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Interleukin-1으로 유도된 흰쥐 급성폐손상에서 Aerosolized Vitamin-E의 전처치 효과
정진홍 ( Jin Hong Chung ),신경철 ( Kyeong Cheol Shin ) 영남대학교 기초/임상의학연구소 2007 Yeungnam University Journal of Medicine Vol.24 No.2S
Background:Interleukin-1 (IL-1) and neutrophil appear to contribute to the pathogenesis of acute respiratory distress syndrome (ARDS). Reactive oxygen species, as well as elastase released from activated neutrophil, are thought to play pivotal roles in the experimental models of acute lung leak. This study investigated whether aerosolized vitamin E can attenuate acute lung injury induced by IL-1 in rats. Materials and Methods:We intratracheally instilled either saline or IL-1 with and without pretreatment with aerosolized vitamin E in rats. After 5 hours of intratracheal instillation, lung lavage neutrophils, lung lavage protein concentration, lung myeloperoxidase (MPO) activity and lung wet weight to dry weight ratio (WW/DW) were measured in rat. Results:In rats given IL-1 intratracheally, lung lavage neutrophils, lung lavage protein concentration, lung MPO activity and WW/DW were higher, Pretreatment with aerosolized vitamin E decreased lung lavage neutrophils, lung MPO activity and WW/DW in rats given IL-1 intratracheally. 1) Conclusion:These results suggest that direct pulmonary supplement of vitamin E decreases lung inflammation and leak in rats given IL-1 intratracheally.
고립성 폐결절의 감별진단에서 Dynamic CT의 역할
정진홍 ( Jin Hong Chung ),박원종 ( Won Jong Park ),조인호 ( Ihn Ho Cho ) 영남대학교 기초/임상의학연구소 2008 Yeungnam University Journal of Medicine Vol.25 No.2
Background:Malignant pulmonary nodules account for 30 to 40 percent of all solitary pulmonary nodules (SPNs). Therefore, characterization of SPNs is very important for treatment. Recently, dynamic CT has been widely used for tissue characterization and formation of differential diagnoses. The purpose of this study was to evaluate the ability of dynamic CT to formulate the differential diagnosis of SPNs. Materials and Methods:Nineteen patients with SPNs underwent dynamic CT (unenhanced scans, followed by a series of images at 20, 40, 60, 80, 100, 120, 140, 160, and 180 sec after intravenous injection of contrast medium). Diagnosis of SPN was performed based on pathologic findings in needle biopsy samples. Peak enhancement, net enhancement, slope of enhancement, and maximum relative enhancement ratio of the SPN were measured on dynamic CT, and Levene`s test was performed to assess benignancy and malignancy. Results:Twelve SPNs were confirmed to have malignant pathology. There were no significant differences between benign and malignant nodules with respect to peak enhancement (p=0.787), net enhancement (p=0.135), or slope of enhancement (p=0.698). The maximal enhancement ratio was increased in malignancy compared to benignancy, but the difference was not statistically significant (p=0.094). Conclusion:In our study, the hemodynamic characteristics of dynamic CT were not significantly different between benign and malignant nodules. Therefore, long-term studies of larger patient samples are required to confirm our findings.
급성심근경색에서 Doppler 심초음파도로 진단된 승모판폐쇄부전
정진홍(Jin Hong Chung),황진용(Jin Yong Whang),곽충환(Choong Hwan Kwak),채성철(Schung Chull Chae),전재은(Jae Eun Jun),박의현(Wee Hyun Park) 대한내과학회 1989 대한내과학회지 Vol.36 No.4
N/A In 40 patients with acute myocardial infarction (MI), mitral regurgitation (MR) was determined from the apical 4-chamber and parasternal long-axis views with pulsed Doppler and compared with physical and echocardiographic findings. MR was detected in 19 of the 40 patients (48%) and had a similar frequency in patients with anterior (12 of 24 or 46%) and inferior MI (7 of 14 or 50%). A systolic murmur was heard in 8 of 19 patients with MR detected by Doppler and the murmur was directly related to the degree of Doppler MR, Left atrial and left ventricular (LV) dimensions, mitral annulus circumference and LV ejection fraction were similar in patients with and without Doppler MR. However, the prevalence of Dopopler MR in patients with an LV ejection<30% and/or LV diastolic dimension>5.7cm was 71% (12 of 17) but in those without both it was only 30% (7 % of 23).