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혼성 Bivalent Ligand 퀴놀론 유도체의 합성
이상필,임채욱,김동순,임철부,Lee, Sang-Pil,Im, Chae-Uk,Kim, Dong-Soon,Yim, Chul-Bu 대한약학회 1994 약학회지 Vol.38 No.6
Eighteen new hybrid bivalent ligand quinolones that contain two different type of pharmacophores in a single molecule were prepared and evaluated for in viかo antibacterial activity. Hybrid bivalent ligands p-nitrobenzyloxycarbonyl quinolones were prepared by the treatment of active esters of succinyl fluoroquinolones with 1,7-disubstituted fluoroquinolone carboxylic acids in DMF. Eighteen final quinolone carboxylic acids were obtained by the reduction of compounds $25{\sim}42$ with hydrogen in the presence of 10% Pd-C. Among these derivatives, compound[56] showed the most potent antibacterial activity against a wide range of microoranisms.
한국인의 외국어 발화오류 검출을 위한 음성인식기의 발음 네트워크 구성
이상필,권철홍,Lee Sang-Pil,Kwon Chul-Hong 대한음성학회 2004 말소리 Vol.49 No.-
An automatic pronunciation correction system provides learners with correction guidelines for each mispronunciation. In this paper we propose an HMM based speech recognizer which automatically classifies pronunciation errors when Koreans speak Japanese. We also propose two pronunciation networks for automatic detection of mispronunciation. In this paper, we evaluated performances of the networks by computing the correlation between the human ratings and the machine scores obtained from the speech recognizer.