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NC/Nga 마우스에서의 아토피피부염 유사 병변에 대한 Light Emitting Diode의 치료 효과
임윤영 ( Yun Young Lim ),장우선 ( Woo Sun Jang ),김형미 ( Hyeong Mi Kim ),김인수 ( In Su Kim ),이진웅 ( Jin Woong Lee ),김명남 ( Myeung Nam Kim ),김범준 ( Beom Joon Kim ) 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.3
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease. It is caused by immunological abnormalities, abnormalities of the skin barrier, and environmental/ genetic factors. We did a preclinical trial to identify the effects of the 633-nm light- emitting diode (LED) and 830-nm LED for AD-like lesions in NC/Nga mice. Methods: AD-like skin lesions were induced by topical application of Dermatophagoides farinae extract on the skin of 5-week-old NC/Nga mice for 2 weeks, and then was treated with 630-nm or 830-nm LED for 1 week. We identified any therapeutic effects on AD using modified SCORAD index, skin biopsy, and measurements of both transepidermal water loss (TEWL) and proinflammatory cytokines. Results: Both of 630-nm and 830-nm LED treatment groups showed significantly reduced SCORAD indices and TEWLs at the end of treatment, compared to the non-treatment group. In addition, the levels of proinflammatory cytokine levels in both of the LED treatment groups were significantly decreased compared to those in the non-treatment group. Conclusion: These results show that 633-nm and 830-nm LED treatments can improve -like lesions in NC/Nga mice. (Korean J Asthma Allergy Clin Immunol 2011;31:207-214)
StoneTouch(R) 적외선조사기를 이용한 동물 모델에서의 피부 안전성 시험과 아토피피부염의 증상개선 효과에 관한 연구
임윤영 ( Yun Young Lim ),김형미 ( Hyeong Mi Kim ),장우선 ( Woo Sun Jang ),서수홍 ( Soo Hong Seo ),안효현 ( Hyo Hyun Ahn ),김명남 ( Myeung Nam Kim ),김범준 ( Beom Joon Kim ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.3
Background: Atopic dermatitis is a chronic inflammatory skin disease. It is caused by immunological abnormalities, abnormalities of the skin barrier, environmental factors and genetic factors. Atopic dermatitis destroys the skin barrier and passes through the skin, triggering an immune response. To treat atopic dermatitis, we anticipate use of hypoallergenic cures to hydrate skin that has been dried by destruction of the skin barrier. Objective: We did a preclinical trial to identify inhibitory effects of the StoneTouch(R) infrared scanner on atopic dermatitis. We conducted skin safety tests, comparing the use of infrared energy to drug treatment. We then confirmed the effects of the StoneTouch(R) infrared scanner through animal tests using Nc/Nga mice as a model of atopic dermatitis in order to identify any inhibition of the immune response in atopic dermatitis. Methods: We irradiated Nc/Nga mice using a StoneTouch(R) infrared scanner under a variety of conditions. During skin safety tests of the StoneTouch(R) infrared scanner on hairless mice, we assessed immune response and burn risk in irradiated mouse skin. We identified any inhibitory effects on atopic dermatitis using Dermoscope assessments, measurements of transepidermal water loss (TEWL) and IgE levels, measurements of pro-inflammatory cytokines, H&E staining and immunofluorescence staining (IF) of substance P and CGRP as neurotransmitters on the backs and ears of Nc/Nga mice irradiated by the StoneTouch(R) infrared scanner. Results: We did not observe any skin abnormalities after using the StoneTouch(R) infrared scanner on Nc/Nga mice. We confirmed the inhibitory effect of the StoneTouch(R) infrared scanner irradiation on atopic dermatitis. We found that irradiated epidermis was thinner than that of the epidermis in Nc/Nga mice in which atopic dermatitis was induced. We observed no significant between groups differences in expression level of substance P. The expression of CGRP in mice with atopic dermatitis was decreased, but, the increased irradiation led to greater expression of CGRP in irradiated skin. Conclusion: The StoneTouch(R) infrared scanner does not as a function of irradiation dosage. It inhibits the development of atopic dermatitis. (Korean J Dermatol 2011;49(3):217∼226)
무모생쥐를 이용한 Disk 형태(DTS) 미세침롤러의 피부안정성에 관한 연구
박귀영 ( Kui Young Park ),이진웅 ( Jin Woong Lee ),김동하 ( Dong Ha Kim ),임윤영 ( Yun Young Lim ),김범준 ( Beom Joon Kim ),김명남 ( Myeung Nam Kim ) 대한천식알레르기학회 2010 천식 및 알레르기 Vol.30 No.3
Background: The transdermal drug delivery system has been studied for several decades as an alternative tool. Even though it has many advantages such as stability of drug to the destination, safety to the liver, there are some limitations in crossing the stratum corneum. Microneedle can perforate the skin directly, which make it possible for drugs to penetrate into the subcutaneous tissue. Objective: The purpose of this study to evaluate the stability of Diskmicroneedle Therapy System (DTS) and directly compare them with conventional Microneedle Therapy System (MTS(R), Clinical Resolution Lab, California, USA). Method: We used 3 sizes of Manual and electric Disk-microneedle Therapy System (DTS; 0.25 mm, 1.0 mm and 1.5 mm) to perforate the skin. We performed a comparative study of 0.5 mm manual DTS and Microneedle Therapy System (MTS(R)). To evaluate the stability, visual inspection and biopsy were conducted. Result: Manual and electric DTS of all 3 sizes did not induce significant abnormalities of the skin on visual inspection and biopsy. DTS and MTS produced similar results on the stability for the skin. Conclusion: Similar to the preexisting MTS, DTS is a safe transdermal delivery system, and the size should be chosen carefully. (Korean J Asthma Allergy Clin Immunol 2010;30:222-227)
황금추출물의 추출 방법에 따른 세포 독성 평가 및 피부 안전성 평가
김형미 ( Hyeong Mi Kim ),임윤영 ( Yun Young Lim ),조수묵 ( Soo Muk Cho ),김민영 ( Min Young Kim ),손인평 ( In Pyeong Son ),석장미 ( In Pyeong Son ),박진오 ( Jin Oh Park ),박종호 ( Jong Ho Park ),조재위 ( Jae We Cho ),김범준 ( Beom 대한피부과학회 2012 대한피부과학회지 Vol.50 No.11
Background: Scutellaria baicalensis Georgi extract is used as a traditional herbal medicine. The efficacy of Scutellaria baicalensis Georgi extract is known for antioxidative activity, antiinflammation effect, antibacterial effect, inhibitory effect of melanin synthesis, sun protection effect, antiallergy effect, and etc. Objective: We confirmed the cell viability or inhibitory effect of melanin synthesis in HaCaT (human keratinocyte cell line) and B16F10 (murine melanoma cell line) cells and the skin safety test through a clinical test (dermal irritation study) for Scutellaria baicalensis Georgi extract, according to the extraction methods. Methods: We checked the cell viability, using MTT assay and inhibitory effect of melanin synthesis in B16F10 cells or HaCaT cells for thirty one Scutellaria baicalensis Georgi extract, according to the extraction methods. Then, we evaluated the skin safety for selected eight Scutellaria baicalensis Georgi extract through a primary dermal irritation test. Results: Among the thirty one Scutellaria baicalensis Georgi extracts, according to the extraction methods, we selected eight Scutellaria baicalensis Georgi extracts that were not detected with cell toxicity in HaCaT cells and B16F10 cells, and could have inhibited the melanin synthesis in B16F10 cells. The selected eight Scutellaria baicalensis Georgi extracts identified the skin safety through a primary dermal irritation test. Conclusion: We expect clinical trials for whitening efficacy based on inhibitory effect of melanin synthesis and human skin safety for Scutellaria baicalensis Georgi extracts. (Korean J Dermatol 2012;50(11):959∼968)
한국의 아토피피부염 환자에서 혼합생약추출물 함유 로션의 효능에 대한 예비연구
손인평 ( In Pyeong Son ),임윤영 ( Yun Young Lim ),김형미 ( Hyeong Mi Kim ),김민영 ( Min Young Kim ),석장미 ( Jang Mi Suk ),김영희 ( Young Heui Kim ),김기호 ( Ki Ho Kim ),김범준 ( Beom Joon Kim ),김명남 ( Myeung Nam Kim ) 대한천식알레르기학회 2012 천식 및 알레르기 Vol.32 No.1
Background: The choice of topical agents is very important for patients with atopic dermatitis (AD) because mild to moderate AD-related symptoms and skin lesions could be significantly relieved with appropriate topical treatment. This study was performed to evaluate the effectineness of a mixed herbal extract lotion containing the extract of Sophorae Radix, Cinnamomi Cortex, Saururi Herba Seu Rhizoma and Aurantii Immaturus Fructus in relieving symptoms and skin lesions associated with AD. Methods: A total of 24 patients who were suffering mild to moderate AD applied topical lotions, i.e. the test lotion on the right antecubital fossa and the control lotion on the left antecubital fossa twice daily for up to 4 weeks. The treatment efficacy was evaluated by the measurement of skin hydration and trans-epidermal water loss (TEWL) on the same site at each visit. Additional evaluation methods were the investigator global assessment (IGA) and the visual analogue scale visual analogue scale for pruritus. Results: The test lotion-applied right antecubital fossa achieved more clinical improvement than the control lotion-applied left antecubital fossa. TEWL on the test side more significantly decreased than that on the control side after 4 weeks of lotion application. There were slightly more improvements in both the IGA and patient assessment of pruritus on the test side. Conclusion: Mixed herbal extract lotions containing the extracts of Sophorae Radix, Cinnamomi Cortex, Saururi Herba Seu Rhizoma and Aurantii Immaturus Fructus can relieve symptoms, such as pruritus, in AD patients. (Korean J Asthma Allergy Clin Immunol 2012;32:26-33)
유광호 ( Kwang Ho Yoo ),홍유진 ( Yu Jin Hong ),임윤영 ( Yun Young Lim ),한경연 ( Kyeung Eun Han ),이갑석 ( Kap Sok Li ),김범준 ( Beom Joon Kim ),김명남 ( Myeung Nam Kim ),홍혁기 ( Hyuck Ki Hong ),최연식 ( Yeon Shik Choi ),조영창 ( 대한피부과학회 2009 대한피부과학회지 Vol.47 No.3
Background: The imaging system that`s currently being used in the field of dermatology is based on such instruments as the dermoscope, phototrichograph and camera. In recent years, the use of an image magnification system based on polarization has become popular. Objective: In this study, optical quantification was performed based on the multiwavelength imaging analysis of the structures that form dermatologic diseases, and an attempt was made to enhance the image quality by using polarization technology. Methods: The lesions of three patients who were clinically diagnosed with cherry angioma, melanocytic nevus and inflammatory lesions in acne and freckles were measured at the outpatient clinic of the Department of Dermatology of the authors` hospital. All the patients were female, and their mean age was 29.3 years. Results: The optical characteristics of the patients` various skin lesions, including cherry angioma, melanocytic nevus and inflammatory lesions in acne and freckles, were distinguishable by their wavelength. Conclusion: The use of different kinds of information may be helpful for measuring and diagnosing various skin lesions that have not been differentiated with using the previous modalities. Further, if the various environmental factors that may be generated during the measurement process can be controlled, then these study results can be applied to a standard diagnostic modality in the field of dermatology. (Korean J Dermatol 2009;47(3):303∼308)
아토피피부염 환자에서 민들레 추출물 함유제(AF-343)의 효과에 관한 연구
김지현 ( Ji Hyun Kim ),이혜인 ( Hye In Lee ),박주희 ( Ju Hee Park ),임윤영 ( Yun Young Lim ),김범준 ( Beom Joon Kim ),임인석 ( In Seok Lim ),김명남 ( Myeung Nam Kim ),김현석 ( Hyun Suck Kim ),김종근 ( Jong Keun Kim ),한성훈 ( Sung 대한천식알레르기학회 2010 천식 및 알레르기 Vol.30 No.1
Background: Taraxacum platycarpum has been investigated for its antiallergic activity in bronchial asthma, but few studies have been conducted to evaluate its efficacy for the treatment of atopic dermatitis (AD). Objective: This study was designed to evaluate the efficacy of the extracts of Taraxacum platycarpum (AF-343) for the treatment of AD. Method: Seventy-five patients with AD were randomly assigned either to a low-dose, high-dose or control groups. AF-343 and placebo were ingested for 8 weeks. The SCORing Atopic Dermatitis (SCORAD) scores, skin hydration, transepidermal water loss (TEWL), eosinophil, total IgE, eosinophil catinonic protein and cytokines were measured before and at the end of treatment. Result: A significant reduction in the SCORAD scores at the end of treatment were observed in the control, low-dose and high-dose groups when compared with the initial scores (P=0.028, P<0.001 and P<0.001, respectively). High-dose treatment increased the skin hydration (P=0.013), but no significant change was observed in the low-dose and control groups (P=0.056 and P=0.624, respectively). The low-dose and high-dose treatment groups showed a significant reduction of TEWL from baseline (P=0.002 and P=0.031, respectively). High-dose treatment induced an increase in eotaxin and a decrease in IL-5 (P=0.021 and P=0.028, respectively). Conclusion: These results show that AF-343 treatment can improve the severity and skin hydration in patients with mild AD. (Korean J Asthma Allergy Clin Immunol 2010;30: 36-42)