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LPS로 활성화된 RAW 264.7 cell에서 하경(荷梗)의 염증매개물질 억제효과
이원욱,조미정,박상미,정지윤,김상찬,Lee, Won-Uk,Jo, Mi-Jeong,Park, Sang-Mi,Jung, Ji-Yun,Kim, Sang-Chan 대한한의학방제학회 2009 大韓韓醫學方劑學會誌 Vol.17 No.1
Petiolus Nelumbinis, branches of lotus leaf or lotus flower is a traditional oriental herbal medicine widely used for treating a superheat or disorder of qi flow. Although there are many clinical results and literature study, it has been rarely conducted to evaluate the immuno-biological activity. The present study was conducted to examine the anti-inflammatory effects of PNM (Petiolus Nelumbinis MeOH extract) in vitro. To determine cytotoxic concentration of PNM, the cells were treated with PNM for 24 h after LPS addition, and the cell viability was tested by MTT assay. Both of dosages (30 and 100 ${\mu}g/ml$) of PNM had no cytotoxicity. In these concentrations, PNM significantly reduced the elevated levels of NO and $PGE_2$ by LPS. These inhibitory effects of PNM were due to the reduced expressions of iNOS and COX-2 protein. TNF-$\alpha$, IL-1$\beta$ and IL-6 are frequently encountered pro-inflammatory cytokines, and LPS plays a key role in inducing to the massive production of these cytokines. Thus, we next determined the levels of these cytokines. Although PNM had no significant inhibitory effect on the production of TNF-$\alpha$, the elevated levels of IL-1$\beta$ and IL-6 by LPS were dose-dependently reduced in PNM-treated groups. These results demonstrate that PNM has anti-inflammatory effects by inhibiting the production of proinflammatory cytokines, NO and $PGE_2$ in LPS-activated macrophage. Moreover, the reduction of NO and $PGE_2$ levels was due to the inhibition of iNOS and COX-2 protein expression by PNM.
Stenotrophomonas maltophilia 감염의 임상 양상
이원욱(Won Uk Lee),김병준(Byoung Joon Kim),안우석(U . Seouk Ahn),원현상(Hyun Sang Won),김기중(Ki Joong Kim),성낙천(Nak Cheon Seong),김구엽(Gu Yeup Kim),서환조(Hwan Jo Suh) 대한내과학회 1997 대한내과학회지 Vol.53 No.3
N/A Objective: Stenotrophomonas maltophilia has been emerging as an important nosocomial pathogen in recent years in patients with impaired host- defense mechanism or who has been exposed to large amount of inocula. This organism is usually resistant to multiple (commonly used) antimicrobial agents, particularly to those of the beta-lactam class. To evaluate the clinical feature of Stenotrophomonas maltophilia infection and in vitro anti- microbial susceptibility, we performed a retrospective study. Methods: We analyzed the result of in vitro antimicrobial susceptibility test for 200 isolates of S. maltophilia and the annual isolation rate during the period between January 1990 and December 1994 in our institution, and performed a retrospective study for the available records of 165 cases among them. The data were obtained with only the first isolation of the organism for each patients. Results : Total of 165 initial isolates, the isolates were from wounds in 50(30.3%), urine in 47(28.5%), the respiratory tract in 37(22.4%), blood in 9(5.5%), bile in 6(3.6%), and miscellaneous sources in 16(9.7%). The 84.2% of isolates were hospital-acquired isolate and 58.3% of these patients had received antecedent antibiotic therapy: polymicrobial growth was demonstrated in 61.9% of the cases. In vitro antimicrobial susceptibiiity test, ofloxacin was active against the isolates in 89.2%, moxalactam in 85.9%, ciprofloxacin in 83.9%, TMP-SMX(trimethoprim-sulfamethoxazole) in 64.2%, As expected, S. maltophilia isolates were, in general, not susceptible to cephalosporins, penicillins. The annual isolation rate at Kyung Hee University hospital was not increased significantly from 1990 to 1994, 19.53 per 10,000 patients dismissals in 1990, 13.56 in 1994. The major underlying diseases of patients were malignancy(17.6%), cerebrovascular disorder(17%), diabetic mellitus(13.3%). Mortality rate is 10.3%. Conclusion: S. maltophilia has been emerging as an important nosocomial pathogen in immunocompromised patients, especially those receiving broad-spectrum antimicrobial therapy. And this organism is resistant to multiple antimicrobial agents, particularly to those of the beta-lactam class. When antimicrobial treatment is necessary, the clinician should be guided by results of in vitro susceptibility testing because of the notable in vitro resistance of S. maltophilia to commonly used antibiotics. And when S. maltophilia has been recovered from a patient, wound and contact isolation is warranted.
원현상(Hyun Sang Won),안우석(U Seouk Ahn),이규춘(Ku Chun Lee),이원욱(Weon Uk Lee),김기중(Ki Jung Kim),성낙천(Nak Cheon Seong),김구엽(Koo Yup Kim),서환조(Hwan Jo Suh) 대한내과학회 1997 대한내과학회지 Vol.52 No.3
N/A Objectives: Aeromonas species is a gram-negative, facultative anaerobe of the family Vibrionaceae. The organism has been recognized as a pathogen associated with illness in human, such as acute gastroenteritis, cellulitis, septicemia, and other rare diseases. Methods: To evaluate the clinical significance of Aeromonas bacteremia in Korea and it's susceptibility of antibiotics, we evaluated the 17patients with Aeromonas bacteremia. Identification was done by use of API 20E system and antibiotic susceptibility was tested with disk diffusion method. Results: Male to female ratio was 11:6, and mean age was 54.1years(8-85years) old. Liver cirrhosis was the most common underlying disease(10cases of 17patients, 58.8%a). Other underlying diseases were as follows: gallstone in 2cases, cholangiocarcinoma in 2cases, and aplastic anemia in 1case, cerebral infarction in 1case. But one had no underlying disease. So Aeromonas bacteremia were occurred in 14immunocompromised patients(82.3%), and in 10patients with hepatobiliary diseases, A. hydrophila was most commonly isolated(13cases, 764%), and the A sobria(4cases, 23.5%) was infrequently isolated. The overall fatality was 47%, and there had no significant difference in fatality between A. hydrophila and A sobria All Aeromonas species had resistance to ampicillin and carbenicillin. Conclusion: Because Aeromonas bacteremia may occur through water-borne route, especially in immunocompromised host. We should pay attention to immunocompromised patients, espacially having hepatobiliary disease.
이천석(Cheon-Suk Lee),이원욱(Won-Uk Lee),장성철(Sung-Cheol Jang),이중섭(Chung-Seob Yi) 한국기계가공학회 2017 한국기계가공학회지 Vol.16 No.1
This study is about the development and revision of a blower design for a ventilation system. In this study, to describe the flow in the 4000CMM grade blower, 3-dimensional steady-state turbulence was assumed to govern the flow equation. The flow field with velocity distribution according to the elbow duct of the ventilation system is also compared. Finally, vibration was observed in the blower at the installation to ventilation system. The cause was due to a problem in the manufacturing process of the airfoil type impeller.
Ti-(42, 44)%Al 합금의 고온내산화성에 미치는 Nb, V 및 Cr의 영향
이영찬,김미현,김성훈,이원욱,백종현,이동복,Lee, Yeong-Chan,Kim, Mi-Hyeon,Kim, Seong-Hun,Lee, Won-Uk,Baek, Jong-Hyeon,Lee, Dong-Bok 한국재료학회 1999 한국재료학회지 Vol.9 No.10
6종류의 조성을 가진 TiAl계 합금, 즉 Ti-(42, 44)Al-2Nb-4V, Ti-(42, 44)Al-4Nb-2V 및 Ti-(42, 44)Al-4Nb-2Cr을 아크용해법으로 제조한 후, 이들의 산화성질을 조사하였다. 700, 800 및 $900^{\circ}C$의 대기 중, 50시간동안의 등온 및 반복 산화실험으로부터, 산화저항은 Ti-(42, 44)Al-2Nb-4V, Ti-(42, 44)Al-4Nb-2V 및 Ti-(42, 44)Al-4Nb-2Cr의 순으로 증가함을 알 수 있었다. 내산화성에서 V은 해로운 원소이고 Cr은 유익한 원소이었다. 산화 중 모든 모재 구성원서는 외부확산하였고 분위기중으로 부터의 산소는 내부확산하는 상호확산이 관찰되었으며, 생성되는 산화물은 최외각 $\textrm{TiO}_2$층, 상부 ($\textrm{TiO}_2+\textrm{Al}_2\textrm{O}_3$) 혼합층 및 하부 $\textrm{TiO}_2$-잉여층으로 이루어진 3층 산화물구조로 구성되어 있었다. Alloys of TiAl with six different compositions. i. e., Ti-(42, 44)Al-2Nb-4V. Ti-(42, 44)Al-4Nb-2V and Ti -(42, 44)Al-4Nb-2Cr, were manufactured by arc-melting. and their oxidation behavior was studied. Both isothermal and cyclic oxidation tests were performed at 700, 800 and $900^{\circ}C$ in air for 50hr. The oxidation resistance increased in the order of Ti-(42, 44)Al-2Nb-4V, Ti-(42, 44)Al-4Nb-ZV and Ti-(42, 44)Al-4Nb-2Cr. It was found that V was a deleterious element, while Cr was a beneficial element in terms of oxidation resistance. During oxidation, a simultaneous interdiffusion was observed. All the constituent elements in the base alloys diffused outward. whereas oxygen from the atmosphere diffused inward, to form triple oxide layers composed of an outermost $\textrm{TiO}_2$ layer. upper ($\textrm{TiO}_2+\textrm{Al}_2\textrm{O}_3$) mixed layer, and lower $\textrm{TiO}_2$-rich layer.
말벌 식별 및 피해 방지를 위한 지능형 양봉통 설계 및 제작
김은총(Eun Chong Kim),우예빈(Ye Bin Woo),이원욱(Won Uk Lee),한지수(Ji Su Han),이인수(In Soo Lee) 한국정보기술학회 2022 Proceedings of KIIT Conference Vol.2022 No.12
본 논문에서는 등검은말벌과 장수말벌에 의한 양봉 농가의 피해를 최소화하고자 꿀벌과 장수말벌, 등검은말벌 3종에 대하여 비행소리를 FFT와 인공신경망을 활용하여 실시간으로 분류하였다. 그리고 각 말벌 종류마다 서로 다른 사냥 방식에 근거하여 적절한 퇴치 방법을 찾고 이를 구현하는 과정을 수행하였다. 본 연구를 통해 꿀벌의 피해를 줄임으로써 양봉 농가의 꿀벌 개체 수 보존과 수입 증대에 도움이 될 것으로 전망한다. In this paper, the buzzing sound was classified in real time using FFT (Fast Fourier Transform) and artificial neural networks for three types of Honey bees, Asian giant hornets, and Asian predatory wasps in order to minimize damage to bee farms caused by Asian giant hornets and Asian predatory wasps. In addition, a process of finding and implementing an appropriate eradication method was performed based on different hunting methods for each wasp type. It is expected that it will help bee farmers preserve the bee population and increase their income by minimizing the damage of bees through this study.
내시경적 역행성 췌담도 조영술로 진단한 Fascioliasis 1예
김영준,김병호,김효종,임성식,장린,동석호,이원욱,장영운,이정일 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.1
Fascioliasis is a zoonotic disease caused by Fasciola hepatica, a liver fluke, for which human acts as an accidental host. Fascioliasis, while common in some tropical countries, is rare in Korea. Endoscopie retrograde cholangiopancreatography(ERCP) has been described in only a very few cases as a useful technique for the diagnosis of fascioliasis. We report a case of fascioliasis diagnosed by ERCP, after endoscopic sphinchterotomy adult worms were removed by Dormia basket.