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신장 이식 환자에서 통상적인 용량의 비스무트 포함 약제 복용 후 발생한 피부 과다색소침착 1예
최우석 ( Woo Suk Choi ),최하늘 ( Han Ul Choi ),정지용 ( Ji Yong Jung ),장제현 ( Jae Hyun Chang ),정우경 ( Woo Kyung Chung ),이현희 ( Hyun Hee Lee ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.6
A 59-year-old male presented with multiple hyperpigmented skin with hyperkeratotic scaly patches on hands, feet and face. Bismuth containing compound had been prescribed two months before then due to epigastric pain, an adverse effect of steroid pulse therapy for acute rejection of transplanted kidney. Laboratory findings showed acute kidney injury and elevated liver enzyme. He stopped taking bismuth containing compound and all symptoms were gone after two months. Although there is no report on interaction between bismuth and immunosuppressant, it requires precaution to prescribe bismuth containing compounds in transplanted patients with acute kidney injury.
진기남,정우경,장승연,Jin, Ki-Nam,Chung, Woo-Kyung,Jang, Seung-Yon 대한예방의학회 1997 예방의학회지 Vol.30 No.2
The purpose of this study is to examine the factors influencing the allergic rhinitis patients' satisfaction with laser surgery. The data were collected by telephone interviews with 211 patients who visited I university hospital. The statistical methods used for the analysis were factor analysis, reliability test, and hierarchical multiple regression. We find that satisfaction level is a function of not only the surgery outcome but also the socio-psychological experience during treatment. With the improvement in nasal allergic condition, patients were more likely to be satisfied with medical services. And patients who had positive experience with physicians and facilities reported higher satisfaction level. While the surgery outcome explained 68% of the variation of satisfaction level, socio-psychological experience explained 23% of it. This result clearly shows that physicians need to pay attention to the socio-psychological aspect as well as the technical aspect of medical services.
증례 : 신장 ; 결절성경화증 환자에서 신장과 간 혈관근지방종 및 폐 침범 2예
이현희 ( Hyun Hee Lee ),정우경 ( Woo Kyung Chung ),장제현 ( Jae Hyun Chang ),정지용 ( Ji Young Jung ),성지윤 ( Ji Yoon Sung ),나선영 ( Sun Young Na ),성연미 ( Yon Mi Sung ) 대한내과학회 2010 대한내과학회지 Vol.79 No.6
결절성경화증은 지능저하, 간질, 피지선종이 특징적으로 나타나는 상염색체 우성 유전 질환으로 뇌, 눈, 심장, 폐, 간, 콩팥, 피부 등 여러 장기에 양성 종양성 병변을 일으키는 질환이다. 혈관근지방종은 혈관, 평활근, 지방조직으로 구성된양성 종양으로, 결절성경화증과 연관되어 발생하는 경우도 많다. 혈관근지방종은 신 실질에 가장 흔하며, 이외 간, 비장, 자궁관, 림프조직 등의 복부 장기 및 폐, 심장에서 발생하기도 한다. 결절성경화증에서 종양이 여러 장기에 동시에 생긴예는 매우 드물다. 저자들은 결절성경화증 환자에서 신장과간에 혈관근지방종이 있고 임파관평활근종증 혹은 다발성 미세결절폐세포증식증 등의 폐 침범을 나타내는 2예를 경험 하였기에 보고하는 바이다. Tuberous sclerosis (TS) involves multiple organs. Angiomyolipoma of the liver or kidney is one of the clinical manifestations of TS. However, coexistent renal and hepatic angiomyolipoma associated with TS is a rare condition. Pulmonary involvement is extremely rare, and occurs in only 0.1~1% of TS. We report two cases of concurrent renal and hepatic angiomyolipomas with pulmonary involvement in patients with TS. The first case was a 35 year-old woman who showed multiple angiomyolipomas in the liver and both kidneys and cystic parenchymal changes in the lungs. The other case was a 27-year-old woman who showed multiple angiomyolipomas in the liver and both kidneys, and multinodular pulmonary shadows. To the best of our knowledge, this is the first reported case of renal and hepatic angiomyolipomas associated with pulmonary involvement in Korea. (Korean J Med 79:705-709, 2010)
증례 : 진성다혈구증에 병발된 사구체간질 증식성 사구체 신염 1예
박철희 ( Cheul Hee Park ),정낙소 ( Nak So Chung ),정우경 ( Woo Kyung Chung ),방수미 ( Soo Mee Bang ),이종호 ( Jong Ho Lee ),정재걸 ( Jae Gul Chung ),이준승 ( Joon Seung Lee ) 대한내과학회 2005 대한내과학회지 Vol.69 No.-
진성다혈구증과 동반한 사구체신염의 병발은 매우 드문 것으로 보고되어 있다. 진성다혈구증에 병발한 사구체간질 증식성 사구체신염의 보고가 있었으나 면역형광 현미경 검사가 없어서 IgA 신증을 배제하지 못하였다. 저자들은 단백뇨 및 비장비대를 주소로 내원한 환자에서 면역형광 현미경검사를 포함한 신생검으로 사구체간질 증식성 사구체신염과 세계보건기구 진단 기준에 따른 진성다혈구증으로 진단된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. There are only a few reports of glomerulonephritis associated with polycythemia vera (PV). These cases include diffuse mesangial proliferative glomerulonephritis (mesPGN), Henoch-Schonlein purpura nephritis, focal segmental glomerulonephritis and IgA nephropathy. In 1983, Plomley et al. reported on 3 cases of mesPGN in patients with PV for the first time. However the possibility that these cases were IgA nephropathy could not be excluded since there was no data of electron microscopic or immnunofluorescent (IF) study. We report a case of idiopathic mesPGN combined with PV. A 46-year-old male was referred to our hospital because of proteinuria and splenomegaly on his routine medical examination. While undergoing investigation for the proteinuria, the patient was found to have a high hemoglobin (22.3 g/dL) and hematocrit (68.8%) levels. At that time, the urinary protein excretion was 3.0 g in 24 hour. We diagnosed the patient as a case of PV by World Health Organization criteria. The renal biopsy revealed focal mesangial proliferation with expansion of the matrix. On IF study, there was no deposition of IgA, IgG and C3 in the mesangium. (Korean J Med 69:S884-S889, 2005)
김근호(Gheun Ho Kim),진호준(Ho Joon Jin),정우경(Woo Kyung Chung),안규리(Cu Rie Ahn),김성권(Suhng Gwon Kim),이정상(Jung Sang Lee) 대한내과학회 1995 대한내과학회지 Vol.49 No.1
N/A Objectives: Past researches on the biochemical properties and pathogenicity of hantavirus have been mainly from rodent isolates, and we performed this study to obtain human isolates from patients with hemorrhagic fever with renal syndrome (HFRS) and to analyze the rate and source of viral isolation. Methods: Blood and urine specimens were collected from 48 patients with HFRS and inoculated onto subconfluent monolayers of Vero-E 6 cells, and human isolates of hantavirus were identified by direct and indirect immunofluorescent techniques, immunoblot analysis, and reverse transcriptase-directed polymerase chain reaction(RT-PCR). Results: Nineteen viral isolates(31 samples) were recovered from the blood and urine of 48 patients(90 samples) during days 3-11 following the onset of illness. Isolation rates of the virus from whole blood, serum, plasma, urine, and peripheral blood monuclear cells were 75%, 30%, 25%, 25%, and 18%, respectively. Viruses were more frequently isolated during days 3-9 of the illness(37%) than after day 9 (17%). Specific hantavirus antigens of isolates were identified by both indirect and direct immunofluorescent techniques and immunoblot analysis. The hantairus genomic sequences were detected in some of the isolates by RT-PCR. Conclusion: Nineteen hatavirus isolates were successfully recovered from 48 HFRS patients, mainly in the whole blood. Further investigations will be required to elucidate the differences in the pathogenicity of these human isolates using serologic and molecular biologic methods.
증례 : 신장 ; 복막투석 환자에서 발생한 Tsukamurella tyrosinosolvens 복막염 1예
박재찬 ( Jae Chan Park ),홍준식 ( Jun Shik Hong ),서종구 ( Jong Goo Seo ),정우경 ( Woo Kyung Chung ),서일혜 ( Yiel Hae Seo ),이현희 ( Hyun Hee Lee ) 대한내과학회 2009 대한내과학회지 Vol.76 No.2
복막염은 지속적 외래 복막투석 환자에서 가장 흔한 감염성 합병증이다. Tsukamurella속에 의한 복막염은 외국에 2예의 보고가 있었으나 국내에는 아직 보고된 증례가 없기에 문헌고찰과 함께 저자들이 경험한 증례를 보고하는 바이다. Tsukamurella속은 정확한 균주의 동정이 어렵고 고식적인 항균제 치료에 반응을 보이지 않기 때문에 난치성 복막염에서 항산성의 균이 관찰되거나 그람 양성 간균이 반복적으로 동정되었을 때 Tsukamurella속을 원인 균으로서 생각해 보아야 하며 근절을 위해서는 복막 투석용 도관의 제거를 고려하여야 한다. A case of Tsukamurella peritonitis associated with continuous ambulatory peritoneal dialysis (CAPD) in a 54-year-old woman is described. Peritonitis is a common complication of peritoneal dialysis in patients with end-stage renal disease. Tsukamurella has been reported to cause rare opportunistic infections in humans, and most cases have been reported in immunocompromised patients or patients with indwelling foreign bodies. This organism is difficult to identify and has been mistaken for Corynebacterium and atypical Mycobacteria. Here, we describe the first case of CAPD-related peritonitis caused by Tsukamurella tyrosinosolvens in Korea. It was treated with CAPD catheter removal. (Korean J Med 76:225-228, 2009)