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손수정(Soo Jung Sohn),강현구(Hyun Gu Kang),이선우(Sun Woo Yi),서수경(Soo Kyung Suh),박인숙(In Sook Park),안미령(Mee Ryung Ahn),최홍석(Hong Seok Choi),조재민(Jae Min Cho),손동환(Dong Hwan Sohn),유태무(Tae Moo Yoo),양지선(Ji Sun Yang) 한국환경성돌연변이발암원학회 2001 한국환경성돌연변이·발암원학회지 Vol.21 No.2
4-tert-octylphenol (OP) is a surfactant additive widely used in the manufacture of a variety of detergents and plastic products. Also, OP is known to have estrogenic activity by interacting with development and functions of endocrine system. This study was carried out to obtain toxicokinetic parameters of OP in male<br/> Sprague-Dawley rats. Male rats were administered OP, by either single oral (gavage) applications of 50, 100 or 200 mg/kg body weight. or a single intravenous injections of 1, 5 or 10 mg/kg body weight. Blood samples taken at several time intervals after administration were obtained from the femoral artery. Analysis of blood samples for OP was performed by gas chromatography mass spectrometry (GC/MS). The detection limit of OP was 1.9 ng/ml at SIM (selected ion monitoring) mode of GC/MS. Calibration curve for analysis of the concentrations of OP in plasma was (OP/butylphenol peak area ratio) = 0.0294 × (plasma conc.) + 0.028 (r²= 0.9991). The OP plasma concentration was 3921 ng/ml immediately after single intravenous application, decreased rapidly within 45 min, and was detectable at low concentration up to 6 hr after application. When administered orally in rats (50, 100 and 200 mg/kg), OP was detected in the blood early after gavage administration, indicating the rapid initial uptake from gastrointestinal tract, with Tmax obtained from 0.67~0.83 hr. Using the AUC (area under the curve) of plasma concentration vs. time, low oral bioavailabilities of 1.2, 5.0 and 5.3% were calculated for the 50, 100 and 200 mg/kg groups, respectively.
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Curcumin이 microglia의 활성화에 미치는 영향
정기경(Ki Kyung Jung),이상진(Sang Jin Lee),이선우(Sun Woo Yi),강석연(Seog Young Kang),김태균(Tae Gyun Kim),강주혜(Ju Hye Kang),홍성렬(Sung Youl Hong),주일로(Ilo Jou),김승희(Seung Hee Kim),한형미(Hyung Mee Han) 대한약학회 2000 약학회지 Vol.44 No.5
Microglia, brain resident macrophages, play a central role in the inflammatory responses of the brain and are activated in brain injuries and several neurodegenerative diseases such as Alzheimer's and Parkinson's disease, thereby aggravating the course of these diseases. In this study, the effects of plant-derived compounds such as curcumin or gingerol on the microglial activation were examined. Microglial cultures were prepared from 2-3 week mixed primary glial cultures obtained from the cerebral cortex of 1-2 day old rats and identified by immunocytochemistry using microglial-specific antibody OX-42. Microglia were activated by lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) and the effect of curcumin or 6-gingerol on the microglial activation was examined. Specific parameters measured to monitor microglial activation were nitric oxide (NO), prostaglandin E2 (PGE2) and tumor necrosis factor-alpha (TNF-alpha) release. Curcumin (1-10mcM) inhibited NO release induced by LPS and IFN-gamma in a dose-dependent manner whereas 6-gingerol (2-20mcM) did not have any effect on LPS/IFN-gamma-induced NO release. The levels of PGE2 and TNF-alpha induced by LPS and IFN-gamma were also inhibited by 1-10pM curcumin in a dose-dependent manner. These results showed that curcumin could modulate microglial activation.
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공정단위장치로부터의 휘발성유기화합물질의 비산 배출량 산정
박영근,문정우,고민수,박현수,차순우,이선우,홍승철,김화용,이종협 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.3
공장내 설치되어 있는 수천개의 비산배출원으로부터 배출되는 VOCs의 양을 산정하기 위해서는 많은 비용과시간이 소요된다. 이러한 노력을 줄이기 위하여 전산모사방법을 이용하여 배출량을 예측하는 방법을 제시하였다. 예측된 값의 검증을 위하여 밸브, 플랜지 등의 비산배출원으로 구성되어 있는 실험장치를 고안하고 내부를 흐르는 유체의 종류 및 조건에 따른 배출량을 백포집법에 의해 샘플링하여 GC로 분석한 후, 분석된 데이터를 전산모사를 통해 얻은 결과와 비교하였다. 그 결과, 전산모사를 이용하여 밸브, 플랜지, 개방식라인으로부터 배출되는 벤젠과 톨루엔의 양을 예측할 수 있었다. Considerable effort and expense have been devoted to the estimation and acquisition of the amounts of VOCs relesed thousands of the fugitive emission sources installed in chemical processes. In order to reduce the effort required on the estimation of VOC release, a methodology using a computational fluid dynamics (CFD) was proposed. The estimated values were compared the experimental data obtained using a designed experimental apparatus that was composed of fugitive emission sources such as valves, pump, and flange. The emissions were sampling tedlar bags for a variety of volatile compounds at different pressures. The components were analyzed by a portable gas chromatograph. In conclusion, the amount of benzene and toluene released from fugitive emission sources could be successfully estimated using the CFD technique.
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고혈압치료제의 in vitro및 in vivo 이용률간의 상관성 연구(Ⅱ)
서수경,강현구,조재민,박인숙,안미령,이선우,최흥석,유태무,손수정,이용복,양지선 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-
의약풍이 생체내로 흡수되는_파정에서 생리학적 인자 및 제제학적 인자들에 의해 생체이용률이 달라져 약물의 흡수과정을 연구함으로써 약물의 생체이용률을 예측하는 것이 가능하다. 그러나 제제학적 측면에서 용출시험과 흡수과정인. 장관막 투과도 나아가서 생체이용률간의 띤구가 미흡한 상태이다. 따라서 약물의 흡수과정을 연구하벼 생체이용률을 예측하기 위하여 장관막 투과도 및 혈중농도사이의 상관관계를 예견할 수 있는 모델을 개발하고자 1999년도 연구사업으로 고혈압치료제중 베타-차단약 (아테놀올, 메토프롤올, 프라프라놀꼴)을 선택하여 웅출시험과 장관막 투과도계수를 측정하여 사람의 흡수을을 예측할 수 있는 장관막 투파도 모델을 확림하였고, 2000년도에는 계속사업으로서 각 약물에 대한 횐쥐에서의 생체이용를 파라메타를 측정하고 1999년도 연구사업결과에서 얻은 장관막 투과도 시험결과를 가지고 생체이용률과의 상관섞을 구하고자 하였다. 각 베타-차단약을 경구 및 정맥투여하고 시간별로 채혈한 후 분리한 혈장으로부터 각 약물에 대한 EfLC를 이용한 분석준건을 확지하여 혈중농도를 측정하고 생체이용률 파라메타(AUC, Cma, Tme, 등)를 구하였다. 횐쥐의 소장을 이용하여 diffusion chamber 법으로 측정한 장관막 투과도계수와 각 생체이용률 파라미터 사이의 상관성을 구찬 결과 양호한 상관관계를 보였다. 이와 같은 연구결과를 통하여 약물의 특성에 따라 동물의 장관막 투도. 모델을 이용하여 사람의 생체이용률도 예측할 수 있을 것으로 사료된다. A biopharmaceutics drug classification system for correlation f'H uf'fro dissolution and rH ui'ㄴo bio3vailabi3ity is proposed based on recognizing that drug dissolution andgastrointestinal permeability are the fundamental parameters controlling rate and extent of drugabsorption. The objective of this stud)· was to assess whether partition coefficient and intestinalPermeabilit)'can be rorrelateo with l'H vluo bioalFaifability. Beta-blockers were administeredorall? and intrauenousl)· to rats and pkarrnacokinetlc parameters were calculated. The goodcorre)ations between fermeability and log P (n~octanol/buffer) was demonstrated in previous ratexpenments performed in our laboratory. In this study, good correlations were obseFYedbetuTeen panitlon coefficient and permeabilit)·· or I'n ui'vo bioayilability These resuats indiEatethat rat intestinal perme3bilit3T model couBd be used to predict intestinal absorption ofbeta-blockeTs f'H uiuo.
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