한약을 이용한 항암 실험 연구의 경향과 연구 방향

임성우,Lim, Seong-Woo 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.1

After examining and analysing the medicinal herbs of fifty-three experimental papers, we studied their effects on immediate tumors in specific cancers. We did not study the influence on the life span of general cancerous cells. We looked to see if the combined usage of medicinal herbs and anticancer agents inhibited the tumor cell's growth. The serum test and blood cell count test showed if the medicinal herbs inhibited the side effects of the anticancer agent. The test showed that more than 80 percent of used medicinal herbs, brought anticancer activities. However, anticancer experimental studies using medicinal herbs have draw-backs. First, it is difficult to choose a prescription using the standards of Oriental Medicine because we are testing a mouse not a man. Second, because we only observed the indirect effect on the whole physiological regulation caused by the synergic effects of the complex prescription, we are not able to understand the detailed mechanism of the herbs. Therefore; if the anticancer effect of the herbs is proved by the experiment, we need to research the concrete medical action of medicinal herbs and the immunological analysis of herbal medicines on the body.

니코틴이 사람태아골모세포의 광물화 과정에 미치는 영향

임성우,한상헌,이성진,유석주,신형식,유형근,Lim, Sung-Woo,Han, Sang-Heon,Lee, Seong-Jin,You, Suk-Joo,Shin, Hyung-Shik,You, Hyung-Keun 대한치주과학회 2003 Journal of Periodontal & Implant Science Vol.33 No.4

Nicotine is one of the major components of cigarette smoking which causes various systemic and local diseases to human body. The purpose of the present study was to investigate the effects of nicotine on bone mineralization in human fetal osteoblasts cell line(hFOB1). To compare the alkaline ph-osphatase(ALP) synthesis, hFOBl were cultured with DMEM/F-12 1:1 Mixture and 100 pg/ml, 1 ng/ml, 10 ng/ml, 100 ng/ml, 1 ${\mu}g$/ml, 10 ${\mu}g$/ml, 100 ${\mu}g$/ml of nicotine. And to compare the calcium accumulation, hFOB1 cultured for 23 days were quantified and photographed. ALP activity of hFOB1 exposed to nicotine was not significantly changed at a lower concentrations of nicotine, but was significantly decreased at a higher concentrations (10 ${\mu}g$/ml, 100 ${\mu}g$/ml) of nicotine (p<0.05). A quantified calcium acculation in hFOB1 was significantly decreased at 1,10, and 100${\mu}g$/ml of nicotine (p<0.05). Significantly decreased calcium deposition was observed at 1, 10, and 100${\mu}$/ml of nicotine. These results indicate that a higher concentration of nicotine show a negative effects on mineralization of hFOB1.

십이지장 궤양, 출혈성 위염, 미란성 위염 병발 환자의 치험 1례

임성우,Lim, Seong-Woo 대한한방내과학회 1995 大韓韓方內科學會誌 Vol.16 No.1

A previous study suggested that there might be an association between use of herb medicine and peptic ulcer. The past history of patient with perforated duodenal ulcer was treated with herb medicine. We identified that the mucosa of stomach & duodenum were completed healed by herb medicine treatment on the gastro-endoscopy and the systom. Author report ths case with a brief review of literatures.

수종 한약 처방 전탕액(煎湯液)의 허피즈바이러스에 대한 효능 검색

임성우,Lim, Seong-Woo 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.2

Objective : In order to find antiviral compounds against Herpes simplex virus type I(HSV-1) and II(HSV-2) from herb medicines, a convenient virus-induced cytopathic effect(CPE) inhibition assay was introduced. Methods : Fourteen purchased herbal medicines, and their toxicity of infected cell and anti-viral activities were evaluated. Among them, the major part of herbal medicines showed cell stability compared with the contrast. Results : Cytotoxic concentration (CC) of the $H_2O$ extracts of Hyongbangpaedoksan against HSV-1 and HSV-2 was 181.12. This is high level cytotoxic concentration compared with the contrast. Therefore, we assumed that the high level cytotoxic concentration of herbal medicine play a major role in improvement of antiviral activity at the first infective cell. But antiviral effect was unable to figure out for selective index(Sl)=CC50/EC50. The other herbal medicines were unable to showed potent anti-HSV activity. Conclusions : The antiviral activation using herbs in this thesis have unlimited objects, to select research object will help to show the direction of antiviral drug development that have less side effect and more excellent efficiency.

Mouse의 십이지장 점막 염증에 대한 사삼맥문동탕의 면역반응 연구

임성우,최준혁,Lim Seong-Woo,Choi Jun-Hyuk 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.2

Objectives : This study was carried out to investigate the effects of Sasammaickmoondong-tang(SME) on duodenal mucosal lesions induced by indomethacin in mouse. Methods : The normal group is that no inflammation elicitated mouse. Control group is that gastro-inflammation elicitated mouse. Sample group is that SME administered mouseice after gastro-inflammation elicitation. Results : In the common morphology and histochemical change, control group was observed various injury-mucous surface cell, micro-villi, paneth cell, surface epithelial cell, goblet cell-by hemorrhagic erosion, while sample group was as same as normal group. In the immunohistochemical change, the distributions of COX-1, Bcl-2, and BrdU treated with SME noticeably increased than control group(p<0.05). The distributions of TUNEL, $NF-{\kappa}B$, COX-2, $IL-2R-{\alpha}$, NK-1.1, ICAM-1, and CD11b/18 treated with SME noticeably decreased than control group(p<0.05). And the distribution of SBA was as same as normal group. Conclusion : According to the above results, it is supposed that Sasammaickmoondong-tang is applicable to duodenal mucosal lesions.

Screening for Various Herb Medicines Extracts against Human immunodeficiency virus & Herpes simplex virus type I and Herpes simplex virus type II

임성우,안덕균,우은란,박호균,Lim, Seong-Woo,Ahn, Duk-Kyun,Woo, Eun-Rhan,Park, Ho-Koon The Society of Korean Medicine 1998 대한한의학회지 Vol.19 No.2

면역 결핍 바이러스와 허피즈 바이러스 -1,2에 대한 한약의 항바이러스 작용을 관찰하기 위하여, 세포 바이러스 검색에 초기 독성과 감염 바이러스의 생존 세포 수를 비교적 단기간내 볼 수 있는 96-well plate를 이용한 MTT assay로 측정하였다. 본 실험은 예비 실험 단계에서 사용된 총 85가지의 한약중 단미제 6가지와 복합처방 44가지를 선정하였으며 복합처방은 유사한 치법으로 분류하였고 한약의 시료 추출은 순수하게 물로 전탕하여 여과하였다. 실험 결과 파두와 맥아가 면액 결핍 바이러스에 대해 감염초기 유의성이 있었으며 호장근, 갈근우방자탕과 형방패독산이 허피즈 바이러스-1,2에 대해 감염초기 유의성이 있었으나 실험의 시간 경과에 따른 지속적인 약효 안정성을 보이지는 못하였다. 이 실험을 통하여 한약을 이용한 우수한 바이러스 치료를 개발하기 위해서는 단미제나 복합 처방에서 항바이러스 작용이 큰 유효성분의 대량 분리와 세포 실험에 있어서 오차를 줄 일 수 있는 세포면역학적 실험의 도입 등이 필요할 것으로 사료된다.

정치적 어휘로서의 자극어

임성우 ( Seong Woo Lim ) 한국독일언어문학회(구 독일언어문학연구회) 2008 독일언어문학 Vol.0 No.42

Die vorliegende Untersuchung behandelt Reizworter in der politischen Kommunikation. Hierbei geht es um den semantisch-pragmatischen Ansatz politischer Sprachverwendung. Der Hauptteil dieses Aufsatzes besteht aus zwei Kapiteln. Im Kapitel Ⅱ werden die wichtigsten Argumente und Tendenzen der aktuellen politolinguistischen Forschung skizziert. Darauf folgt im dritten Teil die AnaIysemethode des politischen Vokabulars und die Textanalyse mit den Reizwortern. In diesem Aufsatz versteht man unter Reizwortern diejenigen Worter, bei denen die Konnotationen die Denotationen uberwiegen, und die die Emotionen bzw. Bewertungen beim Horer auf Grund ihrer konnotierten Bedeutung oder nach der Intention der Eigengruppe evozieren. Somit erregen solche Reizworter Aufmerksamkeit, bewirken Betroffenheit und losen positive und/oder negative Konnotationen aus. Konnotationen der Reizworter spiegeln die kommunikativen Bedingungen wider. Sie verweisen als kommunikative Rahmenbedingungen auf den politischen Geltungsbereich des Wortgebrauchs. Worter in der politischen Offentlichkeit werden fur unterschiedliche Funktionen verwendet, und zwar zur denotativen Bezeichnung, zur konnotativ-evaluativen Bewertung und zur konnotativ-deontischen Aufforderung zu bestimmten Handlungen. Dazu dienen die Reiz- und Schlagworter. Die Eigenschaften des Wortschatzes sind bei der Auswahl unterschiedlich zu berucksichtigen und zu beschreiben: Die Worter lassen sich durch Konnotationen bzw. feine Bedeutungs-und Lesartenkonkurrenz voneinander unterscheiden, so dass man in der politischen Sprachverwendung seine Aussage-Absicht/Bewertung bzw. politische Intention verwirklichen kann. Die Eigenschaft der Reizworter bezieht sich auf die Determination ihrer Bedeutung durch die Deutungen und Wertungen sozialer Gegebenheiten. Solche Reizworter haben die Funktion, die komplexe Wirklichkeit vereinfachend sowie verdichtend darzustellen, so dass sie in der offentlich-politischen Kommunikation auf Grund ihrer Reduktionsleistung leicht verfugbar sind und eine starke "emotionale Anziehungskraft" auf die Horer ausuben.

설명적 텍스트통사론을 위한 이론적 고찰

임성우 ( Seong Woo Lim ) 한국독일어문학회 2006 독일어문학 Vol.32 No.-

정치 연설문에 나타나는 대립의 응집관계와 텍스트결속 -대조 연결사 aber의 사용맥락을 중심으로

임성우 ( Seong Woo Lim ) 한국독일어문학회 2016 독일어문학 Vol.73 No.-

Hierbei geht es also darum, inwiefern es moglich ist, mit Hilfe der Kohasionsmittel die Koharenzrelation nachzuweisen. Ich gehe davon aus, dass die Kohasionsmittel im Text eine Koharenzrelation markieren. Dabei soll gezeigt werden, dass die Kohasionsmittel wie Wiederaufnahmen sowie Konnektoren die Hauptfaktoren des Textzusammenhangs sind. Das zweite Kapitel der vorliegenden Arbeit bereitet die theoretische und methodische Grundlage fur die analytische Untersuchung vor. In dem dritten Kapitel wird nach der vorerwahnten Untersuchungsmethode eine detaillierte textsyntaktische Analyse durchgefuhrt, die sich auf die Koharenzrelationen und den Textzusammenhang konzentriert. Dabei werden einzelne textsyntaktischen Methoden, die fur die Analysebeschreibung geeignet sind, wie die Wiederaufnahme von Brinker und die thematische Progression von Danes verfolgt. Nach der Erfassung der Problemfelder bei der Analyse werden die Ergebnisse zusammengefasst und ausgewertet. Die Koharenzrelationen ``direkter Kontrast`` und ``indirekter Kontrast`` sind nach wie vor strittig. Im folgenden versuche ich erklaren und beschreiben, wodurch und inwiefern diese unterschiedlichen kontrastiven Koharenzrelationen in Bezug auf den Textzusammenhang auf der textsyntaktischen Ebene jeweils charakterisiert werden.

주변 언어적 요소와 니체 글쓰기의 문체적 특징 : Jenseits von Gut und Bose 9장을 예로 들며

임성우 ( Seong Woo Lim ) 한국독일어문학회 2007 독일어문학 Vol.36 No.-