CARE 지침에 따른 대한한방소아과학회지의 증례보고에 대한 질평가

이혜림,김지환,이명수,이주아,Lee, Hye Lim,Kim, Ji Hwan,Lee, Myeong Soo,Lee, Ju Ah 대한한방소아과학회 2018 대한한방소아과학회지 Vol.32 No.3

Objectives The purpose of this study is to assess the quality of case reports from the Journal of Pediatrics of Korean Medicine. Methods Case reports were selected from the Journal of Pediatrics of Korean Medicine from January 2015 to April 2018, by utilizing Oriental Medicine Advanced Searching Integrated System (OASIS). The quality of the reports were reviewed based on the Consensus-based Clinical Case Reporting Guideline Development (CARE) guideline. Results Total of 13 case reports were finally selected for the assessment. 73.08% of the case reports included necessary information based on the CARE guideline but the rest of the reports did not. More than 50% of the reports were missing data regarding 'Timeline', 'Diagnostic challenges', 'Intervention adherence and tolerability', 'Adverse and unanticipated events', or 'Patient perspective or experience'. Also, the reports did not include 'Key word', 'Introduction in abstract', 'Case presentation in abstract', or 'The rationale for conclusions' information. Conclusions Case reports from the Journal of Pediatrics of Korean Medicine have important role in pediatrics. Efforts are needed to improve the quality of the case reports as well as to develop reporting guidelines for the Journal of Pediatrics of Korean Medicine.

청기거양탕(淸肌祛痒湯)의 RBL-2H3 비만세포와 OVA/alum 감작 생쥐의 알레르기 염증 반응 억제 효과

이혜림,한재경,김윤희,Lee, Hye-Lim,Han, Jae-Kyung,Kim, Yun-Hee 대한한방소아과학회 2012 대한한방소아과학회지 Vol.26 No.1

$CheongGiGeoYangTang$ has been used for anti-allergenic purpose. However there was no experimental study about its effect. Therefore, this study was designed to investigate the anti-allergenic effect of $CheongGiGeoYangTang$. Methods Modifiability of RBL-2H3 mast cells' IL-4, IL-13 was analyzed by qRT-PCR and ELISA. Also, the suppressive effect of GATA-1, GATA-2, NF-AT1, NF-AT2, AP-1 and NF-${\kappa}B$ p65 transcription factors was observed by western blotting. OVA-specific IgE, IL-4 and IL-13 production in ovalbumin allergy model was examined as well. Results It was showed that the RBL-2H3 mast cells treated with $CheongGiGeoYangTang$ extract(CGGYT) was significantly suppressed mRNA expression, production of IL-4 and IL-13, and prominently inhibited the expression of transcription factors including GATA-1, GATA-2, NFAT-1, NFAT-2, c-Fos and NF-${\kappa}B$ p65 but not c-Jun. The administration of CGGYT was suppressed the amount of OVA-specific IgE, IL-4 and IL-13 in OVA/alum-sensitized mice. Conclusions We considered CGGYT would regulate the allergic inflammation as inhibition of IL-4 and IL-13 production in activated mast cells and Th2 cells.

심박변이도 분석을 통한 심계 허약아의 자율신경계 특성

이혜림,한재경,김윤희,Lee, Hye Lim,Han, Jae Kyung,Kim, Yun Hee 대한한방소아과학회 2013 대한한방소아과학회지 Vol.27 No.3

Objectives The purpose of this study is to evaluate the characteristics of autonomic nervous system in heart-weakened children via analyzing heart rate variability (HRV) compare to healthy children. Methods Among the children who have visited the department of pediatrics at OO oriental medicine hospital, the subjects were composed of 62 elementary school students without cardiac disorder, who have yet develop secondary sexual characteristics. Results 1. Mean HRT and SDNN of the heart-weakened group of children were lower than the healthy group, but with no statistical significance. 2. Heart-weakened children had higher LF norm and LF/HF ratio, but lower HF norm than healthy children. The rest of the Frequency Domain Index have no significant differences. 3. Heart-weak score showed a positive correlation with Mean HRT and LF/HF ratio. Conclusions Heart-weakened children had an imbalance in autonomic nervous system due to increase of sympathetic nerve activity and decrease of parasympathetic nerve activity.

대전지역 다문화가정 자녀의 성장에 대한 보고

이혜림,Lee, Hye Lim 대한한방소아과학회 2014 대한한방소아과학회지 Vol.28 No.4

Objectives The purpose of this study is to evaluate the current growth via Growth indices, Obesity indices, Metabolic risk factors of Multicultural Families' Children in Dae-jeon area. Methods 5 to 12 year old children from 56 multicultural families were enrolled in this study, and were examined their bone age and body composition, and have received blood tests. Results 1. In Growth indices, average height percentile was $53.64{\pm}25.59%$. The AHP and MPH respectively, were converted into 20 years old adult height percentile, AHP of a girls was 40 percentile and MPH was 19 percentile, AHP of boys was 57 percentile and MPH was 21 percentile. 2. In Obesity indices, average of BMI pecentile was $44.16{\pm}29.52$; low-weight group (6 boys, 4 girls), normal-weight group (20 boys, 18 girls), over-weight group (8 girls). Average PWH was $100.51{\pm}15.66%$; low-weight group (9 boys, 5 girls), normal-weight group (14 boys, 15 girls), over-weight group (3 boys, 5 girls), obesity group (5 girls). 3. The results of the relationship between Growth indices and Obesity indices, 1) As RH percentile in boys was increased, skeletal maturity, AHP and AHP-MPH were also increased. Similarly, as RH percentile in girls was increased, skeletal maturity, AHP and AHP-MPH were also increased. 2) As skeletal maturity in boys was increased, BMI percentile was also increased. As skeletal maturity in girls was increased, AHP-MPH was decreased but had no significant differences. Conclusions Current growth of children in multicultural families was above the average when compared to that of average children in the same age. It was predicted that the boys' height were still above the average adult height, but the girls' height were below the average. Also this study showed that girls were more prone to be overweight than boys, thus requiring more intensive management and training in regards to eating habits and exercise.

특발성 성조숙증으로 진단받은 환아 2례에 대한 증례보고

이혜림,유화승,박승찬,Lee, Hye Lim,Yoo, Hwa Seung,Park, Seung Chan 대한한방소아과학회 2017 대한한방소아과학회지 Vol.31 No.1

Objectives The purpose of this study is to report the case of precocious puberty in two children treated by taking herbal medicine. Methods Two patients diagnosed with precocious puberty were prescribed Jogyeongseongjang-tang and were observed the effect of treatment on height, body weight, body composition, sex hormone test. Results During the treatment period, rapid progression of puberty was inhibited, and slow changes in sex hormones and steady growth were achieved. Conclusions This study showed the long-term effects of herbal medicine in treating precocious puberty, but further studies should be conducted for scientific validation.

다문화가족 어머니의 구강건강행동과 자녀의 치아우식경험에 관한 연구

이혜림,이광희,라지영,안소연,김윤희,Lee, Hye-Lim,Lee, Kwang-Hee,La, Ji-Young,An, So-Youn,Kim, Yun-Hee 대한소아치과학회 2012 大韓小兒齒科學會誌 Vol.39 No.2

다문화가족 어린이와 일반가족 어린이의 구강건강상태를 비교하고 다문화가족 어머니와 일반가족 어머니의 자녀에게 행하는 구강건강행동을 비교하는 한편, 어머니의 사회적 특성, 구강건강행동과 자녀의 구강건강상태 사이의 관련성을 밝혀 다문화가족 어머니와 어린이의 구강건강증진을 위한 프로그램을 구축하는데 필요한 기초 자료를 제공하고자 전라북도 익산시 인근 시, 군 지역 다문화가족지원센터 한국사회적응교육에 참여한 다문화가족 어머니와 그 자녀 132쌍, 그리고 익산시내 2개소 유치원 원아와 어머니 131쌍을 대상으로 조사하여 다음과 같은 결론을 얻었다. 1. 다문화가족 어린이의 우식경험유치지수(dft index)는 4.17개로 일반가족 어린이의 2.69개보다 높았고, 다문화가족 어린이의 우식경험유치면지수(dfs index)는 6.67면으로 일반가족 어린이의 4.63면에 비해 높게 나타났다($p$ <0.05). 2. 다문화가족 어린이들의 하루 평균 칫솔질 횟수는 2.32회로 일반가족 어린이들의 2.73회에 비해 적었다($p$ <0.01). 다문화가족 어린이에서 하루 평균 칫솔질 횟수가 증가할수록 우식 발생이 감소하는 것으로 나타났다($p$ <0.01). 3. 다문화가족 어머니가 일반가족 어머니에 비해 자녀의 구강질병예방을 위해 어머니가 자녀에게 행하는 구강건강행동(칫솔질 지도, 구강건강 중요성 교육, 당분 섭취의 제한, 치과 방문)을 적게 실천했다($p$ <0.01). 자녀의 구강질병 예방을 위해 어머니가 자녀에게 행하는 구강건강행동은 어린이의 우식경험과 통계학적으로 유의한 관련성이 없었다($p$ >0.05). The objectives of this study were to evaluate oral health status of children in multicultural families and compare oral health behaviors of multicultural mothers with those of ordinary Korean families. The mothers' social characters, oral health behaviors and oral health status of children were investigated so that the data from this study can be utilized in developing programs for oral health care promotion especially designed for multicultural families. The subjects were 135 pairs of multicultural mothers and their children who participated in the community programs in suburban areas of Ik-san city and 168 pairs of ordinary Korean mothers and their children residing in Ik-san city. The results were as follows : 1. The dft index and dfs index of multicultural subjects were 4.17 and 6.67, respectively, while ordinary Korean subjects were found to have 2.69 and 4.63($p$ <0.05). 2. The frequency of tooth brushing per day of children from multicultural families was lower than that of children from ordinary Korean families($p$ <0.01). 3. The ratio of practice of oral health behaviors of mothers from multicultural families was lower than that of mothers from ordinary Korean families($p$ <0.01). Tooth brushing instructions were the most frequently carried out by multicultural mothers, which was followed by teaching the importance of oral health, restriction of carbohydrates, and dental check-ups. Significant correlations were not detected between mothers'oral health behaviors and children's dental caries experiences($p$ >0.05).

골성숙도와 심박 변이도의 상관성에 대한 연구

이혜림,한재경,김윤희,Lee, Hye-Lim,Han, Jae-Kyung,Kim, Yun-Hee 대한한방소아과학회 2012 대한한방소아과학회지 Vol.26 No.3

Objectives The purpose of this study is to examine the relationship between skeletal maturity and heart rate variability (HRV) based on the bone age and HRV parameters. Methods 103 children from 6 years to 17 years of age, who do not have any disease-related symptom, and visited ${\bigcirc}{\bigcirc}$ oriental medicine hospital, are measured based on their bone age and short-term spectral analysis of HRV. Results 1. Skeletal maturity was significantly correlated with HRV indices: mean HRT and SDNN. As the skeletal maturity increases, the mean HRT was decreased and the SDNN was increased. 2. When classifying according to the skeletal maturity score, the mean HRT was higher in the 'below -0.4' group compare to '-0.3~0.7' group and '0.8~1.9' group. SDNN was higher in the '0.8~1.9' group compare to '-0.3~0.7' group, 'below -0.4' group 3. When classifying according to the sex, age and secondary sexual characteristics, as the skeletal maturity was increased, the mean HRT was significantly decreased and the SDNN was significantly increased only in the boys who did not develop secondary sexual characteristics. Conclusions Skeletal maturity could be statistically significant with HRV indices, especially to the boys and the children than the girls and the teenagers.

소아용 입욕제품의 분석 및 고찰

이혜림,한재경,김윤희,Lee, Hye-Lim,Han, Jae-Kyung,Kim, Yun-Hee 대한한방소아과학회 2011 대한한방소아과학회지 Vol.25 No.2

Objectives: The purpose of this study is to analyze the baby bath preparation and provide necessary information on the upcoming herbal bath preparation for atopic dermatitis. Methods: We selected 113 baby bath preparation by searching typing in "baby bath preparation" in 6 major web-search-engines, and 17 web shopping malls in Korea. 11 items were evaluated under three criteria : type of product, function and ingredient of goods. Results: Result showed that the most common type of bath preparation were liquid type. 96% of the products contained medical agents. Ingredients of the medical agents were herbal medicine, aroma oil, spring and sea ingredients, vitamin and extract. 33% of the products were bath preparation for the atopic dermatitis and 74% of the products were only for the baby. Conclusions: It is necessary to make a government level guideline for natural materials used in bath preparation, and to develop new products contained herbal medicine abide by oriental medical theory.

허약아와 성장지표의 상관성에 대한 연구

이혜림,한재경,김윤희,Lee, Hye Lim,Han, Jae Kyung,Kim, Yun Hee 대한한방소아과학회 2014 대한한방소아과학회지 Vol.28 No.2

Objectives The purpose of this study is to investigate the relationship between weak children and growth indices. Methods One hundred twenty-six of the first and the second grade elementary school students who didn't have to develop yet their secondary sexual characteristics answered the questionnaire. Their bone age and body composition were measured. Results 1. According to the Weak Children questionnaire analysis, respiratory problem was one of the biggest problems in the weak children group (35.7%), followed by digestive problems (23.0%), psycho-neurological problems (22.2%), neuromotor problems (9.5%), and urogenital problems (8.7%). 2. From the comparison between growth indices of weak children and that of normal children are as follows: 1) The group of children who had problem in their digestive system had lower growth indices than the normal average children group. The growth indices includes mean height, weight, total body water, protein mass, mineral mass, body fat, skeletal muscle mass, body fat percentage, body mass index (BMI), and basal metabolic rate (BMR). 2) The children who had urogenital weakness had lower mean height, RH (Recent Height), RH - MPH {Recent Height(%) - Mid-Parental Height(%)}, RUS (Radius, Ulna and Short bone) score, weight, protein mass, body fat, BMI, and visceral fat than the normal children group. 3. The results of the multiple comparisons of growth indices and weak children groups are as follows: 1) Digestive weak children were the lowest in total body water, protein mass, mineral mass, skeletal muscle mass, and basal metabolic rate. 2) Urogenital weak children were the lowest in height, RH, RH - MPH, RUS score, and weight. Conclusion These results showed that children's growth is strongly correlated to their own growth problems, especially to those children who have digestive and urogenital problems. Therefore, this may be an effective way for children growth treatment in Korean medicine to treat weak symptoms.

청소년의 신체활동이 성장에 미치는 영향

이혜림,Lee, Hye Lim 대한한방소아과학회 2015 대한한방소아과학회지 Vol.29 No.2

Objectives The purpose of this study is to investigate the relationship between physical activity and growth indices. Methods 5963 of 12 years old adolescents were participated in the 10th Korea Youth Risk Behavior Web-Based Survey (KYRBWS-V) project in 2014. These data was analyzed to show the relationship between physical activity and height, BMI. Results According to the Physical Activity guidelines, the mean height was higher in the each male and female group with 'moderate physical activity for at least 60 min ${\geq}7$ days/week', 'vigorous physical activity ${\geq}3$ days/week', and 'muscle-strengthening activity ${\geq}3$ days/week' compare to the group who did not. The mean BMI was lower in the male group of 'sitting for watching TV or computer, etc on a weekday < 3 hr/day' compare to group who did not. Conclusions These results showed that physical activity in adolescence is correlated to growth. Therefore, this research can be one of the reference data to show the proper physical activity is important in the growth.