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各種 病原菌의 Josamycin^� 및 몇가지 抗生劑에 대한 感受性에 관하여
全在殷,權國賢,權寧輳,李長白 慶北大學校 醫科大學 1975 慶北醫大誌 Vol.16 No.1
Sensitivity tests to Josamycin(JM), a new macrolide antibiotic, and several other antibiotics in common clinical use were done by the disc plate method on 61 strains of pathogens isolated from patients with various infections. Pathogens subjected to the tests were staphylococcus aureus, streptococcus hemolyticus, diplococcus pneumoniae and enterococcus. Other antibiotics tested were chloromycetin (CM), erythromycin(EM), kanamycin(KM), penicillin-G(PC), streptomycin (SM) and tetracycline(TC). All strains of diplococcus pneumoniae were sensitive to JM and four out of 15 strains of alpha-hemolytic streptococci were resistant to JM. Five out of six strains of enterococci were sensitive to JM. Nearly all strains of staphylococcus aureus and beta-hemolytic streptococci were sensitive to JM: only one out of 25 strains being resistant in the former and one out of 11 strains in the latter, respectively. These results suggested that JM was a dependable drug for the control of various infections caused by these organisms. Staphylococcus aureus was more sensitive to JM than CM, KM, PC, SM, and TC. Its sensitivity to JM was comparable to that of EM. Hemolytic streptococci were almost equally sensitive to JM, EM, PC or TC but less so to CM, KM, and SM. Sensitivity of diplococcus pneumoniae to JM, PC, and EM was comparable. Enterococci were more sensitive to JM and PC than to the other antibiotics tested. Almost all strains of staphylococcus aureus resistant to all the non-macrolide antibiotics tested were sensitive to JM. Thus, it seemed that cross-resistance of organisms to JM with other antibiotics was not a problem of clinical significance in the treatment of staphylococcus aureus infection and JM was a reliable drug for this infection.