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간경보사(肝經補瀉)가 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine로 유도된 파킨슨병 동물 모델에 미치는 영향
김승태 ( Seung Tae Kim ),박히준 ( Hi Joon Park ),채윤병 ( Youn Byoun Chae ),김연정 ( Yun Jung Kim ),강민정 ( Min Jung Kang ),정미영 ( Mi Young Jung ),정주호 ( Joo Hoo Chung ),함대현 ( Dae Hyun Hahm ),이상재 ( Sang Jae Lee ),이혜정 대한경락경혈학회 2006 Korean Journal of Acupuncture Vol.23 No.4
Objectives: This study was designed to compare the effects of tonification and sedation methods of Liver Meridian in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson`s disease mice model. Methods: We injected MPTP (30 mg/kg, i.p.) or saline for 5 consecutive days. Acupuncture treatments were given to the mice with MPTP at LR8 and LR4 to tonify Liver Meridian (Liver+) or LR4 and LR2 to sedate it (Liver-) for 12 day. At the 12th day after first injection, mice were perfused, and then tyrosine hydroxylase (TH)-immunohistochemistry was performed in substantia nigra (SN) of their brains. After counting the number of TH-positive neurons, we compared their numbers among experimental groups. Results: The number of TH-positive neurons of Liver+ group was significantly increased compared to that of MPTP group in the SN. That of Liver- group was also increased more than MPTP group, but not significantly. Conclusions: Tonifying Liver Meridian might be effective therapeutic tools for the neuroprotection in subchronic MPTP-induced mice model.