중풍 용어 표준화 및 영번역 방안에 관한 연구

이주아,이정섭,강병갑,고미미,문태웅,고호연,박성영,정희,방옥선,Lee, Ju Ah,Lee, Jung Sup,Kang, Byung Kab,Ko, Mi Mi,Mun, Tae Ung,Go, Ho-Yeon,Park, Sun-Young,Jung, Hee,Bang, Ok Sun 대한중풍순환신경학회 2010 대한중풍.순환신경학회지 Vol.11 No.1

Background : Currently, the absence of a unified terminology and proper translation about Traditional Korean Medicine is a problem that should be solved. Although Traditional Korean Medicine has undergone steady growth in popularity during the past years, the Westerner's poor access to information has been drawback to its reception in the West. Objective : This research is aimed to seek system for standardization of stroke terminology and proper translation into English. Conclusion : We proposed the method of making unified terminology and translation about stroke in Traditional Korean Medicine.

한의 중풍변증표준안-III에 대한 보고

이주아,이정섭,강병갑,고미미,문태웅,조기호,방옥선,Lee, Ju-Ah,Lee, Jung-Sup,Kang, Byung-Kab,Ko, Mi-Mi,Mun, Tae-Ung,Cho, Ki-Ho,Bang, Ok-Sun 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.2

Objectives : The purpose of this study was to develop the Korean standard pattern identifications for stroke-III (KSPIS-III). KSPIS-III includes 4 major pattern identifications (PIs) and clinical indicators for each. Methods : To extract the indicators for 4 major PIs, we analyzed 1548 clinical data from 15 traditional Korean medicine hospitals. Patients got acute stroke within 30 days from onset. Two physicians independently checked 65 indicators and performed pattern diagnosis. If the PI were diagnosed the same, PI would be confirmed. First we built an assumption model that set up the relationship among pattern identifications. Second, we extracted the indicators for fire-heat pattern and qi deficiency pattern by comparison between excessive and deficiency group, heat and non-heat group. By comparing yin deficiency pattern and 3 other patterns respectively, we extracted the indicators for yin deficiency pattern. Dampness-phlegm pattern indicators were extracted by the same method. Results : After cross tabulation with 65 indicators on the basis of our assumption model, we finally extracted 19 indicators for fire-heat pattern, 11 for qi deficiency pattern, 7 for yin deficiency pattern, and 7 for dampness-phlegm pattern. Conclusions : KSPIS-III was more improved than KSPIS-II because it was based on more clinical data. Further study to establish the PI diagnostic model would be required for practical use in the clinical field.

DSS으로 유발된 생쥐의 대장점막손상에 대한 도체탕(導滯湯)의 효과

이주아,공경환,Lee, Ju-Ah,Kong, Kyung-Hwan 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.3

Objectives : This study was carried out to investigate the effects of Doche-tang on colonic mucosal ulcer induced by dextran sulfate sodium(DSS). Method : The group was divided into three. The normal group consisted of mice that were not inflammation-induced. The control group was composed of untreated colitis elicited mice. The sample group was administered Doche-tang after colitis elicitation. The effects on colonic mucosal ulcers were evaluated by the morphological change of colonic mucosa, the anti-oxidant effect, HSP 70, $NF-{\kappa}B$, COX-1, COX-2 and iNOS. Results : In terms of immunohistochemical findings, the distribution of COX-1 in mice treated with Doche-tang noticeably increased more than that in the control group. The distribution of HSP70, $NF-{\kappa}B$, COX-2, iNOS in mioe treated with Doche-tang decreased more than that in the control group. Regeneration of surface epithelial cell and goblet cell in mucosa was observed by transmission electron microscope. Conclusion : According to the results, Doche-tang is practicable treatment for colonic mucosal ulcer.

사설 아동발달센터의 부모상담 실태와 인식

이주아(Ju Ah Lee),안성우(Seongwoo Ahn) 한국언어치료학회 2022 言語治療硏究 Vol.31 No.3

목적 : 본 연구에서는 아동발달센터 내원 아동의 보호자가 인식하는 부모상담의 실태와 인식을 살펴보고 대상자의 특성에 따른 인식의 차이와 실태에 따른 인식의 차이를 알아보고자 한다. 방법 : 부산ㆍ경남지역에 소재한 아동발달센터에 다니고 있는 만 6세 이하의 학령전기 장애유아의 부모 108명을 대상으로 실시하였다. 예비조사와 타당도 검증을 통해 기초배경정보, 실태, 인식에 관련한 19문항의 설문지를 작성하였다. 결과 : 첫째, 부모상담 실태에서 평균 상담 횟수는 회기 당 .5회 이상에서 1회 미만, 상담시간은 1분 이상에서 5분 미만, 상담방법은 대면상담, 상담장소는 치료실, 상담내용은 치료 계획 및 과정이 가장 많았다. 둘째, 부모상담 인식은 전반적 인식, 정보 제공, 치료사 태도, 부모상담 효과의 항목에서 긍정적인 반응을 보였으나 상담 환경의 항목과 정보 제공 중 심리적 문제에 대한 중재 항목에 대한 인식에서는 부정적인 반응을 보였다. 셋째, 대상자 특성에 따라 다양한 차이를 보였으며 조부모와 50세 이상의 연령 집단에서 부모상담에 대한 부정적인 인식을 나타내었고 월 수익이 높을수록 환경에 대한 부정적인 인식을 나타내었다. 결론 : 아동발달센터에서 이루어지는 부모교육은 부모와 아동 발달에 중요한 요소로써 대상아동의 보호자들은 전반적으로 만족하고 있는 것으로 나타났다. 보다 나은 부모상담을 위해 심리적 중재, 조부모, 상담환경, 상담시간에 대한 개선이 필요할 것으로 기대된다. Purpose : The purpose of this study is to investigate the status and preception of parental counseling of childrens parents in child development centers and to compare the differences in perception, status, awareness and characteristics of the subjects. Methods : A questionnaire was administered to 108 parents of disabled children aged 6 and under in a child development center. The questions were related to basic background information, status, and perception. Results : The average frequency of counseling sessions was found to be more than 0.5 and less than 1 per session. Each session lasted on average more than 1 minute and less than 5 minutes. The method was face-to-face, the place was the therapy room, and the content was a therapeutic program. Second, parental counseling responded positively to overall awareness, offer information, therapist attitude, and counseling effect. However, negative responses were found in counseling environment and intervention of psychological problems that offer information. Third, there were various differences according to characteristics of subjects. Grandparents and age groups over 50 showed a negative awareness about parental counseling; subjects with high monthly income showed a negative awareness about the environment. Conclusions : Parental counseling at the child development center is an important factor for parent and child development; guardians of disabled children are generally satisfied with parental counseling.

종설 : 비만과 대사증후군에 관한 임상시험의 최근 경향

이주아 ( Ju Ah Lee ),공경환 ( Kyung Hwan Kong ),고호연 ( Ho Yeon Ko ),배광호 ( Kwang Ho Bae ),박선영 ( Sun Young Park ),박경무 ( Kyung Moo Park ),송윤경 ( Yun Kyung Song ),박정현 ( Jung Hyeon Park ),김호준 ( Ho Jun Kim ),박선주 ( 한방비만학회 2009 한방비만학회지 Vol.9 No.1

Objectives The aim of this study is to review and analyze the status on the recent clinical trials of ``obesity`` and ``metabolic syndrome``. Methods We search ``www.clinicaltrail.gov`` for research trend of obesity and metabolic syndrome. Search terms used were ``obesity`` and ``metabolic syndrome``. In order to see detail review, searching was performed from 01, 01, 2007 to 05, 31, 2009 with intervention, phase Ⅲ or phase Ⅳ. 16 And we classified all the searched studies into design, intervention, purpose, end point, diseases and condition. Results We could search total 232 trials. Of them, we found 32 trials with intervention, phase Ⅲ or phase Ⅳ from 01, 01, 2007 to 05, 31, 2009. Also we could see various design of clinical trials. Conclusion To improve obesity and metabolic study in Traditional Korean Medicine, it is need to activate clinical trial, meta analysis, develope of clinical practice guidelines, co-works with conventional medicine and etc.

사상체질 식이 중재연구 보고에 대한 질 평가

김지환,이주아,Kim, Ji Hwan,Lee, Ju Ah 사상체질의학회 2020 사상체질의학회지 Vol.32 No.4

Objectives The purpose of this study was to evaluate quality of reporting of intervention studies on Sasang Constitutional diet (SCD) based on the Consolidated Standards for Reporting of Trials (CONSORT) and Transparent Reporting of Evaluations with Nonrandomized Designs (TREND) statements. Methods We searched for Randomized controlled trials (RCT) and Non randomized studies for intervention (NRSI) on SCD in 4 databases and other sources, selected them by the inclusion criteria, and then evaluated quality of reporting of them. Results 1. A total of 10 studies (1 RCT and 9 NRSI) from 1999 to 2006 were selected and evaluated. The detailed items of up to 78%, at least 40%, and median value of 59% in the CONSORT and TREND statements were not reported. 2. One RCT was reporting 4 (11%) sufficiently, and 4 (11%) insufficiently among the 37 detailed items in the CONSORT statement while it was not reporting 29 (78%) items. 3. Nine NRSI were reporting 7 (12%) items sufficiently, and 2 (3%) items insufficiently among the 58 detailed items in the TREND statement while they were not reporting 15 (26%) items. Twenty (34%) items in the TREND statement were reported in some papers but not in more than half. Conclusions The quality of reporting of intervention studies on SCD has been assessed to be generally low. Subsequent researchers are recommended to select an appropriate statement for research design, and use it as a checklist from the time of designing the study to the time of reporting.

선학초(짚신나물) 경구투여시 항암효과 탐색 및 약물 대사효소의 변화

이시형,정희,이주아,고호연,최유경,박종형,김지혜,고성규,전찬용,Rhee, Si-Hyung,Jung, Hee,Lee, Ju-Ah,Go, Ho-Yeon,Choi, Yu-Kyung,Park, Jong-Hyung,Kim, Ji-Hye,Ko, Seong-Kyu,Jun, Chan-Yong 대한예방한의학회 2009 대한예방한의학회지 Vol.13 No.2

Objective : This research was aimed to investigate the anti-tumor effect, safety, mechanism and metabolizing enzyme of Agrimonia pilosa LEDEB(APL) in female C57B/L mouse. Methods : At first, to evaluate the anti-tumor activity of APL, we divided into four groups, normal, control, APL100(100mg/kg), APL150(150mg/kg). LLC obtained American Type Culture Collection was used. LLC had been inoculated to induce tumor. To measure the anti-tumor effect of APL, we calibrate tumor size and weight. To study for mechanism of anti-tumor in APL, we used western blotting and to know metabolizing enzyme in APL we used to real-time PCR. Results : APL100, APL150 inhibited tumor growth after medicine injected. APL did not only induced caspase-dependent apoptosis in LLC-bearing mouse tumor. In APL100, it were decreased 72% in CYP3A11. In APL150, it were decreased 62%, 75% in CYP3A11 and MRP1a respectively. Conclusion : These results suggests that APL has some anti-tumor effects in female C57B/L mouse tumor. APL should be careful use with other drugs related with CYP3A11 or MRP1a.

2015년부터 2018년까지 사상체질의학회지에 보고된 증례에 대한 보고의 질 평가 : CARE지침을 바탕으로

김지환,이혜림,이주아,이명수,Kim, Ji Hwan,Lee, Hye Lim,Lee, Ju Ah,Lee, Myeong Soo 사상체질의학회 2018 사상체질의학회지 Vol.30 No.2

Objectives The purpose of this study is to evaluate the quality of case reports about Sasang Constitutional Medicine(SCM). Methods Case reports published from March, 2015 to March, 2018 in Journal of SCM were identified by searching from Oriental Medicine Advanced Searching Integrated System(OASIS). We assessed the quality of reporting of them based on CAse REport (CARE) guideline. Results A total of 39 case reports were finally included for the assessment. Overall quality of reporting was acceptable because case report even less reporting items mentioned 70.4% of them. However, the quality level was uneven because the maximum report rate was 77.8 %, the minimum 44.4 %, and the median 66.7 % when rigorously assessed. More than 50% of 39 case reports did not report 6 items about intervention adherence and tolerability, Diagnostic challenges, patient's perspective on interventions, informed consent, timeline, and adverse events, and did not sufficiently report 4 items about inclusion of terms such as case reports or SCM in keyword, symptoms of patient in abstract, information such as occupation relevant with psychosocial history, and the rationale for conclusions. Conclusions Efforts to improve the quality of reporting in SCM, and to develop case reporting guidelines appropriate for SCM are required.

어혈처방 3종이 지방전구세포 분화에 미치는 영향

이호영 ( Hoyoung Lee ),심은형 ( Eun Hyoung Shim ),이명수 ( Myeong Soo Lee ),이주아 ( Ju Ah Lee ) 대한본초학회 2016 大韓本草學會誌 Vol.31 No.6

Objectives : Blood stasis (BS) is related to be caused by blood circulation and stagnation which are cancer, atherosclerosis and hyperlipidemia in traditional medicine. We extracted 3 kinds of BS formula; Seogakjihwang-tang (SGT), Tonggyuhawlhyul-tang (THT), Hyulbuchukeo-tang (HCT). This study was conducted to investigate whether the 3 kinds of herbal formula extracts have inhibitory efficacy association with anti-adipogenesis. Methods : To investigate the anti-adipogenesis, we used the mouse fibroblast cell line, 3T3-L1 which differentiated into adipocytes in response to insulin, IBMX and dexamethasone (MDI). Cytotoxicity of herbal formula extracts were examined by CCK-8 kit. Intracellular lipid droplets were detected by Oil-Red-O staining. Triglyceride (TG) and leptin were measure using elisa kit. Results : The yield of water extracts was 14.62% (SGT), 21.27% (THT), 20.02% (HCT). Lipid accumulation was reduced significantly by 3 kinds of herbal formula compared to control. Especially, THT and HCT decreased lipid droplet, respectively at all concentration. The TG and leptin were also inhibited by 3 kinds of herbal formula. The IC50 of TG were 280.51 ㎍/㎖ (SGT), 52.62 ㎍/㎖ (THT), 313.99 ㎍/㎖ (HCT). The IC50 of leptin were 348.76 ㎍/㎖ (SGT), 164.02 ㎍/㎖ (THT), 257.00 ㎍/㎖ (HCT). THT was better than other herbal formula on anti-adipogenesis. Conclusion : kinds of herbal formula inhibited adipogenesis in MDI-induced 3T3-L1 adipocytes, as indicated by the significant reduction in TG and leptin concentration without cytotoxicity. Therefore, 3 kinds of herbal formula for BS might act as a therapeutic agent for preventing lipid diseases, such as obesity and atherosclerosis.

한방병원에 내원한 급성기 중풍환자에 대한 기술 분석

고호연,정미경,박선영,이주아,신미란,공경환,고성규,선승호,박종형,조기호,전찬용,Go, Ho-Yeon,Jung, Mi-Kyung,Park, Sun-Young,Lee, Ju-Ah,Shin, Mi-Ran,Kong, Kyungwhan,Ko, Seong-Kyu,Sun, Seong-Ho,Park, Jong-Hyung,Cho, Ki-Ho,Jun, Chan-Yong 대한중풍순환신경학회 2010 대한중풍.순환신경학회지 Vol.11 No.1

Objective : This study is aimed to investigate the present status in acute stroke patients in Koran medicine hospital. Method : We used the Korean medicine stroke database. We collected data from 4 Korean medicine hospital from Feb. 2010 to Aug. 2010. We surveyed past history, motive, diseases, diagnostic machines, the day from onset to admission in acute stroke patients. Results : 1. In Korean medicine hospital, it has been grown up the portion of cerebral infarction and age. 2. In Korean medicine hospital, the patients within 1 day from onset to admission were 63case(34.60%) 3. In Korean medicine hospital, the diagnotic machine has been well used, but MRA utilzation was low. 4. Acute stroke patients were not well known the risk factor, and the patients cerebral infarction didn't know that they had hyperlipidemia. Conclusions : In this study, we know the present status in acute stroke patients. It seems necessary to investigate more further study.