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RKO 대장암세포에서 3-헵틸아미노-6-알릴티오피리다진과 3-디펜틸아미노-6-알릴티오피리다진의 항암기전
임현경,권유미,송지윤,김경미,김채원,박명숙,정주희,Lim, Hyun Kyung,Kwon, Yumi,Song, Jiyun,Kim, Kyoung Mee,Kim, Chaewon,Park, Myung-Sook,Jung, Joohee 대한약학회 2016 약학회지 Vol.60 No.3
Allylthiopyridazine derivatives were synthesized and evaluated for anti-proliferative activities in the previous study. In this study, selected two allylthiopyridazine derivatives (compound I, 3-heptylamino-6-allylthiopyridazine and compound II, 3-dipentylamino-6-allylthiopyridazine) were assessed for cytotoxicity and chronic proliferation in human colon carcinoma RKO cells. Two derivatives dose-dependently inhibited cell viability and proliferation. To elucidate the anticancer mechanism of two derivatives, we investigated the expression level of apoptosis-related proteins in RKO cells. Compound I induced the activation of JNK and expression of p53 and p21. On the other hand, compound II showed no change of p53 level. Interestingly, compound II inhibited the nuclear translocation of NF-${\kappa}B$. This result suggested that compound II suppressed cell proliferation. These different mechanisms of these compounds might have occurred through different steric conformation.
일측 폐환기 중 피떡에 의한 좌측 주기관지 완전 폐쇄 발생 및 이중내강튜브 좌측관의 직접 흡인을 통한 피떡의 제거
임현경 ( Hyun Kyoung Lim ),최춘길 ( Chun Gil Choi ),송장호 ( Jang Ho Song ),김건식 ( Keon Sik Kim ),이두익 ( Doo Ik Lee ) 경희대학교 경희의료원 2014 慶熙醫學 Vol.29 No.2
Airway obstruction may lead to fatal ventilatory disturbance. We are unaware of any similar cases in which a blood clot, causing a total obstruction of the left main bronchus during a left upper lobectomy, was removed by direct suction to the left bronchial lumen of the double lumen tube without the tube removal. If endobronchial suctioning with suction catheter fails to evacuate the blood clot cast, and when other methods such as bronchoscopic removal or using the Fogarty catheter are either difficult to perform or unavailable, direct suctioning of the affected endobronchial lumen can be an option for removal of the blood clot, before attempting other invasive procedures like surgical removal.
임현경(Hyun Kyoung Lim),정종권(Chong Kweon Chung) 대한통증학회 1998 The Korean Journal of Pain Vol.11 No.1
Dysmenorrhea(cyclic pain associated with menses) is a frequent disorder, with as many as 50% of young women experiencing the symptom, and up to 10% being unable to function normally for some time each month. The most recent theory of the cause of the pain of dysmenorrhea incriminates uterine ischemia and sensitization of uterine pain fibers resulting from excessive myometrial contractility after prostaglandin stimulation. We administered stellate ganglion block for the treatment of dysmenorrhea and had good results in two cases. From our experience, we recommend the stellate ganglion block may be an effective treatment for a dysmenorrhea.
증례보고 : 복와위에서 요추 후방 융합술 중 발생한 횡문근융해증 환자의 치료 경험 2례
임현경 ( Hyun Kyoung Lim ),박상규 ( Sang Kyu Park ),정종권 ( Jong Kwon Jung ),이춘수 ( Choon Soo Lee ),이두익 ( Doo Ik Lee ),한정욱 ( Jeong Uk Han ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.4
The spine surgery performed in the prone position could cause severe complications such as visual acuity impairment, spinal infarct and rhabdomyolysis. When treating rhabdomyolysis, it is important to prevent acute renal failure from accompanying rhabdomyolysis due to the poor prognosis. We have experienced two cases of rhabdomyolysis after spine surgery where dark urine was present during spine surgery under general anesthesia. Anesthesiologists should pay attention for early diagnosis and treatment of the rhabdomyolysis developing during the spine surgery. (Korean J Anesthesiol 2009;57:528∼30)
안면 경련 환자에서 진단투시기를 이용한 안면 신경 차단
임현경(Hyun Kyoung Lim),곽노길(No Kll Kwak),이영복 대한통증학회 1995 The Korean Journal of Pain Vol.8 No.1
N/A Hemifacial spasm is a distressing condition characterized clinically by paroxysmal and an in- voluntary movement in muscles innervated by the facial nerve on one side of the face. Block- ade of the facial nerve can be performed percutaneously, without any serious complications. There are certain clinical problems associated with the conventional procedure, such as se- vere pain and technical difficulties to find facial nerve. This report describes a fluoroscope guided facial nerve block. This new technique reduced the difficulties in identifying the facial nerve and decreased the suffering associated with the conventional way of facial nerve block.
선경,이서원,김정택,김광호,임현경,Sun, Kyung,Lee, Seo-Won,Kim, Joung-Taek,Kim, Kwang-Ho,Lim, Hyun-Kyoung 대한흉부심장혈관외과학회 1999 Journal of Chest Surgery (J Chest Surg) Vol.32 No.7
소아의 흉부기관협착증 2례에 대해 자가심막을 이용해 전방 기관성형술을 실시\ulcorner였다. 증례 1은 9세된 여 아에서 발견된 선천성 기관협착증의 경우로 인공폐의 보조 아래 기관성형과 동반된 좌폐동맥 기시이상을 동 시에 근치하였다. 환아는 이식된 심막편이 종격조직에 고정될 때까지 수술 후 10일 간 기계호흡을 실시하였 다. 증례 2는 8세된 남아에서 기관절개술 후 하부기관협착이 발생한 경우로, 심막편 바깥을 늑연골편으로 보 강함으로써 수술 직후 기도삽관을 제거할 수 있었다. 2례 모두 수술 후 1년 이상의 관찰기간 동안 기관내경 이 잘 유지되고 있으며, 기관재건부위가 성장하는 소견을 보인다. We describe here two cases of anterior tracheoplasty utilizing an autologous pericardial patch. One patient was a 9 year-old female who had a congenital long tracheal stenosis associated with major vascular anomalies including pulmonary artery sling. One-stage correction was done under the support of an extracorporeal membrane oxygenation system. She required a prolonged ventilation support for 10 days postoperatively until the implanted pericardium was fixed to the mediastinal structures. The other patient was a 8 year-old male who had acquired tracheal stenosis following a complicated tracheostomy. By applying additional support over the pericardial patch with the costal cartilage, an endotracheal tube could be removed immediately after the operation. Both patients have been doing well in a postoperative follow-up of over a year, and there have been evidences of growth in the reconstructed trachea.
증례보고 : 소아 환자에서 Sevoflurane 마취 후 발생한 급성 간 손상
송장호 ( Jang Ho Song ),임현경 ( Hyun Kyoung Lim ),이춘수 ( Choon Soo Lee ),백완기 ( Wan Ki Baek ),윤정원 ( Jung Won Yoon ),신혜란 ( Helen Ki Shinn ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.53 No.6
Postoperative hepatotoxicity may develop from many causes. One of them is direct injury to the liver cell due to anesthetic agents. Each agent has different hepatotoxic risk. Sevoflurane is known to have a very low potential for hepatotoxicity. We report a case of severe hepatic dysfunction after anesthesia with sevoflurane in a pediatric patient who underwent cardiopulmonary bypass surgery. (Korean J Anesthesiol 2007; 53: 781∼4)
증례보고 : 전신마취 유도 중 발생한 Vecuronium에 의한 아나필락시스
신헬렌키 ( Helen Ki Shinn ),임현경 ( Hyun Kyoung Lim ),송장호 ( Jang Ho Song ),한정욱 ( Jeong Uk Han ),고두현 ( Du Hyun Ko ),정인준 ( In Jun Jung ),정종권 ( Jong Kwon Jung ) 대한마취과학회 2008 Korean Journal of Anesthesiology Vol.55 No.5
Anaphylaxis is one of major causes of morbidity and mortality during anesthesia. Muscle relaxants are the most common cause of anaphylaxis during anesthesia. A 54-year-old woman was scheduled for thyroidectomy. She had no history of allergy and had never previously undergone general anesthesia, Lidocaine, propofol and vecuronium were injected sequentially to induce general anesthesia. Two minutes after the vecuronium injection, severe hypotension, tachycardia and bronchospasm developed, and delayed skin rashes appeared. The patient recovered without any significant complications after immediate proper intensive care. The operation was delayed and a skin test was performed on the 7th day after discharge. She revealed a positive skin test for vecuronium. The anesthesia was re-induced without muscle relaxant and maintained with propofol and remifentanil infusion. Surgery was completed uneventfully, and the patient recovered without any adverse reaction. (Korean J Anesthesiol 2008;55:613~7)
기관재건술 후 발생한 심부 종격염 -흉골 절제, 위망 이식, 근피성형을 병합한 근치술-
이서원,김정택,김광호,이충재,김영모,임현경,선경,Lee, Seo-Won,Kim, Jung-Taek,Kim, Kwang-Ho,Lee, Choong-Jae,Kim, Young-Mo,Lim, Hyun-Kyoung,Sun, Kyung 대한흉부심장혈관외과학회 1999 Journal of Chest Surgery (J Chest Surg) Vol.32 No.2
기관재건술 후 발생한 심부 종격염 2례에 대해 흉골절제, 대위망 자유이식 혹은 전치술, 근피성형술을 병행하여 좋은 결과를 얻었기에 보고한다. 증례 I은 8세된 남아에서 흉골 정중절개로 전방기관성형술을 실시한 후 심부 종격염과 흉골 골수염이 발생한 경우였으며, 증례 II는 50세된 여자에서 상부 흉골의 부분 정중절개로 기관절제 및 단단문합을 실시한 후 종격농양과 흉골 골수염이 발생한 경우였다. 치료는 두례 모두 배농을 시키고 일정기간 세척한 다음, 골수염이 생긴 흉골을 광범위 절제하고 대위망으로 종격을 덮은 후 양측 대흉근을 피부와 함께 박리하여 전흉벽을 재건하였다. 이때 증례 I의 경우는 대위망을 분리한 뒤 횡격막을 통해 종격부위에 위치시켰으며 (in-situ pedicled grafting), 증례 II의 경우는 대위망을 자유이식편으로 만들어 우횡경동맥과 외경정맥에 연결한 후 피하출구을 통해 상부종격에 위치시켰다 (free grafting). 양례 모두 술후 쾌회복하였으며 외래를 통해 추적관찰 중이다. We report here 2 cases of deep-seated mediastinitis combined with sternal osteomyelitis after tracheal reconstruction which were successfully treated with sternectomy, in-situ or free omental transfer, and pectoralis major myocutaneous flap. In case I, an 8 year-old boy with deep seated mediastinitis and sternal osteomyelitis that developed after anterior tracheoplasty through a standard midline sternotomy. In case II, a 50 year-old female patient with mediastinal abcess and sternal osteomyelitis that developed after resection and end-to-end anastomosis of the trachea through an upper midline sternotomy. Treatments consisted of drainage and irrigation followed by wide resection of the infected sternum, placement of the viable omentum into the anterior mediastinal space, and chest wall reconstruction with a pectoralis major myocutaneous flap. The omentum was transferred as an in-situ pedicled graft in case I and a free graft in case II. Both patients have recovered smoothly wit out any events and have been doing well postoperatively.
종격에 자유이식된 대공막의 혈관조영 및 전산화 단층촬영 추적결과 - 1례 보고 -
선경,김정택,김광호,이충재,김영모,임현경,Sun, Kyung,Kim, Jung-Taek,Kim, Kwang-Ho,Lee, Choong-Jae,Kim, Young-Mo,Lim, Hyun-Kyoung 대한기관식도과학회 1998 大韓氣管食道科學會誌 Vol.4 No.1
Partial splitting of the upper sternum provides an excellent surgical view in reconstruction of the intrathoracic trachea. However, when deep-seated mediastinitis develops postoperatively, it is difficult to manage especially when combined with sternal osteomyelitis. It also needs an additional consideration compared to the usual treatment modality applied to mediastinitis following a standard median stemotomy because the lower part of the stemum remains intact. We treated a 50 year old female patient with deep-seated mediastinitis and sternal osteomyelitis following resection and end-to-end anastomosis of the trachea through an upper midline sternotomy. The patient underwent extensive stemectomy, omental free grafting, and pectoral myocutaneous flap. Postoperative viability of the free-grafted omentum was evaluated by angiography and CT scan.