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각종 간 질환에서의 종양유전자 및 성장인자 표현에 관한 연구
전우기,염범우 고려대학교 의과대학 1995 고려대 의대 잡지 Vol.32 No.3
The current concept of the carcinogenesis is that activated oncogenes or mutation of suppressor genes might inhibit the programmed cell death and permit cells to live forever. There are structural and functional similarities between the oncogenes and growth factors. Both substances act their functions by autocrine and paracrine effects on target cells and they appear in fetal, regenerating and sometimes in normal cells. In this study, I tried to find out which oncogenes and growth factors are involved in the process of carcinogenesis of the human liver. 53 cases of needle biopsied or resected liver specimens were used in immunohistologic study with anti sera of c-H-ras, c-myc. erbB2 and bcl-2 and antisera of TGFα and EGF. The results are as followings. 1. The antisera of EGF and TGFα revealed positive reaction on most of the normal liver tissue, hepatitis, cirrhosis and hepatoma. 2. The c-myc anti serum reveals positive reaction on only two cases of hepatoma. 3. c-H-ras antiserum revealed positive reaction on 1 case of CAH, cirrhosis and hepatoma. 4. The antisera of erbB2 and bcl-2 revealed negative reaction on all liver tissues. These findings are highly suggestive that c-H-ras and c-myc are responsible for causative oncogenes of hepatoma rather than bcl-2 and erbB2.
김동순,김용균,서연림,권성운,정광호,전우기 대한내과학회 1993 대한내과학회지 Vol.45 No.5
Primary pulmonary amyloidosis is a rare disorder. It can be classified into tracheo-bronchial, diffuse alveolar septal and nodular parenchymal form. Tracheo-bronchial amyloidosis can be further subdivided into diffuse and focal varieties. We report a case of diffuse tracheo-bronchial amyloidosis in a 49-year old man comfirmed by broncos-copic biopsy. He has suffered from cough and exertional dyspnea over 20 years and recently atelectasis of fright middle and lower lobe was found on chest X-ray with aggravation of symptom. The chest CT showed irregular thickening of tracheo-bronchial wall with calcification in addition to collapse of right middle and lower lobe. The bronchoscopy showed multiple variable sized submucosal nodules in lower trachea and both sides of bronchi, and biopsy revealed amyloid deposition at the subepithelial layer. We discussed this case with review of literature.