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Sprague-Dawley 랫드를 이용한 선폐정천탕의 단회투여독성시험
이응석,한종민,양수영,김민희,김승형,남궁욱,박양춘,Lee, Eung-Seok,Han, Jong-Min,Yang, Su-Young,Kim, Min-Hee,Kim, Seung-Hyung,NamGung, Uk,Park, Yang-Chun 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.1
Objectives : This study aimed to evaluate the single oral dose toxicity of Seonpyejeongcheon-tang (SJT) in male and female Sprague-Dawley rats. Methods : In this single oral toxicity study, rats were orally administrated in a single dose of 0 or 5,000 mg/kg SJT. There were 7 rats in each group. After single administration, mortality, clinical signs, body weight changes and gross pathological findings were observed for 14 days. Organ weight, clinical chemistry and hematology were tested after 14 days. Results : There was no mortality or other clinical signs for 14 days. There were also no significant differences in body weight, organ weights, hematological and serum chemical parameters between the SJT and control groups. Conclusions : The results obtained in this study suggest that the 50% lethal dose of SJT is over 5,000 mg/kg, so this finding can be expected to provide scientific evidence for the safety of SJT.
이응석,위현곤,정주노,Lee, Eung-Seok,Wi, Hyeon-Gon,Jeong, Ju-No 대한기계학회 1997 大韓機械學會論文集A Vol.21 No.6
A method for measuring the accuracy of rotating objects was studied. Rotating axis errors are significant; such as the spindle error of a manufacturing machine which results in the surface roughness of machined work pieces. Three capacitance type displacement sensors were used to measure the rotating master ball position. The sensors were mounted to the three orthogonal points on the spindle axis. The measurement data were analyzed and shown for rotating spindle accuracy, not only for average roundness error but also for spindle volumetric positional error during the revolutions. This method is simple and economical for industrial field use with regular inspection of rotating machines using portable equipment. Measuring and analyzing time using this method takes only a couple of hours. This method can also measure microscopic amplitude and 3-dimensional direction of vibrating objects.
연구논문 : 생명과학 ; 프로페논 화합물의 배양 대식세포에서 NFκ-B활성화 억제를 통한 NO 및 TNF-α 생성억제
이응석 ( Eung Seok Lee ),주혜경 ( Hye Kyung Ju ),문태철 ( Tae Churl Moon ),이은경 ( Eun Kyung Lee ),장영동 ( Yurng Dong Jahng ),이승호 ( Sung Ho Lee ),손종근 ( Jong Keun Son ),백석환 ( Suk Hwan Baek ),장현욱 ( Hyeun Wook Chang 영남대학교 약품개발연구소 2004 영남대학교 약품개발연구소 연구업적집 Vol.14 No.-