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B 임파구(淋巴球)와 비만세포(肥滿細胞)에서 모단피(牡丹皮) 추출물(抽出物)의 항(抗)알러지 작용(作用)에 관(關)한 연구(硏究)
진속창,이한배,김성균,이승희,서영배,이용구,이영철,장성익,Jeen Sok-Chang,Kim Sung-Kyun,Lee Han-Bae,Lee Seung-Hee,Seo Young-Bae,Lee Yong-Gu,Lee Young-Chul,Jang Sung-Ik 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.1
Objective : This study was carried out for the purpose of proving the effect of anti-allergic efficacy on B cells and the mast cells of the BALB/C mouse by the abstraction from a Moutan cortex. Methods & Results : In order to know what the effect of an abstraction from Moutan cortex and about the expression of CD23 and IgE, IC-2 cell (mouse mast precursor cells that was dependent on IL-3), it was necessary to be activated. We then analyzed it from the flow of cytometry on the increase and the divorce of the B cells activated by anti-CD40. In order to know what the effect of it was on the organization of cytokine gene expression from the increase and divorce of the B cells and allergic acting by Moutan cortex, we found it necessary to examine the IC-2 cells and B cells. At the same time, as we examined the histamine release of IC-2 cells by ELISA method, we also examined the effect of Moutan cortex on the increase and divorce of the B cells by 3H-thymidine uptake method. We then analyzed the release of IL-4, IgE and histamine. Conclusions : As a results, Moutan Cortex promoted blood supply by extending the blood vessel of nasal mucous, which was contracted by the hypertrophied nasal mucous.