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불균질 대수층에서 유선 시뮬레이션을 이용한 다수 오염원의 용질 이동 모사
정승필,최종근,Jung Seung-Pil,Choe Jong-Geun 한국지하수토양환경학회 2005 지하수토양환경 Vol.10 No.3
2차원 불균질 대수층에서 다수의 오염원이 있음 경우 오염물의 거동을 모사할 수 있는 방법을 제시하였다. 이 방법은 유선 시뮬레이션을 기반으로 하며 다차원의 계산을 다수의 일차원으로 분해하여 계산하는 방법으로서 불균질한 매질에서 수두 계산을 한 후, 관심영역에 유선을 분포시키고 그 유선을 띠라 오염물이 전파되는 농도를 계산한다. 개발된 모델을 Visual MODFLOW를 이용하여 검증하였고 시간에 따른 농도 분포나 관측정에서의 용질 도달 곡선이 잘 일치함을 확인할 수 있었다. 개발된 모델은 시뮬레이션 수행 시간에 대한 효율 면에서 Visual MODFLOW보다 뛰어나 많은 연산을 필요로 하는 대규모 대수층의 용질거동 예측이나 반복 계산을 필요로 하는 역산 모델링에서 효과적으로 사용될 수 있다. This study presents a contaminant transport model suitable for a 2-dimensional heterogeneous aquifer with multiple contaminant sources. It uses a streamline simulation, which transforms a multi-dimensional problem into multiple 1dimensional problems. It runs flow simulation, streamline tracking, and calculation of contaminant concentrations by turns. The model is verificated with a Visual MODFLOW by comparing contaminant concentration distributions and breakthrough curves at an observation well. Due to its fast simulation, it can be applied to time consuming simulations such as in a fine-grided aquifer, an inverse modeling and other applications.
가족집적성을 보이는 B형간염 바이러스 만성보유자에서 바이러스 유전자의 돌연변이와 주조직접합체 양상 - 질병발현 형태와의 관련성을 중심으로 -
정승필,이효석,김정룡,안윤옥,Jung, Seung-Pil,Lee, Hyo-Suk,Kim, Chung-Yong,Ahn, Yoon-Ok 대한예방의학회 2000 Journal of Preventive Medicine and Public Health Vol.33 No.3
Objectives : Chronic HBsAg carriers are the principal source of infection for other susceptible people, and are themselves at high risk of developing serious liver diseases. In Korea, it has been estimated that 65-75% of the HBsAg positives remained as persistent carriers. Additionally, familial clustering of MBV infection has frequently been observed among carriers. Some would become progressive, chronic hepatitis patients, and others would not. The aim of this study was to evaluate the association between various factors, such as the duration of infection, type of virus, mutation of precore/core region in HBV, major histocompatibility class-I, and developing chronic liver diseases among familial HBV carriers. Methods : Chronic carrier status was identified by repeated serological tests for HBsAg at intervals of six months or more. A familial chronic carrier was defined when the disease was observed in a family member over two generations. Two families were recruited, among which a total of 20 chronic HBsAg carriers(11 carriers in No.1, and 9 in No.2 family) were identified. Data on the general characteristics and liver disease status were collected. Identification of the HBV-DNA was successful only for 13 subjects among the 20 carriers. Analysis of viral DNA in terms of subtype, pre-core and core region mutations was carried out. The type of major histocompatibility class-1 for the 13 subjects was also analysed. Results & Conclusions : Seven of 10 chronic HBV carriers of the 1st generation and one of 10 of the 2nd generation were clinical patients with chronic hepatitis, the others, three of the 1 st and nine of the 2nd generation, were asymptomatic carriers. This data indicates that the duration of HBV carriage is one of the major factors for disease severity. The subtype of HBsAg analysed using MBV-DNA identified in 13 carriers were adr, and the pattern of precore nonsense mutation in HBV-DNA was identical among family members, which meads that the same virus strains were transmitted between the family members. The association between the precore or core mutations in HBV-DNA and the disease severity was not observed. While it was suggested that a specific type of MHC class-I may be related to disease progression.
원발성 알도스테론증으로 부신 절제술 받은 환자의 수술 후 결과에 대한 분석
류재민,정승필,이정희,김지영,최민영,이세경,길원호,최준호,이정언,김지수,남석진,양정현<SUP>1<.SUP>,김정한,Jai-Min Ryu,M.D.,Seung-Pil Jung,M.D.,Jeong-Hee Lee,M.D.,Ji-Yeong Kim,M.D.,Min-Yeong Choi,M.D.,Se-Kyung Lee,M.D.,Won-Ho Kil,M.D.,Jun-Ho C 대한갑상선-내분비외과학회 2011 The Koreran journal of Endocrine Surgery Vol.11 No.4
Purpose: Primary aldosteronism (PA) is characterized by hypertension (HTN), hypokalemia, suppressed plasma renin activity, and inappropriate aldosterone secretion. The purpose of this study was to analyze postoperative results on blood pressure (BP), and to determine the factors associated with resolution of HTN after adrenalectomy for PA. Methods: One hundred eight patients (66 females and 42 males) with a mean age of 46 years underwent adrenalectomy for PA between January 1, 1996 and September 30, 2009. Their clinical characteristics and biochemical parameters were reviewed retrospectively. Results: All patients had HTN preoperatively and 20 patients (18.1%) had uncontrolled HTN. Hypokalemia was evident in 89.1% of patients, cardiovascular events in 4.5% and cerebrovascular events in 8.2%. There was a significant decrease in both systolic BP and diastolic BP postoperatively, as compared with that before operation. Median systolic BP decreased from 150 mmHg to 125 mmHg at the last follow-up (P<0.01), and median diastolic BP decreased from 93.5 mmHg to 81.5 mmHg (P<0.01). Sixty two (57.4%) patients were cured of HTN and did not require any hypertensive agent, and 38 (35.1%) patients had an improvement in BP control, whereas 9 (8.3%) patients had no change in BP. Univariate analysis showed that duration of HTN and more than two HTN treatment agents were independent factors predicting sustained hypertension after surgery. Conclusion: The duration of HTN and the severity of HTN are factors influencing persistence of HTN after operation for a PA. (Korean J Endocrine Surg 2011;11:276-282)
변형 근치 경부 림프절 절제술시 Iron-Intern 사용의 초기 경험
박융석<SUP>1<,SUP>,정승필<SUP>1<,SUP>,구민영<SUP>2<,SUP>,최준호<SUP>1<,SUP>,김정한<SUP>1<,SUP>,김지수<SUP>1<,SUP>,Yoong Seok Park<SUP>1<,SUP>,Seung Pil Jung<SUP>1<,SUP>,Min Young Koo<SUP>2<,SUP>,Jun-Ho Choe<SUP>1<,SUP> 대한갑상선-내분비외과학회 2013 The Koreran journal of Endocrine Surgery Vol.13 No.1
Purpose: Modified radical neck dissections (MRND) in papillary thyroid cancer surgery usually leave a long incision in the neck, causing cosmetic problems. We introduce a new surgical approach to MRND, with minimal lateral extension of transverse collar incisions, using the Iron-Intern. Methods: Between Jan 2008 and Dec 2008, 135 patients with papillary thyroid cancer who had undergone MRND were enrolled in this study. Total thyroidectomy and central node dissection with Kocker transverse collar incision with minimal additional lateral extension were performed before MRND. MRND were performed including level II, III, IV and V. Among 135 patients, we performed MRND with the Iron-Intern in 70 patients (Group I) and 65 patients who had MRND performed without the Iron-Intern (Group II) were included as a control group. In Group I, the Iron-Intern, with some modifications, was applied during the dissection of the level II area. The postoperative outcomes of the patients were analyzed and compared retrospectively. Results: The median hospital stay was significantly lower in Group I compared to Group II (P=0.003). The median operation time was significantly higher in Group I than Group II (P=0.002). The median numbers of harvested central and lateral lymph nodes were 10, 29 (group I) and 8, 23 (group II), respectively (P=0.073, P=0.148). Median levothyroxine off thyroglobulin levels were 1.2 and 1.8 in Group I and II, respectively (P=0.110). Conclusion: MRND, with minimal lateral extension using the Iron-Intern, can be easily and safely performed, leaving only minor scars in the neck.
정평안 ( Pyung An Jung ),정승필 ( Seung Pil Jung ),이정희 ( Jung Hee Lee ),김지영 ( Ji Yeong Kim ),최민영 ( Min Yeong Choi ),이세경 ( Se Kyung Lee ),최준호 ( Jun Ho Choe ),이정언 ( Jeong Eon Lee ),김지수 ( Jee Soo Kim ),남석진 ( S 대한임상종양학회 2011 Korean Journal of Clinical Oncology Vol.7 No.2
목적: 최근 국내에서 발병이 증가하고 있는 피부암 환자에서 시행한 서혜부 림프절 곽청술의 술기를 소개하고 수술에 따른 합병증 및 수술 결과에 대해 고찰하고자 하였다. 방법: 2002년 3월부터 2010년 7월까지 피부암의 서혜부 림프절전이로 서혜부 림프절 곽청술을 시행한 43예의 환자를 대상으로 수술 후 합병증, 생존률, 재발 유무 등을 후향적으로 분석하였다. 결과: 서혜부 림프절 곽청술을 시행한 43명의 환자 중 편평 세포암 8명, 악성 흑색종 35명이었다. 평균 12.6개의 림프절을 절제하였고 평균 2.46개의 림프절에서 전이가 확인 되었다. 수술 후 35예(81.4%)의 환자에서 하지 림프 부종, 피부 괴사, 장액종의 합병증이 발생하였으나 모두 보존적 치료 후 호전되었다. 평균 24.5(3-83)개월의 외래 추적 관찰 기간 동안 20명(46.5%)의 환자에서 재발이 발생하였고 8명(18.6%)의 환자가 사망하였다. 결론: 림프절로 전이된 피부암은 불량한 예후를 보이고 서혜부림프절 곽청술은 많은 합병증을 동반하는 술식이지만 경험 있는 외과의에 의해 적절히 시행된다면 심각한 합병증과 재발을 줄일 수 있다. 국내에서 피부암은 드물 질환이지만 서혜부 림프절 곽청술의 술기 및 술후 경과에 대해 잘 파악하고 있는 것이 이 질환의 치료를 위해 중요하다. Purpose: To evaluate the results and experience of inguinal lymph node dissection in patients with skin cancer. Methods: 43 patients were underwent inguinal lymph node dissection for skin cancer spread to the lymph nodes in SMC between Mar 2002 and Jul 2010. We investigated postoperative complications, recurrence rate, survival rate from their medical records, retrospectively. Results: Among 43 patients, 35 cases were diagnosed as malignant melanoma and 8 were diagnosed as squamous cell carcinoma. 12.6 lymph nodes were retrieved, and 2.46 lymph nodes were metastasized on average. Complications such as lymphedema in lower extremities, skin necrosis, seroma were occurred in 35 patients (81.4%). But most were recovered with conservative management. During 24.5(3-83) months of follow up periods, 20 patients (46.5%) had recurrences of skin cancer and 8(18.6%) of them were expired. Results: Generally, skin cancer spread to lymph nodes shows poor prognosis and inguinal lymph nodes dissection is a procedure resulting in high rate of complications. However, if this is performed properly by experienced surgeons, the recurrence and serious complications could be reduced.
Predictining ADHD in children using Vibraimage technology
Imran Ashraf(임란 아시라프),Soojung Hur(허수정),Gunzung Kim(김건정),Seung-Pil Jung(정승필),Yongwan Park(박용완) 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.2
Attention deficit/hypersensitivity deficiency (ADHD) is one of the most common neurodevelopmental problems in children and adolescents. Differential diagnosis of ADHD is very difficult because its symptoms overlap with other diseases. Currently, ADHD is identified using subjective diagnosis which involves observing for various impulsive symptoms during different activities. An objective approach needs to be devised to diagnose ADHD for in time treatment. This study proposes Vibraimage technology to diagnose ADHD in children using a non-invasive approach.
의과대학생의 스마트폰 중독 척도와 사회심리학적 요인들과의 관계
김혜인 ( Hye In Kim ),천성희 ( Seong Hi Cheon ),강화정 ( Hwa Jeong Kang ),이근미 ( Keunmi Lee ),정승필 ( Seung Pil Jung ) 영남대학교 의과대학 2017 Yeungnam University Journal of Medicine Vol.34 No.1
Background: Smartphone addiction, academic stress and anxiety of university students are increasing gra-dually; however, few studies have investigated these factors in medical school students. Therefore, this study investigated associations between smartphone addiction scale and sociopsychological aspects in medical school students. Methods: A total of 231 Yeungnam University College of Medicine students were enrolled in this study in March 2017. Gender, school grade, type of residence, and smartphone usage patterns of the students were surveyed. The Korean Smartphone Addiction Proneness Scale and each Korean version scale were used to assess sociopsychological aspects such as loneliness, stress and anxiety. Results: There was a direct statistical correlation between loneliness, stress of negative perception, anxiety and smartphone addiction scales. There was also a negative statistical correlation between stress of positive perception and smartphone addiction scales. There was a higher level of anxiety among female students than male students. Additionally, there was a higher level of stress associated with negative perception and anxiety among medical students in the first grade than other students. Moreover there was a higher level of loneliness, stress of negative perception and anxiety among students who live with friends than students who live with their own family. Conclusion: Smartphone addiction scale and sociopsychological aspects significantly correlated. Moreover, the results suggest that female medical students in the first grade who have been separated from their family need more attention and management of loneliness, stress and anxiety to avoid smartphone addiction.