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흰쥐 자궁과 부정소에서의 Luteinizing Hormone (LH) 유전자 발현
이성호,이영기,Lee, Sung-Ho,Lee, Young-Ki 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.2
Recent studies clearly demonstrated that the novel expression of LH gene in the rat testis, and suggested the local action of the LH-like molecule. The present study was performed to analyze the expression of LH genes in the rat accessory reproductive organs. Expression of LH subunit genes in the rat uterus and epididymis was demonstrated by reverse transcription-polymerase chain reaction (RT-PCR) and specific LH radioimmunoassay (RIA). The $LH_{beta}$ transcripts in these organs contained the published cDNA structure, the pituitary type exons 1-3, which encoded the entire $LH_{beta}$ polypeptide. Presence of the transcripts for the ${\alpha}$-subunit in the rat reproductive tissues were also confirmed by RT-PCR. In the LH RIA, significant levels of LH were detected in crude extracts from the rat ovary, uterus and epididymis. The competition curves with increasing amount of tissue extracts were parallel with those of standard peptide, indicating that the immunoreactive LH-like materials in these tissues are similar to authentic pituitary LH molecule. In rat epididymis, the highest amount of immunoreactive LH was detected in corpus area. Our findings demonstrated that the genes for LH subunits are expressed in the rat accessory reproductive organs, and suggested that these extrapituitary LH may act as a local regulator with auto and/or paracrine manner.
이성호,Lee, Sung-Ho 대한생식의학회 1996 Clinical and Experimental Reproductive Medicine Vol.23 No.3
Biosynthesis and secretion of anterior pituitary hormones are under the control of specific hypothalamic stimulatory and inhibitory factors. Among them, Growth Hormone Releasing Hormone (GHRH) is the major stimulator of pituitary somatotrophs activating GH gene expression and secretion. Human GHRH is a polypeptide of 44 amino acids initially isolated from pancreatic tumors, and the gene for the hypothalamic form of GHRH is organized into 5 exons spanning over 10 kilobases (kb) on genomic DNA and encodes a messenger RNA of 700-750 nucleotides. Several neuropeptides classically associated with the hypothalamus have been found in the extrahypothalamic regions, suggesting the existence of novel sources, targets and functions. GHRH-like immunoreactivity has been found in several peripheral sites, including placenta, testis, and ovary, indicating that GHRH may also have regulatory roles in peripheral reproductive organs. Furthermore, higher molecular weight forms of the GHRH transcripts were identified from these organs (1.75 kb in testis; 1.75 and >3 kb in ovary). These tissue-specific expression of GHRH gene suggest the existence of unique regulatory mechanism of GHRH expression and function in these organs. In fact, placenta-specific and testis-specific promoters for GHRH transcripts which are located in about 10 kb upstream region of hypothalamic promoter were reported. The use of unique promoters in extrahypothalamic sites could be refered in a different control of GHRH gene and different functions of the translated products in these tissues. Somatotrophs and lactotrophs have been thought to be derived from a common bipotential progenitor, the somatolactotrophs, which give origins to either phenotypes. Although the precise mechanism responsible for the lactotroph differentiation in the anterior pituitary gland has not been yet clalified, there are several candidators for the generation of lactotrophs. In human, the presence of GHRH peptides with different size from authentic hypothalamic form in the normal anterior pituitary and several types of adenoma were demonstrated. Recently our group found the existence of immunoreactive GHRH and its transcript from the normal rat anterior pituitary (gonadotroph> somatotroph> lactotroph), and the GHRH treatment evoked the increased proliferation rate of anterior pituitary cells in vitro. The transgenic mouse models clearly shown that GHRH or NGF overexpression by anterior pituitary cells induced development of pituitary hyperplasia and adenomas particularly GH-oma and prolactinoma. Taken together, we hypothesize that the pituitary GHRH could serve not only as a modulator of hormone secretion but as a paracrine or autocrine regulator of anterior pituitary cell proliferation and differentiation. Interestingly enough, the expression of Pit-1 homeobox gene (the POU class transcription factor) was confined to somatotrophs, lactotrophs and somatolactotrophs in which GHRH receptors are expressed commonly. Concerning the mechanism of somatolactotroph and lactotroph differentiation in the anterior pituitary, we have focused following two possibilities; (1) changes in the relative levels or interactions of both hypothalamic and intrapituitary factors such as dopamine, VIP, somatostatin, NGF and GHRH; (2) alterations of GHRH-GHRH receptor signaling and Pit-1 activity may be the cause of lactotroph differentiation or pituitary hyperplasia and adenoma formation. Extensive further studies will be necessary to solve these complicated questions.
이성호,Lee, Sung-Ho 한국식품영양학회 2012 韓國食品營養學會誌 Vol.25 No.4
청송약수가 가진 Ca, Mg 등의 풍부한 미네랄 성분을 면 제조에 이용하기 위한 기초연구를 하였다. 실험결과를 증류수와 수돗물을 이용한 면과 비교하였다. 약수로 제조한 면을 증류수로 조리한 실험 결과, 중량, 부피, 수분흡수율, 탁도, 명도(L)에서 가장 큰 값을 보였으며, 적색도(a)는 가장 큰 음의 값을 나타내었다. 이는 약수를 이용할 때에 증류수나 수돗물보다 더 큰 중량, 부피, 수분흡수율, 탁도, 명도를 가진 초록색을 띤 조리된 면을 만들 수 있었다. 분산분석 결과, 중량과 부피에서 증류수로 제조된 면과 유의한 차이를 보였으며, 수분흡수율, 탁도, 명도(L), 적색도(a), 황색도(b)에서 증류수, 수돗물로 제조된 면과 유의한 차이를 보였다. 또한 시판 칼국수의 조리에 약수를 이용한 결과, 중량과 적색도(a)에서 증류수, 수돗물로 조리된 면과 유의한 차이를 보였으며, 무게, 부피, 명도(L)에서 증류수로 조리된 면과 유의한 차이를 보였다. This is a basic study of Cheong-song mineral water, which has high contents of Ca and Mg for making noodles as well as for general cooking. The test results of the noodles manufactured and cooked with mineral water were compared to those manufactured and cooked with distilled water and tap water. Noodles manufactured with mineral water showed higher values than others in the cooked weight, volume, water absorption ability, turbidity, lightness (L) and redness (a) on the minus scale. This means that we can manufacture cooked noodles that have high weight, high volume, high water absorption ability and high lightness (L) along with a slight green color with Cheong-song mineral water. Cooked noodles manufactured with mineral water showed significant differences in the cooked weight and volume compared to those manufactured with distilled water. Also, cooked noodles manufactured with mineral water showed significant differences in moisture absorption, turbidity, lightness (L), redness (a) and yellowness (b) compared to those manufactured with distilled water and tap water. Commercial noodles cooked in mineral water showed significant differences in the cooked weight and redness (a) compared to those cooked in distilled water and tap water. Further, commercial noodles cooked in mineral water showed significant differences in weight, volume and brightness (L) compared to those cooked in distilled water.
Lee's 메뉴엔지니어링 분석법(LME)의 적용 - 이탈리아 피자류를 중심으로 -
이성호,Lee, Sung-Ho 한국식품영양학회 2020 韓國食品營養學會誌 Vol.33 No.1
The purpose of this study is an application of Lee's Menu Engineering (LME) method for menu analysis on the eight kinds of pizza selected from 17 kinds of pizza served by an Italian restaurant near by the Keimyung College University campus. The eliminated nine items were in the third quadrant or below the trend line. The LME method is more efficient than generally used methods such as the Miller, Kasavana & Smith, Uman, Pavesic and Merricks & Jones method. The LME method comprises reference lines and four quadrants created by x, y axes and its average values. The x and y axes comprise the sales ratio (MM%, percentage of the Menu Mix) and the weighted contribution margin (WCM%, percentage of the Weighted Contribution Margin) respectively. The obtained results are such that total sales increased by 1.59% from 58,747,200 won to 59,684,000 won, despite the decrease in sales volume. Total contribution margin also increased from 35,248,320 won to 35,810,400 won. The trend line also shows from y=0.9147x (R<sup>2</sup>=0.703) to y=0.9944x (R<sup>2</sup>=0.9893). These results indicate that the LME method is superior in practical applications.
나트륨 섭취량 추정을 위한 소변 중 Cl<sup>-</sup>의 간이적 측정방법의 유용성 검증
이성호,이채준,주성미,이현주,라왕연,김순옥,Lee, Sung-Ho,Lee, Chae-Joon,Ju, Sung-Mi,Lee, Hyun-Joo,Ra, Wang-Yeon,Kim, Soon-Ok 한국식품영양학회 2016 韓國食品營養學會誌 Vol.29 No.1
The purpose of this study was to measure concentrations of $K^+$, $Na^+$, $Cl^-$ by ionometer with check salt strip, simple salimeter and Ion-selective electrode (ISE) and compare the results of each mensuration; furthermore, the possibility of inferring the $Na^+$ concentration from $Cl^-$ concentration of urine and the impact of $K^+$ on the concentration of each ion was examined. The results showed that ISE determined $Na^+$ and $Cl^-$ concentrations in the urine are highly interrelated (R=0.9039); in addition, concentrations of $Cl^-$, measured with strip and ISE from urine are highly interrelated (R=0.9338). The concentration of $Na^+$ in urine, inferred by measuring $Cl^-$ concentration with strip, has a high relationship (R=0.8580) with the concentration of $Na^+$ in urine, measured by ISE. The results of our study will increase awareness of $Na^+$ intake and the utility of check salt strip, as well as the possibility of inferred $Na^+$ concentration from measures of $Cl^-$ concentration as a screening test for reducing sodium intake.
이성호,Lee, Sung-Ho 한국식품영양학회 2021 韓國食品營養學會誌 Vol.34 No.1
The purpose of this study is to measure the levels of eluted and dissolved CO2, and CO, volatile organic substances and radiation composition of Cheongsong mineral water which were collected from November 2019 to July 2020 during the autumn, spring, and summer seasons at collection points located in the upper, middle and lower spring waters. Data of the upper, middle and lower spring waters include the following: the amount of eluted water (average value±standard deviation, mL/min) was 30.07±0.52, 15.03±0.16, 23.73±0.42, and the amount of CO2 gas was 1,000 ppm or more. In addition, there was no detection of CO or total volatile organic substances (TVOC) and the radiation dose was 0.08 to 0.13. μSv/h. A blank test value of 0.08 to 0.10 μSv/h, when compared with the median value, showed a high value of 0.02 μSv/h, and the uranium test results provided by the Cheongsong-gun Office were 0.0118 mg/L (date 2019.06.18) and 0.0091 mg/L (date 2020.06.04.) respectively, which was less than the permission limit of 0.03 mg/L. However, it is believed that further research using more precise devices is needed in order to guarantee the safety and health of the water.
이성호,이요섭,김홍덕,이경수,황경모,Lee, Sung Ho,Lee, Yo Seob,Kim, Hong Deok,Lee, Kyoung Soo,Hwang, Kyeong Mo 한국압력기기공학회 2015 한국압력기기공학회 논문집 Vol.11 No.2
Local wall thinning and integrity degradation caused by several mechanisms, such as flow accelerated corrosion, cavitation, flashing and/or liquid droplet impingement, is a main concern in secondary steam cycle piping system of nuclear power plants in terms of safety and operability. Thinned pipe management program (TPMP) has being developed and optimized to reduce the possibility of unplanned shutdown and/or power reduction due to pipe failure caused by wall thinning. In this paper, newest technologies, standards and regulations related to the integrity assessment, repair and replacement of thinned pipe component are reviewed. And technical improvement items in TPMP to secure the reliability and effectiveness are also presented.
이성호,Lee, Sung-Ho 한국벤처창업학회 2012 벤처창업연구 Vol.7 No.1
본 연구는 벤처기업의 성과를 제고시키기 위하여 지식경영에 대한 지식중심문화와 협동학습의 영향을 파악하고자 문헌연구와 실증분석을 수행하였다. 지식이 경쟁우위의 핵심역량이 되어 가고 있는 지식경제하에서 기업 조직 성공의 관건은 지식경영을 선도할 구성원들의 자율성과 풍토가 마련된 가운데 효율적인 학습을 위한 협동적 분위기가 적실히 요구되고 있다. 실증분석 결과는 지식중심문화의 자율성과 조직풍토가 성과에 영향을 미칠 때 협동학습의 조절효과가 없었으며, 규모별 비교에서 중소벤처기업의 경우에는 조절변수인 협동학습이 성과에 유의적인 영향을 미치고 있었고, 대벤처기업의 경우에는 조절변수인 협동학습이 성과에 유의적인 영향을 미치고 있었으며, 조직풍토는 유의적인 영향을 미치고 있는 것으로 나타났다. This paper analyzes the relationships between knowledge-centered culture, learning process, and knowledge/learning outcomes. Knowledge management researches have emphasized the important role of a knowledge-centered culture in venture business. After a literature review, research model is developed and the research hypothesis is made. And then, the hypothesis is tested using regression analysis with data collected from venture firms. The results of the empirical study show that cooperative learning does not strengthen the knowledge outcomes on the autonomy and organizational climate of knowledge-centered culture.
Zig-Zag 결선 및 Open-Delta 방식을 이용한 새로운 고조파 저감장치의 개발
이성호,김기성,유상봉,Lee, Sung-Ho,Kim, Gi-Sung,Yoo, Sang-Bong 한국조명전기설비학회 2005 조명·전기설비학회논문지 Vol.19 No.1
지금까지의 고조파 필터는 중성선 리액터와 지그재그결선의 영상 고조파 전류를 제거하였으나, 부하율에 따라 고조파 저감율이 변하여 경부하에서는 고조파 저감율이 낮아지는 특성이 있고, 중성선 리액터 과열로 중성선 단선 위험의 문제가 발생하였다. 본 Zig-Zag 결선 및 Open Delta 방식을 이용한 새로운 고조파 저감장치(HANOS)는 Zig-Zag 결선의 Core Block내에 추가로 Open Delta 방식을 결선하여 중성선에 연결함으로써 중성선에 흐르는 영상 고조파 전류가 과열 없이 안전하게 제거되는 것을 시험 분석한 결과로 증명하였다. The conventional harmonic filters to reduce zero harmonic current from neutral reactors and Zig-Zag connection, have several disadvantages of the decreased reduction rate of harmonics under a light load, because they have the load factor-dependent reduction rate of harmonics, and the risk of potential breaking in the neutral line by heated neutral reactor. Based Zig-Zag connection and Open-Delta mode, this new harmonic eliminating device (HANOS) adopts the combination of Zig-Zag connection and Open-Delta mode-the latter is additionally applied to the transformer's core block for connection to the neutral line. The results of this study demonstrated that the new device could eliminate safely zero harmonic current running in the neutral line without heating.
이성호,Lee, Sung-Ho Korean Data and Information Science Society 1992 한국데이터정보과학회지 Vol.3 No.1
Some results relating to $C_{0}(R)\;and\;L^{1}(R)$ spaces with application to kernel density estimators will be introduced. First, random elements in $C_{0}(R)\;and\;L^{1}(R)$ are discussed. Then, complete convergence limit theorems are given to show that these results can be used in establishing uniformly consistency and $L^{1}$ consistency.