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COVID-19로 인해 발생한 업무의 피로도와 직무소진의 상관관계 및 직무스트레스와의 회귀분석 연구 -물리치료사를 대상으로-
이상열,최수홍,김인균,오강오,윤성영,석힘,허재석,Lee, Sang-Yeol,Choi, Su-Hong,Kim, In-Gyun,Oh, Kang-O,Yoon, Sung-Young,Seok, Him,Heo, Jae-Seok 대한고유수용성신경근촉진법학회 2021 PNF and Movement Vol.19 No.2
Purpose: This study was conducted to investigate the type of physical therapist response work and its intensity, along with the prolonged prevalence of COVID-19, to determine the impact on physical therapists' occupational stress and occupational burnout. Methods: An online survey was conducted with 118 physiotherapists and collected the participants' gender, final educational background, clinical work experience, workplace type, additional workload, and fatigue associated with COVID-19. After excluding one participant who submitted an incomplete questionnaire, 117 respondents were included in the final data. Results: Additional COVID-19-related workloads and response reliability for fatigue, occupational burnout, and occupational stress were shown to have Cronbach's alpha measures of 0.76, 0.89, and 0.87, respectively. Groups who had experienced a new epidemic in the past showed higher fatigue levels (3.06±0.94) than those groups who had no such experience (2.49±0.84; p < 0.05). Correlation analysis of COVID-19 work fatigue and occupational burnout scales showed a positive correlation (r = 0.19; p < 0.05). The regression of occupational burnout and occupational stress showed a regression model of Y = 20.00+0.43X<sub>1</sub> (X<sub>1</sub>: job stress; p< 0.05) and an explanatory power of 24.8% with an adj.R<sup>2</sup> = 0.25. Conclusion: Based on the results, it is suggested that various institutions, such as medical institutions, educational institutions, and physiotherapists' associations, should seek ways to manage and alleviate physiotherapists' stress.
H2-M3의 세포 표면 발현이 NK 세포의 활성에 미치는 영향 분석
이상열,전태훈,Lee, Sang-Yeol,Chun, Tae-Hoon 대한약학회 2009 약학회지 Vol.53 No.3
H2-M3 (M3) is a unique antigen presenting molecule which provides N-formylated peptide to certain type of T cells. Previous observation indicated that NK cell activity is significantly diminished during listerial infection in $H2-M3^{-/-}$ mice. To explore the possibility that M3 expression directly effect on NK cell activity, we measured NK cell activity with or without stimulation of N-formylated peptide on antigen presenting cells. Results indicated that the expression of M3 is not directly influence on NK cell activity. Further study will be focused on the indirect effect of M3 on regulating NK cell activity.
Purification and Biochemical Characterizations of Calmodulin from Bovine Brain
이상열,권헌영,김정희,이서구,Lee, Sang-Yeol,Kwon, Heun-Young,Kim, Jung-Hye,Rhee, Sue-Goo 생화학분자생물학회 1990 한국생화학회지 Vol.23 No.2
세포내에서 칼슘이 작용하는 반응을 조절하는 calmodulin 단백질을, 소의 뇌로부터 순수 분리하여 여러 가지 생화학적 성질을 연구하였다. 이것은 칼슘의 존재하에서 분자량이 15,000으로 나타나고, 칼슘을 제거한 상태의 분자량은 21,000으로 나타남으로써, 칼슘이 calmodulin에 결합하여 단백질의 3차원적 구조에 상당한 변화를 유발시킨다는 사실을 알 수 있었다. 또한 자외선스팩트럼을 조사해본 결과 259, 265, 279 nm의 세 군데에서 최대 흡수 peak가 나타났는데, 이것은 calmodulin 단백질의 아미노산 조성 중 tryptophan이 존재하지 않으므로 인하여, phenylalanine과 tyrosine의 흡광도에 의한 영향으로 생각된다. 또한 칼슘과 calmodulin 농도를 변화시키면서, Ins(1, 4, 5) $P_3$-Kinase의 효소 활성도를 측정하여 본 결과, $6{\mu}M$ calmodulin이 효소반응용액에 존재할 경우 이들을 첨가하지 않은 때에 비하여 최대 7배까지의 효소 활성도를 증가시켰다. 이러한 실험 결과로부터, 최적 농도의 $Ca^{2+}$/calmodulin 복합체는 기질과 반응하기에 부적합한 구조의 target 효소와 결합하여, 활동적이고 반응하기에 매우 좋은 조건의 구조를 갖는 효소로 바꾸어 줌으로써 생체내의 반응조절에 중요한 역할을 한다는 사실을 알 수 있었다. Calmodulin, a heat stable $Ca^{++}$-binding protein, is a multifunctional modulator, mediating many of the $Ca^{++}$ effects in cellular functions. This protein interacts reversibly with $Ca^{++}$ to form a protein/$Ca^{++}$ complex, whose activity is regulated by cellular flux of $Ca^{++}$. Calmodulin from bovine brain was purified to complete homogeneity by heat, acid treatment and hydrophobic interaction chromatography. The biochemical properties of the purified protein were examined under various criteria. It was estimated to have an apparent molecular weight of 21K and 15K in the absence or presence of $Ca^{++}$ respectively, which would mean the great conformational changes were induced by the binding of $Ca^{++}$ to calmodulin. The calmodulin had distinct ultraviolet absorption peaks at 259, 265, and 279 nm due to phenylalanine and tyrosine residues. Also, this protein activated the Ins(1,4,5) $P_3$-Kinase of which role is very important in cellular signal transduction, about seven folds (at $6{\mu}M$ $Ca^{++}$ and $1.0{\mu}M$ calmodulin) with a $Ca^{++}$-dependent manner.
이상열,Lee, Sang-Yeol 대한물리치료과학회 2015 대한물리치료과학회지 Vol.22 No.1
Purpose : The purpose of this study is to introduce the necessity of introduction and to proposal the methods of introduce for animal physical therapy in Korea. Method : This study is a literature study with books, article and the information through every route for introduction of animal physical therapy in Korea. Results : Animal physical therapy should be introduced to Korea with global trend. For this, it should be need academic exchanges of veterinary and physiotherapy. And there is an urgent need for an educational framework and an institutional framework. And physiotherapist requires preparation and understanding of the animal anatomy. Conclusion : There is an urgent need for an animal physical therapy to welfare and medical benefit of Korean animal companion. The physiotherapist should be prepare educational framework, institutional framework and clinical strategy.