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원인 불명 반복유산 환자에서 태반 항원에 대한 말초혈액 단핵구의 반응에 대한 연구
이순곤 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2
Peripheral blood mononuclear cells(PBMCs) from many women with unexplained recurrent abortion(URA) respond to trophoblast extracts in vitro by both proliferating and releasing soluble factors that adversely affect embryo and trophoblast viability, while PBMCs from parous women with a history of normal pregnancies and women with recurrent abortion due to maternal chromosomal or anatomic causes do not commonly show this response. Other studies have demonstrated that TH1-type cytokines, especially IFN-r and tumor necrosis factor-α, impair early embeyo development and trophoblast growth and function in vitro, and cause abortion in mice. In contrast, TH2-type cytokines are secreted at the maternal-fetal interface during normal murine pregnancy and may play an important role in normal pregnancy by suppressing cellular immune responses that could endanger the fetus, while maintaining humoral immunity vital for maternal defense against pathogens. Therefore, reproductive success may depend on cytokine regulation of the maternal immune response. In this study, we investigated whether or not PBMCs from women with a history of URA produce TH 1-type cytokines, IL-2 and tumor necrosis factor-α, following exposure to trophoblast extracts. We detected tumor necrosis factor-α(mean, 33±19.8pg/mL) in trophoblast-activated PBMC culture supernatants from URA patients. None of the trophoblast-activated PBMC culture supernatants from reproductively normal women contained tumor necrosis factor-α. None of the trophoblast-activated PBMC culture supernatants from URA patients and reproductively normal women contained IL-2. Supernatants from unstimulated cultures contained neither IL-2 nor tumor necrosis factor-α.
이권해,이순곤,이임순,이환구,이정재,김민관,남계현,조태호 순천향대학교 1993 논문집 Vol.16 No.4
The platelet count was investigated in a group of patient with severe preeclampsia. We prospectively reviewed the charts 98 women with severe preeclampsia who were admitted for delivery to the department of Obstetrics and Gynecology in Soonchunhyang University Hospital from January, 1990 to December, 1991. The results were as follow: 1. The number of platelet was low significantly in severe preeclampsia group. 2. In severe preeclampsia, reduced maternal level of circulating paltelets were found to correlate with fetal complications and/or maternal complications. Furthermore, a low platelet count may be an indicator that the fetus is at extra-risk and that is even though the severe preeclampsia is under control.