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Behcet 증후군의 혈액내 림프구와 면역글로불린에 관한 연구
이은소(Eun So Lee),방동식(Dong Sik Bang),이승헌(Seung Hun Lee),이성낙(Sung Nack Lee) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.6
In our investigation, various immunologic aspects of 129 patients with complete and incomplete type of Behcet's syndrome were taken under consideration : quantitation of total T-cells by E-rosette method and B-cells by EAC-rosette rnethod, helper/inducer T and suppressor/cytotoxic T-cells by monoclonal antibody technique(OKT4, OKT8), lymphocyte transformation test with PHA, quantitation of serum r-globulin by electro phoresis and quantitations of serum IgG, IgA, IgM, C3, C4 by immunodiffusion. From the results, the cell mediated immunity in Behcet's syndrome is not influenced by the number of patterns of four major symptoms or the activity of each major symptom at the time of test. However the humoral immunity is considered to be influenced by the above parameters.
이은소 ( Eun So Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
The autoinflammatory diseases are a group of diseases characterized by seemingly unprovoked inflammation, without evidence of infection, of high titer autoantibodies, or antigen-specific T cells. Recent studies have shown that activation of the interleukin 1β pathway is a common mechanism in the pathogenesis of autoinflammatory diseases. Beneficial effects on interleukin-1 blockade have been reported in all monogenic autoinflammatory diseases. Interleukin-1-targeting drugs consists of anakinra, a recombinant IL-1 receptor antagonist, canakinumab, a human monoclonal antibody-targeting IL-1b and rilonacept, an IL-1 neutralizing fusion protein. The success and safety profile of drugs targeting IL-1 in the treatment of CAPS (cryopyrin associated periodic syndromes) and DIRA (deficiency of IL-1 receptor antagonist)have encouraged their wider use in other autoinflammatory syndromes including the classic hereditary periodic fever syndromes (familial Mediterranean fever, TNF receptor-associated periodic syndrome, and hyperimmunoglobulinemia D with periodic fever syndrome) and additional immune dysregulatory conditions that are not genetically well defined, including Still’s, Behcet’s, and Schnitzler diseases. The fact that the accumulation of metabolic substrates such as monosodium urate, ceramide, cholesterol, and glucose can trigger the NLRP3 inflammasome connects metabolic stress to IL-1β-mediated inflammation and provides a rationale for therapeutically targeting IL-1 in prevalent diseases such as gout, diabetes mellitus, and coronary artery disease. Early treatment can prevent IL-1-mediated organ damage in patients with autoinflammatory syndromes, thus stressing the importance of early diagnosis and treatment.
Behcet 증후군의 분류아형과 현증상에 따른 백혈구 이동억제검사 성적
이은소(Eun So Lee),양동순(Dong Soon Yang),이승헌(Seung Hun Lee),방동식(Dong Sik Bang),이성낙(Sung Nack Lee),최인홍(In Hong Choi),이봉기(Bong Ki Lee),윤정구(Jung Koo Youn) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.6
This study was undertaken to investigate the immunological mechanism of Behqet s syndrome, considered to be important in the pathogenesis of the disease. Seventy- three patients with complete, incomplete and suspected types of Behget's syndrotne were tested for leukocyte migration ingibition factor(LIF), one of the lymphokines. The results were as follows : 1. There was no difference between the average LIF activity of all the patients and that of eontrol. 2. LIF activity of complete type, according to Shirnizus classification, was significaritly lower than the control value. 3. LIF activity of ocular type, according to Lehners classification, was signficantly lower than the control value. 4. LIF activity for patients with 4 clinical symptoms was well below the value for patients with less symptomes 5. For patients with single clinical symptom, LIF activity of complete type was well below the values of incomplete and suspected types. 6. In suspected and mucocutaneous types, LIF activity was low when the patients showed two clinical symptoms than one. Thus, LIF activity was low for patients with complete, ocular and neurological types and with multiple symptorns.
이은소 ( Eun So Lee ) 대한류마티스학회 2013 대한류마티스학회지 Vol.20 No.4
Many rheumatic diseases may involve any organ system of the body including the skin. Proper understanding of rheumatic skin disease is necessary for making a diagnosis. In addition, there are important relationships existing between the cutaneous and systemic manifestations of rheumatic diseases. In management of these diseases, the interdisciplinary approach could generate better results. Among rheumatic diseases, the cutaneous manifestations of three major rheumatic diseases such as lupus erythematosus (LE), dermatomyositis (DM)/polymyositis and scleroderma/systemic sclerosis (SSc) will all be reviewed.
Before you write a paper 2 (WP 2) : What is authorship?
이은소 ( Eun So Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Authorship confers credit and has important academic, social, and financial implications. Authorship also implies responsibility and accountability for published work. Recently several issues concerning authorship in Annals of Dermatology have been raised. Annals of Dermatology follows the recommendations for authorship by the International Committee of Medical Journal Editors (ICMJE, 2013, http://www.icmje.org) and the Good Publication Practice Guidelines by the Korean Association of Medical Journal Editors (KAMJE, 2013, http://kamje.or.kr). The ICMJE recommends that authorship be based on the following 4 criteria: 1. Substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work; AND 2. Drafting the work or revising it critically for important intellectual content; AND 3. Final approval of the version to be published; AND 4. Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. In addition to being accountable for the parts of the work he or she has done, an author should be able to identify which co-authors are responsible for specific other parts of the work. In addition, authors should have confidence in the integrity of the contributions of their coauthors. All those designated as authors should meet all four criteria for authorship, and all who meet the four criteria should be identified as authors. Those who do not meet all four criteria should be acknowledged.