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임성혁,정주철,정지훈 중앙대학교 의과대학 의학연구소 2007 中央醫大誌 Vol.32 No.4
Acanthopanax senticosus is a widely used oriental drug that has an immunomodulating and homeostatic effect on human body. The aims of the present study were to investigate an effect of an extract of Acanthopanax senticosus on hair loss in balding C57BL6 mice. In order to evaluate the effect of the treatments, C57BL6 mice were treated daily for 3 weeks on half of the dorsal skin with 5% minoxidil, Acanthopanax extract and saline. After the treatments, we measured hair growth with naïve eye, testosterone level and follicle number with histological assay. Saline-treated mice showed no effect on restoration of hair loss in each experiment. However, both of minoxidil and Acanthopanax extract had a mild effect on hair growth with naïve eye observation. In contrast, histological assay showed that Acanthopanax extract restored the number and activity of hair follicles more than 5% minoxidil. The testosterone level was kept higher in Acanthopanax group than in 5% minoxidil group. These results reveal that Acanthopanax senticosus may be an alternative therapy for hair loss.