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HIP처리가 플라즈마 용사된 열차폐 코팅층의 접착강도와 고온특성에 미치는 영향
박영규,김성휘,김두수,이영찬,최철,정진성,김길무,김재철,Park, Young-Kyu,Kim, Sung-Hwi,Kim, Doo-Soo,Lee, Young-Chan,Choi, Cheol,Jung, Jin-Sung,Kim, Gil-Moo,Kim, Jae-Chul 한국재료학회 2000 한국재료학회지 Vol.10 No.4
HIP처리가 가스터빈 고정익 등 고온부품에 적용되는 열차폐 코팅층의 접착강도 및 고온특성에 미치는 영향을 조사하였다. 시편은 IN738LC 초합금 표면에 8wt%Y$_2$O$_3$-$ZrO_2$분말을 플라즈마 용사법으로 코팅한 후 $1200^{\circ}C$, 100MPa의 고온, 고압에서 4시간 동안 HIP 처리하여 준비하였다. 실험결과 HIP 처리된 코팅의 경우 미세균열과 기공이 상당량 감소하였으며 EDX분석을 통해 계면에서 원자간 상호확산이 발생한 것을 확인하였다. 이러한 코팅층의 치밀화 및 상호확산으로 인해 HIP처리된 코팅층의 접착강도는 48% 이상 크게 증가하였으며 조직 또한 균질화 되었다. 반면 가열과 냉각이 반복되는 환경에서 코팅층의 내구력은 HIP 처리된 경우가 다소 저하되었다. 이는 코팅과 모재와의 열팽창 차이로 인한 변형을 완화시켜주는 기공과 미세균열이 감소되었기 때문으로 판단된다. A study has been made to investigate the effects of hot isostatic pressing(HIP ping) on bond strength and elevated temperature characteristics of thermal barrier coating(TBC). The specimens were prepared by HIPping of TBC which is composed of the ceramic top coat(8wt%$Y_2$$O_3$-$ZrO_2$) and the metallic bond coat on the matrix of IN738LC superalloy. The results showed that the porosity and microcracks in the ceramic top coat of TBC were significantly decreased by HIP. As a result, the bond strength of the HIPped coating was increased above 48% compared to that of as-coated specimen and microstructure was homogenized. It was found that the thermal cycle resistance of HIPped coating was inferior to that of as-coated specimen. It was considered that this result was mainly caused by the reduction of internal defects in the top coat layer which could play a role in relaxing the thermal stress due to a large difference in thermal expansion between TBC and matrix.
Epigenetic Approaches to the Treatment of Renal Cell Cancer
Seong Hwi Hong(홍성휘),Jiyoung Lee(이지영),Eun Bi Jang(장은비),Sung Yul Park(박성열),Hong-Sang Moon(문홍상),Young Eun Yoon(윤영은) 대한비뇨기종양학회 2020 대한비뇨기종양학회지 Vol.18 No.2
To summarize the epigenetics in renal cell carcinoma (RCC) and discuss the potential use of epigenetic modifiers as RCC biomarkers and treatments. Pertinent articles available on PubMed and google scholar database pertaining to kidney cancer and epigenetics were reviewed. Metastatic RCC is one of the most difficult cancers to treat. Although RCC is commonly known to be caused by VHL mutations, it is not enough to understand the complete pathophysiology of RCC. Epigenetic factors can play a fundamental role in the pathogenesis of RCC. Epigenetic regulators are classified as epigenetic writers, readers, and erasers according to their role. In this review, we discuss the potential role of epigenetic regulators as a biomarker for RCC. We also review medications that target epigenetic enzymes and are currently tried in RCC therapy.
박건현,박수현,이성휘,표성운,Park, Kun-Hyun,Park, Su-Hyun,Lee, Sung-Hwy,Pyo, Sung-Woon Korean Association of Maxillofacial Plastic and Re 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.5
Purpose: Although it is generally accepted that patients with controlled diabetes have similar rates of success for dental implants as healthy individuals, the use of dental implants in diabetic patients is controversial. In addition, the impact of diabetes on the healing of bone associated with immediately place dental implants is not completely understood. The purpose of this study was to measure bone response to implants radiologically in uncontrolled and insulin-controlled diabetic rats. Materials and Methods: Twenty rats were divided into control, insulin-treated and diabetic groups. The rats received streptozotocin (60 mg/kg) to induce diabetes; animals in the insulin-treated group also received three units of subcutaneous slow-release insulin. Two titanium implants ($1.2{\times}3$ mm) were placed in the extraction socket of the maxillary first molars of the animals and were harvested at 3 days, 1, 2 and 4 weeks. The bone density was measured by digital radiography using gray-level analysis (histogram) in the regions of interest (ROI) at four points: two mesial and two distal to both sides of the implant. Results: The results showed that the osseointegration of the implants was impaired in the diabetic rats compared to the control and the insulin-treated rats. The radiographic evidence demonstrated marked destruction of bone around the implants in the diabetic group. Both the control and the insulin-treated groups had a significantly higher bone density on radiograph than the diabetic group from the 1 week of the experiment (P<0.05 for each comparison). Conclusion: The present study revealed that the immediate placement of titanium implants in the maxilla of diabetic rat lead to delay in the maturation of bone adjacent to implants. It is expected that the reduced predictability of success of immediate implantation in patient with the uncontrolled diabetes.
구재량(Koo Jae Raeyang),김성휘(Kim Sung Hwi),고우식(Koo Woo Sik),이우광(Lee Woo Kwang),김연환(Kim Yeon Hwan),황재현(Hwang Jae Hyeon) 대한기계학회 2004 대한기계학회 춘추학술대회 Vol.2004 No.4
Amount of Electricity which product generator decide control valve at Turbine. Operating method of Control valve have two mode. First operating method is Partial Arc Admission, and second operating method is Full Arc Admission. Failure of Control Valve have on serious damage electricity lineage. In this Paper, We have investigated resonance that Control Valve spring casing.