八正散이 Estradiol로 유도한 백서의 만성 비세균성 전립선염에 미치는 효과

이승욱,나현영,유정화,안영민,안세영,김영옥,이병철,Lee, Seung-wook,Na, Hyun-young,Yoo, Jeong-hwa,Ahn, Young-min,Ahn, Se-young,Kim, Young-ock,Lee, Byung-cheol 대한한방내과학회 2015 大韓韓方內科學會誌 Vol.36 No.2

Objectives: This study investigated the effects of Paljeong-san on chronic nonbacterial prostatitis induced in rats by estradiol. Methods: Rats were divided into three groups. The normal group included rats with no intervention after sham castration. The control group included rats with prostatitis induced by 17β-estradiol after orchiectomy; these rats were orally administered normal saline. The sample group rats were administered Paljeong-san after prostatitis induction. Evaluations included changes in epithelial score, body weight, and prostate weight and volume, as well as histopathological changes in prostate tissue and gene expression of TNF-α, COX-2, and CD68. Results: Paljeong-san inhibited histopathological changes and monocyte/macrophage infiltration of the prostate. The epithelial score was higher for the sample group than for the control group (P<0.05). Paljeong-san administration decreased the gene expression of TNF-α and CD68. Conclusions: Paljeong-san shows prostate-protective effects by inhibiting infiltration by monocytes/macrophages and by reducing TNF-α gene expression. Conclusions: Paljeong-san shows prostate-protective effects by inhibiting infiltration by monocytes/macrophages and by reducing TNF-α gene expression.

고속 스위칭 Voltage Down Converter 회로 설계에 대한 연구

이승욱,김명식,Lee, Seung-Wook,Kim, Myung-Sik 대한전자공학회 2001 電子工學會論文誌-SC (System and control) Vol.38 No.2

본 논문은 IC chip내에서 전압을 낮추는 목적으로 사용되는 VDC 회로의 주파수 특성을 향상시키기 위한 새로운 회로를 제안한다. 제안된 회로에는 적응 바이어싱 방법을 통해 저전력소모 및 고속동작을 동시에 만족하는 두 개의 센서와 이 센서로 구동되는 3개의 transistor가 부가적으로 첨가되어 구동 transistor의 gate 충.방진 전류를 보상하여 구동회로의 정상동작을 유지시켜준다. 본 연구에 사용된 회로는 $0.62{\mu}m$ N well CMOS 공정을 사용하였으며, H spice simulation 결과, 내부전압의 변화폭은 부하전류가 0에서 $200m{\Lambda}$까지 5ns동안 증가할 경우 약 1.0V로, $200m{\Lambda}$에서 0으로 감소할 경우 약 0.6V로, 내부전압 회복시간은 증가시 7ns, 감소시 10ns로, 일반적인 구동방식에 비해 성능이 향상되었으며 전체 회로에 소모하는 power는 약 1.2mW로 매우 작았다. This paper presents a new voltage down converter(VDC) using charge and discharge current adjustment circuitry that provides high frequency application. This VDC consist of a common driving circuit and compensation circuits: 2 sensors and each driving transistors for controlling gate current of driving transistor. These sensors are operated as adaptive biasing method with high speed and low power consumption. This circuit is designed with a $0.62{\mu}m$ N well CMOS technology. In H-spice simulation results, internal voltage is bounded ( IV, +0.6V) in proposed circuitry when load current rapidly increases and decreases during Gns between 0 and $200m{\Lambda}$. And the recovery time of internal voltage is about 7ns and 10ns when load current increases and decreases respectively. That is fast better than common driving circuit. Total power consumption is about 1.2mW.

꿀벌부채명나방[Galleria mellonella (L.)] 사육을 위한 경제적 인공사료 개발

이승욱,이동운,추호렬,Lee, Seung-Wook,Lee, Dong-Woon,Choo, Ho-Yul 한국응용곤충학회 2007 한국응용곤충학회지 Vol.46 No.3

본 연구는 꿀벌부채명나방의 경제적 사육을 위한 인공사료 개발을 위하여 수행하였다. 가격이 비싼 벌꿀을 대체하여 물엿과 설탕을 이용한 사료별 꿀벌부채명나방의 발육과 발육기간 및 산란수, 성충 수명 등을 조사하였다. 당 종류별 유충의 두폭과 체장은 비슷하였으나 체중은 1/2벌꿀 + 1/2물엿 처리가 255.5 mg으로 가장 무거웠고, 설탕은 144.3 mg으로 가장 가벼웠다. 꿀벌부채명나방 번데기의 체중도 1/2벌꿀+1/2물엿이 196.7 mg으로 가장 무거웠다. 당 종류별 꿀벌부채명나방의 유충 발육기간은 벌꿀이 포함된 사료가 30.9일로 가장 짧았으며 설탕은 36.5일로 가장 길었다. 꿀벌부채명나방의 용화율과 우화율은 79.3% 이상이었다. 모든 사료에서 꿀벌부채명나방의 교미 성충의 수명은 암컷이 $6.3{\sim}8.0$일이었고, 수컷은 $7.9{\sim}11.2$일이었다. 사료별 꿀벌부채명나방 암컷 성충의 산란수는 설탕물 첨가 사료에서 1,269개로 가장 많았다. 당 종류별 인공사료 조성에 대한 비용은 밀기울이 쌀겨보다 10배 정도 많았으며, 벌꿀은 물엿과 설탕의 6배와 13배였다. This research was carried out to develop economical artificial diets of the greater wax moth, Galleria mellonella (L.). Diets were mixed with malt or sugar instead of whole honey for cheaper ones. fecundity, developmental period, pupation rate, emergence rate and adult longevity of G. mellonella depending on diet were examined. The head width and length of larvae were not significantly different among diets tested. However, the weight of larva was the heaviest, 255.5 mg, at 1/2 honey + 1/2 malt diet and lightest, 144.3 mg, at sugar diet. The weight of pupa was also the heaviest at 1/2 honey + 1/2 malt representing 196.7 mg. Larval period was the shortest at honey diet as 30.9 days but the longest at sugar diet as 36.5 days. Pupation and emergence rates were over 79.3% at all diets. The longevity of mated females was ranged from 6.3 to 8.0 days and those of mated males ranged from 7.9 to 11.2 days. The highest number of eggs, 1269, was obtained at sugar diet. Artificial diets replaced by rice bran, malt, and sucrose reduced costs compared with wheat bran plus honey diet. The cost of rice bran was only 10% of wheat bran. Honey was much more expensive than malt and sugar, that is 6 and 13 times, respectively.

과체(瓜?)를 이용한 토법(吐法)의 안전성에 대한 후향적 연구 : 임상반응, 간기능, 신기능을 중심으로 한 평가

이승욱,설미현,나현영,유정화,안영민,이병철,안세영,Lee, Seung-wook,Seol, Mi-hyeon,Na, Hyun-young,Yoo, Jeong-hwa,Ahn, Young-min,Lee, Byung-cheol,Ahn, Se-young 대한한방내과학회 2015 大韓韓方內科學會誌 Vol.36 No.4

Objectives This study was conducted to report the safety of vomit-inducing treatment (Tu Fa, 吐法) by Melonis Calyx, particularly with respect to clinical features and liver and kidney functions.Methods Patients treated with Melonis Calyx powder between September 2013 and September 2014 were assessed retrospectively.Results Less than 3 grams of Melonis Calyx powder can induce mild abdominal discomfort and produce no harmful effects on liver and kidney functions.Conclusions Through this study, a vomit-inducing treatment using less than 3 grams of Melonis Calyx can be considered safe enough to be used in clinics, with a cautious approach with respect to dehydration.

상용 CAD와 연계한 후판 구조의 아이소-지오메트릭 해석

이승욱,구본용,윤민호,이재옥,조선호,Lee, Seung-Wook,Koo, Bon-Yong,Yoon, Min-Ho,Lee, Jae-Ok,Cho, Seon-Ho 한국전산구조공학회 2011 한국전산구조공학회논문집 Vol.24 No.3

The finite element method (FEM) has been used for various fields like mathematics and engineering. However, the FEM has a difficulty in describing the geometric shape exactly due to its property of piecewise linear discretization. Recently, however, a so-called isogeometric analysis method that uses the non-uniform rational B-spline(NURBS) basis function has been developed. The NURBS can be used to describe the geometry exactly and play a role of basis functions for the response analysis. Nevertheless, constructing the NURBS basis functions in analysis is as costly as a meshing process in the FEM. Since the isogeometric method shares geometric data with CAD, it is possible to intactly import the model data from commercial CAD tools. In this paper, we use the Rhinoceros 3D software to create CAD models and export in the form of STEP file. The information of knot vectors and control points in the NURBS is utilized in the isogeometric analysis. Through some numerical examples, the accuracy of isogeometric method is compared with that of FEM. Also, the efficiency of the isogeometric method that includes the CAD and CAE in a unified framework is verified. 유한요소법은 수학과 공학을 비롯한 다양한 분야에서 활용되고 있으나 해석대상을 유한 개의 다각형 요소로 분할하여 모델링하기 때문에 기하학적인 형상을 정확하게 기술하지 못하는 어려움이 있다. 그러나 최근에는 NURBS(Non-Uniform Rational B-Spline)를 기저함수로 사용하는 아이소-지오메트릭 해석법(Isogeometric analysis)이 개발되었는데 NURBS는 기하학적 모델을 정확하게 표현할 수 있을 뿐만 아니라 해석의 기저함수로서 응답해석에 사용될 수 있다. 그러나 NURBS 기저함수를 해석에서 따로 구성하는 일은 유한요소해석에서 요소망을 구성하는 만큼 시간과 노력이 많이 요구된다. 아이소-지오메트릭 해석법은 CAD(Computer-Aided Design)와 기하학적 정보를 공유할 수 있기 때문에 CAD 코드로 부터 해석모델의 정보를 직접 얻는 것이 가능하다. 본 논문에서는 상용 CAD 코드인 Rhinoceros 3D를 이용하여 CAD 모델을 작성하고 이를 STEP 파일로 출력하여 NURBS의 노트벡터와 조정점 등의 정보를 아이소-지오메트릭 해석법에 활용하는 기법을 소개한다. 몇몇 수치예제를 통하여 아이소-지오메트릭 해석법의 정확도를 유한요소해석 결과와 비교하여 검증하고, 상용 CAD와 CAE(Computer-Aided Engineering)가 결합된 아이소-지오메트릭 해석법의 효율성을 입증한다.

감수(甘遂)를 이용한 사하법(瀉下法)의 안전성에 대한 후향적 연구: 임상반응, 간기능, 신기능을 중심으로 한 평가

이승욱,권오준,나현영,안영민,이병철,안세영,Lee, Seung-Wook,Kwon, Oh-Jun,Na, Hyun-Young,Ahn, Young-Min,Lee, Byung-Cheol,Ahn, Se-Young 대한한방내과학회 2014 大韓韓方內科學會誌 Vol.35 No.4

Objectives: The purpose of this study was to report the safety of diarrhea-inducing treatment (Xie-xia Fa, 瀉下法) by Euphorbia kansui Radix, especially in the respect of clinical features, liver and kidney functions. Methods: Patients who were treated with Euphorbia kansui Radix powder between September 2013 and September 2014 were assessed retrospectively. Results: Less than 6 grams dosage of Euphorbia kansui Radix can induce several mild intestinal reactions but have no harmful effects on liver and kidney functions. Conclusions: Through this study, diarrhea-inducing treatment by less than 6 grams of Euphorbia kansui Radix can considered safe enough to be used in local clinics, but a cautious approach is needed.

재래식 및 개량식 된장의 아이소플라본 분포 및 $\beta$-glucosidase 활성 연구

이승욱,박영우,장판식,이재환,Lee, Seung-Wook,Park, Yong-Woo,Chang, Pahn-Shick,Lee, Jae-Hwan 한국식품과학회 2010 한국식품과학회지 Vol.42 No.2

숙성기간이 다른 재래식 된장 12종과 개량식 된장 4종의 아이소플라본과 $\beta$-glucosidase 활성도를 비교하였다. 재래식 된장의 전체 아이소플라본 함량(TI)은 $370-723\;{\mu}g/g$이었고, 개량식 된장은 $179-537\;{\mu}g/g$으로 유의적으로 낮은 함량을 보였다. 된장의 주요 아이소플라본은 비배당체 형태였으며 재래식 된장의 경우 42.98-89.96%, 개량식 된장은 35.51-93.48%이었다. 아이소플라본 함량 분포에 대한 주성분 분석 결과 재래식 된장은 개량식 된장과 차별화가 가능하였다. 개량식 된장의 경우 $\beta$-glucoside 형태는 검출되지 않았는데 이는 과도한 열처리를 받았거나 발효에 관여한 미생물의 $\beta$-glucosidase 활성이 높았음을 의미한다. 된장시료에서 $\beta$-glucosidase 활성도는 날콩에 비해 낮았으며 재래식 및 개량식 된장간에 유의적인 차이 및 아이소플라본의 분포와의 상관관계는 명확하지 않았다. Isoflavone distribution and $\beta$-glucosidase activity in 16 commercially available doenjang samples were determined. Twelve of the samples were home-made doenjang (HMD) with a relatively long fermentation period and 4 of the samples were factory-produced doenjang (FPD) from four different manufactures. Total isoflavones (TI) in the HMD ranged from $370-723\;{\mu}g/g$, while those in FPD ranged from $179-537\;{\mu}g/g$. The isoflavone distribution in HMD was different from those in FPD. Generally, the TI in HMD was higher than those in FPD. The major isoflavone was aglycones, which ranged from 42.98 to 89.96% in HMD and from 35.51 to 93.48% in FPD. Isoflavones in the $\beta$-glucoside forms were not detected in tested FPD samples. Principal components analysis (PCA) of the isoflavone profiles showed that HMD were differentiated from FPD. First principal component (PC1) and second principal component (PC2) expressed 43.6 and 22.9% of the data variability, respectively. $\beta$-Glucosidase activity in doenjang was lower than that in raw soybeans. The results of this study can be used to understand the differences in the isoflavone distribution in traditionally manufactured and factory produced doenjang.

민들린 평판의 아이소-지오메트릭 형상 설계민감도 해석

이승욱,조선호,Lee, Seung-Wook,Cho, Seonho 한국전산구조공학회 2013 한국전산구조공학회논문집 Vol.26 No.4

본 논문에서는 아이소-지오메트릭 기법을 기반으로 민들린 후판에 대한 형상 설계민감도 해석법을 제시하였다. 아이소-지오메트릭 기법은 정확한 기하학적 형상의 표현, 요소 사이의 높은 연속성 등 바람직한 강점들을 가지고 있으며 궁극적으로는 해석해로의 빠른 수렴성과 정확한 설계민감도를 제공한다. 선형 형상함수를 사용하는 유한요소법과는 달리 아이소-지오메트릭 기법에서는 높은 차수의 NURBS 기저함수를 활용하여 CAD 형상의 법선벡터와 곡률을 정확하게 고려한다. 전단 잠김(Shear locking) 현상을 극복하기 위해서 선택적 감소적분(Selective reduced integration) 기법을 사용하였다. 이 간단한 방법은 복잡한 정식화 과정 없이 정확한 아이소-지오메트릭 형상 설계민감도 해석을 수행한다. 굽힘 문제에 대한 수치예제를 통하여 제안된 아이소-지오메트릭 해석과 유한요소 해석을 비교하였으며, 유한차분 설계민감도와 비교하여 아이소-지오메트릭 형상 설계민감도는 매우 정확함을 확인하였다. In this paper, a shape design sensitivity analysis(DSA) method is presented for Mindlin plates using an isogeometric approach. The isogeometric method possesses desirable advantages; the representation of exact geometry and the higher order inter-element continuity, which lead to the fast convergence of solution as well as accurate sensitivity results. Unlike the finite element methods using linear shape functions, the isogeometric method considers the exact normal vector and curvature of the CAD geometry, taking advantages of higher order NURBS basis functions. A selective reduced integration(SRI) technique is incorporated to overcome the difficulty of 'shear locking' phenomenon. This simple technique is surprisingly helpful for the accuracy of the isogeometric shape sensitivity without complicated formulation. Through the numerical examples of plate bending problems, the accuracy of the proposed isogeometric analysis method is compared with that of finite element one. Also, the isogeometric shape sensitivity turns out to be very accurate when compared with finite difference sensitivity.

경도의 발달장애 아동의 시지각 및 주의력 향상을 위한 시기능 훈련의 임상사례

이승욱,장우영,Lee, Seung-Wook,Jang, Woo-Yeong 한국임상보건과학회 2017 한국임상보건과학회지 Vol.5 No.3

Purpose. The purpose of this study was to investigate the effect of visual field training on visual function, visual perception and attention enhancement. Methods. We examined the changes of visual function and visual perception tests for children with mild developmental disabilities through vision therapy. Results. At the time of the initial visit of the child, the ability to control not only distant and near visual function, but also accommodation, was also very limited. Also, the visual perception score was measured at 80 points. Through vision therapy, it was confirmed that the improvement of control ability as well as the visual function and visual perception function test results were also improved to 108 points. Conclusion. It was confirmed that vision therapy results in an improvement of visual function, improved visual perception ability, as well as visual perception ability, It was concluded that visual function affected visual perception, and that vision therapy used in order to prevent visual function deterioration was found to be very helpful.

전립선비대증의 치료로 Sildenafil과 Finasteride 병용요법의 안전성 및 유효성

이승욱(Seung Wook Lee),이승환(Seung Hwan Lee),김규식(Kyu Shik Kim),이석영(Seokyoung Lee),정재훈(Jae Hoon Chung) 대한비뇨기종양학회 2018 대한비뇨기종양학회지 Vol.16 No.2

Purpose: The 5-alpha reductase inhibitors (5ARI) are one of the most commonly used medications for the treatment of benign prostatic hyperplasia (BPH). Phosphodiesterase type-5 inhibitors are also used to treat BPH. 5ARI is a drug with adverse effects of sexual dysfunction. In this study, we investigated the safety and efficacy of coadministration of finasteride and sildenafil on sexual function and lower urinary symptoms in patients with BPH. Materials and Methods: We retrospectively reviewed the medical records of patients who were receiving finasteride and sildenafil daily regimens for treatment of BPH in 2 university hospitals. Patients with adverse effects, vital sign, physical exam, laboratory test, 5-item version of the international index of erectile function (IIEF-5), International Prostate Symptom Score (IPSS), quality of life (QoL) were analyzed. Results: The number of patients analyzed in this study was 218. The mean age of the patients was 62.63±8.37 years and the mean duration of medication was 18.23±10.97 weeks. Significant changes were not observed in the vital signs measured before and after the drug administration. Compared with before treatment, improvement of lower urinary tract symptom (IPSS: 17.56±4.21 vs. 11.64±5.33, p<0.001) was observed and improvement of sexual function (IIEF-5: 9.44±5.21 vs. 12.73±6.81, p<0.001) was also confirmed. Conclusions: Daily coadministration of finasteride and sildenafil for the treatment of BPH could be used safely, and improvement of lower urinary tract symptom as well as improvement of sexual function could be expected.