위암환자에서 대장과 직장의 질환에 대한 분석

구소령 ( So Ryung Gu ),강성구 ( Seong Ku Kang ),신동규 ( Dong Gue Shin ),박상수 ( Sang Soo Park ),윤진 ( Jin Yoon ),이경복 ( Kyung Bok Lee ),유병욱 ( Byung Ook You ),김일명 ( Il Myung Kim ) 대한임상종양학회 2010 Korean Journal of Clinical Oncology Vol.6 No.2

목적: 위암으로 진단 및 치료를 받은 환자들의 생존율이 향상됨에 따라, 재발과 함께 다른 부위에 발견되는 질환 중에 대장병변의 발생이 정상인에 비해 증가되어 있다는 보고가 있다. 본 연구에서는 위암으로 진단되고 수술한 환자들에게서 대장병변의 발생율과 그 특성을 분석하고자 하였다. 대상 및 방법: 2000년 3월부터 2010년 5월까지 서울의료원에서 위암으로 진단을 받고 수술을 한 244명의 환자들을 대상으로 하였고, 이들 중에 대장에 대한 검사를 받은 병력이 있는 104명의 환자들을 의무기록지와 병리조직검사결과지를 후향적으로 조사하였다. 44명의 환자들에서 대장병변이 있었으며, 대장병변의 발생양상과 병리조직학적 특징들을 조사하였다. 결과: 전체 204명 환자들의 평균 연령은 62.6세(범위: 34-90세)였으며 남자와 여자의 성비는 2.6:1이었다. 대장에 대한 검사를 받은 104명의 환자들 중에 44명(42.3%)에서 대장병변을 관찰되었다. 용종이 28명(63.6%), 괴양성 대장염 2명(4.5%), 대장암 9명(20.5%), 대장게실 및 기타 질환 5명(11.4%)으로 진단되었다. 28명의 용종환자들과 9명의 선암종 환자들에 대한 병리조직학적 형태를 분류하였다. 결론: 위암환자들에게서 대장병변의 발견율이 높다는 것을 확인하였다. 위암으로 진단되는 경우 수술을 시행하기 전에 대장내시경 검사나 3차원 CT 대장조영술을 시행하여 대장병변을 확인하여야 한다. 수술 후에도 환자들에 대한 정기적인 추적검사에 대장에 대한 검사를 추가하여 대장병변을 조기에 발견하고자 하여야 할 것으로 보인다. Background and Objectives: Stomach cancer is the most common, showing the highest prevalence in Korea. In stomach cancer patients, the coincidence of colorectal diseases is reported in an increasing frequency compared to normal people. In this study, the incidence and characteristics of colon diseases in patients who had been diagnosed and treated with stomach cancer were analized. Subjects and Methods: From September 2000 to October 2007, 244 patients who had been diagnosed with stomach cancer and received operation were subjected. 104 patients of those had colon evaluation before or after the operation and they are studies further. We investigated retrospectively the pattern of the occurrence of colon neoplasia and non-neoplasia and their histopathological characteristics. Results: The mean age of the 244 patients was 62.6 (34~90), and the ratio of males to females was 2.6:1. Of the 104 patients with colorectal examinations, lesions were observed in 44 (42.3%), of which 28 (63.6%) were polyp, 2 (4.5%) were ulcerative colitis, 9 (20.5%) were colon cancer, and others were 5 (11.4%). The cases of adenocarcinoma were classified with sex and their characteristics. Conclusions: The incidence of colon neoplasia and non-neoplasia is high in stomach cancer patients. Accordingly, patients who are diagnosed with stomach cancer should be strongly advised to do colonoscopic examination or 3- dimensional CT colonography, before and after the operation. It should be examined actively for early detection of colon cancer.

북방전복 Haliotis discus hannai 정자의 미세구조적 분화

김혜진,김현진,신소령,백은란,이정식,Kim, Hyejin,Kim, Hyeon Jin,Shin, So Ryung,Baek, Eun Ran,Lee, Jung Sick 한국해양생명과학회 2021 한국해양생명과학회지 Vol.6 No.1

북방전복 Haliotis discus hannai 웅성생식세포의 분화과정과 정자의 형태를 미세구조적으로 기재하였다. 정자의 분화과정은 정원세포기, 정모세포기, 정세포기 및 정자기의 4단계로 구분하였다. 정원세포기에서 정모세포기로의 분화과정은 형태학적 변화가 크지 않았다. 그러나 정자변태과정 동안 염색질 응축, 핵의 형태 변화, 첨체와 중편 및 편모 형성 등의 급격한 형태학적 변화를 나타냈다. 북방전복의 정자는 두부, 중편 및 미부로 구성되며, 두부의 길이는 약 5.3 ㎛로 전자밀도가 높은 핵과 총알형의 첨체로 이루어져 있었다. 중편은 기저체와 미토콘드리아로 구성되어 있었으며, 기저체를 중심으로 5개의 미토콘드리아가 한 층으로 배열되어 있었다. 미부의 횡단면은 "9+2"의 미세소관 구조를 보였다. 이러한 형태 및 구조적 특징은 북방전복의 정자는 원시형(primitive type) 정자임을 보여주는 결과이다. The differentiation process of male germ cells and sperm morphology of the abalone Haliotis discus hannai were described in ultrastructure. The differentiation process of sperm was divided into four stages: spermatogonium, spermatocyte, spermatid and sperm. The process of differentiation from spermatogonium to spermatocyte did not show significant morphological changes. However, during the spermiogenesis there were distinct morphological changes such as chromatin condensation, morphological changes of the nucleus, and formation of acrosome, midpiece and flagellum. The sperm of the abalone consisted of head, midpiece and tail. The head of approximately 5.3 ㎛ in length was composed of a nucleus of high electron dense and bullet-shaped acrosome. The midpiece was composed of the basal body and mitochondria, and five mitochondria were arranged in single layer around the basal body. The cross section of the tail showed a "9+2" axonemal structure. These morphological and structural features are the result of showing that the sperm of H. discus hannai is a primitive type.

일부 사립대학 교직원들에 대한 직무스트레스 요인 평가

최선영 ( Sun Young Choi ),이소령 ( So Ryung Lee ),최슬기 ( Seul Gi Choi ),김은진 ( Eun Jin Kim ),최상준 ( Sang June Choi ) 대구가톨릭대학교 자연과학연구소 2013 자연과학연구논문집 Vol.11 No.1

Job stress can be defined as the harmful physical and emotional responses that occur when the requirements of the job do not match the capabilities, resources, or needs of the worker. Job stress can lead to poor health and even injury. The aim of this study was to evaluate the job stressors of the staffs working at private university in Daegu. This study was conducted using online questionnaire made by the google docs. A questionnaire consisted of 43 questions according to the KOSHA GUIDE H-67-2012. We sent e-mail containing questionnaire to 402 staffs. A total of 65(16.2%) questionnaires were collected. Among the eight fields of stressors, the job demands (men 54.2) was higher than the median value of Korean workers. For each male and female workers in each department when compared to the median, for men the headquarters job demand (+12.4), and workplace culture (+8.3) area, for women job demands Headquarters (+4.1) was significantly higher than the median area, College / graduate man relationship conflict (+24.9), organizational structure (+19.0), job demands (+4.1) was significantly higher than the median area, College / graduate women the organization system (+2.4) were higher than the median area. I felt fine for each of the items look the most significant burden, Headquarters for both men and women who get the job done now instructed to make a case before the other day and several tasks at the same time is when you need to. University / School of the man, ``My boss to help you complete the task that is not sufficient`` is a case, College / graduate women my career development and promotion are expected to be a passably good point lower part is feeling the greatest burden. For the management of stress factors and other wise control of overload the amount of work, personnel management system (promotion, department placed, etc,) also can be an important element refleted impartialement and raisonnable. Prevention management of job stress methods : ask to a specialist to personally, make a recommendation immediate supervisor, change of work shifts cycles, write worker``s daily schedule and other, self- observation, relaxation training, meditation, Psychiatric treatment, yoga, massage and so on.

둥근전복속 교잡종(둥근전복♀*왕전복♂) 치패의 먹이조건에 따른 생물지표

김현진 ( Hyeon Jin Kim ),신소령 ( So Ryung Shin ),이정식 ( Jung Sick Lee ),황두진 ( Doo-jin Hwang ),김재원 ( Jae Won Kim ) 한국수산해양기술학회 2021 수산해양기술연구 Vol.57 No.4

The purpose of this study was to investigate the improvement effect of biomarkers through the supply of natural diet in the juvenile hybrid abalone (Haliotis discus discus♀*H. madaka♂). For the study, the shell length of about 17 mm and the total weight of 0.83 g were used. The feeding conditions were set as the natural diet group (dried laver) and the formulated diet group, and the experiment duration was 16 weeks. The survival rate was about 14% higher in the natural diet group than the formulated diet group, and growth was also faster in the natural diet group. Shell malformation rate was lower in the natural diet group (7.5%) than the formulated diet group (21.5%). In the biochemical composition, except for carbohydrates, both experimental groups showed similar values. The degeneration of epithelial cells in the hepatopancreatic tubule was lower in the natural diet group than the formulated diet group, and the activity of basophilic cell was higher in the natural diet group. These results indicate that it is worth considering the supply of natural diet for the breeding of juvenile hybrid abalone and the improvement of the quality of the formulated diet (H. discus discus♀*H. madaka♂).

저온온열치료에 의한 종양 내 저산소상태 개선효과를 18F-Fluoromisonidazole의 섭취 변화를 이용한 평가

이상욱(Sang-wook Lee),류진숙(Jin Sook Ryu),오승준(Seung Joon Oh),임기천(Ki Chun Im),천기정(Gi Jeong Chen),이소령(Ryung Lee),송도영(Do Young Song),임수정(Soo Jeong Im),문은숙(Eun Sook Moon),김종훈(Jong Hoon Kim),안승도(Seung Do Ahn),신 대한방사선종양학회 2004 Radiation Oncology Journal Vol.22 No.4

목 적: 종양 내에서 산소공급 부족현상으로 발생하는 저산소증 조직에서 저온온열치료(42oC)와 nicotinamide 에 의한 perfusion limited 저산소증의 개선 효과를 마우스 종양 모델을 이용하여 종양 내 [18F]FMISO 섭취변화 를 이용하여 증명할 수 있는지 알아보고자 하였다. 대상 및 방법: C3H 마우스에 [18F]FMISO를 정주하고 11개 장기에서 %ID/g을 구하여 biodistribution을 관찰하였다. 또한 같은 마우스에 동종 종양세포인 SCC7을 이식하여 종양모델을 만들고 저온온열치료(42oC)와 nicotinamide를 투여한 마우스와 대조군 마우스에서 [18F]FMISO의 섭취정도 차이를 %ID/g, autoradiography, PET scan을 시행하여 비교하고자 하였다. 결 과: 대조군에서 종양의 FMISO의 섭취는 5.1+/-2.28 %ID/g였고, 종양/근육, 종양/혈액의 섭취비는 2.2와 1.8이었다. 실험군에서는 각각 2.4+/-0.64 %ID/g, 1.4와 1.2를 나타내어 대조군보다 유의하게 낮았다(p<0.021). Autoradiography에서 대조군의 종양 내부에 FMISO가 섭취됨을 확인하였고, 저온온열치료와 nicotinamide를 투여한 실험군에서는 섭취가 감소된 것을 관찰하였다. 결 론: C3H 마우스와 동종 종양세포인 SCC-VII을 이용한 종양모델에서 [18F]FMISO가 종양내에 섭취가 되어 자산소증 종양모델로 적절함을 확인하였고, 저온온열치료(42oC)와 nicotinamide에 의한 perfusion limited 저산소증 개선효과를 [18F]FMISO의 종양 내 섭취가 감소하는 것을 통하여 확인할 수 있었다. Purpose: The aims of this study were to evaluate the change of [18F]fluoromisonidazole ([18F]FMISO) uptake in C3H mouse squamous cell carcinoma-VII (SCC-VII) treated with mild hyperthermia (42oC) and nicotinamide and to assess the biodistribution of the markers in normal tissues under similar conditions. Methods and Materials: [18F]FMISO was producedby our hospital. Female C3H mice with a C3H SCC-VII tumor grown on their extremities were used. Tumors were size matched. Non-anaesthetized, tumor-bearing mice underwent control or mild hyperthermia at 42oC for 60 min with nicotinamide (50 mg/kg i.p. injected) and were examined by gamma counter, autoradiography and animal PET scan 3 hours after tracer i.v. injected with breathing room air. The biodistribution of these agents were obtained at 3 h after [18F]FMISO injection. Blood, tumor, muscle, heart, lung, liver, kidney, brain, bone, spleen, and intestine were removed, counted for radioactivity and weighed. The tumor and liver were frozen and cut with a cryomicrotome into 10-μm sections. The spatial distribution of radioactivity from the tissue sections was determined with digital autoradiography. Results: The mild hyperthermia with nicotinamide treatment had only slight effects on the biodistribution of either marker in normal tissues. We observed that the whole tumor radioactivity uptake ratios were higher in the control mice than in the mild hyperthermia with nicotinamide treated mice for [18F]FMISO (1.56±1.03 vs. 0.67± 0.30; p=0.063). In addition, autoradiography and animal PET scan demonstrated that the area and intensity of [18F]FMISO uptake was significantly decreased. Conclusion: Mild hyperthermia and nicotinamide significantly improved tumor hypoxia using [18F]FMISO and this uptake reflected tumor hypoxic status.

학위복 디자인 연구

전혜정(Hei Jung Chun),나현신(Hyun Shin Na),이경아(Kyung Ah Lee),이소령(So Ryung Lee),김희균(Hee Kyun Kim),안창현(Chang Hyun An),박진영(Jin Young Park) 한국복식학회 2008 服飾 Vol.58 No.8