. 각 지역의 농업특성은 자연조건·농경지 분포·주요작물·농법·농업생산력 등 『천일록』에서 추출해 낼 수 있는 몇 가지 지표를 통해 분석하였다. 그 결과, 당시의 농업은 오늘날과 달리 각 지역마다 뚜렸한 특성을 지니고 있었다. 그리고 이러한 농업의 지역성은 일차적으로 자연환경의 차이에 기인하여, 지형·기후·토양 등 자연조건이 농경지의 분포와 이용, 주요 작물 등을 좌우하였으며 농업생산력에도 결정적인 영향을 미치는 경우가 많았다. 각 지역의 고유한 농법 역시 농민들이 지역 나름의 자연조건을 감안하여 반복된 시행착오를 거치며 개발·발전시켜 온 것들이었다. 이와 더불어, 각 지역의 인구, 농업노동력의 양과 질, 토지소유의 다과, 수리시설을 비롯한 농업기반시설의 충실도 등 사회·경제적 상황도 농업의 지역성을 심화시키는 데 지대한 역할을 하였다. This paper analyzes Wu Ha Youngs Cheonilrok in order to reconstruct the regional characteristics of farming in the late, 18th century Korean countryside. The projected objective is approached through the examination of various indices drawn from the volume such as environment, distribution of arable lands, major crops. agricultural techniques, and productivity. The main finding of this research is that unlike todays homogenous picture of agriculture, quite significant difference.; of agrarian practices existed across the countn in the past. The regional differentiation was attributable foremost to natural environment. To elaborate, landform, climate and soil influenced the distribution arid use of land plots. the kinds of main crops prtduced. and the agricultural productivity. The region-specific agricultural techniques result from the cumulative processes of trial and error against the given environment. Other social and economic conditions which include population, skill of the peasants, size of landownership, and irrigation facilities sustained the regional differentiation of agriculture.
한국인 비흡연 여성에서 폐암의 유전적 감수성 표지자로서의 GSTTI 유전자형
장상수 ( Jang Sang Su ),정치영 ( Jeong Chi Yeong ),이신엽 ( Lee Sin Yeob ),이재희 ( Lee Jae Hui ),전효성 ( Jeon Hyo Seong ),박선하 ( Park Seon Ha ),손지웅 ( Son Ji Ung ),이용배 ( Lee Yong Bae ),김창호 ( Kim Chang Ho ),감신 ( Gam 대한결핵 및 호흡기학회 2003 Tuberculosis and Respiratory Diseases Vol.54 No.5
마미숙,정은정,김주연,최상경,홍순찬,이영준,주영태,정치영,정상호,박태진,곽승진박지호,이정희1,Mi-Sook Ma,Eun-Jung Jung,Ju-Yeon Kim,Sang-Kyeong Choi,Soon-Chan Hong,Yeong Jun Lee,Young-Tae Joo,Chi- Young Jeong,Sang-Ho Jeong,Tae-Jin Park,Seung-J 대한갑상선-내분비외과학회 2014 The Koreran journal of Endocrine Surgery Vol.14 No.1
Hyalinizing trabecular tumor (HTT), a type of thyroid lesion, was first reported by Carney in 1987 and has since been reported continuously. Due to its histological non-specificity, HTT can be misdiagnosed as papillary thyroid cancer or medullary thyroid cancer. For this reason, over treatment might occur; for example, total thyroidectomy and lymphade-nectomy. Diagnosis and treatment is a challenge because there is still controversy regarding HTT characters. We report on two cases. One patient was a 48-year-old female and the other was a 46-year-old female. Both patients complained of a thyroid mass and were diagnosed as HTT.
한국인에서 XPC 유전자의 다형성과 원발성 폐암의 위험도
김경록 ( Kim Gyeong Log ),이수연 ( Lee Su Yeon ),최진은 ( Choe Jin Eun ),김경미 ( Kim Gyeong Mi ),장상수 ( Jang Sang Su ),정치영 ( Jeong Chi Yeong ),강경희 ( Kang Gyeong Hui ),전경녀 ( Jeon Gyeong Nyeo ),차승익 ( Cha Seung Ig ) 대한결핵 및 호흡기학회 2002 Tuberculosis and Respiratory Diseases Vol.53 No.2