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장준복,김승보,이경섭,조정훈,Jang, Jun-Bock,Kim, Seung-Bo,Lee, Kyung-Sub,Cho, Jung-Hoon 한방비만학회 2002 한방비만학회지 Vol.2 No.1
Objectives: To compare the body composition of the postpartal female weight-gained over the recommended during pregnancy with that of normal female with same age. female diagnosed as obesity and postpartal female weight-gained within the recommended during pregnancy. Methods: From Apr. 1. 2001 to Feb. 28. 2002, there were 745 delivery in Dept. of Obstetrics & Gynecology, Kyung-Hee Medical Center. 32 mothers of them wanted to be investigated about the weight gain during their pregnancy. We excluded 12 persons who had gained within the recommended weight$(15{\beta}{\prod})$ and had diagnosed as the diseases inducing pathologic edema, preeclamsia. gestational heart or renal diseases, for example. In 2 days after delivery(nomal) or 5 days after(Caesarean section) we analysed the body composition of 20 persons. Results: 1. Compared with normal female, body weight, body mass index and body fat of the women gained over the recommended were increased and there made alternation to the increase of the percentage of body fat or the decrease of the percentage of lean body mass. 2. Compared with obese women who had same body mass index, the women gained over the recommended showed a little increase of body fluid, protein and mineral, but had a little decrease of the percentage of body fat. 3. The percentages of body fat increased with the women gained over the recommended, the women gained within the recommended and the obese women in order. This could imply the relation between the pregnancy, weight gain during pregnancy and the obesity. 4. The weights before pregnancy were same in the women gained over the recommended and the women gained within the recommended. But the weights just after delivery kept the gap happened during pregnancy between them and its main cause was the increase of body fat. Conclusions : The women gained over the recommended during pregnancy experienced the chage of body composition and its main cause was the increase of body fat. So compared with the women gained within the recommende, postpartal obesity more frequently could happen.
虎杖根(호장근)의 파골세포 분화 억제 효과와 기전 연구
장희재 ( Hee Jae Jang ),황덕상 ( Deok Sang Hwang ),이진무 ( Jin Moo Lee ),이창훈 ( Chang Hoon Lee ),이경섭 ( Kyung Sub Lee ),장준복 ( Jun Bok Jang ) 대한한방부인과학회 2014 大韓韓方婦人科學會誌 Vol.27 No.1
This study was conducted to evaluate the inhibitory effect of polygoni cuspidati radix (PCR) extract on osteoclast differentiation. Methods: MTT-assay was performed to estimate cytotoxicity of PCR extractin BMMs stimulated with RANKL. Tartrate resistant acid phosphatase (TRAP)staining, TRAP activity and RT-PCR were performed to know the inhibitory effecton osteoclast differentiation. actin ring formation were analysed to observe the effect of PCR extract. Results: PCR decreased the number of TRAP positive cells and TRAP activitiesin BMMs stimulated with RANKL and M-CSF. PCR restrained the formation ofactin ring. PCR down regulated the induction of NFATc1, c-Fos, TRAP and OSCARby RANKL. PCR inhibited NF-κB activity by inducing degradation of IκBα. Conclusions: We suggest that PCR Extracts can be an effective therapeutic agenton osteoclast differentiation caused by diseases such as osteoporosis.
조정훈,장준복,이경섭,김인중,Cho, Jung-Hoon,Jang, Jun-Bock,Lee, Kyung-Sub,Kim, In-Joong 대한한의정보학회 2005 大韓韓醫情報學會誌 Vol.11 No.1
Obesity can cause abnormality of ovarian function, which can also result disorder of menstruation. According to several studies, to reduce weights is the effective treatment in order to cure amenorrhea such as disorder of menstruation caused by obesity. This study shows a case that an obese woman by sumdam(濕痰) recovered from abnormality of menstruation as losing her weight due to a dose of Yijintang(二陳湯).
이재성,장준복,송병기,Lee, Jae-Sung,Jang, Jun-Bock,Song, Byoung-Key 대한한의학회 1998 대한한의학회지 Vol.19 No.2
Medication used during pregnancy may affect the growth of fetus and maintenance of pregnancy so that it may cause fetal deformity or abortion. Before 1940 it was recognized that only genetic factor could affect the incidence of fetal deformity and the teratogen was protected by placenta barrier. But since the report that Thalidomide caused phocomelia was announced in l962 and 1962, it was acknowledged that the placenta barrier was imperfect. In oriental medical care, there were so many prescription used during pregnancy for nausea, threatened abortion, recurrent spontaneous abortion and it was acknowledged that those medication did not harm both maternity and fetus. Most of them are composed of the material that was not classified as prohibition during pregnancy. But we thought that it should be demonstrated through objective methods that these materials do not affect the incidence of fetal deformity or abortion and have the effect of preventing abortion and maintenance of pregnancy. As the first step of that study we researched 78 prescription and each materials, their kinds and using frequency, used for illness and symptoms during pregnancy written in Dongeuibokam(東醫寶鑑) so that we got to know the tendency about what materials are used for each illness and symptoms.
습관성 유산에 대한 최신 연구 경향 및 실험적 방법 연구
조정훈,장준복,이경섭,김인중,Cho, Jung-Hoon,Jang, Jun-Bock,Lee, Kyung-Sub,Kim, In-Joong 대한한의정보학회 2005 大韓韓醫情報學會誌 Vol.11 No.1
Objectives : Recurrent pregnancy loss occurs in approximately 0.5-3% of women. There are many studies concerning immunological factor recently. Therefore, aim of this study is to examine the latest trend of researches concerning recurrent pregnancy loss, and controlled experiment on animals about antiphospholipid antibody. Method : We referred Pubmed site by using searching word of 'recurrent pregnancy loss' (Limits : 2000.1-2004.3, animal) Results and conclusions : 1. We searched 29 papers. Immunological factor : 18 ( about antiphospholipid antibody : 10 ), Chromosomal abnormality : 6, The others : 5 2. In five papers about controlled experiment on animals, (1) Materials : 8-12 weeks old mice / 11.5-day old-rat embryos / New Zealand rabbit (2) Inductions : inject intraperitoneally with human IgG containing antiphospholipid antibodies / culture in a solution of 1 ml medium which contained IgG purified from sera of women / inject intradermally with cardiolipin (3) Treatments : inject intraperitoneally with complement component before / culture in a solution of 1 ml medium which contained IgG purified from sera of women with SLE and RPL or from healthy women / inject intradermally with TFX, 0.9% NaCl (4) Measurements : weight fetuses and placentas, calculate frequency of fetal resorption / after culture, examine the embryos / examine platelet counts, APTT and numbers of live and dead newborns, resorbed fetuses, body mass, newborn viability and survival rates.