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베타3-아드레날린 수용체 유전자 변이와 규칙적인 운동이 체지방 분포 및 지질대사에 미치는 영향
이선장,이종균,서영성 啓明大學校 生活科學硏究所 2002 科學論集 Vol.- No.-
Obesity is influenced by gene and environmental factors such as physical activity and calory intake β3-adrenoceptor(β3AR) gene is very important structure in the human body composition. Stimulation of β3AR in adipose tissue causes grater energy expenditure and increases thermogenesis and lipolysis. Mutatation of the gene(64Arg) may be the cause of greater increases in body mass and the decrease in basic metabolism. Regular exercise has been shown to improve control of lipid abnormalities, diabetes mellitus, hypertension and obesity. Therefore in this study, effects of the β3AR gene mutation in women according to regular exercise were investigated. Materials and methods: The study group consisted of 62 premenopausal female subjects from K medical center in Daegu Korea. Genotyping of the Trp64Arg in β3-adrenoceptor gene was processed by the standard protocol. Blood samples were obtained in the morning after 10 hour fasting. Serum lipid and blood glucose were measured by an autoanalyzer. BMI, WHR, visceral fat amount, subcutaneous fat, VSR and total body fat percent were measured. Results: Women with β3AR wild type gene, no difference was found in body mass, body fat composition and total cholesterol between the regular exercise group and the sedentary group. In the group with mutant type of β3AR gene, a significant difference was detected in body mass and body fat composition between the regular exercise group and the sedentary group. The sedentary group compared with the regular exercise group, has higher waist circumference(86.2cm vs 76.60cm, p=0.042) and subcutaneous fat amount(254.49㎠ vs 157.35㎠). These results support the previous studies which suggested regular exercise may attenuate the deleterious effects of polymorphism in the obesity related genes. Conclusions: Physical activity may countervalence the effect of genetic predisposition to increase body fat, insulin resistance and body weight. The identification of genetic effects that are modified by exercise and the application of this genetic information to exercise prescription may be one way to improve the efficacy of exercise as a preventive measure for chronic diseases such as diabetes mellitus, obesity, hypertension, cadiovascular disease.