시호(柴胡)의 뇌해마 신경세포 보호효능에 대한 연구

이원철,신광식,Lee, Won-Chul,Shin, Kwang-Sik 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.4

Objective : This study was performed to investigate neuroprotective effects of Bupleuri Radix against oxidative and ischemic damages. Method : To observe the neuroprotective effects against ischemic damage, ischemic insult was induced by oxygen/glucose deprivation (OGD) on organotypic hippocampal slice cultures (OHSC) from 1 week-old Sprague-Dawley rats. Propidium iodide (PI) fluorescence-stained neuronal dead-cell areas, area percentages and TUNEL-positive apoptotic cells in CA1 and dentate gyrus, and LDH levels in culture media of the OHSC were measured following Bupleuri Radix extract treatment. Result : The following results were obtained: (1) The $5\;{\mu}g/ml$ of Bupleuri Radix treatment demonstrated a significant decrease in PI fluorescence-stained neuronal dead-cell areas and area percentage in CA1 region of the OHSC from 18 hrs to 48 hrs following the OGD. The $50\;{\mu}g/ml$ of Bupleuri Radix treatment was also significant from 6 hrs to 48 hrs following the OGD and was more effective. (2) The 5 and $50\;{\mu}g/ml$ of Bupleuri Radix treatment demonstrated a significant decrease in PI fluorescence-stained neuronal dead-cell areas and area percentage in DG region of the OHSC from 6 hrs to 48 hrs following the OGD. The $50\;{\mu}g/ml$ treatment was more effective than the $5\;{\mu}g/ml$ treatment. (3) Bupleuri Radix treatment demonstrated a significant decrease in TUNEL-positive apoptotic cells in CA1 region (with 5 and $50\;{\mu}g/ml$) and in DG region (with $50\;{\mu}g/ml$) of the OHSC damaged by the OGD. (4) Bupleuri Radix treatment demonstrated a significant decrease in LDH concentrations in culture media of the OHSC damaged by the OGD. Conclusion : These results suggest that Bupleuri Radix has neuroprotective and control effects on inflammatory and immune responses where there has been ischemic damage to the central nervous system.

폐암(肺癌)에서 전이(轉移)된 뇌종양환자(腦腫瘍患者)의 한방(韓方) 치험(治驗) 1례(例)

이원철,신광식,Lee, Won-Chul,Shin, Kwang-Sik 대한암한의학회 1999 大韓癌韓醫學會誌 Vol.5 No.1

We have experienced a case of metastatic brain tumor originated from lung cancer treated by oriental medicine (Herbal medication, Acupuncture therapy, Moxa therapy) and We have a good result from that case to report it. According to the therapentic effects, it could be suggeted that Younggyaechulgamtanggagambang extracts and oriental medical symptomatic treatment were significant in improvement of the patient.

직업성 안상해(眼傷害)에 관한 기술역학적 연구

이원철,이강숙,맹광호,이승한,정상문,Lee, Won-Chul,Lee, Kang-Sook,Meng, Kwang-Ho,Lee, Seung-Han,Chung, Sang-Moon 대한예방의학회 1988 Journal of Preventive Medicine and Public Health Vol.21 No.1

A total of 181 cases of industrial ocular injuries hospitalized and treated at the St. Mary's Hospital, Seoul during the 5-year period was studied on their epidemiological characteristics. Of these patients 96.7% were males, and 43.6% were in twenties, 49.7% of the cases were injured on left eyes. There were no statistically significant differences in frequencies of study subjects by day of the week and month of the year. Most common injury hour were between 10- <12 AM(13.6%) and between 2- <4 PM(20%). Of the total 101 cases, 37.6% were working less than 6 months, and 73.7%, less than 2 years. Of the total, 42.3% were involved in machinary work and 13.9%, in construction work. According to the American National Standard Method of recording basic facts relating to the nature and occurrence of work injuries, 62%, among all source of injuries was metal item and the most common accident type was struck by flying objects(76.2%). Among 181 cases, only 2 cases were wearing protective equipment when the accidents occurred.

Logistic Analysis를 이용하여 분석한 인공유산이 속발성불임에 미치는 영향

이원철,Lee, Won-Chul 대한예방의학회 1982 Journal of Preventive Medicine and Public Health Vol.15 No.1

The methods controlling the confounding factors were discussed using the data of secondary infertility with induced abortion. Mantel-Haenszel method and logistic model were applied in the analysis to find out which factors were confounding and/or effect modification variables. In the logistic analysis, the main effect of induced abortion, spontaneous abortion, age and interaction effect between induced abortion and spontaneous abortion were chosen as independent variables being regressed into logistic functions. Spontaneons abortion was interpreted as a potential confounder and at the same time potential effect modifier and age was interpreted as potential confounder. Spontaneous abortion was shown to be more important influencing factor than age to the secondary infertility. In the course of logistic analysis, the problem of parameter estimation and hypothesis testing, assessing the fitness of a model, and selection of the best model were briefly explained. For the program of logistic model, FUNCAT Procedure of SAS package was chosen.

RPWM기법을 이용한 세탁기용 유도전동기 구동 시스템의 소음 및 진동 저감

이원철,김이훈,배우리,장봉안,양하영,원충연,Lee, Won-Chul,Kim, Lee-Hun,Bae, Woo-Ri,Jang, Bong-An,Yang, Ha-Yeong,Won, Chung-Yuen 한국조명전기설비학회 2005 조명·전기설비학회논문지 Vol.19 No.3

본 연구에서는 유도전동기 구동 시스템에서 새로운 RPWM 방식을 제안하였다. 유도전동기 구동 시스템에서 발생하는 소음을 줄이기 위하여 공간벡터 RPWM방식에 기반을 둔 RPWM방식을 제안하였다. 제안된 RPWM방식을 드럼 세탁기에 적용하여 세탁기에서 발생하는 소음과 진동을 측정하였으며 그 결과를 비교하였다. 제안된 방식의 타당성을 입증하기 위하여 시뮬레이션과 실험을 수행하였다. The random pulse width modulation(RPWM) in inverter-fed induction motor drive is presented. This paper describes a RPWM method based on space vector PWM strategy for shaping the switching noise spectrum in such a way it can merge with the natural system noise. To verify the validity of the proposed RPWM scheme, the experiment based on the DSP56F803 microprocessor was executed finally, the simulation and experimental results will be given to demonstrate the effectiveness of the unposed RPWM scheme.

한국표준질병사인분류중 한방내과영역의 분류체계 개선 및 진단명 구성에 관한 연구

이원철,Lee, Won-Chul 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.1

Objectives : It is necessary that the international classification of diseases (ICD) be examined in order to comprise the third revision of the Korean Classification of Disease on Oriental Medicine (KCD-OM) and disease classification in the oriental internal medicine field. It is essential that the selection, classification and definition of disease and pattern names of oriental concepts in internal medicine be clear. Since 2008, the fifth revision of the Korean Classification of Disease (KCD-5) has been used in Korea. It was required to use the reference classification from the Oriental medicine area based on the ICD-10. Methods : In this review, the necessity for, meaning of and content of the third revision are briefly described. The ICD system was reviewed and KCD-OM was reconstructed. How diagnosis in the oriental internal medicine area had changed is discussed. Review and Results : In 1973, the disease classification of oriental medicine was established the basis on the contents of Dongeuibogam. It was irrespective of the ICD. As to the classification system in the Oriental internal medicine field, systemic disease was comprised of wind, cold, warm, wet, dryness, heat, spirit, ki, blood, phlegm and retained fluid, consumptive disease, etc. Diseases of internal medicine comprised a system according to the five viscera and the six internal organs and followed the classification system of Dongeuibogam. The first and second revisions were of the classification system based on the curriculum in 1979 and 1995. In 1979, in the first revision, geriatric disease and idiopathic types of disease were deleted, and skin disease was included among surgery diseases. This classification was expanded to 792 small classification items and 1,535 detailed classification items to the dozen disease classes. In 1995, in the second revision, it was adjusted to 644 small classes and 1,784 detailed classification items in the dozen disease classes. KCD-OM3 did KCD from this basis. It added and comprised the oriental medical doctor's concept names of diseases considering the special conditions in Korea. KCD-OM3 examined the KCD-OMsecond revised edition (1994). It improved the duplex classification, improper classifications, etc. It is difficult for us to separate the disease names and pattern names in oriental medicine. We added to the U code and made one classification system. By considering the special conditions in Korea, 169 codes (83 disease name codes, 86 pattern name codes) became the pre-existence classification and links among 306 U codes of KCD-OM3. 137 codes were newly added in the third revision. U code added 3 domains. These are composed of the disease name (U20-U33, 97 codes), the disease pattern name (U50-U79, 191 codes) and the constitution pattern name of each disease (U95-U98, 18 codes). Conclusion : The introduction of KCD-OM3 conforms to the diagnostic system by which oriental medical doctors examine classes used with the basic structure of the reference classification of WHO and raises the clinical study and academic activity of the Korean oriental medicine and makes the production of all kinds of nation statistical indices possible. The introduction of KCD-OM3 promotes the diagnostic system by which doctors of Oriental medicine examine classes using the association with KCD-5. It will raise the smoothness and efficiency of oriental medical treatment payments in the health insurance, automobile insurance, industrial accident compensation insurance, etc. In addition, internationally, the eleventh revision work of the ICD has been initiated. It needs to consider incorporating into the International Classification of Diseases some of every country's traditional medicine.

교정치료후의 변화에 관한 상악치열궁의 모형분석에 의한 연구

이원철(Won-Chul Lee) 대한치과교정학회 1974 대한치과교정학회지 Vol.4 No.1

The author has selected 70 non-extraction and extraction cases. The linear measurements were made in the maxillary dental cast at pre-and post-treatment. The purpose of this study was to detect out the changes occured during orthodontic treatment. On the basis of findings of this study, the following results are made: 1. In extraction cases: 1) The maxillary intercanine width increased. 2) The maxillary dental arch width decreased. 3) The maxillary inter first molar width decreased. 4) The maxillary dental arch length decreased. 5) The maxillary dental arch length (I-3) increased. 2. In non-extraction cases, the maxillary intercanine width decreased in Angle´s class III.

실리콘 Cavity 및 IPD 공정을 이용한 밀리미터파용 소형 대역 통과 필터

이원철(Won-Chul Lee),육종민(Jong-Min Yook) 대한전자공학회 2022 대한전자공학회 학술대회 Vol.2022 No.6

폴리 ( 프로파길 페닐 에테르 ) 의 합성과 그 특성에 관한 연구

이원철(Won Chul Lee),갈영순(Yeong Soon Gal),류문삼(Moon Sam Ryoo),한성호(Sung Ho Han),최삼권(Sam Kwon Choi) 한국고분자학회 1991 폴리머 Vol.15 No.3

전이금속촉매에 의한 프로파길 유도체들의 중합

이원철(Won Chul Lee),손진언(Jin Eon Sohn),갈영순(Yeong Soon Gal),최삼권(Sam Kwon Choi) 한국고분자학회 1988 폴리머 Vol.12 No.8