치명적인 Amiodarone 폐독성 4예

이승우,이상학,여동승,이숙영,김석찬,김관형,문화식,송정섭,박성학,정은선,Lee, Seung-Woo,Lee, Sang-Haak,Yeo, Dong-Seung,Lee, Sook-Young,Lee, Seok-Chan,Kim, Kwan-Hyoung,Moon, Hwa-Sik,Song, Jeong-Sup,Park, Sung-Hak,Jung, Eun-Sun 대한결핵및호흡기학회 2002 Tuberculosis and Respiratory Diseases Vol.53 No.6

Amiodarone 폐독성은 약제 복용력이 있는 환자에서 새로운 증상과 X-선의 변화가 있을 때 의심하여야 하며 울혈성 심부전이나 폐감염증, 폐색전증, 악성종양 등과 감별하는 것이 중요하다. 진단은 임상적, 방사선학적, 조직학적 소견을 종합하여 내릴 수 있으며 대부분의 경우에는 약제 중단을 통해서 폐독성의 호전을 기대할 수 있으나 일부에서는 호흡부전으로 진행하거나 기존의 심부정맥의 재발 등으로 인하여 사망하는 경우도 있다. 저자들은 심부정맥으로 amiodarone을 사용하던 환자에서 치명적인 폐독성이 발생한 4예를 경험하였기에 이를 문헌고찰과 함께 보고하는 바이다. The lungs are frequently the site of adverse drug reactions because of their higher oxygen concentration, the distinctive properties of the pulmonary circulation, and the close proximity of the alveolar epithelium to the blood. Amiodarone, an iodinated benzofuran derivative, is an effective antiarrhythmic drug commonly used for refractory tachyarrhythmia. However, it has a wide range of adverse effects, the most serious of which is lung disease. Most patients present with the insidious onset of dyspnea and a nonproductive cough, and generally recover after withdrawing the drug. We recently experienced four fatal cases of amiodarone pulmonary toxicity. Therefore, we discuss these unusual drug-induced pulmonary toxicity cases with a review of the relevant literature.

Multi SHA 구조의 파이프라인 아날로그-디지털 변환기 설계

이승우,나유찬,신홍규,Lee, Seung-Woo,Ra, Yoo-Chan,Shin, Hong-Kyu 한국통신학회 2005 韓國通信學會論文誌 Vol.30 No.2a

In this paper, Pipelined A/D converter with multi SHA structure is proposed for high speed operation. The proposed structure incorporates a multi SHA block that consists of multiple SHAs of identical characteristics in parallel to improve the conversion speed. The designed multi SHA is operated by non-overlapping clocks and the sampling speed can be improved by increasing the number of multiplexed SHAs. Pipelined A/D converter, applying the proposed structure, is designed to satisfy requirement of analog front-end of VDSL modem. The measured INL and DNL of designed A/D converter are $0.52LSB{\sim}-0.50LSB\;and\;0.80LSB{\sim}-0.76LSB$, respectively. It satisfies the design specifications for VDSL modems. The simulated SNR is about 66dB which corresponds to a 10.7 bit resolution. The power consumption is 24.32mW. 본 논문에서는 고속 동작을 위한 multi SHA(ammple and hold amplifier) 구조의 파이프라인 A/D 변환기 (analog-to-digital converter)를 제안하였다. 제안된 구조는 변환 속도를 높이기 위해, 동일한 SHA를 병렬로 연결하여 multi SHA를 구성하였다. 이를 비중첩 클럭(nonoverlapping clock)에서 동작하도록 하여 셀을 구성하는 SHA의 수와 비례한 빠른 샘플링 속도를 얻을 수 있도록 하였다. 제안된 구조를 적용하여 VDSL(very high-speed digital subscriber line) 모뎀의 아날로그 front-end단의 요구 사항을 만족하는 파이프라인 A/D 변환기를 설계하였다. 설계된 A/D 변환기의 DNL(differential nonlinearity)과 INL(integral nonlinearity)은 각각 $0.52LSB{\sim}-0.50LSB,\;0.80LSB{\sim}-0.76LSB$의 특성을 나타내어 설계 사양을 만족함을 확인하였다. 또한 2048 point에 대한 FFT를 수행한 결과 SNR이 약 66dB로 10.7 비트의 해상도가 얻어짐을 확인하였으며, 전력 소모는 24.32mW로 측정되었다.

입자크기를 달리한 Cp-Ti의 미세구조 관찰 및 SBF하에서의 부식거동

이승우,김윤종,류재경,박중근,김원수,김택남,Lee Seung-Woo,Kim Yun-Jong,Ruy Jae-Gyeoung,Park Joong-Keun,Kim Won-Soo,Kim Taik-Nam 한국재료학회 2005 한국재료학회지 Vol.15 No.9

Titanium and Titanium alloys are widely used as an orthopedic and dental implant material because of their excellent biocompatibility and mechanical strength. In this study, ECAP Cp-Ti and Cp-Ti were heat treated for different annealing time of 30 min, 90 min and 3 hours. The grain size for each condition was studied. The micro-Vicker hardness test was carried out f3r each different heat treated samples. The micro-Vicker hardness test for ECAP Cp-Ti, Cp-Ti and Cp-Ti (3hr) revealed hardness values of 239.5, 182 and 144 Hv, respectively. The grain size was increased from approximately $70{\mu}m\;to\;300{\mu}m$ with the increase in heat treatment time from 30 min to 3 hours. The heat treated samples were tested for their biocompatibility in simulated body fluid (SBF) and corrosion rates was determined using Polarization Curve test (PCT). The PCT results showed Cp-Ti with comparatively high corrosion potential of -0.18 V and corresponding corrosion current of $2\times10^{-6}$ A, while the corrosion rate in ECAP Cp-Ti and Cp-Ti (30 min annealed) showed very similar results of corrosion potential about -0.47 V with corresponding corrosion current of $7\times10^{-8}$ A.

각막의 화학손상에 대한 임상적 고찰

이승우,김홍균,김광수,강정훈,Seung-Woo Lee,Hong-Kyun Kim,Kwang-Soo Kim Jung-Hun Kang 대한안과학회 2005 대한안과학회지 Vol.46 No.9

Purpose: To establish a treatment regimen and preventive measures through clinical study and demographic profile of chemical corneal injury cases. Methods: The records of all patients presenting with chemical corneal injuries from January 1 1997 to December 31 2003 were evaluated. One hundred forty-three chemical corneal injuries in seventy-eight patients presenting to the Dongguk University Hospital were analyzed. Patients was divide into three groups in accordance to occupation (Group I, farmer, Group Ⅱ, directly chemical-agents exposure occupation, Group Ⅲ, others). The records were examined to extract information about age, sex, extent of injury, chemical substances involved, place of injury, delay time of arrival at hospital and visual acuity. Classification of corneal burns was scored according to Roper-Hall.1 Results: The patient consisted of 63 males (80.8%) and 15 females (19.2%), with a mean age of 39.21±13.27 years. The most common agent causing corneal injuries was pesticide, followed NaOH. Ninety-eight (68.5%) eyes showed Grade 1 burns, 27 (18.9%) eyes showed Grade 2, 15 (9.1%) eyes Grade 3 and 5 (3.5%) Grade 4. The severity of chemical corneal burn and deterioration of the visual acuity was more severe in group Ⅱ than in the other groups. Conclusions: Chemical ocular injuries may lead to serous visual impairment. Therefore, proper education for appropriate handling of chemicals to prevent the accidents is important.

구보음(九寶飮)이 Sensitized Rat의 기관지평골근(氣管支平滑筋)에 미치는 영향(影響)

이승우,Lee, Seung-Woo 대한한방내과학회 1993 大韓韓方內科學會誌 Vol.14 No.2

This study was carried out to investigate the effects of Gooboeum extract on the inhibitory contractile action of acetylcholine in the control and sensitized rat. The results were obtained as follows: 1. The acetylcholine contractile force of the trachea smooth muscle with epithelium was significantly relaxed by Gooboeum. 2. Dose-response of acetylcholine from the trachea smooth muscle pretreated Gooboeum was not changed. 3. Effect of Gooboeum on the inhibitory contractile action of trachea smooth muscle pretreated propranolol was not significantly inhibited. 4. The inhibitory contractile action of acetylcholine of trachea smooth muscle pretreated indomethacin was not significantly changed by Gooboeum. 5. Effects of Gooboeum extract on the inhibitory contractile action of acetylcholine of trachea smooth muscle pretreated methylene blue was not significant. 6. The contractile force of acetylcholine of the trachea smooth muscle without epithelium was significantly inhibited by Gooboeum. 7. Dose-response of acetylcholine of the trachea smooth muscle pretreated Gooboeum was not significant. 8. Effects of Gooboeum extract on the inhibitory contractile action of acetylcholine of the trachea smooth muscle pretreated propranolol was significantly inhibited. 9. Effects of Gooboeum extract on the inhibitory contractile action of acetylcholine of the trachea smooth muscle pretreated indomethacin decreased. 10. Effects of Gooboeum extract on the inhibitory contractile action of acetylcholine of the trachea smooth muscle pretreated methylene blue was not significant.

기상측정(機上測定) 시스템 개발

이승우,김선호,Lee, Seung-Woo,Kim, Sun-Ho 대한산업공학회 1998 산업공학 Vol.11 No.1

This paper describes the development of on-the-machine measuring(OMM) system which can directly measure the two and three dimensional machined accuracy using a scanning probe in milling machine. Two algorithms, NC program based continuous path(CP) measurement and CAD data assisted point to point(PTP) measurement, are developed for three dimensional measurements, with consideration of the characteristics of the scanning probe. The algorithms are used to develop an auto measuring system. The delveloped system is compared with the CMM (Coordinate Measuring Machine) in terms of accuracy and repeatability. The OMM system is expected to realize measurement time reduction and hence result in high productivity.

기후변화와 광물탄산화

이승우,방준환,채수천,Lee, Seung-Woo,Bang, Jun-Hwan,Chae, Soo-Chun 한국건설순환자원학회 2016 한국건설순환자원학회지 Vol.11 No.4

지출환(枳朮丸)의 흰쥐 위(胃) 운동성(運動性)에서 정상 상태 및 위벽 국소손상 후에 대한 효능

이승우,윤상협,Lee, Seung-Woo,Yoon, Sang-Hyub 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.1

Background & Objective : Jichul-hwan(JCH) has been used for the treatment of functional dyspepsia, regarded as a gastric dysmotility disease. We investigated the effects of JCH on gastric motility and its mechanisms of action in rats. Methods : The gastric wall was injured by tracting a part of stomach body in rats. Gastric emptying was measured after administration of normal saline(NS) or JCH in normal rats and gastric wall injured rats. To evaluate the mechanism of JCH under delayed gastric emptying conditions, normal rats were treated with atropine sulfate(1mg/kg, s.c.), quinpirole HCl(0.3mg/kgg, i.p.), $NAME(N^{G}-nitro-L-arginine$ methyl ester, 75mg/kg s.c.) and cisplatin(10mg/kg, i.p.). The gastric slow waves were measured for 30 minutes before and after administration of each solution(NS, JCH). Results : JCH 110.1mg/kg improved gastric emptying for 2 hrs(p=0.014). JCH 110.1mg/kg improved gastric emptying in the gastric wall injured rats(p=0.001). Under the delayed gastric emptying, JCH 110.1mg/kg improved gastric emptying in the group treated with atropine $sulfate(1.83{\pm}0.96$ vs $8.43{\pm}8.46$, p=0.003), but aggravated it with quinpirole $HCl(4.7{\pm}2.9$ vs $1.61{\pm}2.09$, p=0.021). Administration JCH 110.1mg/kg increased EGG power in rats. Conclusions : JCH stimulates gastric motility through the cholinergic pathway, so we expect that it would be effective in the treatment of dysmotility-like functional dyspepsia with low activity of vagus nerve.

컴퓨터프로그래밍과 관련된 교과목 내용분석

이승우,Lee, Seung-Woo 한국수학사학회 2009 Journal for history of mathematics Vol.22 No.2

컴퓨터프로그래밍은 문제해결능력 향상과 논리적 사고력 함양을 위한 도구로서, 본 연구에서는 컴퓨터교육의 방향설정과 문제해결과정에서의 프로그래밍 교육의 역할을 알아보고자한다. 또한 수학/통계학과의 컴퓨터프로그래밍 특성화를 위하여 수학/통계학과와 IT학과를 연계한 프로그래밍 교과목을 분석한다. 이를 통하여 컴퓨터프로그래머로서 능력 있는 인재를 양성해서 사회에 배출하고자 한다. The computer programming is a useful tool to cultivate the logical thinking and encourage the problem solving competence. With the purpose of specifying the computer programming, this study mainly concerns with what the computer programming is in the Math/Stat education, and the role of the computer programming when it regards the problem solving procedure. This provides the possibility of Math/Stat major to be specified with the connection of IT related courses, and eventually the specified Math/Stat major enables more qualified graduates to be educated.

인구통계학적 요인 및 나트륨 섭취와 건강관련 삶의 질 간의 연관성: 경주지역 성인을 중심으로

이승우,황지윤,김인선,이수진,정경식,고광필,백영화,Lee, Seung-Woo,Hwang, Ji-Yun,Kim, In Seon,Lee, Sujin,Jeong, Kyungsik,Ko, Kwang-Pil,Beak, Younghwa 한국식생활문화학회 2021 韓國食生活文化學會誌 Vol.36 No.1

Sodium intake has been associated with the health-related quality of life (HRQoL). This study examined the demographic factors related to HRQoL and whether there is an association between sodium intake and HRQoL in adults residing in rural areas. A total of 1,980 adults (aged ≥20 years) were selected from a cross-sectional study conducted between December 2013 and February 2014 in Gyeongju, South Korea. The sodium intake and HRQoL were measured using a validated food frequency questionnaire and the EuroQol Five-Dimension (EQ-5D) (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression), respectively. The education levels (<5 years) were inversely associated with all five dimensions of HRQoL. Men had better EQ-5D scores for each of the five components examined. Adults living with spouses had better scores related to usual activities and anxiety/depression, whereas widowers had decreased scores of mobility and self-care. Unlike older adults aged 70-79 years, adults aged <60 years were more likely to have greater scores related to mobility, usual activities, and pain/discomfort. The income levels were also inversely related to the scores for self-care, usual activities, pain/discomfort, and anxiety/depression. Sodium intake was positively associated with the HRQoL related to self-care, usual activities, and pain/discomfort, but it was negatively associated with anxiety/depression. In conclusion, these findings suggest that the demographic factors and sodium intake were independently associated with HRQoL. The results highlight the need to provide tailored, targeted policies and interventions that consider personal characteristics and dietary intake to improve the overall HRQoL in adults residing in rural areas.