만성 C형간염에서 페그인터페론과 리바비린의 병합치료 시 지속바이러스반응에 대한 순응도의 효과

정승원 ( Soung Won Jeong ),김진동 ( Jin Dong Kim ),우현영 ( Hyun Young Woo ),유찬란 ( Chan Ran You ),이승원 ( Sung Won Lee ),송명준 ( Myeong Jun Song ),장정원 ( Jung Won Jang ),배시현 ( Si Hyun Bae ),최종영 ( Jong Young Choi ) 대한간학회 2009 Clinical and Molecular Hepatology(대한간학회지) Vol.15 No.3

목적: 만성 C형간염에서 페그인터페론과 리바비린 병합요법 치료 시 지속바이러스반응에 영향을 미치는 다양한 예측인자들이 알려져 있지만, 치료 순응도의 효과에 대해서는 구체적으로 밝혀져 있지 않다. 본 연구에서는 지속바이러스반응에 대한 치료순응도의 효과를 조사하였다. 대상과 방법: 페그인터페론 또는 리바비린 치료를 받은 만성 C형 간염 환자 122명 중에서 페그인터페론과 리바비린 병합치료를 받은 92명의 환자를 후향적으로 분석하였다. 환자들은 유전자 1형과 비1형을 치료 프로토콜에 따라서 각각 3그룹으로 분류하였다. 그룹 1은 80% 이상의 페그인터페론 및 리바비린 용량으로 80% 이상의 치료 기간 동안 치료받은 환자들이고, 그룹 2는 60% 미만의 페그인터페론 및 리바비린의 용량으로 60%미만의 기간 동안 치료받은 환자들이며 그리고 그룹 3은 이 두 그룹에 포함되지 않은 모든 환자들로 분류하였다. 결과: 치료 순응도가 달랐던 세 그룹 사이에 초기바이러스반응(early virologic response: EVR), 치료종료반응(end of treatment response: ETR) 그리고 지속바이러스반응(sustained virologic response: SVR)이 각각 의미있는 차이를 보였다. 유전자 1형 그룹들의 SVR률은 그룹 1이 86.7%, 그룹 2가 26.7% 그리고 그룹 3이 66.7%였다(P=0.003). 유전자 비1형 그룹들의 SVR은 그룹 1이 100%, 그룹 2가 16.7% 그리고 그룹 3이 88.9%였다(P<0.001). 결론: 치료 순응도는 SVR에 도달하는 데 있어서 결정적인 역할을 하며, 치료 순응도를 높이기 위한 여러 가지 지지요법들이 전체적인 SVR률을 높일 것이다. Background/Aims: Various predictive factors for peginterferon alpha and ribavirin therapy in chronic hepatitis C have been reported, but the effect of adherence to therapy has not been established. We investigated how adherence affects the sustained virologic response (SVR). Methods: We analyzed 92 chronic hepatitis C patients receiving peginterferon alpha and ribavirin combination therapy. Patients were first identified as having either genotype 1 or genotype non-1 infection and then categorized into three groups according to their adherence to the treatment protocol: (1) patients who received ≥80% of the recommended dosage of both peginterferon alpha and ribavirin for ≥80% of the intended duration of therapy, (2) patients who received <60% of the recommended dosage of both peginterferon alpha and ribavirin for <60% of the intended duration of therapy, and (3) patients who were not included in either group 1 or 2. Results: The rates of early virologic response, end of treatment response, and SVR differed significantly with the degree of adherence to the treatment. The SVRs of genotype 1 patients were 86.7%, 26.7%, and 66.7% in groups 1, 2, and 3, respectively (P=0.003), and those of genotype non-1 were 100%, 16.7%, and 88.9%, respectively (P<0.001). Conclusions: Adherence to therapy is a key factor in achieving an SVR. Supportive strategies to improve adherence will increase overall SVR rates. (Korean J Hepatol 2009;15:338-349)

전해산화수를 이용한 김치의 초기 미생물 제어 효과

정승원(Sung-Won Jung),박기재(Kee-Jai Park),김영호(Young-Ho Kim),박병인(Byoung-In Park),정진웅(Jin-Woong Jeong) 한국식품영양과학회 1996 한국식품영양과학회지 Vol.25 No.5

김치 제조시 보다 철저한 재료 세척과 이에 따른 김치제품의 초기 미생물제어를 목적으로 전해산화수를 세척매체로 이용하였다. 원료배추를 전해산화수로 1회 세정한 결과 전해산화수를 사용한 처리구는 수도수 처리에 비해 총 균수 및 대장균수가 약 1/2 수준으로 감소됨을 알 수 있었다. 그러나 김치양념에 대한 수도수 및 전해산화수 처리에 따른 미생물수의 차이를 볼 수는 없었으며 이는 주로 양념 중의 고춧가루에 기인하는 것으로 판단되었다. 절임수를 전해산화수로 사용했을 경우 절임수 자체의 총 균수에서는 매우 큰 차이를 나타내어 전해산화수를 사용했을 때가 약 1/270 정도의 수준을 보였다. 절임배추를 전해산화수로 세정한 경우에는 총 균수가 수도수 처리구에 비해 1/16 수준으로 감소하였고 대장균군 및 대장균은 검출되지 않았다. 절임 전후를 비교했을 때 전해산화수를 사용했을 경우에는 절임 후 총 균수가 1/4 수준으로 감소했으며, 대장균군은 거의 완전히 사멸한 것으로 나타난 반면 수도수를 사용한 처리구에서는 총 균수가 오히려 1.7배 정도 증가하였다. 이러한 증가는 제조 공정 중의 2차적인 오염이 그 원인일 것으로 추정되었다. 배추김치의 발효 중 총 균수 변화에 있어서 발효 15일까지는 전해산화수 처리구가 비교적 낮은 총 균수를 나타내었으나 발효 20일경이 지나서는 큰 차이가 없는 것으로 나타났다. 김치 발효 중 PH는 발효 15일까지 다소 차이를 보였으나 20일경부터는 차이가 매우 미미하였으며, 이러한 경향은 산도에서도 유사하여 발효 20일 부터는 거의 차이를 나타내지 않았다. To lessen the initial level of microorganisms, electrolyzed acid-water was used as washing and brine water in the manufacturing process. On the washing and salting processes, application of electrolyzed acid-water showed a possibility to lessen the microorganism level of Chinese cabbage effectively. Microbial level of Chinese cabbage was reduced to about 1/4 level by salting and washing process with electrolyzed acid-water while Chinese cabbage salted with tap water increased to about 1.7 times. And no coliform and E. coli were detected. However significant differences between seasoning mixtures prepared with electrolyzed acid-water and with tap water were not observed in microbial levels. Relatively low level of total count in kimchi prepared with electroyzed acid-water was kept until 15 days of fermentation at 10℃. Any significant difference between them was not observed after 20 days of fermentation. pH and acidity were showed the same tendencies as microbial count.

소풍탕이 Glutamate에 의한 C6 Glial Cell의 Apoptosis에 미치는 영향

정승원(Seung Won Jeong),최철원(Chul Won Choi),김봉상(Bong Sang Kim),문병순(Byung Soon Moon) 한의병리학회 2008 동의생리병리학회지 Vol.22 No.6

지역사회기반 장애인 일자리 사업에 관한 탐색적 연구: 충청북도 ‘상생 일자리 사업’을 중심으로

정승원(Jeong, Seung Won),황의태(Hwang, Eui Tae),김창수(Kim, Chang Soo),하성규(HA, Sung Kyu) 한국직업재활학회 2021 職業再活硏究 Vol.31 No.1

본 연구는 충청북도 장애인 일자리 사업인 ‘1인 1기 장애인⋅기업 상생 맞춤형 일자리 사업’의 사업담당자 의견을 듣고 분석하여, 지역기반 장애인 일자리 사업의 운영 과정에서 나타나는 애로사항과 사업성과에 미치는 영향요인이 무엇인지 찾아내고, 이를 바탕으로 향후 개선사항을 도출하고자 하였다. 초점집단인터뷰를 통해서 얻은 자료를 분석한 결과, ‘애로사항’, ‘영향요인’, ‘개선방향’ 등 3가지 범주로 구분되었다. 각 범주는 하위범주로 구분되었는데, 세부적으로 애로사항은 ‘참여자 모집의 어려움’, ‘기업체 모집의 어려움’, ‘홍보의 어려움’, ‘인력 부족’ 등 4가지 하위범주로, 영향요인은 ‘코로나-19 요인’, ‘지역특성 요인’, ‘지자체 요인’, ‘사회인식 및 제도적 요인’ 등 4가지 하위범주로, 개선방향은 ‘사업운영 부분 개선’, ‘인력 부분 개선’, ‘지원 부분 확대 및 개선’과 같은 3가지 하위범주로 구분되었다. 이를 바탕으로 충청북도형 장애인 일자리 사업의 개선방안을 논의하였다. This study was to find out the difficulties and influencing factors in Job Creation Project for people with disabilities in Chungcheongbuk-do using focus group interview(FGI) of the project manager and to derive the improvement plan. As a result, 3 categories were identified as follows: ‘Difficulties’, ‘Impact Factors’ and ‘Improvement Directions’. In addition, each category had several subcategories. ‘Difficulties’ category included 4 subcategories such as “difficulties in recruiting participants with disabilities”, “difficulties in recruiting companies”, “difficulties in promoting”, and “lack of professional manpower”. ‘Impact Factors’ category included 4 subcategories such as ‘COVID-19 factor’, ‘regional characteristic factor’, ‘local government factor’, and ‘social awareness and institutional factor’. And ‘Improvement Directions’ category included 4 subcategories such as ‘improvement of the project operation’, ‘improvement of the workers’ and ‘expanding and improving the support’. Based on the analysis criteria, we discussed how to improve the job creation project for people with disabilities in Chungcheongbuk-do.

절제 불가능한 원발성 간세포암종에 대하여 DC beads(r)를 사용한 반복적인 경동맥 화학색전술 후 간절제술을 시행한 1예

송정엽 ( Jeong-yeop Song ),김영석 ( Young Seok Kim ),이재명 ( Jae Myeong Lee ),진수지 ( Soo Ji Jin ),최규성 ( Kyu Sung Choi,),이윤나 ( Yun Nah Lee ),김상균 ( Sang Gyune Kim ),정승원 ( Sung Won Jeong ),장재영 ( Jae Young Jang ) 대한간암학회 2013 대한간암학회지 Vol.13 No.1

In patients with unresectable hepatocellular carcinoma (HCC) and no anti-cancer treatment, the prognosis is quite poor. But in some cases, repeated sessions of transcatheter arterial chemoembolization (TACE) reduce the tumor size even to resectable, and post-TACE resection may prolong the survival time. We present a case of 50-year-old HBV carrier woman with abdominal distension. The diagnosis was huge HCC with intrahepatic metastasis. Repeated intra-arterial injections of adriamycin mixed lipiodol or DC beads(R) (100-300/300-500/500-700 μm, ⓒBIOCOMPATIBLES UK LTD) were instituted through ten sessions for 13 months. The tumor size became reduced with a partial response after 10th TACE and post-TACE resection was performed. No visible HCCs and decreased tumor markers were noted on the examinations 3 months after the resection.

아파치 카프카를 활용한 블랙박스 영상에서의 차량 번호판 인식 방법

정상원 ( Sang-won Jung ),정승원 ( Seung-won Jung ),황인준 ( Een-jun Hwang ),정창성 ( Chang-sung Jeong ) 한국정보처리학회 2017 한국정보처리학회 학술대회논문집 Vol.24 No.1

차량의 블랙박스와 CCTV, 드론 등 다양한 채널에서 촬영된 영상의 증가로, 차량 및 교통 상항과 관련된 데이터의 양 또한 폭발적으로 증가하고 있다. 본 연구에서는 이러한 데이터들의 고속 처리를 위해, 실시간 메시지 분산처리 시스템인 아파치 활용하여 블랙박스 영상의 프레임을 여러 노드에 분배하였다. 또한, 각각의 노드에 들어온 블랙박스 영상의 프레임을 입력으로 하여, 영상처리 기법을 통한 번호판의 지역화와 문자 분할 및 이를 안식하기 위한 연구를 수행하였다.

재래감귤 팔삭의 과피 추출물이 LPS로 활성화 된 RAW264.7 대식세포에서 염증매개물질 억제에 미치는 효과

김철원,김성무,정승원,김소미,안광석,Kim, Chul-Won,Kim, Sung-Moo,Jeong, Seung-Weon,K., So-Mi Cho,Ahn, Kwang-Seok 대한암한의학회 2011 大韓癌韓醫學會誌 Vol.16 No.2

Objectives : Citrus is the fruit that is readily available around us. Therefore, we investigated the anti-inflammatory effects of fraction isolated from the Citrus hassaku pericarp in RAW264.7 macrophage cells. Methods : The effects of fraction from Citrus hassaku pericarp on cell viability on RAW264.7 cells were measured by the MTT assay. The mRNA levels of iNOS and COX-2, its protein level by fraction of Citrus hassaku pericarp treatment in RAW264.7 macrophage cells were investigated by RT-PCR and immunoblots. Nitrite accumulation in the culture was measured colorimetrically by the Griess reaction using a Griess reagent. The amount of IL-6 and TNF-${\alpha}$ production was determined using an enzyme-linked immunosorbent assay (ELISA) kit. Results : The results indicated that the fraction of Citrus hassaku pericarp concentration highly suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO) and IL-6 productions without a cytotoxic effect on RAW264.7 cells. fraction of Citrus hassaku pericarp inhibited the expressions of LPS-induced iNOS and COX-2 protein and their mRNA in a dose-dependent manner. Particularly, fraction of Citrus hassaku pericarp suppressed the level of nuclear factor-${\kappa}B$ (NF-${\kappa}B$) activity, which was linked with the suppression of LPS-induced phosphorylation of p65 at serine 276 and p65 translocation into nuclei, but not MAPK signaling. In addition, treatment with fraction of Citrus hassaku pericarp inhibited the production of IL-6 and TNF-${\alpha}$ in LPS-stimulated RAW264.7 cells. Conclusion : Our results indicate that fraction of Citrus hassaku pericarp potentially inhibits the biomarkers related to inflammation through the blocking of NF-${\kappa}B$ p65 activation, and it may be a potential therapeutic candidate for the treatment of inflammatory diseases.

위 정맥류 출혈에 대한 내시경적 정맥류 폐색술, 내시경적 정맥류 결찰술, 역행성 경정맥 위정맥류 폐색술 간의 치료효과 비교

김부성 ( Boo Sung Kim ),박재우 ( Park jae woo ),민슬기 ( Seul Ki Min ),김상균 ( Sang Gyune Kim ),김영석 ( Young Seok Kim ),배준용 ( Jun Yong Bae ),이종찬 ( Jong Chan Lee ),김홍수 ( Hong Soo Kim ),정승원 ( Soung Won Jeong ),장재영 대한소화기학회 2011 대한소화기학회지 Vol.57 No.5

Background/Aims: Endoscopic variceal obliteration (EVO), endoscopic variceal ligation (EVL), and balloon-occluded retrograde transvenous obliteration (BRTO) are used to manage gastric variceal bleeding. We compared the re-bleeding rates and survival times of these modalities. Methods: The study enrolled 103 patients with suspected gastric variceal bleeding between July 2001 and May 2009. For the management of gastric variceal bleeding, 52 patients underwent EVO; 36, EVL; and 15, BRTO. We evaluated their laboratory results and vital signs, and calculated the Child score, Child classification, and Model for End-stage Liver Disease score. Rebleeding was defined as new-onset hematemesis, hematochezia, melena, or endoscopically proven bleeding. Time-to-rebleeding and survival time were examined by Kaplan-Meyer analysis. A value of p<0.05 indicated statistical significance. Results: There were no significant differences in baseline characteristics among the three groups. The overall follow-up period averaged 65.13 months. During follow-up, rebleeding occurred in 17 patients (11 EVO, 5 EVL, and 1 BRTO). The times-to-rebleeding were 63.59, 75.79, and 51.41 months for EVO, EVL, and BRTO, respectively, and did not differ significantly (p=0.515). The median survival times were 77.42, 70.14, and 42.79 months, respectively, and also were not different significantly (p=0.978). Conclusions: There were no significant differences in the time-to-rebleeding or survival time among EVO, EVL, and BRTO. Further prospective, large-scale studies are needed. (Korean J Gastroenterol 2011;57:302-308)

2009년 국내 Influenza A의 대유행과 급성 A형간염 발병률의 감소

김부성 ( Boo Sung Kim ),박재우 ( Park jae woo ),변진명 ( Jin Myung Byun ),김상균 ( Sang Gyune Kim ),( Yuan Yuan Zhang ),김영석 ( Young Seok Kim ),정승원 ( Soung Won Jeong ),장재영 ( Jae Young Jang ),홍수진 ( Soo Jin Hong ),문 대한소화기학회 2012 대한소화기학회지 Vol.59 No.5

Background/Aims: There was a spiking incidence of acute hepatitis A (AHA) in 2009 summer, but it went down drastically after an outbreak of influenza A (H1N1). We assessed the relationship between 2009 H1N1 pandemic and AHA prevalence from August to December 2009. Methods: We compared AHA cases nationwide and in our hospital for the period from the latter half of 2008 to the end of 2010. H1N1 cases in our hospital from August 2009 to December 2009 were included in the study and the correlation between 2009 H1N1 pandemic and AHA prevalence was assessed. Results: The national surveillance system reported 2,233, 7,895, 15,231 and 7,660 AHA cases from 2007 to 2010, respectively. A similar trend was noted in our hospital in the same periods. Although the national total incidence was increased in 2009, it showed steep decreasing trend line in the final 21 weeks of 2009 (weeks 32-52), as compared with 2008 and 2010. The mean weekly incidence percentage (AHA cases in a week/total in a year) in weeks 32-52 of 2009 was 1.17±0.55%, significantly lower than that in 2008 and 2010 (1.61±0.43% and 1.56±0.51%; p<0.001). Furthermore, we found a significant negative correlation between 2009 H1N1 pandemic and AHA in our hospital for weeks 32-52 of 2009 (r=-0.597; p<0.001). Conclusions: The widespread occurrence of 2009 H1N1 pandemic highlighted the benefits of health care and good hygiene, such as effective hand washing and wearing of masks, which may have also interrupted hepatitis A virus transmission. (Korean J Gastroenterol 2012;59:360-365)

뇌전이가 된 진행성 간세포암종 1예

김의배 ( Eui Bae Kim ),정승원 ( Soung Won Jeong ),장재영 ( Jae Young Jang ),이세환 ( Sae Hwan Lee ),김상균 ( Sang Gyune Kim ),김영석 ( Young Seok Kim ),김홍수 ( Hong Soo Kim ),김부성 ( Boo Sung Kim ),장아람 ( A Ram Jang ) 대한간암학회 2012 대한간암학회지 Vol.12 No.2

Hepatocellular carcinoma (HCC) is the sixth most common tumor worldwide and the third leading cause of tumor mortality. The majority of tumors are diagnosed when advanced and then a 5-year survival rate of HCC is below 5%. However, recent progress in the diagnosis and treatment of HCC has made it possible for the patient to survive longer, and as a result, distant metastasis from HCC has increased and attracted more attention than before. HCC can be metastasized to all organs through blood and lymphatic channel. Of the various metastatic sites, the most common site is the lungs, followed by the lymph nodes, musculoskeletal, adrenal and omentum. Also, spleen, small bowel, large bowel and esophagus can be invloved. Brain metastasis can be occurred rarely, and then it is regarded to oncologic emergency. We report a patient who present with brain metastasis of progressing HCC despite of treatment.