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두경부암 환자에서 식도암의 선별검사로서의 협대역 영상 내시경의 유용성
정재훈 ( Jae Hoon Cheong ),김광하 ( Gwang Ha Kim ) 대한소화기학회 2010 대한소화기학회지 Vol.56 No.1
협대역 영상(narrow band image, NBI) 시스템은 미세혈관구조와 점막의 패턴을 보여줄 수 있는 새로운 기술로, 특히 표재성 식도 병변의 확대 영상 평가 시 유용한 것으로 알려져 있다. 이번 연구는 두경부암 환자들에서 식도암에 대한 선별검사로서 NBI 내시경검사의 유용성을 평가 하기 위하여 수행되었다. 일본 오카야마대학병원에서 2006년 4월부터 2008년 6월까지 두경부 편평세포암종(squamous cell carcinoma, SCC)으로 진단된 142명의 환자를 대상으로 NBI 내시경검사 후 루골 색소 내시경검사를 시행하여, SCC와 고도 상피내이형성(high grade intraepithelial neoplasia, HGIN)의 발견율을 평가하였다. 환자군의 평균 나이는 64세(29-86세)였고 약 3/4이 남성이었다. 16명의 환자에서 총 21개의 병변이 NBI 내시경검사 도중에 발견되었으며, 이 중 4개의 병변은 조직검사에서 SCC, 11개의 병변은 HGIN으로 진단되었다. 이외에도 루골 색소 내시경검사 후 추가적으로 5 mm 이상의 루골 불염대가 19명의 환자에서 22개가 발견 되었고, 이 중 1개의 병변은 HGIN으로, 나머지 21개의 병변은 저도 상피내이형성(low grade intraepithelial neoplasia, LGIN) 또는 이상소견이 없는 병변이었다. 식도 SCC와 HGIN를 발견하기 위한 NBI 내시경검사의 민감도는 90.9%(95% 신뢰구간, 58.7-99.8), 특이도는 95.4% (95% 신뢰구간, 90.3-98.3), 정확도는 95.1% (95% 신뢰구간, 90.1-98.0)이었다. 결론적으로 NBI는 두경부암 환자에서 식도 SCC에 대한 선별검사로서 유용하고 신뢰할 만한 검사라 할 수 있겠다.
선천적 등쪽 췌장 발육 부전증을 동반한 다비장 증후군 환자에서 나타난 급성 췌장염 와 내시경 초음파의 역할
정재훈 ( Jae Hoon Jeong ),김광하 ( Gwang Ha Kim ),송근암 ( Geun Am Song ),이동건 ( Dong Gun Lee ),문지윤 ( Ji Yoon Moon ),정재훈 ( Jae Hoon Cheong ),김석 ( Suk Kim ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.1
A 49-year-old female was admitted to our hospital for acute pancreatitis. The abdomen CT scan incidentally showed midline liver with hepatomegaly, centrally located gallbladder, pancreas truncation, right sided small bowel, left sided large bowel, interruption of the inferior vena cava with azygos continuation, preduodenal portal vein, and multiple spleens in the left upper quadrant. In MRCP, the head of pancreas was enlarged and short main pancreatic duct without accessory duct was showed. EUS revealed enlarged ventral pancreas with a main pancreatic duct of normal caliber, absence of the accessory pancreatic duct and the dorsal pancreas. She was diagnosed as polysplenia syndrome with agenesis of dorsal pancreas. It is a rare congenital anomaly frequently associated with various visceral anomalies including multiple spleens, impaired visceral lateralization, congenital heart diseases, gastrointestinal abnormalities and azygos continuation of the inferior vena cava. We report a case of polysplenia syndrome with agenesis of dorsal pancreas presenting acute pancreatitis. (Korean J Gastroenterol 2012;60:47-51)
알코올 중독 형성에 관여하는 신경생물학적 요소들에 관한 고찰
정재훈(Jae Hoon Cheong) 대한약학회 2017 약학회지 Vol.61 No.6
Alcoholism known as alcohol use disorder is a complex psychiatric disease with alcohol dependence and abuse. Addiction formation and the severity are determined by psychological, genetic, biological and social factors. Genetic vulnerability is important in alcoholism development. Gene candidates working on each step in addiction formation are reported by Genome-Wide Association Studies. Also, repeated drinking is reported to induce epigenetic changes. It is accepted that the major neural circuit influencing on the formation of alcoholism is the dopaminergic pathway comprising ventral tegmental area, nucleus accumbens, and prefrontal cortex. The dopaminegic system is modulated by GABA, glutamate, serotonergic neurons and opioid system. In addition, changes in dendrites, BDNF and neural cell number play an important role in the formation of alcoholism. Pharmacotherapy for alcoholism includes making alcohol ingestion unpleasant and reducing its reinforcement.
GRIN3A가 과발현된 유전자 조작 마우스의 행동특성 연구
우태선,정재훈,Woo, Taeseon,Cheong, Jae Hoon 대한약학회 2016 약학회지 Vol.60 No.4
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels that play a significant role in synaptic plasticity, learning, memory, and other behaviors. NMDARs are composed of various subunits and display unique properties depending on their subunit composition. The GluN3A subunit is thought to suppress NMDAR activity, however its exact function has not been well studied. Thus, we designed a transgenic mice overexpressing GRIN3A to assess the role of this gene on various behaviors. GRIN3A-overexpressing mice were subjected to an array of behavioral experiments including locomotor activity test, rota-rod test, elevated plus-maze (EPM) test, and Y-maze test. GRIN3A-overexpressing mice displayed hypoactivity but no effects on the rota-rod test, EPM test and Y-maze test. The GRIN3A-overexpressing mice that we have created can be utilized in elucidating the role of the GRIN3A gene and its product, the GluN3A subunit of NMDARs, on various behaviors associated with neuropsychiatric disorders, such as ADHD, and in finding possible therapeutic targets for these disorders.
Illite 분제 원액의 육모 활성 시험 및 단회 투여 경구 독성시험
이충재(Choong Jae Lee),박형섭(Hyung Sup Park),임동술(Dong Sool Yim),김박광(Bak Kwang Kim),정재훈(Jae Hoon Cheong) 한국응용약물학회 2001 Biomolecules & Therapeutics(구 응용약물학회지) Vol.9 No.4
N/A The hair-growth effect of Illite was suggested by some people who were using Illite as a beautifying material. We investigated the hair-growth effect of Illite powder. The hair-growth effects were investigated by two methods; the activity of hair-growth after shaving the hairs on the black mouse (C57BL/6) and the recovery activity of hair-growth after hair-loss induced by cyclophosphamide treatment. Suspension of Illite powder was applied to the back of the black mouse by method of skin paste. Illite promoted significantly the hair growth of mouse in both conditions of shaving and hair-loss. And then we investigated the toxicity which may be induced by Illite when it was administrated orally as a single dose. We could not find out any significant toxicity induced by single dose oral administration of Illite.
진행성 췌장암을 가진 노인환자에서 Gemcitabine 항암화학요법의 안정성과 효과 - 노인에서 Gemcitabine의 안정성 -
최유이,김동욱,정재훈,이봉은,김광하,송근암,You Ie Choi,Dong Uk Kim,Jae Hoon Cheong,Bong Eun Lee,Gwang Ha Kim,Geun Am Song 대한소화기암연구학회 2013 Journal of digestive cancer reports Vol.1 No.1
Background/Aims: Gemcitabine is regarded as a reference regimen for advanced pancreatic cancer and shows relatively safe toxicity profiles compared with other cytotoxic agents. However, many oncologists are appeared to be still reluctant to treat elderly pancreatic cancer patients with cytotoxic chemotherapy because of predicted low response rate and potential adverse events. Methods: All patients who were received gemcitabine based chemotherapy between 2007 and 2010 were identified and clinical, laboratory, radiographic data were retrospectively reviewed. Patients were divided into two groups based on their ages: less than 65, and equal or more than 65 years old. Gemcitabine, at a dose of 1,000 mg per square meter of body surface area, was administered by intravenously over 30 minutes weekly for 3 weeks followed by 1 week rest, alone or along with other chemotherapeutic agents including cisplatin, capecitabine and erlotinib. Results: A total of 61 patients were identified and all patients were not eligible to receive operation because of advanced stage at diagnosis. Twenty three patients (37.7%) were equal or more than 65 year of age. Mean age was 56 years old and 71 years old in each group. Laboratory data including CA 19-9 were not significantly different. More gemcitabine monotherapy was delivered (56.5% vs. 26.3%, p=0.029) and less second or third line therapy was adminis- tered (17.4% vs. 50.0%, p=0.014) in elderly group. Cholangitis occurred and stent placement were performed similarly in both groups. Conclusion: Gemcitabine based chemotherapy can be administered safely to elderly pancreatic cancer patients and comparable response rate and progression free survival can be expected as young patients.