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장영운,김병호,임익태,Jang, Young-Woon,Kim, Byung-Ho,Im, Ik-Tae 한국반도체디스플레이기술학회 2009 반도체디스플레이기술학회지 Vol.8 No.4
In this study, a thin plate-type heat pipe, instead of a solid aluminium heat sink, is used to eliminate heat released from LED components for lighting. Effects of the heat pipe size and installation angle are studied both in numerically and experimentally. According to the results, temperature on LED chip, when a heat pipe is used, is $1.2^{\circ}C$ lower than using the conventional metal PCB. The overall temperature drop is $32^{\circ}C$ if the heat pipe is properly used. The highest cooling performance is obtained in the case when the angle of a heat pipe installation is $90^{\circ}$.
김병호(Byung Ho Kim),정용희(Young Hee Joung),장영운(Young Woon Chang),민선기(Sun Kee Min),문주영(Ju Young Moon),한요셉(Yo Seb Han),이동근(Dong Keun Lee),동석호(Seok Ho Dong),김효종(Hyo Jong Kim),이정일(Jung Il Lee),장린(Rin Chang) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.4
Alendronate (Fosamax), an aminobisphosphonate and a selective inhibitor of osteoclast-mediated bone resorption, is used to treat postmenopausal osteoporosis and Paget's disease. In recent years, reports of severe esophageal injury in patients who took alendronate have evoked attention to the irritant effects of this drug on the mucosa of the upper gastrointestinal tract. We present a case of gastric ulcer caused by alendronate. The patient chiefly complainted of epigastric pain during 14 days. She had taken mefenamic acid for pain control for 3 years and she took once-weekly 70 mg of alendronate for 2 weeks for treatment of osteoporosis before the symptom started. Upper gastrointestinal endoscopy revealed two active gastric ulcers in the low body. The results of rapid urease test (CLO test) and modified Giemsa test for the detection of Helicobacter pylori infection were negative. After withdrawal of alendronate, the symptom resolved completely in one week. Six weeks later, follow-up endoscopy showed complete healing of the ulcer. (Korean J Gastroenterol 2001;38:284-287)
Galactosamine으로 급성간부전이 유도된 흰쥐에서 간세포이식의 효과
김병호(Byung Ho Kim),은연기,김효종(Hyo Jong Kim),장영운(Young Woon Chang),장린(Rin Chang),이정일(Jung Il Lee) 대한내과학회 1991 대한내과학회지 Vol.40 No.4
N/A Although the mortality rate following acute hepatic failure is still high, it is possible to recover completely if patients survive. So temporary hepatic support that can sustain life during the period of hepatic insufficiency is important in the treatment of acute hepatic failure. Despite the fact that various therapeutic modalities have been described for treating acute liver failure, none has proven to be clinically useful except for the liver transplantation. But liver transplantation is not used widely because of the difficulty in obtaining cadaver donor organs especially in eastern countries, techinical difficulties, and high cost. As the alternatives to liver transplantaion, several investigators developed various techniques of hepatocellular transplantation, which has significantly enhanced the survival rate in the animal from chemically or surgically-induced acute liver failure. According to the evidence provided by the aforementioned studies, we investigated the efficacy of allogeneic hepatocellular transplantation on the survival rate following galactosamine-induced acute liver failure in the Sprague-Dawley male rat, The results were as follows: 1) In the preliminary study for determining the amount of d-galactosamine HC1 (Sigma), intraper- itoneal injection of 1.3g/kg of galactosamine induced a mortality rate of 75% within 5 days in 12 rats (210~280g). 2) Isolation of hepatocytes was performed by a modification of the method of Seglen, collagenase (Sigma, type I) two-step perfusion technique. The mean number of obtainable total hepatocytes from 7 rats was 2.2 ×108±0.7×108, with an average viability of 50±3%. 3) There was no significant difference in the survival rate between group I, which was administered only galactosamine, and group II, which was treated by intraperitoneal transplantation of 2×107 viable hepatocytes at 51 to 55 hours after administration of galactosamine (33% VS 40%). In conclusion, we couldn't note any improvement of survival after hepatocellular transplantation in rats with galactosamine-induced acute hepatic failure. But this result doesn't mean that hepatocellular transplantation had no effect in the treatment of acute hepatic failure. In the future, we will need further study about our method of hepatocytes isolation to increase the viability of isolated hepatocytes, adequate time of the transplantation after galactosamine administration, and syngeneic hepatocellular transplantation in order to evaluate more exactly the efficacy of hepatocellular transplantation.
내시경적 정맥류 결찰요법의 단기 치료성적 및 안정성 - 내시경적 경화요법과의 비교 -
김병호 ( Byung Ho Kim ),김효종 ( Hyo Jong Kim ),김영관 ( Young Kwan Kim ),장린 ( Rin Chang ),이정일 ( Joung Il Lee ),동석호 ( Seok Ho Dong ),장영운 ( Young Woon Chang ) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.5
N/A Endoscopic sclerotherapy is an effective method for bleeding esophageal varices, however it is often associated with local and systemic complications which may limit its usefulness. A newly developed endoscopic treatment for bleeding esophageal varices, endoscopic variceal li- gation, which uses small rubber bands to occlude and eradicate the varices, may cause less damage to the esophagus and have no systemic complication theoretically. We compared the effectiveness and safty of the two techniques retrospectively. The patients had proved bleeding from esophageal varix and showed advanced liver cirrhosis. Nineteen patients were treated with ligation, and 20 patients with sclerotherpy. They were followed for a mean of 4 months. Acitve bleeding was controlled by ligation in 2 of 3 patients(67% ) and by sclerotherapy in 3 of 4 patients(75%). The eradication of varices was achieved by ligation in 6 of 14 patients(43 A ) and by sclerotherapy in 10 of 15 patients(67% ). But the mean number of treatments with ligation was lower than that with sclerotherapy(3.4 vs 4.2) ar J than other ligation treatment group(4-5). There was no significant difference in recurrent hernorrhage between two groups. There were one case of pleural effusion and one case of sepsis with acute renal failure in scle- rotherapy treated-patients, whereas none of these complications occurred in ligation treated patients. Two cases of treatment induced bleeding were developed in ligation group. Endoscop- ic variceal ligation has fewer local and/or systemic complications than sclerotherapy. To eradi- cate varices more completely and to achieve denudation of lower esophageal mucosa for pre- vention of recurrent hemorrhage, combination with sclerotherapy would be effective rather than ligation alone.(Korean J Gastroenterol 1994; 26: 765 770)
한국인 대장 선종성용종 환자에서의 MYH 유전자 변이에 대한 연구
김한수 ( Hansoo Kim ),김효종 ( Hyo Jong Kim ),지성길 ( Sung Gil Chi ),주광로 ( Gwang Ro Joo ),동석호 ( Seok Ho Dong ),김병호 ( Byung Ho Kim ),장영운 ( Young Woon Chang ),이정일 ( Jung Il Lee ),장린 ( Rin Chang ) 대한장연구학회 2005 Intestinal Research Vol.3 No.1
Background/Aims: Recently, germ-line mutation in the base-excision-repair gene MYH was identified to cause a novel autosomal recessive form of familial adenomatous polyposis (FAP). Interestingly, a striking evidence for MYH mutations within different ethnic groups has been demonstrated. We have screened 30 patients with multiple adenomatous polyps for MYH mutations to assess its prevalence and ethnic specificity in Korea. Methods: Thirty patients with multiple adenomatous polyps were examined for MYH mutations. Twenty-one men and 9 women presented at a median age of 62.3 years. The mean number of adenomas per patient was 10.0. Sixteen exonic regions and its intronic sequences were amplified by PCR and subjected to SSCP and DNA sequencing analyses. Results: None of the patients was identified to carry any truncating or sequence alterations in MYH. Our screening for the mutational regions, which were recognized from Caucasian patients or affected Indian families, also failed to detect sequence substitutions. Conclusions: Mutation in MYH may be rarely involved in the pathogenesis of multiple sporadic colorectal adenomas in Korea, although large-scale analysis will be required to clarify the presence of specific MYH variants in a subset of patients and its role for the predisposition of multiple colorectal adenomas in Korea. (Intest Res 2005;3:27-32)
김효종(Hyo Jong Kim),김윤화(Youn Hwa Kim),정혜전(Heo Jeon Cheong),동석호(Seok Ho Dong),김배영(Bae Young Kim),김병호(Byung Ho Kim),이정일(Joung Il Lee),장영운(Young Woon Chang),장린(Rin Chang),양문호(Moon Ho Yang) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1
N/A Background/Aims: Multiple genetic alterations in tumor suppressor genes(APC, MCC, DCC, p53) and oncogenes(K-ras) have been implicated in the development of colorectal carcinomas(CRCs). Recently, mutator genes(hMSH2, hMLH1, hPMS1, hPMS2), which are characterized by the development of particular form of genetic instability, termed RER(replication error) was reported in CRCs. It is postulated that RER may be required for multiple genetic alterations in the development of CRCs. But the mode of genetic alterations caused by RER is not certain. To evaluate the mode of genetic alterations caused by RER in multistage carcinogeneis, we compared the frequency of p53 expression, known to be involved in the pathogenesis of CRC, in two groups of tumors. RER(+); those demonstrating RER, and RER( ); those lacking such genetic alterations. Methods: RER test at microsatellite loci; DNA was extracted from normal and tumor tissues using cryostat sectioning method. Purified DNA was subjected to a PCR-based technique in which(CA)n repeat sequence were amplified and RERs were detected when a change in allele length was detected. Immunohistochemical analysis of p53 expression; Deparaffinized section of formalin-fixed tumor tissue samples were immunostained for p53 protein, using a monoclonal p53-specific DO7 antibody. Results: The frequency of RER in sporadic CRC was 40.1%(9/22). P53 expression was observed in 6 of 18 carcinoma(33.3%). The frequency of p53 immunostaining was lower in tumors demonstrating RER(25% vs. 40%). All tumor demonstrating RER at multiple loci did not exhibited p53 immunostaining. Conclusions: These results suggest that RER is likely to play an important role in the pathogenesis of CRCs probably by the different mode of genentic alterations from those lacking RER. (Korean J Gastroenterol 1996;28: 36-46)
장린(Rin Chang),김병호(Byung Ho Kim),장영운(Young Woon Chang),이정일(Jung Il Lee),김효종(Hyo Jong Kim),김영관(Young Kwan Kim),동석호(Seok Ho Dong),정형근(Hyung Keun Chung),김배영(Bai Young Kim) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.1
N/A In most young adults with colorectal cancer, tumors are already in advanced stage at the initiation of the treatment and the prognosis has been considered unfavorable. However, some recent articles have shown that it is not necessarily dismal. Therefore, we evaluated retrospectively the incidence, the clinical characteristics and the prognosis in 50 patients with colorectal cancer less than 40 years of age who admitted to the Kyung Hee University Hoapital from Jan. 1981 to Jan 1991. The incidence of colorectal cancer in patients less than 40 years af age was 6.8% (50/739) and the male versus female ratio revealed 1:1. The patients whose clinical, symptom had been for over 6 months before visiting the hospital was 74%, but the duration of clinical symptom had no significant relation to overall survival. The most common pathologic type was moderately differentiated adenocarcinoma. The 5 year cumulative survival rate was 39%. In conclusion, the clinical characteristics of colorectal cancer in patients less than 40 years of age were not different from those of overall colorectal cancer patients, and the prognosis was not unfavorable.
포스터 전시 : 간 10 ; 고콜레스테롤혈증, 고칼슘혈증, 저혈당증, 적혈구증가증의 부종양증후군을 동시에 나타낸 간암 1예
김진혁 ( Jin Hyuk Kim ),김병호 ( Byung Ho Kim ),이태희 ( Tae Hee Lee ),정용희 ( Yong Hee Joung ),이병욱 ( Bung Yuk Lee ),한요셉 ( Yo Seb Han ),동석호 ( Seok Ho Dong ),김효종 ( Hyo Jong Kim ),장영운 ( Young Woon Chang ),이정일 ( Jo 대한소화기학회 2002 대한소화기학회 추계학술대회 Vol.2002 No.-