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태반 영양모세포주의 class I 인체백혈구 항원 발현에 미치는 감마 인터페론의 역할
정인배 ( In Bai Chung ),한혜경 ( Hey Kyoung Han ),김나옥 ( Na Ok Kim ),하정식 ( Jung Sik Ha ),박현숙 ( Hyun Sook Park ),박주영 ( Joo Young Park ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.2
지난 반세기 동안 태아가 모체의 면역 거부반응으로부터 회피될 수 있는 기전은 아직까지 정확히 규명되지 못하고 있다. 태아모체간 계면에서의 면역학적 기전이상은 자연 유산 및 습관성 유산을 비롯한 각종 임신 합병증들의 병인으로 작용하므로 그 기전 규명은 매우 중요하다. 핵심은 융모외 세포영양모세포 (extravillous cytotrophoblasts)가 표현하는 인체백혈구 항원 (HLA-C, E, G)과 NK 세포 수용체 (receptor)들과 상호 관계 Precise mechanism which the fetus can escape from mother`s immune rejection is not well understood yet during last 50 years. The clarification of immune mechanism at the feto-maternal interface is very important, because this can be a common pathogenesis
태반 영양모세포주의 혈관내피성장인자 분비에 미치는 Th1형 사이토카인들의 영향
정인배(In Bai Chung),최선주(Sun Ju Choi),홍민(Min Hong),최현일(Hyun Il Choi),이영심(Young Sim Lee),고춘명(Choon Myung Koh),박주영(Joo Young Park) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.5
N/A Embryo implantation and development are critically dependent upon the regulation of angiogenesis and adequate immunologic acceptance. These local angiogenesis and vascular permeability are regulated by the interaction between fetal trophoblast, uterine decidua, and endothelial cells through the key mediator, vascular endothelial growth factor (VEGF). Problem : The mechanism through which VEGF regulation occurs at the feto-maternal interface is poorly understood. The Th1 type cytokines are known to be harmful to the successful maintenance of early pregnancy at the feto-maternal interface. Objective : To clarify whether the Th1 type cytokines could be involved in the regulation of VEGF secretion at the feto-maternal interface. Method of Study : we investigated the effects of Th1 type cytokines on VEGF secretion in human first trimester trophoblast cell-line by using reverse transcription polymerase chain reaction(RT-PCR)and enzyme-linked immunosorbent assay (ELISA). Results : The trophoblast cells expressed VEGF constitutively and the main isoforms were VEGF121 and VEGF165. When cultured in the presence of IFN-γ or IL-2, VEGF secretion was most significantly increased by IFN-γ treatment but not affected by IL-2 treatment. The level of intracellular VEGF was also increased by IFN-γ treatment. Conclusion : These results suggest that IFN-γ, despite of harmful Th1 type cytokine to the maintenance of early pregnancy, may regulate the production of VEGF in early gestational trophoblasts.
산전 초음파로 진단된 무뇌증이 동반된 Cantrell씨 증후군
조형찬 ( Hyoung Chan Cho ),정인배 ( In Bai Chung ),최성진 ( Seong Jin Choi ),이용희 ( Yong Hee Lee ),하종원 ( Jong Won Ha ),이정주 ( Jung Ju Lee ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.12
Pentalogy of Cantrell was very rare congenital anomaly and represent a regional prevalence of 5.5/1 million live births. The syndrome, Cantrell`s pentalogy is characterized by defects in the lower sternum with ectopia cordis, anterior diaphragm defects, m
발육제한 태아에서 placental ratio 와 신생아 이환률과의 관계
이준희(Jun Hee Lee),정인배(In Bai Chung),이영심(Young Sim Lee),최중호(Jung Ho Choi),이정렬(Jeong Yel Lee),한혁동(Hyuck Dong Han),이영진(Young Jin Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.12
N/A An increased placental ratio has known to be associated with the occurrence of cardiovascular complications in adulthood among the intrauterine fetal growth restriction. A retrospective study on 202 singleton growth-restricted infants without major congenital anomalies born from Jan. 1995 to Feb. 2001 was performed to determine the relationship between placental ratio and neonatal morbidity. The cases were categorized into three groups according to the placental ratio (<1SD below the mean, within 1SD of the mean, >1SD above the mean). There were no differences in the maternal characteristics and antenatal complications except pregnancy induced hypertension between high placental ratio group and the other groups. It presented the trend that was toward the increase of placental weight and the decrease of birth weight in high placental ratio group. The infants with a high placental ratio had increasing tendencies of meconium stained amnionic fluid, hypocalcemia, phototherapy, asphyxia.