치환 옥사졸의 양성자 친화도에 대한 ab initio 연구

이현미,이송은,장만식,박병각,이갑용,Lee, Hyun-Mee,Lee, Song-Eun,Chang, Mahn-Sik,Park, Byung-Kak,Lee, Gab-Yong 대한화학회 1995 대한화학회지 Vol.39 No.7

옥사졸 고리를 포함하는 lexitropsin에서, DNA minor groove의 염기쌍(G-C sequence)과 결합하는 부분인 옥사졸의 최적화된 기하학적 구조를 MM+ 및 ab initio(Hartree-Fock) 계산을 통해 밝혔다. 최적화딘 구조에 대해 6-31G 및 $6-31G^{\ast}$ basis set를 사용하여 양성자 친화도와 전자적 구조를 계산하였다. 아울러 옥사졸의 양성자 친화도에 미치는 치환기 효과를 알아보기 위해 전자를 주는 기와 전자를 끄는 기를 갖는 여러 치환 옥사졸에 대해 양성자 친화도를 조사하였다. 그 결과 전자를 주는 기는 옥사졸의 양성자 친화도를 증가시키는 반면 전자를 끄는 기는 양성자 친화도를 감소시킴을 알았으며, 이 결과를 치환 옥사졸의 산소의 atomic charge와 전자밀도로 설명할 수 있었다. The geometry optimization of oxazole, relevant to the binding of lexitropsin that contains this ring to the base pair (G-C sequence) of minor groove of DNA, is performed with the aid of MM+ and ab initio (Hartree-Fock) calculations. The proton affinity and electronic structure are calculated at the 6-31G and $6-31G^{\ast}$ level for the optimized geometry. The proton affinities are also studied for various substituted oxazoles with the electron-donating and -withdrawing groups to estimate the substituent effect on the proton affinities of oxazoles. It is shown that the electron-donating substituents increase the proton affinity of oxazole, while the electron-withdrawing substituents decrease it. This result can be explained with atomic charge and electron density at oxygen of substituted oxazoles.

기체조와 두유섭취가 중년여성들의 신체조성, 혈청지질, 성선자극호르몬에 미치는 영향

이현미,곽이섭,김세종,예정복,백영호,Lee, Hyun-Mi,Kwak, Yi-Sub,Kim, Se-Jong,Ye, Jung-Bok,Park, Young-Ho 한국생명과학회 2007 생명과학회지 Vol.17 No.4

부산에 거주하는 Y1동의 45-60세 중년여성40명을 대상으로 기체조와 두유(360 ml)를 12주 섭취하여 대조군(12명:A), 기조체군(14명:B), 기체조+두유군(14명:C)으로 분류하여 운동 전 후에 측정한 신체조성, 혈중지질, 성선자극호르몬에 대한 결과 신체조성 중 weight, percent fat, fat mass, muscle mass, BMI 의 측정결과는 weight, percent fat, fat mass 에 대한 집단간의 변화에서 대조군이 기체조군과 기체조+두유군보다 각 각 유의한 증가를 나타냈고, T-C의 집단내의 변화에서 대조군은 사전보다 사후에서 유의하게 증가했고(p<.05), 기체조군은 사전보다 사후보다 유의하게 감소했으며(p<.05), HDL-C의 집단내의 변화에서 기체조군과 기체조+두유섭취군이 사후에서 증가했고, LDL-C의 집단 내에서 기체조군과 기체조+두유섭취군이 사후에서 감소했고, 집단간의 유의도는 나타나지 않았다. 이상과 같이 기체조와 두유섭취가 중년여성들의 weight, percent body fat, fat mass의 문제를 감소시키는데 긍정적인 효과이며, 또한 콜레스테롤문제 해결에도 도움이 되리라 사료된다. 그리고 중년여성들의 생리주기를 파악하여 FSH, LH 혈중치 변화를 정확히 규명하여 중년여성들의 건강과 행복된 삶을 영유할 수 있도록 하고자 한다. The purpose of this study was to investigate the effect of Gi exercises and soybean milk supplement on the body composition and the physiological parameters including blood level of lipids and related hormones in middle-aged women. The Gi exercise program was composed of warming-up(10 min), main exercise(40 min) and cooling-down(10 min). The 40 middle-aged women between 40 and 60 years old were divided into four groups; the control group(12 women), the Gi exercise group(14 women), the soybean milk supplement group(11 women), and the Gi exercise group with soybean milk supplement(14 women). The Gi exercise program was applied three times a week and two packs of the soybean milk per day were given. The result of this study was as follows 1. The control group showed the increase of body weight, percent body fat, and fat mass than other groups. 2. The blood level of T-C was increased in the control group and the Gi exercise group and exercise with supplemented group were decreased 3. The blood level of HDL-C was significantly decreased in the control group than other groups. 4. The blood level of LDL-C was significantly increased in the control group than other groups. 5. The level of TG were not significantly changed in all groups 6. The follicular stimulating hormone (FSH) and luteinizing hormone (LH) hormone levels were not significantly changed in all study groups

이미다졸의 양성자 친화도에 미치는 치환기 효과에 대한 이론적 연구

이현미,이갑룡,Lee, Hyeon Mi,Lee, Gap Ryong 대한화학회 1994 대한화학회지 Vol.38 No.1

이미다졸 고리를 포함하는 lexitropsin에서, DNA minor grooved의 염기쌍(G-C sequence)과 결합하는 부분인 치환이미다졸의 양성자 친화도를 확장분자궤도함수법으로 조사하였다. 그 결과 메틸이미다졸의 경우 염기중심 질소의 $\alpha$위치에 치환된 이미다졸이 N에 치환된 이미다졸보다 양성자 친화도가 약간 더 크게 나타났으며 다른 치환이미다졸의 경우에는 N에 치환된 이미다졸이 ${\alpha}$위치에 치환된 이미다졸보다 양성자 친화도가 더 크게 나타났다. 예상한 바와 같이 이미다졸의 N에 전자를 미는기가 치환될 때 모두 양성자 친화도가 증가함을 알 수 있었다. The proton affinities of substituted imidazoles, relevant to the binding of lexitropsins that contain imidazole ring to the base pair (G-C sequence) of minor groove of DNA, are studied with the aid of EHT calculations. It is shown that proton affinity of imidazole substituted at position $\alpha$ to the basic nitrogen is slightly larger than that of imidazole substituted at N for the methylimidazole. Proton affinities of N-substituted imidazoles are found to be larger than those of imidazoles substituted at position ${\alpha}$ for a selected set of the other derivatives. As predicted the proton affinity increases when electron-donating group is attached at position N of imidazole.

독삼팔물군자탕(獨參八物君子湯)으로 호전된 소음인(少陰人) 울광증(鬱狂症) 발열 치험 3례

이현미,박세정,전수형,김오영,김종원,Lee, Hyun-Mi,Park, Se-Jung,Jeon, Soo-Hyung,Kim, Oh-Young,Kim, Jong-Won 사상체질의학회 2009 사상체질의학회지 Vol.21 No.3

1. Objectives: Fever is an abnormal elevation of body temperature, usually as a result of a pathologic process. Fever can cause chilling, myalgia, headache and other related symptoms. We have tried researching effect of herbal medicine Doksampalmulkunja-tang(獨蔘八物君子湯) on fever. 2. Methods: The subjects are three patients who were on diagnosed Soeumin Woolgwang-incurable disease. They are treated by Doksampalmulkunja-tang(獨蔘八物君子湯). 3. Results: Doksampalmulkunja-tang(獨蔘八物君子湯) was effective on the subjects. Their fever and related symptoms were improved. 4. Conclusions: This case study shows that the treatment with herb-medicine may have effect on fever of Soeumin by rasing the stagnant yang qi.

옥사졸의 양성자 친화도에 대한 DFT 연구

이현미,이갑용,Lee, Hyun-Mee,Lee, Gab-Yong 대한화학회 2007 대한화학회지 Vol.51 No.1

옥사졸 고리를 포함하는 lexitropsin에서, DNA minor groove의 구아닌-시토신 염기쌍의 구아닌과 수소결합을 형성하는데 중요 역할을 하는 옥사졸에 대해, 양성자화 될 때 가능한 두 가지 형태에 대해 DFT 계산을 통해 구조를 최적화시켰다. 최적화된 구조에 대해 B3LYP/6-31G* 수준에서 양성자 친화도를 계산하였다. 그 결과 옥사졸의 가능한 두 가지 형태 가운데 옥사졸의 질소 원자가 DNA minor groove 쪽으로 배향된 구조가 산소 원자가 minor groove 쪽으로 배향된 구조보다 양성자 친화도가 더 큼을 알 수 있었으며, 분자정전기 전위로 확인할 수 있었다. 아울러 양성자 친화도에 미치는 치환기 효과를 알아보기 위하여 여러 전자 주는 기와 전자 받는 기를 치환시켜 치환기 성질에 따른 양성자 친화도를 조사하였으며, 전자를 받는 기 보다 전자를 주는 기가 치환 되었을 때 양성자 친화도가 증가함을 알았다. The oxazole plays an important role in the binding of lexitropsin to the guanine-cytosine base pair from minor groove of DNA. The geometry optimization is performed with DFT calculations for the two possible conformations of the protonated oxazole. The proton affinities are calculated at B3LYP level of theory with 6-31G* basis set for the optimized geometry. It is found that the proton affinites of the conformations in which the oxazole nitrogen is the protonation center are greater than that of the conformations in which the oxazole oxygen is the protonation center. This result is in good agreement with molecular electrostatic potential (MEP) contour map. The proton affinities are also studied for various substituted oxazoles with the electron-donating and -withdrawing groups to estimate substitutent effect on the proton affinity at the hydrogen bonding site of the oxazoles. it is shown that the electron-donating substituents increase the proton affinity of oxazole, while the electron-withdrawing substituents decrease it.

한약 복용 환자와 미복용 환자의 사상체질 진단정확률 비교 연구

이현미,류동훈,전수형,김규곤,김종원,Lee, Hyun-Mi,Ryu, Dong-Hoon,Jeon, Soo-Hyung,Kim, Kyu-Kon,Kim, Jong-Won 사상체질의학회 2011 사상체질의학회지 Vol.23 No.2

1. Objectives: The purpose of this study was done to compare Sasang Constitution diagnostic rate between taking Sasang Constitution herb medicine patients and non taking group. 2. Methods: We collected data from 430 patients who were visited at the Department of Sasang Constitution, College of Oriental Medicine, Dong-eui University from November 2006 to September 2010. We classified them into two group. One was taking Sasang Constitution herb medicine patients group, the other was non taking group. For Sasang Constitution Diagnosis, they all have done SSCQ-P questionnaire. and a Sasang Constitution specialist diagnosed constitution. According to reactions after taking herb medicine, the patients of taking group were confirmed their constitutions. We checked Sasang Constitution diagnostic rate from each groups'(the whole subjects, taking herb medicine patients group, non taking herb medicine patients group) discriminant function. And to find out Sasang Constitution diagnostic rate, we applied discriminant functions to each other. 3. Results and Conclusions: 1) The whole subjects' diagnostic accuracy rate was 72.07%. 2) Taking herb medicine group's diagnostic accuracy Rate was 75.08%. Non taking herb medicine group's diagnostic accuracy rate applied taking group's discriminant function was 61.60%. 3) Non taking herb medicine group's diagnostic accuracy rate was 81.06%. Taking herb medicine group's diagnostic accuracy rate applied taking group's discriminant function was 57.14%.

WRF,FLEXPART를 이용한 한반도 동남지역 계절별 공기괴 이동 패턴 분석

이현미 ( Hyun Mi Lee ),이화운 ( Hwa Woon Lee ),이순환 ( Soon Hwan Lee ) 한국환경과학회 2012 한국환경과학회지 Vol.21 No.3

Air pollution inventories are aggregated around south-eastern part of the Korean Peninsular including Busan, Ulsan, and Changwon cities. Because densely populated cities are concentrated in this region, air pollutants emitted from one of these cities tend to be impacted on the air quality of other cities. In order to clarify the seasonal movement pattern of emitted particles, several numerical simulations using WRF/FLEXPART were carried out. Four cases were selected for each season. The Weather Research and Forecasting model (WRF) reproduced atmospheric flow fields with nested grids. The seasonal pattern of air mass of study area was determined by backward and forward trajectories. As a result, the air parcel moves from northwest to southeast due to northwesterly winds in spring and winter. Also air parcel transports from south to north in summer, and moves from west to east. Because the air mass moves differently in each season, these characteristics should be considered when performing air quality analysis.

기초과학연구논집 - 1995 년 연구실적편 - / 화학 : 치환 옥사졸의 양성자 친화도에 대한 ab initio 연구

이현미(Hyun Mee Lee),이송은(Song Eun Lee),장만식(Mahn Sik Chang),박병각(Byung Kak Park),이갑용(Gab Yong Lee) 대구가톨릭대학교 자연과학연구소 1995 基礎科學硏究論集 Vol.9 No.-

광양만 권역의 영역 설정에 따른 입자확산 및 대기질 수치모의 비교

이현미(Hyun Mi Lee),이화운(Hwa Woon Lee),이순환(Soon Hwan Lee) 한국대기환경학회 2010 한국대기환경학회지 Vol.26 No.6

신앙이 말기 암환자 삶의 질에 미치는 영향

강승계,김수호,김신수,박희명,송근옥,원주희,이명숙,이성옥,이은의,이채영,이현미,Gang Seung-Gye,kim Su-Ho,kim Sin-Su,Park Hui-Myeong,Song Geun-Ok,Won Ju-Hui,Lee Myeong-Suk,Lee Seong-Ok,Lee Eun-Ui,Lee Chae-Yeong,Lee Hyeon-Mi 한국호스피스협회 2002 호스피스 학술지 Vol.2 No.2

Background: The purpose of this study is to find out to how much influence religion had on the quality of life in patients admitted to the hospice facility at Saemmul's House. Terminal cancer patients were assessed one to two weeks after admittance to Saemmul's House. Metohd: The subjects of this study were numbered at 75 patients and were admitted to the hospice facility at Sammul's house between January 2002 and July 2002. The data regarding quality of life was collected using a questionnaire prepared by the sammul Hospice and were analyzed by means of ANOVA and T-test. Result: As a result of this study, there was no noticeable difference in quality of physical, psychosocial life between the patients with conviction of salvation and the other patients. However, it shows that the former enjoyed a higher spiritual quality of life than the latter. In case of baptized patients and unbaptized patients, there were no differences in terms of physical and psychosocial quality of life, but the baptized patients demonstrated a higher spiritual quality of life. After admittance, patients were grouped by duration of conviction of salvation I.e., those that believed more than 5 years and those that believed less than 5 years. In terms of physical, psychosocial quality of life, there was little difference between the two groups. However, those who believed more than 5 years demonstrated a higher spiritual quality of life. However, there was no difference in quality of life among patients, regardless of their belief in God, after receiving spiritual care at the hospice. Conclusion: We got a few conclusions in accordance with result gained by this study. First, spiritual support is very important to improving quality of patients' lives in hospices. Second, hospice programs are needed keenly and spiritual support for patients from trained experts is needed 24 hours a day. Third, because trained experts(ministry) are urgently needed to lend spiritual support, hospice courses must be taught at all colleges of theology. Fourth, a hospice program must provide a proper atmosphere that can give spiritual support and therefore all hospices must build such as environment. Fifth, a tool for spiritual support of hospice must be developed.