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스테로이드 저항성 신증후군 환아에서의 Methylprednisolone 충격 요법의 치료 효과
이창연,하일수,정해일,최용,Lee Chang-Youn,Ha Il-Soo,Cheong Hae-Il,Choi Yong 대한소아신장학회 1997 Childhood kidney diseases Vol.1 No.2
목적 : 소아의 스테로이드 저항성 신증후군은 예후가 불량함에도 불구하고 지금까지 효과적인 치료방법이 없는 병이었으나 1990년 Mendoza등이 Methylprednisolone 충격 요법이 스테로이드 저항성 신증후군에서 효과적이라는 것을 보고하였다. 하지만 2년 뒤 Waldo 등은 Methylprednisolone 충격 요법이 Mendoza 등의 보고와는 다르게 스테로이드 저항성 신증후군에 효과가 적었다고 보고하여 이에 저자는 한국 소아에서 스테로이드 저항성 신증후군이 발생한 경우 Methylprednisolone 충격 요법의 효과를 알아보고 위의 보고의 서로 다른 결과를 확인하고자 본 연구를 시행하였다. 방법 : 1990년부터 1995년까지 만 5년간 서울대병원 소아과에 스테로이드 저항성 신증후군으로 입원한 소아를 대상으로 Methylprednisolone 충격 요법을 시행하여 $30{\pm}11$개월동안 추적 관찰하였다. 결과 : 1) Methylprednisolone 충격 요법 치료로 신증후군이 완해가 유도된 환아는 20명중 9명으로 45%이었다. 2) Methylprednisolone 충격 요법 치료후 신증후군의 완해가 유지된 환아는 20명중 9명으로 45%이었다. 3) Methylprednisolone 충격 요법에 반응이 없었던 환아중 만성 신부전으로 이행된 경우는 5례로서 25%이었다. 결론 : Methylprednisolone 충격 요법은 스테로이드 저항성 신증후군 소아의 45%에서 신증후군의 완해를 유도하고 유지시키는 효과적인 치료 방법이었다. Purpose : The Childhood Steroid Resistant Nephrotic Syndrome (SRNS) has a poor prognosis and there has been no effective therapy against SRNS of children. In 1990, Mendoza have reported that methylprednisolone pulse therapy was effective against SRNS of children. But in 1992, Waldo have reported that methylprednisolone pulse therapy was not as effective as in the report of Mendoza. So, retrospectively, we have studied 20 korean children with SRNS to evaluate the effect of methylprednisolone pulse therapy, Methods : Mothylprednisolone pulse therapy were given to 20 korean children with SRNS who admitted to Seoul National University Hospital from 1990 to 1995 and follow up was done Results : 1) During methylprednisolone pulse therapy, remission of nephrotic syndrome was induced in 45% of patients. 2) during follow up after the end of methylprednisolone pulse therapy, remission of nephrotic syndrome was maintained in 45% of patients. 3) 25% of patients has progressed to chronic renal failure. Conclusion : We think that the methylprednisolone pulse therapy is a effective therapy against SRNS of children with the 45%, remission rate of of SRNS in Korean Children
이창연,김주원,장창수,임진혁,양병은,김좌영,배현경,Lee, Chang-Youn,Kim, Ju-Won,Jang, Chang-Su,Yim, Jin-Hyuk,Yang, Byoung-Eun,Kim, Jwa-Young,Pai, Hyun-Kyung 대한악안면성형재건외과학회 2012 Maxillofacial Plastic Reconstructive Surgery Vol.34 No.3
Cemento-ossifying fibroma (COF) is a benign fibro-osseous tumor with fibrous tissue, abnormal cement and bone, or a combination of such elements. These are slow-growing lesions and are more frequent in women. Here, we report the case of a 28-year-old Korean woman. The patient having no underlying disease complained about facial swelling and asymmetry. A firm mass with impacted molars and teeth deviation on the right maxilla was observed. A computed tomography scan was taken and an incisional biopsy was performed. Following this, COF was diagnosed. Complete surgical removal of the lesion was carried out. A post-operative follow-up was conducted and 3 months later the patient reported no discomfort or any sign of recurrence in regards to the lesion. Differential diagnosis with fibrous dysplasia and the COF is important because of the treatment choice. We report a case of COF and offer a review of the literature on this article.
분화된 HL60 세포에서 Granulocyte - Macrophage Colony - Stimulating Factor 에 의한 95kDa 단백질의 Tyrosine 잔기 인산화
이영한,김정옥,민도식,김희숙,김용식,이창연,류성호,서판길 ( Young Han Lee,Jeong Ock Kim,Do Sik Min,Hee Sook Kim,Yong Sik Kim,Chang Youn Lee,Sung Ho Ryu,Pann Ghill Suh ) 생화학분자생물학회 1994 BMB Reports Vol.27 No.5
Human granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotent cytokine which stimulates the proliferation and differentiation of various lineage of hematopoietic cells. We examined whether GM-CSF stimulates protein phosphorylation in HL60 cells pretreated with differentiation-inducing factors such as PMA, 1,25-(OH)₂VD₃ and DMSO. GM-CSF induced tyrosine phosphorylation of 95 kDa protein in PMA- or 1,25-(OH)₂VD₃ but not in DMSO-pretreated cells. Tyrosine phosphorylation of 95 kDa was detected at 1 min and 2 min after stimulation of GM-CSF in PMA- and 1,25-(OH)₂VD₃-pretreated cells, respectively. Kinase activity which phosphorylates tyrosine residues) of the 95 kDa protein appeared to increase in a time dependent manner in PMA-pretreated cells, whereas the expression level of 95 kDa protein was not changed. We also observed that 95 kDa protein was autophosphorylated in immunecomplex kinase assay, suggesting that this 95 kDa protein may be tyrosine kinase which is activated in lineage specific manner. These results suggest that 95 kDa protein may be involved in an early signal transduction pathway of GM-CSF.
분화된 HL60 세포에서 Granulocyte-Macrophage Colony-Stimulating Factor에 의한 95 kDa 단백질의 Tyrosine잔기 인산화
이영한,김정옥,민도식,김희숙,김용식,이창연,류성호,서판길,Lee, Young-Han,Kim, Jeong-Ock,Min, Do-Sik,Kim, Hee-Sook,Kim, Yong-Sik,Lee, Chang-Youn,Ryu, Sung-Ho,Suh, Pann-Ghill 생화학분자생물학회 1994 한국생화학회지 Vol.27 No.5
사람의 granulocyte-macrophage colony-stimulating factor(GM-CSF)는 세포 표면에 존재하는 특이 수용체 자극을 통하여 각종 분화단계에 있는 골수세포의 성장과 분화에 중요한 cytokine이다. HL60 세포에 분화 유도 인자인 phorbol 12-myristate 13-acetate(PMA), $1{\alpha}$,25-dihydroxyvitamine $D_3$[1,25-$(OH)_{2}VD_{3}$] 및 dimethyl sulfoxide(DMSO) 등을 전처리한 후 GM-CSF 자극에 대해 특정 분화단계에서만 활성화되는 세포내 단백질을 조사하였다. SH2-SH3 domain을 인지하는 F7-2 항체로 면역 침전하여 면역 블롯한 결과 미분화 세포와 DMSO를 처리한 세포에서는 GM-CSF 자극에 의해 tyrosine 인산화되는 단백질을 발견할 수 없었지만, PMA와 1,25-$(OH)_2VD_3$를 전처리한 세포에서는 95kDa 단백질의 tyrosine 인산화가 일어남을 관찰하였다. Kinetics 분석결과 95 kDa 단백질의 tyrosine 인산화 반응은 GM-CSF 처리 후 1분 이내에, 1,25-$(OH)_{2}VD_{3}$를 전처리한 세포에서는 2분 이내에 나타나는 신속한 반응이었다. 이 단백질이 세포에서 발현되는 양은 PMA 전처리 시간에 무관하게 일정하였으나 GM-CSF에 의한 인산화는 PMA 전처리 시간에 따라 변화하였다. 또한, 95 kDa 단백질은 in vitro에서도 autophosphorylation되었다. 이러한 결과로부터 95 kDa 단백질은 PMA나 1,25-$(OH)_{2}VD_{3}$로 분화 유도된 HL60 세포에서 GM-CSF의 초기 신호전달 경로에 관여하고 있음을 추측할 수 있었다. Human granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotent cytokine which stimulates the proliferation and differentiation of various lineage of hematopoietic cells. We examined whether GM-CSF stimulates protein phosphorylation in HL60 cells pretreated with differentiation-inducing factors such as PMA, 1,25-$(OH)_{2}VD_{3}$ and DMSO. GM-CSF induced tyrosine phosphorylation of 95 kDa protein in PMA- or 1,25-$(OH)_{2}VD_{3}$ but not in DMSO-pretreated cells. Tyrosine phosphorylation of 95 kDa was detected at 1 min and 2 min after stimulation of GM-CSF in PMA- and 1,25-$(OH)_{2}VD_{3}$-pretreated cells, respectively. Kinase activity which phosphorylates tyrosine residue(s) of the 95 kDa protein appeared to increase in a time dependent manner in PMA-pretreated cells, whereas the expression level of 95 kDa protein was not changed. We also observed that 95 kDa protein was autophosphorylated in immunecomplex kinase assay, suggesting that this 95 kDa protein may be tyrosine kinase which is activated in lineage specific manner. These results suggest that 95 kDa protein may be involved in an early signal transduction pathway of GM-CSF.
급성 연쇄상구균 감염후 사구체 신염에 동반된 고혈압성 뇌병증 3례의 MRI 소견
김형노,윤성민,김종신,이창연,Kim Hyoung-No,Yoon Sung-Min,Kim Jong-Shin,Lee Chang-Youn 대한소아신장학회 1997 Childhood kidney diseases Vol.1 No.1
The hypertensive encephalopathy is one of sudden convulsive cause in patients with acute post-streptococcal glomerulonephritis, but commonly, after the episode we can observe only mild to moderately hypertension in APSGN at ER. So these remains some question of what causes the convulsion in patients with APSGN. In this article, we report 3 cases of convulsion in APSGN with only moderate hypertension, the etiology of which proved to be due to hypertensive encephalopathy by the brain MRI. We believe that the brain MRI is a very useful test to diagnose the etiology of convulsion in APSGN and if brain edema in occipital lobe is detected by brain MRI, the convulsion would be due to hypertensive encephalopathy and the prognosis will be very good.
이창연,장무환 동국대학교 경주대학 1993 東國論集 Vol.12 No.-
It is known that meningoencephalitis is the disease usually characterized by a hstory of headache, high fever and disturbance of consciousness. Its cause is usually virus. In most cases, inflammatory reaction involve the brain diffusely, but occasionally involve brain locally. In those cases in whom inflammatory reaction involved brain locally, specific symptoms appear according to the location involved. Clinically, we can suspect the site of brain where inflammatory reaction involved, according to clinical symptoms. We experienced a case of meningoencephalitis with downbeat nystagmus implying that the inflammatory lesion involve pontomedullary junction. It was confirmed by MRI. So, we report it with review of literatures.
안면부 종창을 동반한 Henoch-Scho¨nlein 자반증 1례
이재휘,서무규,임문환,박성기,김태우,이창연 동국대학교 경주대학 1991 東國論集 Vol.10 No.-
We experienced a case of Henoch-Scho‥nlein purpura with are manifestation of facial swelling in a 7-year-old boy.