갑상선절제술 후 혈종의 임상 양상

정소영(So Young Jung),김형일(Hyung Il Kim),윤종호(Jong Ho Yoon),남기현(Kee Hyun Nam),장항석(Hang-Seok Chang),박정수(Cheong Soo Park) 대한외과학회 2004 Annals of Surgical Treatment and Research(ASRT) Vol.67 No.4

국내생산식품의 아크릴아마이드 함량분석

박재영(Jae-Young Park),김청태(Cheong-Tae Kim),김혜영(Hye-Young Kim),금은희(Eun-Hee Keum),이미선(Mi-Seon Lee),정소영(So-Young Chung),소유섭(You-Sub Sho),이종옥(Jong-Ok Lee),오상석(Sangsuk Oh) 한국식품과학회 2004 한국식품과학회지 Vol.36 No.6

French fries의 아크릴아마이드 생성에 영향을 미치는 인자에 관한 연구

김혜영(Hye-Young Kim),박재영(Jae-Young Park),김청태(Cheong-Tae Kim),정소영(So-Young Chung),소유섭(You-Sub Sho),이종옥(Jong-Ok Lee),오상석(Sangsuk Oh) 한국식품과학회 2004 한국식품과학회지 Vol.36 No.6

식품 중 아목시실린, 암피실린, 옥소린산 및 플루메퀸의 분석

김희연(Hee-Yun Kim),최희주(Hee-Ju Choi),김용훈(Yong-Hoon Kim),최선희(Sun-Hee Choi),정소영(So-Young Cheong),이화정(Hwa-Jeong Lee),김재인(Jae-In Kim),최계선(Gye-Sun Choi),최재천(Jae-Chun Choi) 한국식품과학회 2009 한국식품과학회지 Vol.41 No.5

본 연구에서 확립한 분석법으로 총 393건의 시료를 분석한 결과 넙치에서 아목시실린 9건, 장어에서 옥소린산 4건과 플루메퀸 1건이 검출되었다. 아목시실린의 검출농도는 0.009-0.078 mg/kg의 범위를 나타내었고, 옥소린산의 검출농도는 0.02-0.20 mg/kg의 범위를 나타내었다. 플루메퀸은 잔류허용기준(0.5 mg/kg) 이하의 농도로 장어 1건(0.03 mg/kg)에서 검출되었다. The present study was performed to validate an analytical method for veterinary drugs, including amoxicillin, ampicillin, oxolinic acid and flumequin, in meat, fish, and their products as established in the 2007 Korea Food Code, and to monitor the respective drugs in 6 kinds of foods, namely beef, pork, flatfish, rockfish, freshwater eel and shrimp. Additionally, an HPLC-ESI-MS/MS method was developed for the qualification of these veterinary drugs. As a result of monitoring, these drugs were detected in 14 (3.6%) out of 393 samples. In particular, amoxicillin was detected in 9 flatfish samples, and oxolinic acid and flumequin were detected in 4 samples and 1 sample of freshwater eel, respectively. The detection levels of amoxicillin ranged from 0.009 to 0.078 mg/kg, in which 1 sample of flatfish contained more than the MRL (0.05 mg/kg). Flumequin detected in 1 sample of freshwater eel, was less than the MRL (0.5 mg/kg). Therefore, the majority of detected levels were less than the MRLs, with the exception of 2 samples showing amounts that were 1-2 times higher than the MRLs. The detected veterinary drugs were identified and confirmed by the HPLC-ESI-MS/MS method created in this study.

국내산 녹차의 잔류농약 모니터링

김희연(Hee-Yun Kim),전종섭(Jong-Sup Jeon),김용훈(Yong-Hoon Kim),최희주(Hee-Ju Choi),정소영(So-Young Cheong),이화정(Hwa-Jeong Lee),김재인(Jae-In Kim),김영선(Young-Seon Kim),최계선(Gye-Sun Choi),최재천(Jae-Chun Choi) 한국식품과학회 2009 한국식품과학회지 Vol.41 No.5

국내유통 녹차 100품목 중 조사대상 61종 농약의 잔류실태를 조사한 본 연구의 결과는 다음과 같다. 총 100품목의 시료 가운데 22품목의 시료에서 bifenthrin, chlorpyrifos, dicofol, EPN, chlorfenapyr, tebuconazole, cyhalothrin, difenoconazole 및 tebufenpyrad 등 9종의 농약이 검출되었다. bifenthrin이 1개 품목(검출치: 0.12 ppm, 기준: 0.3 ppm), chlorpyrifos가 3개 품목(검출치: 0.24-0.78 ppm, 기준: 2.0 ppm), dicofol이 2개 품목(검출치: 1.64-4.19 ppm, 기준: 50.0 ppm), EPN이 1개 품목(검출치: 0.13 ppm, 기준: 0.05 ppm), chlorfenapyr가 16개 품목(검출치: 0.01-1.23 ppm, 기준: 3.0 ppm), tebuconazole이 1개 품목(검출치: 0.71 ppm, 기준: 5.0 ppm), cyhalothrin이 5개 품목(검출치: 0.05-0.3 ppm, 기준: 2.0 ppm), difenoconazole이 1개 품목(검출치: 0.23 ppm, 기준: 2.0 ppm), tebufenpyrad가 2개 품목(검출치: 0.06-0.07 ppm, 기준: 2.0 ppm)이었고 이 가운데 2종 이상의 잔류농약이 검출된 것은 7개 품목이었다. 기준치를 초과한 것은 EPN(검출치: 0.13 ppm, 기준: 0.05 ppm) 1종이었고 나머지는 기준치 이하를 보여주었다. 검출 품목의 지역별 분포는 보성산이 5품목, 제주가 14품목이었고, 기타 국내산이 3품목이었다. 검출 품목의 제품유형별 농약 검출수와 종 수는 잎차(leaf green teas)의 경우 우전이 3품목, 1종, 세작이 2품목, 1종, 중작이 3품목, 2종 및 대작이 1품목, 1종이었고 가루녹차(milled green teas)의 경우는 5품목, 6종, 티백(green tea bag)의 경우는 8품목, 6종 이었다. 농약 종 수와 검출율에 있어 가루녹차와 티백이 잎차보다 훨씬 큰 것으로 나타났는바 가루녹차와 티백이 일반 국민이 다소비하는 품목이라는 점에서 중점관리가 필요하다 할 것이다. 녹차에 잔류하는 농약의 잔류수준은 EPN을 제외하고는 비교적 안전한 수준으로 인체에 크게 위협이 되지 않는 수준인 것으로 판단되었다. 검출 농약 중 dicofol과 EPN은 차류의 잔류농약허용기준에 포함되지 않은 농약으로서 향후 관리가 필요한 것으로 사료된다. Herein, we present the results of our investigation of 61 pesticide residues in 100 samples of green teas obtained from Korean markets. Bifenthrin, chlorpyrifos, dicofol, EPN, chlorfenapyr, tebuconazole, cyhalothrin, difenoconazole, and tebufenpyrad were detected in 22 of the 100 green tea samples. The quantity of pesticide residues for bifenthrin was 0.12 ppm (maximum residue limits (MRLs): 0.3 ppm) in one sample, chlorpyrifos was 0.24-0.78 ppm (MRLs: 2.0 ppm) in three samples, dicofol was 1.64-4.19 ppm (MRLs: 50.0 ppm) in two samples, EPN was 0.13 ppm (MRLs: 0.05 ppm) in one sample, chlorfenapyr was 0.01-1.23 ppm (MRLs: 3.0 ppm) in 16 samples, tebuconazole was 0.71 ppm (MRLs: 5.0 ppm) in one sample, cyhalothrin was 0.05-0.3 ppm (MRLs: 2.0 ppm) in five samples, difenoconazole was 0.23 ppm (MRLs: 2.0 ppm) in one sample, and tebufenpyrad was 0.06-0.07 ppm (MRLs: 2.0 ppm) in two samples. More than two pesticide residues were detected in seven samples. All detected pesticide residues (with the exception of EPN) were within the MRLs.

캔 제품의 bisphenol A diglycidyl ether (BADGE), bisphenol F diglycidyl ether (BFDGE) 유도체 및 분해산물 분석법

김희연(Hee-Yun Kim),이진숙(Jin-Sook Lee),조민자(Min-Ja Cho),양지연(Ji-Yeon Yang),백지윤(Ji Yun Baek),정소영(So-Young Cheong),최선희(Sun-Hee Choi),김영선(Young-Seon Kim),최재천(Jae-Chun Choi) 한국식품과학회 2010 한국식품과학회지 Vol.42 No.1

캔제품 중 Biphenol A diglycidyl ether(BADGE), bisphenol F diglycidyl ether(BFDGE) 및 그 분해산물인 BADGE·H₂O, BADGE·2H₂O, BADGE·HCl, BADGE·2HCl, BADGE·HCl·H₂O, BFDGE·H₂O, BFDGE·2H₂O, BFDGE·HCl, BFDGE·2HCl, BFDGE·HCl·H₂O 등의 HPLC/FLD와 HPLC/APCI-MS에 의한 정성 및 정량방법을 확립하고 133개 캔 제품을 사용하여 분석방법의 재현성을 검토하였다. 수용성 식품의 경우 BADGE·2H2O가 13개 제품에서 0.400-0.888 mg/kg, BADGE·HCl·H2O가 1개 제품에서 0.566mg/kg, BFDGE·H2O가 3개 제품에서 0.489-0.664 mg/kg, BFDGE·2H2O가 3개 제품에서 0.455-0.846 mg/kg, BFDGE·HCl·H2O가 2개 제품에서 0.455-0.752 mg/kg의 농도로 검출되었다. 지용성 식품의 경우에는 BADGE가 3개 제품에서 0.093-0.486 mg/kg, BADGE·H2O가 1개 제품에서 0.183 mg/kg, BADGE·HCl이 1개 제품에서 0.097 mg/kg, BADGE·2HCl이 7개 제품에서 0.200-0.452 mg/kg, BFDGE가 3개 제품에서 0.438-0.506 mg/kg, BFDGE·2H2O가 1개 제품에서 0.295 mg/kg, BFDGE·HCl 및 BFDGE·2HCl이 1개 제품에서 0.324 mg/kg의 농도로 검출되었다. 분석방법의 재현성은 우수하였고, 모니터링 결과는 EU 수준과 유사하거나 안전한 수준으로 나타났다. Bisphenol A diglycidyl ether (BADGE) and bisphenol F diglycidyl ether (BFDGE) were obtained by a polymerization reaction of epichlorohydrin (ECH) with bisphenol A (BPA) or bisphenol F (BPF). These compounds are commonly used as monomers or additives such as a polymerization stabilizer and a hydrochloric acid scavenger of epoxy resin, polyvinyl chloride (PVC)-containing organosols and polyester lacquers, that are applied to the internal surface of most canned foods to impart chemical resistance. The unreacted BADGE, BFDGE and their reaction products migrating from epoxy resin, PVC-containing organosol and/or polyester lacquer-based food packaging materials into the foods have recently become an issue of great concern because of increased customer demand for safety. This study was conducted to develop a rapid and sensitive simultaneous analysis method based on HPLC/FLD and HPLC/APCI-mass and to evaluate the concentration of BADGE, BFDGE and their metabolites, BADGE·H₂O, BADGE·2H₂O, BADGE·HCl, BADGE·2HCl, BADGE·HCl·H₂O, BFDGE·H₂O, BFDGE·2H₂O, BFDGE·HCl, BFDGE·2HCl and BFDGE·HCl·H₂O for 133 canned food samples. The method provided a linearity of 0.9997-0.9999, a limit of detection of 0.01-0.13 μg/mL, a limit of quantitation of 0.03-0.44 μg/mL and a recovery (%) of 85.64-118.18. The number of samples containing BADGE, BFDGE or their metabolites were: 28/133 (21.1%), with levels of 0.400-0.888 mg/kg being observed for aqueous foods (19/133) and 0.093-0.506 mg/kg being observed for oily foods (9/133).

식품 중 플루오로퀴놀론계 항생제의 분석

김희연(Hee-Yun Kim),신민수(Min-Su Shin),최희주(Hee-Ju Choi),박세종(Se-Jong Park),송재상(Jae-Sang Song),정소영(So-Young Cheong),최선희(Sun-Hee Choi),이화정(Hwa-Jeong Lee),김영선(Young-Seon Kim),최재천(Jae-Chun Choi) 한국식품과학회 2009 한국식품과학회지 Vol.41 No.6

총 388건의 시료를 분석한 결과, 닭 143건 중 총 12건의 플루오르퀴놀론계 항생제가 검출되었으며 다른 식품군에서는 모두 불검출 되었다. 항생제 별로 보면 엔로플록사신이 12건으로 가장 많았고 시프로플록사신이 5건, 노르플록사신이 1건 순이었다. 검출농도는 엔로플록사신이 0.01-0.73 mg/kg, 시프로플록사신이 0.01-0.03 mg/kg 및 노르플록사신이 0.12 mg/kg이었다. Residual fluoroquinolone levels in animal foods retailed in Korea were monitored according to the method outlined in Korea Food Code using HPLC-FLD and HPLC-ESI-MS/MS for confirmation. The optimum ion transitions were 360→316, 342 m/z for enrofloxacin, 332→314, 288 m/z for ciprofloxacin, 320→301, 230 m/z for norfloxacin, 334→315, 290 m/z for pefloxacin, 362→318, 261, 334 m/z for ofloxacin, and 262→201, 126 m/z for flumequin. Enrofloxacin, ciprofloxacin and norfloxacin residues were found in 12 out of 388 samples. These antibiotics were only found in chicken samples, while no residues were found in beef, pork, milk and egg samples. Using this monitoring method, detection rates of 3.1, 1.3, and 0.3% were obtained for enrofloxacin, ciprofloxacin and norfloxacin, respectively. The levels of enrofloxacin, ciprofloxacin and norfloxacin detected in food samples ranged from 0.01 to 0.73 mg/kg in 12 samples, 0.01-0.03 mg/kg in 5 samples, and 0.12 mg/kg in only a sample, respectively.

시판 농산물의 dithiocarbamates 분석

김희연(Hee-Yun Kim),최희주(Hee-Ju Choi),엄지윤(Ji-Yoon Eom),서은채(Eun-Chae Seo),최승희(Sung-Hee Choi),정소영(So-Young Cheong),최선희(Sun-Hee Choi),이화정(Hwa-Jeong Lee),최재천(Jae-Chun Choi) 한국식품과학회 2010 한국식품과학회지 Vol.42 No.1

HPLC/APCI-MS에 의한 dithiocarbamate계 분석법을 확립하고 아울러 국내에서 dithiocarbamate계 농약이 사용되는 쌀, 배추, 사과 등 20종 농산물에 대해 잔류실태를 조사한 본 연구의 결과는 다음과 같았다. Dithiocarbamate계 농약 검출건수는 복숭아가 10건 중 3건(30%), 고추가 14건 중 7건(50%), 양파가 12건 중 4건(33.3%), 포도가 12건 중 8건(66.7%), 토마토가 17건 중 7건(41.2%), 감자가 14건 중 4건(28.6%), 구기자가 10건 중 9건(90%), 수박이 10건 중 6건(60%), 양배추가 11건 중 8건(72.7%), 배추가 10건 중 7건(70%), 당근이 12건 중 6건(50%), 오이가 13건 중 8건(61.5%), 쌀이 13건 중 6건(46.2%), 감귤이 11건 중 8건(72.7%), 메론이 16건 중 5건(31.3%), 감이 10건 중 1건(10%), 인삼이 11건 중 1건(9.1%), 대두가 10건 중 2건(20%)으로 100건의 시료에서 42.4%의 검출율을 보였으나 사과와 배 각 10건의 시료에서는 검출되지 않았다. 이 중 기준치를 초과한 농산물은 건 구기자 3건이었으나 기준규격을 설정하여 관리되고 있다. To revise the dithiocarbamates residue analysis method and survey the residues in agricultural products that were treated with these fungicides in Korea, we purchased 20 types of foodstuffs (rice, potato, cabbage, apple etc.) from markets in five major cities. 236 samples of the purchased foodstuffs were then analyzed for the presence of dithiocarbamates by HPLC/UV and HPLC/APCI-MS. The R², LOD and LOQ in the range of 0.5-107.3 mg/L were as follows: DCC: y=174.34x+18.315, R²=0.9999, 0.01 mg/L, and 0.04 mg/L; EBDC: y=227.38x?14.715, R²=1.0000, 0.01mg/L and 0.02 mg/L; PBDC: y=38.46x?21.412, R²=0.9999, 0.04 mg/L, and 0.1 mg/L; ETU: y=52.752x?4.4819, R²=0.9?998, 0.02 mg/L and 0.03 mg/L; PTU: y=128.28x+4.4624, R²=0.9998, 0.02 mg/L, and 0.04 mg/L. The levels of DDC, EBDC, PBDC, ETU and PTU in 20 agricultural products fortified to 10.0-107.3 mg/L ranged from 61.7-117.5%, 65.3-110.1%, 61.5-109.6%, 69.3-116.3% and 70.2-97.2%, respectively. Overall, dithiocarbamates were detected in 100 samples and the detection ratio was 42.4%. Among these, only 3 samples (1.3%) of Lycii fructus had residue levels that were above the action limits, while the remaining samples (233 samples) contained levels of dithiocarbamates below the detection limit or below the Korea MRLs (Maximum Residue Limits).

만성 림프구성 백혈병 환자에서 발생한 노카르디아증(Nocardiosis) 1례

정재연,고윤웅,정소영,정윤섭,민유홍,한지숙 大韓血液學會 1999 大韓血液學會誌 Vol.34 No.1

식품 배합을 통한 율무 및 대두 단백질의 PER 상승 효과

김혜진,전형주,정소영,정유경 연세대학교 생활과학대학 1986 婦學 Vol.19 No.-

The body is in a dynamic state with proteins being degraded and resynthesized continuously. In fact, more protein is turned over daily within the body than is ordinarily consumed in the diet and the required amounts of essential amino acids must be provided in everyday's diet. Protein qualities were compared and evaluated among experimental groups Ⅰ (casein), Ⅱ (soybean meal),Ⅲ (Yulmoo, Coix lacrymajobi),Ⅳ (Soybean+Yulmoo), and Ⅴ(Soybean +Yulmoo+0.3% Met.) by measuring Protein Efficiency Ratio(PER) after 18 days of experimental period using growing rats. The Protein Efficiency Ratio is the simplest test of protein quality used widely in comparing nutritive value of proteins in individual foods. The PER value of Yulmoo protein was found to be the lowest among all groups tested, but improved greatly even to higher value than that of casein when given as a mixture of Yulmoo and soybean meal(protein composition: 50/50 by weight: group Ⅳ). The increase in PER was also great when the group Ⅳ diet was supplemented further with 0.3% methionine(group Ⅴ). Values of PER were found to be in the order of Ⅰ>Ⅳ>Ⅴ>Ⅱ>Ⅲ at the first week and Ⅴ>Ⅳ>Ⅰ>Ⅱ>Ⅲ at the 18th day of experimental period. The first limiting amino acids relative to the FAO/WHO protein scoring pattern(1973) were methionine and lysine for groups Ⅰ, Ⅱ and Ⅲ, Ⅳ, Ⅴ respectively. This study emphasizes again the importance of mixing proteins especially plant proteins to improve the protein quality and the amino acid patterns of the various diet components indeed complement each other.