사상 체질 처방의 항염증 효능 비교 연구

이진아,하혜경,이호영,정다영,이준경,황대선,신현규,Lee, Jin-Ah,Ha, Hye-Kyung,Lee, Ho-Young,Jung, Da-Young,Lee, Jun-Kyoung,Huang, Dae-Sun,Shin, Hyeun-Kyoo 사상체질의학회 2010 사상체질의학회지 Vol.22 No.4

1. Objectives 4 herbal formulas (Yanggyeoksanhwa-tang, Yeoldahanso-tang, Cheongsimyeonja-tang and Taeeumjowi-tang) were applied to investigate the anti-inflammatory activities. In many studies, plant-derived anti-inflammatory efficacies have been investigate for their potential inhibitory effects on lipopolysaccharide (LPS)-stimulated macrophages. This study was performed to examine the anti-inflammatory activities of 4 herbal formulas on LPS-stimulated RAW 264.7 cells. 2. Methods The productions of nitric oxide (NO), prostaglandin (PG)$E_2$, interleukin(IL)-6 and tumor necrosis factor (TNF)-${\alpha}$ were examined in the presence of the 4 herbal formulas in RAW 264.7 cells. The cells were incubated with LPS 1 ${\mu}g/mL$ and 4 herbal formulas for 18 hrs. The anti-inflammatory activity of 4 herbal formulas were investigate by carrageenin-induced paw edema in rats. The paw volume was measured at 2 and 4 hrs following carrageenininduced paw edema in rats. 3. Results Yanggyeoksanhwa-tang and Cheongsimyeonja-tang showed inhibitory effect on $PGE_2$ production in LPS-stimulated RAW 264.7 cells and a reduction in carrageenin-induced paw edema on rats. Yanggyeoksanhwa-tang showed inhibitory effect on IL-6 in LPS-stimulated RAW 264.7 cells. 4 herbal formulas not affect on NO and TNF-${\alpha}$ inhibition in LPS-stimulated RAW 264.7 cells. 4. Conclusions These results suggested that Yanggyeoksanhwa-tang and Cheongsimyeonja-tang have anti-inflammatory activity.

사군자탕(四君子湯)의 항염증 효능 연구

이진아,하혜경,정다영,이호영,이남헌,이준경,서창섭,김정훈,이미영,신현규,Lee, Jin-Ah,Ha, Hye-Kyung,Jung, Da-Young,Lee, Ho-Young,Lee, Nam-Hun,Lee, Jun-Kyoung,Seo, Chang-Seob,Kim, Jung-Hoon,Lee, Mee-Young,Shin, Hyeun-Kyoo 대한한의학방제학회 2010 大韓韓醫學方劑學會誌 Vol.18 No.1

Objectives : To provide the information of efficacy for Sagunja-tang (Sijunzi-tang; SG), it was evaluated the anti-inflammatory effect. SG, a widely used herbal formula in tranditional Korean medicine, has been used to treat for the Boki-invigorating. In many studies, plant-derived anti-inflammatory efficacies have been investigated for their potential inhibitory effects on lipopolysaccharide (LPS)-stimulated macrophages. This study was performed to examine the anti-inflammatory effects of SG extract on LPS-stimulated RAW 264.7 cells. Methods : The productions of nitric oxide (NO), prostaglandin (PG)$E_2$, interleukin (IL)-6 and tumor necrosis factor (TNF)-$\alpha$ were examined in a macrophage cell line, RAW 264.7 cells, in the presence of the SG extract. RAW 264.7 cells were incubated with LPS $1\;{\mu}g/mL$ and SG extract for 18 hours. The anti-inflammatory activity of SG was investigated by carrageenin-induced paw edema in rats. The paw volume was measured at 0, 2 and 4 hours following carrageenin-induced paw edema in rats. Results : SG extract showed inhibitory effect on $PGE_2$, IL-6 and TNF-$\alpha$ by LPS-stimulated RAW 264.7 cells. But SG extract was not inhibitory effect on NO by LPS-stimulated RAW 264.7 cells. And administration of SG extract (1 g/kg) showed a reduction in carrageenin-induced paw edema on rats. Conclusions : These results suggest that SG extract has anti-inflammatory activities in vitro and in vivo models.

과학기술위성3호 부탑재체 소형영상분광기 미광 해석

이진아,이준호,Lee, Jin Ah,Lee, Jun Ho 한국광학회 2012 한국광학회지 Vol.23 No.4

This paper reports on the stray light analysis results of a compact imaging spectrometer (COMIS) for a microsatellite STSAT-3. COMIS images Earth's surface and atmosphere with ground sampling distances of 27 m at the 18~62 spectral bands (0.4 ~ 1.05 ${\mu}m$) for the nadir looking at an altitude of 700 km. COMIS has an imaging telescope and an imaging spectrometer box into which three electronics PCBs are embedded. The telescope images a $27m{\times}28km$ area of Earth surface onto a slit of dimensions $11.8{\mu}m{\times}12.1mm$. This corresponds to a ground sampling distance of 27 m and a swath width of 28 km for nadir looking posture at an altitude of 700 km. Then the optics relays and disperses the slit image onto the detector thereby producing a monochrome image of the entrance slit formed on each row of detector elements. The spectrum of each point in the row is imaged along a detector column. The optical mounts and housing structures are designed in order to prevent stray light from arriving onto the image and so deteriorating the signal to noise ratio (SNR). The stray light analysis, performed by a non-sequential ray tracing software (LightTools) with three dimensional housing and lens modeling, confirms that the ghost and stray light arriving at the detector plane has the relative intensity of ${\sim}10^{-5}$ and furthermore it locates outside the concerned image size i.e. the field of view of the optics. 과학기술위성3호 부탑재체인 COMIS(Compact Imaging Spectrometer)는 무게 4.25 kg의 소형영상분광기로써 지표면 및 대기과학을 연구할 목적으로 개발되었다. COMIS는 지표면, 대기, 수면으로부터 반사되는 태양 에너지를 고도 700 km에서 가시광 및 근적외선 영역(0.4 ~1.05 ${\mu}m$)에서 해상도 27 m, 관측폭 28 km, 파장 분해능 2 ~ 15 nm를 갖도록 결상 광학계와 분광 광학계로 구성된다. 먼저 지상 $27m{\times}28km$의 해당되는 지표면에서 반사된 빛은 COMIS의 결상 광학계에 의하여 상면에 위치한 $11.8{\mu}m{\times}12.1mm$의 선형 슬릿으로 맺히고, 이후 약 1.1배의 배율을 갖는 분광 광학계의 상면에 $1.4mm{\times}13.3mm$의 크기를 갖는 분광 스펙트럼 영상으로 나타난다. 이 때 부분 반사 및 산란 등에 의한 신호대잡음비(SNR, signal to noise ratio) 저하를 방지하기 위하여 렌즈 및 거울 면에 무반사 및 고반사 코팅이 적용되었고, 내부에는 미광 차단 구조물 등이 설치되었다. 미광 차단 설계의 적정성을 확인하기 위하여 미광 모델 수립과 상용 프로그램을 이용한 미광 해석을 수행하였다. 해석 결과 미광의 세기는 정상 결상 대비 무시할 정도의 값($10^{-5}$)으로 영상에는 실질적인 영향이 없음을 확인하였다.

홍채에서 발생한 흑색 세포종 1예

이진아,안용선,조양경,Jin Ah Lee,MD,Yong Sun Ahn,MD,Yang Kyung Cho,MD,PhD 대한안과학회 2014 대한안과학회지 Vol.55 No.5

Purpose: To report a case of melanocytoma originating from the iris observed for the first time in Korea. Case summary: A 53-year-old female with an unexpected iris mass was referred to our clinic. A round, 2.5 mm x 3.5 mm-sized iris mass was found on slit lamp examination in the 12 o'clock area of the patient's left eye. The mass was densely pigmented and had a smooth surface. Gonioscopy showed the mass had reached the peripheral cornea frontward and the lens backward. An excisional biopsy was performed for diagnosis. After the operation, a gonioscopic examination showed an intact ciliary body behind the surgical margin of the iris. A melancytoma of the iris was observed on subsequent histopathological examination. The patient has remained symptom-free with no iris mass recurrence since the operation. Conclusions: A few cases of iris melanocytomas have been reported worldwide but not in Korea. We confirmed a case of melanocytoma originating from the iris for the first time in Korea. J Korean Ophthalmol Soc 2014;55(5):789-793

일본의 고령자 지원을 위한 정보통신기술 정책 동향 및 활용

이진아,Lee, Jin Ah 한국정보통신학회 2019 한국정보통신학회논문지 Vol.23 No.11

초고령 사회 일본은 다양한 사회문제 해결 방법 중 하나로 정보통신기술의 활용을 적극적으로 추진하고 있다. 특히 머지않아 초고령 사회에 진입할 우리나라로서는 고령자 지원과 관련한 ICT활용에 대한 일본의 정책 및 현황을 살펴보는 것은 의미가 있을 것이다. 본 연구에서는 문헌조사를 통하여 일본의 고령자 지원관련 ICT정책 및 활용 현황을 살펴보고 우리나라 고령자 지원과 관련하여 다음과 같은 사항을 제안하였다. 고령자 지원관련 현장에서 ICT기술이 실질적으로 활용될 수 있는 기회가 넓혀져야 하며, 일본의 경우처럼 고령자 지원에 있어서 개호와 의료의 연계가 중요하기 때문에 이러한 기관간의 정보연계네트워크 구축을 위한 노력이 필요하다. 또한 다양한 로봇의 개발 및 보급을 통해 개호자와 관련 인력의 서류업무의 간소화 및 개호 부담의 완화를 모색해야 한다. 그리고 ICT활용을 통한 고령자를 위한 정서지지 및 안정을 위한 기술의 보급도 적극 추진되어야 한다. Super aged society, Japan actively uses Information Communication Technology(ICT) as one of solving methods for various social problem. Especially, for Korea where soon will become super aged society, it would be meaningful to examine the current policy trends and utilization of senior support using ICT in Japan. This study explores the policy trends and utilization of senior support using ICT in Japan through literature review, and then proposes some suggestions as follows. Opportunities for practical use of ICT should be widened in the field of senior support, and efforts are needed to build an information linkage network between institutions for senior support because linkage between care sector and medical sector is important for the elderly support. Besides, simplification of paperwork and easing of burden of care providers or workers in the field should be sought by development and dissemination of various robots. Moreover, the spread of technology for emotional support and stability should be actively pursued by using ICT.

퍼지를 적용한 계약망 프로토콜 기반의 네트워크 보안 모델의 설계 및 시뮬레이션

이진아,조대호,Lee Jin-ah,Cho Tae-ho 한국시뮬레이션학회 2005 한국시뮬레이션학회 논문지 Vol.14 No.1

Attempts to attack hosts in the network have become diverse, due to crackers developments of new creative attacking methods. Under these circumstances the role of intrusion detection system as a security system component gets considerably importance. Therefore, in this paper, we have suggested multiple intrusion detection system based on the contract net protocol which provides the communication among multiple agents. In this architecture, fuzzy rule based system has been applied for agent selection among agents competing for being activated. The simulation models are designed and implemented based on DEVS formalism which is theoretically well grounded means of expressing discrete event simulation models.

부직포형 기체 여과재의 구조와 여과 특성

이진아,주창환,Lee, Jin-Ah,Joo, Chang-Whan 한국섬유공학회 2010 한국섬유공학회지 Vol.47 No.2

Various air-filter media by using meltblown (MB) and spunbond (SB) nonwovens were structurally designed with different laying methods to obtain the relationship between structure and characteristic of air filters. Air permeability, pore size, filter efficiency and pressure drop of the designed filter media were investigated experimentally. The layer sequences of designed media showed significant factor on filter efficiency and pressure drop. The optimum filter media was determined as two layer structural design composed of calendering SB and MB nonwovens. In addition, a model equation to predict the pressure drop and filter efficiency of air filter media based on nonwovens was developed. The calculated values from the equation showed good agreement with experimental ones.

말기암환자에서 혈장 내독소 농도가 생존기간에 미치는 영향

이진아,윤호민,최윤선,연종은,이준영,Lee, Jin-Ah,Yoon, Ho Min,Choi, Youn Seon,Yeon, Jong Eun,Lee, June Young 한국호스피스완화의료학회 2014 한국호스피스.완화의료학회지 Vol.17 No.2

목적: 말기암환자의 여명 예측은 치료의 이득과 위해를 판단하는 잣대가 되고, 적절한 의료 중재 제공 및 환자의 자율성에 기초한 의사결정에 중요한 기준이 된다. 특히 많은 수의 말기암환자는 다발성 장기 부전으로 사망에 이르기 때문에 본 연구에서는 이를 반영할 수 있는 혈장 내독소 농도와 생존기간과의 연관성을 알아보고자 하였다. 방법: 2009년 4월부터 10월까지 6개월 동안, 만 20세 이상의 말기암환자 56명을 대상으로 혈장 내독소 농도를 측정하고, 생존기간을 조사하였다. 나이, 성별, 원발 암 부위, 암 치료 경력, 전이여부, 투약상황 및 활력 증후, Karnofsky 수행지수 등의 신체검사, 백혈구 수, 혈색소, 적혈구용적률, aspartate aminotransferase, alanine aminotransferase C-반응성 단백질, 총 빌리루빈, 내독소 등의 혈액검사를 시행하였다. 결과: 혈장 내독소 농도, 성별, 나이, 백혈구 수, 혈색소, 적혈구 용적률, AST, ALT, 총 빌리루빈, C-반응성 단백질, 통증강도를 단변량 분석한 결과 혈장 내독소 농도는 생존기간과 통계적으로 유의한 관계를 보이지는 않았으나, 단변량 분석에서 생존기간에 유의한 영향을 미치는 성별, 백혈구 수, 총 빌리루빈을 포함하여 시행한 다변량 분석에서 혈장 내독소 농도는 생존기간과 통계적으로 유의한 관계가 있는 것으로 나타났다. 결론: 다발성 장기 부전과 관련이 있는 혈장 내독소 농도는 생존기간 예측인자로서 쓰일 수 있는 가능성을 보여 주었다. Purpose: Since most terminally ill cancer patients die of multiple organ failure, plasma endotoxin concentration levels may be used to predict the life expectancy. This study was performed to evaluate the clinical significance of endotoxin level in plasma as a prognostic factor for survival in patients with terminal cancer. Methods: This study was conducted with 56 terminally ill cancer patients, above 20 years old, from April 2009 through October 2009. Demographic characteristics, Karnofsky performance status, and survival time were evaluated. We analyzed blood levels of white blood cell hemoglobin, hematocrit, aspartate aminotransferase, alanine aminotransferase, c-reactive protein, total bilirubin and endotoxin in each patient. Results: We considered following variable for univariate analysis: plasma endotoxin level, sex, age, WBC, hemoglobin, hematocrit, AST, ALT, total bilirubin, CRP and severity of pain. Univariate analysis did not show a significant association between plasma endotoxin level and survival time. However, in a multivariate analysis with factors that were found to be significantly associated with survival sex, WBC count and total bilirubin level in univariate analysis, high levels of plasma endotoxin and short survival time were significantly related. Conclusion: Plasma endotoxin level could be used as a prognostic factor to predict the life expectancy of terminally ill cancer patients.

건강한 성인의 경장근 두께 측정에 대한 초음파영상법의 신뢰도

이진아,김선엽,Lee, Jin-Ah,Kim, Suhn-Yeop 대한물리치료학회 2011 대한물리치료학회지 Vol.23 No.4

Purpose: The objective of this study was to evaluate the inter- and intra-examiner reliability of ultrasonography (US) for measuring the thicknesses and cross-sectional area of the longus colli muscle (LCM) in healthy subjects. Methods: Twenty-five healthy adults participated in this study as subjects and two examiners attended to the study. LCM size was measured at the level of the thyroid cartilage. All subjects were randomly allocated to one of the three different methods. Method 1 was that the examiner A conducts the first measurement and one hour later conducts the second measurement and twenty four hours later conducts the third measurement, respectively. Method 2 was that the examiner B conducts the measurements in the same way as the examiner A. Method 3 was that the examiners A and B randomly conduct the measurements twice at an interval of one hour. Results: The intra-class correlation coefficient (ICC) for the intra-examiner reliability ranged from 0.78 to 0.98 at rest and 0.57 to 0.98 during contraction for the examiner A. The $ICC_{3,3}$ for the intra-examiner reliability ranged from 0.60 to 0.96 at rest and 0.57 to 0.92 during contraction for the examiner B. The $ICC_{2,3}$ for the inter-examiner reliability ranged from 0.80 to 0.91 at rest and 0.84 to 0.93 during contraction. Conclusion: The findings of this study indicate that US is a reliable method for measuring the LCM size.

해양대순환모형을 이용한 해빙의 역할에 관한 수치실험 연구

이진아,안중배,Lee, Jin-Ah,Ahn, Joong-Bae 한국해양학회 2001 바다 Vol.6 No.4

본 연구에서는 기후 시스템 내에서의 해빙의 역할을 살펴보고자 열역학적 방식에 의한 해빙 모형을 개발하고 이를 해양대순환 모형인 MOM에 접합한 해양/해빙 접합 모형을 구축하여 수치적 실험을 하였다. 연구에서는 먼저 접합한 모형을 이용하여 해빙의 계절 평균적인 분포를 모사하였다. 또한 해양대순환 모형이 해빙 모형과 접합한 경우와 접합하지 않은 경우를 비교함으로써 대규모 해양 분포에 나타나는 해빙의 역할을 살펴보았다. 또한 모형의 결과를 다른 모형의 결과 및 관측자료와 비교 분석함으로써 해양/해빙 모형 접합 모형의 결과를 검증하였다. 접합 모형은 양반구 고위도에서의 해빙이 계절적 분포를 전체적으로 적절히 모사하였다. 해양대순환 모형이 해빙 모형과 접합한 경우와 그렇지 않은 경우에 대한 비교 연구에서 해빙은 양반구 고위도에서의 해수온과 염분을 유지시켜주는 중요한 역할을 할뿐만 아니라 South Ocean 순환세포와 남반구 순환세포(Southern Hemisphere circulation cell) 및 북대서양 심층수와 관련한 자오 심해 순환과 남극환류 같은 동서류의 순환도 적절히 모사하였다. In order to find out the role of sea-ice in the climate system, a thermodynamic sea-ice model has been developed and included in the ocean general circulation model, MOM2, for the construction of OGCM/sea-ice coupled model in this study. By using the model developed, seasonal mean sea-ice distribution has been simulated, first of all. The role of sea-ice in the sense of large scale ocean circulation has been studied by comparing the results of OGCM/sea-ice coupled model experiment with OGCM-standalone experiment. At the same time, the coupled model has been verified by comparing and analysing the results of the other models and observation. The coupled model has reasonably simulated the overall seasonal distribution of sea-ice in the high latitudes of both hemispheres. In the comparative analysis between the OGCM/sea-ice coupled and OGCM-standalone experiments, the sea-ice is playing important roles on maintaining not only the distributions of temperature and salinity in high latitudes of both hemispheres, but also the meridional ocean circulation associated with south ocean cell, southern hemisphere cell and zonal ocean circulation such as a circum-polar current.