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이원석,김미경,정한용,우성일,권영준,김종우,이희제,Lee, Won Seok,Kim, Mi Kyung,Jung, Han Yong,Woo, Sung Il,Kwon, Young Joon,Kim, Jong Woo,Lee, Hee Je 대한생물정신의학회 2005 생물정신의학 Vol.12 No.1
Objective:There has been increasing evidence that neurodevelopmental dysfunction is involved in the pathophysiology of schizophrenia. Cadherin is known to be one of the important molecules in neurodevelopment. This study was performed to examine the relationship between T816C polymorphism of CDH2 gene and schizophrenia. Methods:Genoytypes of T816C polymorphism of CDH2 gene were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 156 Korea patents with schizophrenia and 170 controls. Results:No difference was found between the patients with schizophrenia and the controls in genotype and allele frequencies of T816C polymorphism of CDH2 gene. Conclusion:The results of this study do not support an association between T816C polymorphism of CDH2 gene and schizophrenia. However, it is necessary to investigate other polymorphic regions of CDH2 in schizophrenia.
생물반응기 배양을 통한 두릅나무(Aralia elata)의 체세포배 및 유식물체 대량증식
이원석,최은경,김재훈,Lee, Won-Seok,Choi, Eun-Gyung,Kim, Jae-Whune 한국식물생명공학회 2004 식물생명공학회지 Vol.31 No.3
두릅나무의 엽병을 1.0 mg/L 2,4-D가 포함된 MS 고체배지에서 배발생캘러스를 유도하였다. 배발생세포와 배발생세포괴는 1.0 mg/L 2.4-D가 포함된 MS 액체배지에서 배발생캘러스를 2주간 현탁배양하여 대량으로 얻었다. 그물망을 통과한 배발생세포는 1.0 mg/L 2.4-D가 포함된 MS 액체배지에서 배양하면 배발생능이 소실되지 않고 지속적으로 유지 및 증식시킬 수 있었다. 그물망을 통과하지 못한 배발생세포괴를 식물생장조절물질이 첨가되지 않은 1/2 MS 액체배지에 옮겨 2주간 배양하면 구상형의 체세포배로 발달하였다. 구상형의 체세포배는 5 L의 bioreactor를 이용하여 배양하면 심장형, 어뢰형, 자엽형의 배와 유식물체로 발달하였다. Bioreactor 배양을 통해 두릅나무의 체세포배를 효과적으로 대량증식 시킬 수 있었다. Embryogenic calli were induced from petioles of Aralia elata on MS solid medium supplemented with 1.0 mg/L 2,4-D. When embryogenic calli were transferred to MS liquid medium supplemented with 1.0 mg/L 2,4-D, embryogenic cells and embryogenic cell clusters were developed after 2 weeks of culture. Embryogenic cells were filtered through a 250 ${\mu}{\textrm}{m}$ sieve and the passed cells were proliferated and maintained in MS liquid medium supplemented with 1.0 mg/L 2,4-D. Embryogenic cell clusters entrapped on the sieve were transferred to 1/2 MS liquid medium without plant growth regulators, globular-shaped embryos were developed from embryogenic cell clusters after 2 weeks of culture. Numerous early stage somatic embryos could be developed to heart-shaped, torpedo-shaped, cotyledonary embryos and plantlets in 5 L bioreactor. Above results suggest that effective somatic embryo proliferation can be achieved via bioreactor culture systems in Aralia elata.
수평사시 환아에서 수평직근후전술의 수술 결과에 대한 근시 및 안축장 길이의 영향
이원석,이종복,한승한,Won-Seok Lee,Jong-Bok Lee,Seung-Han Han 대한안과학회 2011 대한안과학회지 Vol.52 No.4
Purpose: To assess the influence of axial length for surgical outcome of horizontal recti recession in children with horizontal strabismus. Methods: A retrospective, non-comparative case series. 100 patients, 96 males and 44 females with unilateral or bilateral high myopia and strabismus surgery was performed. All patients had horizontal recti recession and no combined vertical strabismus. There was no history of any ocular trauma or surgery and no history of any other systemic diseases that affect ocular motility. After horizontal recti recession, the patients were followed-up for more than one year. Data was analyzed using SPSS Software for Windows, version 12.0.1. Results: In 100 children, the mean axial length was 23.21 ± 1.38 mm (range, 19.63-26.50 mm) and the mean age was 7.43 ± 2.86 years (range, 1-14 years). Lateral rectus recession was in 89 cases, and medial rectus recession was done in 11 cases. After operation, 86 cases were fully corrected, 11 cases were under corrected and 3 cases were over corrected. Binary logistic regression analysis was performed revealing that, preoperative angle of deviation (p-value 0.062) and axial length (p-value 0.05) were highly correlated with surgical outcome. Conclusions: Age, preoperative angle of deviation, and axial length may influence the surgical outcome of horizontal recti recession in children. In eyes with long axial length, the surgical outcome of horizontal recti recession appears to be poorer than that in eyes with short axial lengths. Adjusting the recession amounts when performing horizontal recti recessions in long axial length eyes may provide better results. J Korean Ophthalmol Soc 2011;52(4):472-476
A Study on Cerebral Ischemia-Reperfusion Injury: Involvement of Platelet-Activating Factor
이원석,임병용,홍기환,Lee, Won-Suk,Rhim, Byung-Yong,Hong, Ki-Whan The Korean Society of Pharmacology 1993 대한약리학잡지 Vol.29 No.1
뇌의 허혈-재관류 손상에 있어서 혈소판 활성인자 (PAF, platelet activating factor)의 관련을 증명하기 위하여 흰쥐와 생쥐에서 양측 총경동맥을 10분간 결찰하고 그후 6시간동안 재관류시켜 허혈-재관류 손상을 야기시켰다. 생쥐에 PAF 길항제인 BN52021과 CV6209 (각각 1 mg/kg, i.p.)를 총경동맥결찰 10분전 또는 재관류 시작 1시간 후에 투여시 McGram stroke index는 심하게 억제되었다. 흰쥐와 생쥐에서 뇌허혈-재관류에 의한 뇌수분함량의 증가는 BN52021 또는 CV6209 전처치에 의하여 유의하게 억제되었다. BN52021 전처치는 허혈 후의 혈압변동을 개선시켰을 뿐만 아니라 뇌연막동맥의 확장지연에 대하여도 효과가 있었다. 이러한 실험결과로 보아 PAF가 뇌허혈-재관류 손상의 발생에 내인성 인자로서 중요한 역할을 하는 것으로 사료된다. 나아가 PAF 길항제가 뇌허혈후의 병리학적 후휴증의 개선 내지는 예방에 사용 될 수 있을 것으로 기대된다. To elucidate involvement of platelet-activating factor (PAF) in cerebral ischemia-reperfusion injury, male Sprague-Dawley rats and albino mice of either sex were subjected to a 10-min bilateral carotid artery occlusion and 6-hr recirculation. The McGraw stroke index in mice was markedly inhibited by PAF antagonists, BN 52021 and CV 6209 (1 mg/kg, i.p., each) When they were administered 10 min before bilateral carotid artery occlusion or 1 hr after reperfusion. The increases in brain water content were significantly attenuated by treatment with BN 52021 or CV 6209 in both animals. BN 52021 exhibited a significant improvement in the postischemic blood pressure change in association with a beneficial effect on the delayed dilatation of pial arterioles after 10 min of ischemia. Thus it is suggested that PAF plays an important role as an endogenous mediator in development of cerebral ischemia-reperfusion injury, and further, specific antagonists to PAF will be able to prevent or reverse the pathological sequelae of cerebral ischemia.
20 MHz 의료용 고주파 선형 배열 초음파 트랜스듀서의 설계 및 제작
이원석,노용래,Lee, Wonseok,Roh, Yongrae 한국음향학회 2016 韓國音響學會誌 Vol.35 No.6
In this work, a medical linear array ultrasonic transducer working in the range of 20 MHz has been developed for high-resolution ultrasonic imaging. After devising the structure of the transducer suitable for the transmission of high-frequency waves, we optimized the dimension of constituent components. Then, the process to fabricate the transducer was developed to realize the designed structure, and a prototype of the transducer was fabricated and characterized. The center frequency of the fabricated transducer was measured to be 19 MHz, and the fractional bandwidth to be 84.5 %, and the standard deviation of the sensitivity over the entire channels to be 0.74 dB. These measurement results showed good agreement with design data, which confirmed the validity of the high frequency ultrasonic transducer structure developed in this work. It was confirmed that the developed transducer with new structure had wider frequency bandwidth and uniform sensitivity than a conventional 20 MHz transducer. 본 연구에서는 고분해능 초음파 영상 획득이 가능한 20 MHz 대역의 의료용 초음파 선형 배열 트랜스듀서를 개발하였다. 먼저 고주파 음파의 전파가 용이한 트랜스듀서의 구조를 고안한 후, 구성소자의 최적치수를 도출하였다. 이후 설계에 따라 트랜스듀서의 제작공정을 개발하고, 트랜스듀서 시편의 제작 및 평가를 수행하였다. 제작된 초음파 트랜스듀서는 중심주파수가 19 MHz이고, 비대역폭이 84.5 %, 감도의 표준편차가 0.74 dB로 측정되었다. 측정 결과는 설계 결과와 잘 일치하였으며, 이에 의해 본 연구에서 개발한 고주파 초음파 트랜스듀서 구조의 타당성을 검증하였다. 개발된 트랜스듀서는 새로운 구조에 의해 기존의 20 MHz 트랜스듀서에 비해 더 넓은 주파수 대역폭과 균일한 감도를 가지는 것으로 확인되었다.