홍삼·백년초 복합물이 관절염 개선에 미치는 효과

이승현,이창현,김홍준,김영식,신민지,김지현,마상용,이세연,권진,오찬호,Lee, Seung-Hyeon,Lee, Chang-Hyun,Kim, Hong-Jun,Kim, Young-Sik,Shin, Min-Ji,Kim, Ji-Hyun,Ma, Sang-Yong,Lee, Se-Youn,Kwon, Jin,Oh, Chan-Ho 대한한의학방제학회 2021 大韓韓醫學方劑學會誌 Vol.29 No.2

Objectives : This study was conducted to evaluate the efficacy of a complex mixture of natural substances of ginseng and baeknyeoncho on the arthritic rats. Methods : In vitro experiments were conducted to ensure the stability of the complex. After setting toxicity and concentration by MTT assay, the antioxidant effect was measured through DPPH and ABTS radical scavenging activity. To confirm the anti-inflammatory effects of the complex, levels of nitric oxide (NO) and pro-inflammatory cytokines (IL-1β, TNF-α) were measured in LPS-treated macrophage cell lines (RAW264.7). We injected monosodium iodoacetate (MIA) 50 μl (60 mg/ml) into knee joints of rats to induce osteoarthritis. The rats were divided into three groups (normal (n=5), control (n=5), and OR (n=5) group). The control group consumed 2 mg/kg of physiological saline once a day for 4 weeks, and the OR group was mixed at a concentration of 416.5 mg/kg of Baengnyeoncho (O) and 208.25 mg/kg of red ginseng (R) and ingested 1 mL each 5 days a week. Results : This complex increased the DPPH and ABTS radical scavenging rate. The complex decreased NO production and pro-inflammatory cytokine production of macrophages. In the OR group, the secretion of cytokine in serum was decreased. In histopathological examination, the joint tissue of the composite showed less damage to the synovial membrane, cartilage, and fibrous tissue than the control group. Conclusions : As a result of this study, natural complexes have antioxidant, anti-inflammatory and cartilage protection effects. Therefore, we expect the complex to be effective in treating osteoarthritis.

〈젊은 세대의 백서〉에 나타난 자본주의와 미국 문화의 영향

이승현(Lee, Seung-Hyun) 한국어문학회 2014 語文學 Vol.0 No.126

Ha Yoo-sang’s drama in 1950’s is well know that they displayed the generational conflict, but Jeolmeun sedaeui baekseo is unlike other works. Ha yoo-sang said that Jeolmeun sedaeui baekseo is human problem related to ‘the illusion’, so it should be is read in other way, not the generational conflict. After Korean war, South Korea is influenced by the Capitalism and the American Culture; English, translations, western clothes, dances and so on. These influences can be checked in Jeolmeun sedaeui baekseo with western style house and Christmas day. These western life styles are understand as the symbol of freedom. On the other hand, characters are affected by negative aspects of the capitalism, so they fell into values of mammonism. These elements are a kind of the influence of the Capitalism and the American culture at that time. Ha Yoo-sang showed negative aspects of the capitalism by defeating the negative characters, Yungisa and Hyeonsu, but Gyeonghui get parents’ permission to get married in spite of a negative character. Moveover, Ha Yoo-sang used English words in Jeolmeun sedaeui baekseo. Ha Yoo-sang knew changes and influences by the Capitalism and the American culture in late 1950’s, so he displayed these social phenomena. However he fell into the ambivalence of the Capitalism and the American culture because he had a popular tendency.

1950년대 이용찬의 작가 의식과 형식 실험 연구

이승현(Lee, Seung-hyun) 한국어문학회 2013 語文學 Vol.0 No.121

Lee Young-chan is well known by his drama Gajok(the Family). He focused on a family and it’s difficulties. He believed that family’s difficulties could are solved by family’s affection. However, his idea of family has a huge problem. It is that his concept of family is based on the patriarchy and the anti-communism. Due to the patriarchy, women who have become others appear from his dramas, so Lee Young-chan’s idea of family can not be completed perfectly. Futhermore, his idea of family is linked with idea of nation and people. Lee Young-chan said that people work for nation not only their families. This his idea is involved in the anti-communism. In the 1950s, the anti-communism is ideology of nation in Korean. At that time, the president Lee Seung-man used the anti-communism to catch state authority. Consequently, Lee Young-chan did not have the different author consciousness from old generation authors. Therefore, his formal experiments from Gajok, Giro, and Pineun Bamedo Jaji Anneunda have limited value. His formal experiments can not express the new generation consciousness, but they can be utilized to overcome the limits of Realism’s time and space.

안운동 이상에서 영상진단의 유용성

이승현,허환,박상우,Seung Hyun Lee,Hwan Heo,Sang Woo Park 대한안과학회 2009 대한안과학회지 Vol.50 No.2

Purpose: To evaluate the usefulness of imaging diagnosis in patients with atypical oculomotor abnormalities and paralytic strabismus. Methods: The magnetic resonance imaging (MRI) or computed tomography (CT) of 3 patients with atypical Y pattern vertical incomitance and medial rectus (MR) paresis after MR impingement reduction and A pattern vertical incomitance were analyzed. High-resolution, surface coil MRI was used to obtain sets of contiguous, 2-mm thick quasi-coronal images in 9-cardinal gaze directions. Digital image analysis was used to evaluate the results. Results: MRI revealed lateral displacement of the superior rectus (SR) and inferior displacement of the lateral rectus (LR) during upper temporal gaze and inferior displacement of the LR during lateral gaze in patients with Y pattern vertical incomitance. In patients with MR paresis, the maximal surface area of MR cross section is in the image plane 10 mm posterior from the orbital center at primary gaze. The maximal surface area of MR cross section is in the image plane 22 mm posterior from the orbital center during medial gaze. Quasi-coronal images show that contraction tends to cause the plane of maximum cross-section to move posteriorly. Surgical treatment was avoided and observational treatment maintained. There is incyclotorsion of both extraocular muscles in patients with A pattern vertical incomitance and upslanted palpebral fissure. Conclusions: Imaging diagnosis of pulley position and rectus muscle contractility is helpful for determining accurate diagnosis and treatment methods at atypical oculomotor abnormalities and paralytic strabismus.

선체 부식 및 손상 부재를 고려한 침몰선박의 구조 안전성 평가에 관한 연구 - 제7 해성호를 중심으로 -

이승현,김원돈,서재준,Lee, Seung Hyun,Kim, Won Don,Suh, Jae-Joon The Korean Society for Marine Environment and Ener 2016 한국해양환경·에너지학회지 Vol.19 No.4

Sunken ships cause damage to the environment due to the dispersal of fuel oil and harmful cargo goods in the hull. Since the sunken ship is mostly flooded by the seabed, it tends to be in a relatively stable condition. However, the heavy body, together with the load of remaining goods in the cargo hold, the constant contact with the seabed, and ocean currents and tidal waves, can affect dispersal of residual fuel oils out of the sunken ship. Corrosion of the sunken ship starts upon sinking, decreasing the thickness of the hull structure and sub-materials. Therefore, it is necessary to assess the structural stability against the potential breakdown of the sunken ship. Whilst evaluating the danger of the sunken ship, this result should be reflected in 'the possible discharge'. This study was undertaken to suggest a procedure for a step by step evaluation to assess the structural stability a sunken ship. The structural stability assessment to estimate the collapsibility of the hull was structure targeted at the sunken ship 'No. 7 HaeSung', which was classified as the prime example for the intensive management of sunken ships. This study was undertaken to suggest a procedure for a step by step evaluation to assess the structural stability a sunken ship and to propose a method to conduct a structural safety assessment that estimates the collapsibility of the hull by targeting the sunken ship 'No. 7 HaeSung',which was classified as the prime example for the intensive management of sunken ships. The collapsibility of the hull structure was estimated Based on the damage size of the hull structure, and the corrosion rate of the hull structure and sub-materials due to the seawater after sinking. It was confirmed that there was a low possibility of the total destruction of the hull structure at the current time. However, there is a high possibility in the potential failure of the hull structure due to increased rate of corrosion thereafter. Therefore, we believe continuous study on influence of corrosion and marine environment change to sunken ship's structural safety is necessary. 침몰선박은 선체 내에 적재되어 있는 잔존연료 및 유해 화물 등의 유출로 인하여 주변 환경과 선박의 안전 항해에 피해 요인으로 작용할 수 있다. 대부분의 침몰선박은 해저에 침수된 상태로 비교적 안정적인 상태로 놓여있지만 선체 자중, 화물창의 잔존화물에 의한 하중과 해저면과의 접촉상태, 조류 및 해류 등의 영향으로 침몰선박 잔존연료 유출에 영향을 줄 수 있다. 침몰선박은 침몰 이후 부식이 진행되어 선체 구조부재의 두께가 지속적으로 감소하고 있는 상황이다. 따라서 침몰선박의 붕괴 가능성에 대한 구조안전성 평가가 필요하며 그 결과는 침몰선박의 위해도 평가요소 중 '유출가능성' 평가 항목에 반영되어야 한다. 본 연구에서는 침몰선박의 구조 안전성 평가 방법에 대한 단계별 절차를 제시하고, 집중관리대상 침몰선박으로 분류된 '제7해성호'를 대상으로 선체구조의 붕괴 가능성을 추정하기 위한 구조 안전성 평가 방안을 제시한다. 침몰 당시 선체 손상 상태와 침몰 이후 선체구조 부재의 부식량 추정을 바탕으로 대상 침몰선박의 선체구조 붕괴 가능성을 산정한 결과, 현 상태에서는 전체적인 선체구조 붕괴가 일어날 가능성이 낮은 편으로 추정되지만, 향후 시간에 따른 부식량 증가로 인한 선체구조 붕괴가 일어날 가능성은 다소 높은 것으로 판단된다. 따라서 부식 및 해양환경 변화가 침몰선체 구조 안전성에 미치는 영향 등의 연구는 지속적으로 수행 되어져야 할 것으로 사료된다.

흙-못치기 공법을 적용한 사면의 거동 비교

이승현,Lee. Seung-Hyun 한국방재학회 2011 한국방재학회논문집 Vol.11 No.4

흙-못치기 공법을 적용한 사면에 대해 법면을 숏크리트로 처리한 사면과 프리캐스트 콘크리트 전면판을 적용한 사면의 경우로 나누어 실물 현장시험이 수행되었다. 현장시험결과 얻은 하중-침하곡선을 비교해 볼 때 전면판을 적용한 경우 하중지지능력이 우수함을 알 수 있었다. 현장시험시 재하판에 가해진 총하중에 대해 재하판의 침하양상은 전면판을 적용한 경우 연성기초가 모래지반에 놓이는 경우와 같은 침하분포를 보인다. 숏크리트를 적용한 경우, 재하판의 침하량은 유사한 총하중 수준에서 전면판을 적용한 침하량에 비해 크고 부등침하의 경향도 크다. 전면판 적용시 보강면에 설치한 하중계에 의한 하중분포와 변형률계에 의한 계측결과, 재하판의 침하양상 그리고 경사계에 의한 수평변위양상을 종합적으로 고려해 볼 때 전면판을 적용할 경우 숏크리트를 적용할 때보다 국부적인 변위를 억제하고 보다 넓은 보강면에 하중을 분산시키는 것으로 생각된다. Full scale field load tests were conducted on two kinds of slopes reinforced with soil nail. One of the two slope is the slope with surface treated by shotcrete. The other slope has a surface placed by precast concrete panel. By comparing load-settlement curves, load bearing capacity for the case of pecast concrete panel was bigger than that for the case of shotcrete. Settlemet distribution of loading plate for the case of precast concrete panel was similar to that for the case in which flexible footing lies on sand. Settlement for the case of shotcrete was bigger than that for the case of the precast concrete panel and also was the differential settlement. By considering overall the test data of all the measurements related with load cell, strain gauge, settlement of loading plate and inclinometer, precast concrete panel has the advantage of load sharing in larger area and restriction of local displacement to the shotcrete treated case.

Dyke-Davidoff-Masson 증후군 환자의 두개골 변형: 증례보고

이승현,이혜경,정희선,Lee, Seung-Hyun,Lee, Hye-Kyung,Jeong, Hii-Sun 대한두개안면성형외과학회 2012 Archives of Craniofacial Surgery Vol.13 No.1

Purpose: The Dyke-Davidoff-Masson syndrome is a rare disease entity that was first reported in 1993, and it is characterized by not only the cerebral hemiatrophy that is accompanied by the ipsilateral ventriculomegaly and ipsilateral compensatory osseous hypertrophy, but also the overgrowth of the paranasal sinuses. No studies have attempted to examine it from perspectives of the skull deformity and plastic surgery. Here, we report our case with a review of the literatures. Methods: A 45-year-old man with Dyke-Davidoff-Masson visited our medical institution with nasal bone fracture. Based on the previously taken brain MRI scans, we measured the degree of craniofacial deformity, and the horizontal distance, which is based on the margin of the skull, as well as the falx cerebri. Results: We made a comparison of the degree of craniofacial deformity. This showed that the mean horizontal distance on the axial view was shorter by approximately 28.46%, as compared with that of the left unaffected side. Conclusion: The Dyke-Davidoff-Masson is characterized by a concurrent presence of the atrophy of the cerebral hemisphere, with the cranial deformity. For the reconstruction of the bone and soft-tissue deformity with Dyke-Davidoff-Masson syndrome, it is needed to perform objective assessments.

분리형 부재 옹벽 설계 프로그램 개발

이승현,윤찬영,Lee. Seung-Hyun,Yune. Chan-Young 한국방재학회 2011 한국방재학회논문집 Vol.11 No.5

본 연구에서는 지압형 보강재를 갖는 분리형 부재 옹벽의 설계에 있어 검토해야 할 세부 검토항목을 살펴보고 설계 프로그램을 개발하였다. 분리형 부재 옹벽의 설계시 세부 설계내용은 외적 안정성 검토, 내적 안정성 검토 그리고 국부적 안정성 검토의 세 가지로 대별할 수 있다. 설계 프로그램에 반영된 외적 안정성 검토는 통상적인 옹벽에 대한 검토와 큰 차이는 없다. 내적 안정성 검토에서 고려해야 할 보강재의 인장파괴에 대한 검토와 인발에 대한 검토 세부 사항을 살펴보았고 국부적 안정성 검토에서 고려해야 할 보강재와 전면부재 사이의 연결강도에 대한 검토와 전면부재의 접촉면 사이의 전단강도에 관련한 벌징(bulging)에 대한 검토 세부 사항을 살펴보고 이를 개발된 프로그램에 구현하였다. 또한, 설계 예를 제시하여 입력자료와 검토결과를 나타냄으로써 개발된 프로그램의 이해를 증진시키고자 하였다. In this study, detailed design requirements for segmental retaining wall (SRW) which were concerned with external stability, internal stability, and local stability were investigated and a computer program for designing the SRW was developed as well. There are little differences in the estimation of the external stability between the algorithm of the developed program and the conventional method for the design of the SRW. Methods for accounting tension failure and pullout of the reinforcement were incorporated in the developed program, which were essentials in the internal stability. Methods for accounting the connection strength between a reinforcement and a facing block and for accounting the bulging concerned with the shear strength of the interface between two blocks were also incorporated in the developed program, which are essentials in the local stability. Design example run by the developed program is presented in order to enhance the knowledge of the developed program.

요로감염 환아에서 방광요관 역류를 예측할 수 있는 인자에 대한 연구

이승현,노성훈,오정은,김민선,이대열,Lee, Seung-Hyun,Noh, Sung-Hoon,Oh, Jeung-Eun,Kim, Min-Sun,Lee, Dae-Yeol 대한소아신장학회 2008 Childhood kidney diseases Vol.12 No.1

목적 : 배뇨성 방광요도 조영술은 초회 열성 요로감염이 있는 환아에게서 선천성 신장 질환이나 동반된 방광요관 역류를 확인하기 위해 시행한다. 그러나 이 시술은 요로 감염에서 방광 천공까지 다양한 합병증 등이 초래될 수 있으므로 본 연구는 배뇨성 방광요도 조영술 이외에 방광요관 역류의 존재를 예측할 수 있는 인자를 알아보고자 하였다. 방법 : 1998년 5월부터 2005년 11월까지 약 7년간 전북대학교 병원 소아청소년과에 입원하여 소변 배양 검사상 확진된 요로 감염 환아를 대상으로 후향적으로 분석하였다. 각각의 환아들에게서 연령, 성별, 발열, 위장관 증상, 뇨 검사 및 뇨 배양, 말초혈액 백혈구수, ESR, CRP, BUN, 혈청 creatinine과 요로계 초음파 및 DMSA 신스캔 결과와 방관요관 역류의 정도를 표준화된 형식을 통해 기록하였다. 결과 : 총 410명의 환아 중, 방광요관 역류가 없는 그룹은 273명이었고 역류가 있는 그룹은 137명 이었다. 방광요관 역류 존재 유무에 따른 두 그룹 간에는 발열, 농뇨, 말초백혈구수, ESR, CRP의 P 값이 0.001 이하의 의미있는 차이를 나타냈다. 그러나, 방광요관 역류 정도에 따른 비교분석 결과 방광요관 역류가 낮은 군(I-II)과 높은 군(III-V) 사이에는 농뇨, 발열, 말초백혈구수, C-반응단백(CRP) 등에서 의미있는 차이를 보이지 않았다(P<0.05). 역류의 유무에 따른 영상의학적 소견의 차이를 보면, 신장 초음파는 민감도 33%, 특이도 73%를 보였으며 DMSA 신스캔은 민감도 76%, 특이도 65%를 나타내었다. 또한 역류가 심할수록 신장 초음파와 DMSA 신스캔 모두 양성률이 높았다. 결론 : 초회 요로감염 환아 중 발열, 농뇨 및 높은 적혈구 침강속도, C-반응단백를 보이는 경우와 DMSA 신스캔상 이상 소견을 보이는 경우는 방광요관 역류가 있을 가능성이 높으므로, 이 경우에는 반드시 배뇨성 방광요도 조영술을 시행하는 것이 좋을 것으로 사료된다. Purpose: The most concerning issue in children with urinary tract infection(UTI) is the probability of underlying genitourinary anomalies and vesicoureteral reflux (VUR), which is frequently associated with renal scarring and eventually end-stage renal disease. Therefore, voiding cystourethrography(VCUG) is usually recommended at the earliest convenient time for children with UTI. However, VCUG is an invasive procedure that requires catheterization and exposure to X-ray. In this study, we aimed to determine the predictability of clinical, laboratory and imaging parameters for VUR in children with UTI. Methods: Data of children with bacteriologically proven UTI who underwent VCUG were evaluated retrospectively for clinical(age, gender, fever), laboratory(leukocytosis, ESR, CRP, pyuria, blood urea nitrogen, serum creatinine) and imaging(renal ultrasound and DMSA renal scan) findings. First, children with UTI were divided into two groups according to the presence of VUR as non-VUR group and with VUR group, and clinical, laboratory variables were compared between these groups. Second, patients who had VUR were reclassified as low-grade VUR(grade I-II) group and high-grade(grade III-V) VUR group according to grading of VUR, and clinical, laboratory and imaging variables were compared between these groups. Results: Among 410 children with UTI, 137 had VUR and 78 high-grade VUR. Fever, leukocytosis, ESR, CRP, pyuria were associated with VUR. In addition, abnormal findings of ultrasonography and DMSA renal scan were closely related to VUR. However, these clinical and laboratory variable in patients with high grade VUR were not different significantly, compared to those with low-grade VUR group. Conclusion: Fever, leukocytosis, ESR, CRP seems to be potentially useful predictors of VUR in pediatric patients with UTI. In addition, renal ultrasonography and DMSA renal scan findings supported the presence of VUR. Further study of these findings could limit unnecessary VCUG in patients with UTI.

건성안 환자의 눈물내의 케모카인 리간드4의 농도와 눈물표면인자와의 상관관계

이승현,임성규,윤경철.Seung Hyun Lee. MD. Seoung Kyu Im. MD. Kyung Chul Yoon. MD. PhD 대한안과학회 2010 대한안과학회지 Vol.51 No.3

Purpose: To investigate the expression of CCL4/MIP-1β in tears of patients with dry eye syndrome and its correlation with the tear surface parameters. Methods: Forty patients with dry eye syndrome (seven Meibomian gland dysfunction and 33 non-Meibomian gland dysfunction patients) and 25 control subjects were recruited. The concentrations of CCL4 in tears were measured using an enzyme-linked immunosorbent assay. The correlations between CCL4 levels and tear surface parameters including tear film break-up time (BUT), basal tear secretion (BST), tear clearance test (TCR), corneal sensation, keratoepitheliopathy (KEP) and conjunctival goblet cell density (GCD) were analyzed in patients with dry eye syndrome. Results: The mean levels of MIP-1β were 4.3±5.2 pg/ml in patients with dry eye syndrome and 81.6±294.3 pg/ml in control subjects (p=0.03). The mean levels in non-Meibomian gland disease patients (90.4±313.9 pg/ml) were significantly higher than those of Meibomian gland dysfunction patients (20.3±23.2 pg/ml, p=0.02). CCL4 levels correlated significantly with BST, TCR, KEP and GCD (p<0.05). Conclusions: The level of MIP-1β is elevated in tears of patients with dry eye syndrome and correlates with disease severity and tear surface parameters. J Korean Ophthalmol Soc 2010;51(3):313-319