염증성 거짓 종양으로 오인된 간 내 발생한 원시신경외배엽종양

이상구,김지은,이지혁,이혜진,이종승,이지현,최연호,Lee, Sang-Goo,Kim, Ji-Eun,Lee, Ji-Hyuk,Lee, Hye-Jin,Lee, Jong-Seung,Lee, Jee-Hyun,Choe, Yon-Ho 대한소아소화기영양학회 2008 Pediatric gastroenterology, hepatology & nutrition Vol.11 No.2

저자들은 발열과 복부 통증을 주소로 내원한 13세 남자 환자에서 염증성 거짓 종양으로 오인된 간 내 원시신경 외배엽 종양 1예를 경험하였으며 문헌고찰과 함께 보고하는 바이다. Primary primitive neuroectodermal tumor (PNET) of the liver is a rare disease with aggressive behavior and poor prognosis. We report a case of a PNET of the liver in a 13-year-old boy. The patient was admitted to the hospital with fever and abdominal pain. Abdominal CT and MRI revealed a 5.5 cm sized, septated, non-enhancing mass in the hepatic hilum. The patient was initially diagnosed with an inflammatory pseudotumor. Despite 9 days of antibiotic therapy, the patient's clinical symptoms did not improve. A liver biopsy was performed in the interest of formulating a differential diagnosis. This procedure revealed tumor cells positive for CD99 on immunohistochemistry. The patient was diagnosed with a PNET.

Influences of Peroxidase on Lysozyme Activity

이상구,김형일,고홍섭,Lee, Sang-Goo,Kim, Hyung-Il,Kho, Hong-Seop Korean Academy of Orofacial Pain and Oral Medicine 2008 Journal of Oral Medicine and Pain Vol.33 No.1

It is well known that many antimicrobial proteins in saliva interact with each other. The purpose of the present study was to investigate the interactions of lysozyme with peroxidase in the aspects of enzymatic activity in vitro. The interactions of lysozyme with peroxidase were examined by incubating hen egg-white lysozyme(HEWL) with bovine lactoperoxidase(bLP). The influence of peroxidase system on lysozyme was examined by subsequent addition of potassium thiocyanate and hydrogen peroxide. Lysozyme activity was determined by turbidity measurement of a Micrococcus lysodeikticus substrate suspension. Peroxidase activity was determined with an NbsSCN assay. The Wilcoxon signed rank test was used to analyze the changes of enzymatic activities compared with their controls. bLP at physiological concentrations enhanced the enzymatic activity of HEWL(P < 0.05) and its effect was dependent on the concentration of peroxidase. However, HEWL did not affect the enzymatic activity of bLP. Thiocyanate did not affect the enzymatic activity of HEWL, either. The addition of potassium thiocyanate and hydrogen peroxide did not lead to additional enhancement of the enzymatic activity of HEWL. The changes of hydrogen peroxide concentration in the peroxidase system did not affect the enzymatic activity of HEWL. Collectively, despite an in vitro nature of our study, the results of the present study provide valuable information on the interactions of lysozyme and peroxidase in the aspects of enzymatic activity in oral health care products and possibly in the oral cavity.

소아 복막 투석 환자에서 발생한 복막염의 경험적 항생제 치료에 관한 연구

이상구,조중범,손영배,박성원,김수진,진동규,백경훈,Lee, Sang-Goo,Cho, Joong-Bum,Sohn, Young-Bae,Park, Sung-Won,Kim, Su-Jin,Jin, Dong-Kyu,Paik, Kyung-Hoon 대한소아신장학회 2008 Childhood kidney diseases Vol.12 No.2

목 적 : 최근 소아 복막염에서 methicillin에 대한 저항성을 갖는 균주가 증가하고 있어서 the International Pediatric Peritonitis Registry(IPPR) 가이드라인에 따른 초치료 경험적 약제의 선택의 효용성에 대해서 논란이 되고 있다. 본 연구에서는 소아에서 발생한 복막염을 중심으로 ISPD 가이드라인을 따른 경험적 항균제 선택의 치료 효과적 유용성을 분석하였다. 방 법 : 2001년 1월부터 2007년 12월까지 7년간 삼성 서울 병원에서 복막 투석을 받은 경험이 있는 환자들을 대상으로 복막염을 일으킨 원인 균의 미생물학적 특성과 ISPD 가이드라인에 따라서 복막염을 치료 했을 때의 임상적 경과 등에 대해서 의무 기록을 후향적으로 조사하였다. 결 과: 복막 투석을 받은 42명의 환자 중, 21명에서 48례의 복막염이 발생하였다. 복막염 발생율은 one episode over 35.3 patient-months였으며, 복막염 발생 전까지의 평균 투석 기간은 18.06$\pm$15.81개월이었다. 그람 양성균에 의한 복막염이 전체의 58.3%를 차지하였으며, 이중 S. aureus와 coagulase negative staphylococcus가 가장 많았다. 동정된 그람 양성균들 중 35.7%는 1세대 cephalosporin에 저항성을 보였으나 4세 이하의 환자에서는 50%가 저항성을 보였다. 그람 음성균 중에서는 E. coli가 가장 많았다. 동정된 모든 균들은 현재 사용중인 1세대 cephalosporin과 ceftazidime의 병합 요법에 64.8%가 감수성을 보였다. 결 론: 국내 소아 복막 투석 환자에서 발생한 복막염에서 경험적 항생제 초치료로 현재 사용중인 1세대 cephalosporin과 ceftazidime의 병합 요법은 여전히 효과적이다. 그러나 4세 미만의 환자에서는 경험적 항생제 초치료로 1세대 cephalosporin 대신 glycopeptide를 사용하는 것이 더 효과적일 것으로 생각된다. Purpose : This study aims to verify the effectiveness of initial empirical antibiotic choice recommended by the International Society for Peritoneal Dialysis(ISPD) guide among Korean children. Methods : We have collected data on peritonitis from January 2001 to December 2007 in Samsung Medical Center. Results : Of the 42 patients, 48 episodes of peritonitis had occurred in 21 patients. The rate of peritonitis was one episode over 35.3 patient-months. Mean dialysis duration before peritonitis was 18.06$\pm$15.81 months. Gram-positive organisms accounted for 58.3% of all episodes. Of the gram-positive organisms, the most common pathogen was Staphylococcus aureus(29.2%), the next common pathogens were Coagulase negative staphylococcus(14.6%) and Streptococcus species(6.3%). 35.7% of gram-positive pathogens were resistant to 1st cephalosporin. However, in patients younger than 4 years old, 50% of gram-positive pathogens were resistant to 1st generation cephalosporin. 10 episodes of peritonitis were methicillin-resistant and were treated by vancomycin. Of the gram-negative organisms, E. coli was the most common (8.3%). 64.8% of all pathogens were sensitive to cephalothin or ceftazidime. Conclusion : The empirical therapy with 1st generation cephalosporin and ceftazidime can be also effective to peritoneal dialysis associated peritonitis in Korean children. However, in patients younger than 4 years old, glycopeptide should be considered as the first empirical therapy in Korean children.

Influences of Animal Mucins on Peroxidase Activity in Solution and on the Surface of Hydroxyapatite

이상구,전은형,고홍섭,Lee, Sang-Goo,Jeon, Eun-Hyoung,Kho, Hong-Seop Korean Academy of Orofacial Pain and Oral Medicine 2008 Journal of Oral Medicine and Pain Vol.33 No.3

Animal mucins have structural characteristics similar to human salivary mucins. Animal mucins have been regarded as suitable substances for saliva substitutes. Since animal mucin molecules in saliva substitutes and host-derived antimicrobial salivary molecules exist simultaneously in whole saliva and the pellicles of patients with dry mouth, interactions may occur between these molecules. The purpose of this study was to investigate the influence of animal mucins on peroxidase activity in solution and on the surface of hydroxyapatite(HA) surfaces. The effects of animal mucins on peroxidase activity were examined by incubating porcine gastric mucin(PGM) or bovine submaxillary mucin (BSM) with either bovine lactoperoxidase(bLPO) or saliva samples. For solid-phase assays, immobilized animal mucins or peroxidase on three different HA surfaces(HA beads, HA disc, and bovine tooth) were used. Peroxidase activity was determined with an NbsSCN assay. The obtained results were as follows: 1. PGM enhanced the enzymatic activity of bLPO in solution phase. PGM did not affect the enzymatic activity of peroxidase in saliva sample(POS). 2. BSM did not affect the enzymatic activities of both bLPO and POS in solution phase. 3. HA-adsorbed PGM increased subsequent bLPO adsorption in all three HA phases. The activity of POS was increased on both the HA beads and bovine tooth. 4. The peroxidase activities on the HA beads and disc were increased when the HA surfaces were exposed to a mixture of bLPO and PGM. 5. The binding affinity of bLPO to PGM was greater than that of bLPO to BSM. Collectively, our results suggest that animal mucins affects the enzymatic activity of peroxidase on the HA surfaces as well as in solution. Saliva substitutes containing animal mucins may affect the function of antimicrobial components in natural saliva and saliva substitutes.

온실가스 감축 제도 및 아산화질소 감축 배출권 현황과 전망

이상구(Sang Goo Lee),하종욱(Jong-Wook Ha),박인준(In Jun Park),김정훈(Jeong-Hoon Kim),손은호(Eun-Ho Sohn),이수복(Soo-Bok Lee) 한국에너지기후변화학회 2017 에너지기후변화학회지 Vol.12 No.2

The important contents of Kyoto mechanism for greenhouse gas emission reduction, and of Korean Greenhouse Emission Trading System and certification method of offset credits were investigated and summarized. High revenue from the sale of CDM certified emission reduction of nitrous oxide from adipic acid production caused the carbon leakage which could not lead to the substantial emission reduction of nitrous oxide. Therefore, European Commission prohibited the use of the international credit for CDM project of nitrous oxide reduction in adipic acid production in EU ETS as of Jan. 1, 2013. It is prospected that the certificated emission reduction of nitrous oxide in adipic acid production will not be permitted in the future. The CDM certificated emission reduction of nitrous oxide in nitric acid production and caprolactam production will be consistently permitted in the future. Additional certificated emission reduction may not be occurred in domestic nitric acid production and caprolactam production because the certificated emission reductions in all domestic production have been issued. In the future, the technologies for emission reduction in nitrous oxide production and semiconductor and LCD production where nitrous oxide is used as an oxidizer will be expected to be developed and there certified emission reduction will be issued at home and abroad.

지능형 멀티미디어 교육 시스템의 교수 모델과 학습자 모델

이상구(Sang-goo Lee),정재헌(Jae-heon Cheong) 한국정보과학회 1995 정보과학회논문지 Vol.22 No.7

사용자와의 다양한 상호 작용과 다양한 매체를 특징으로 하는 멀티미디어 응용 프로그램은 특히 교육/훈련을 위한 시스템에 많이 적용되고 있는데 이러한 시스템에서의 가장 큰 문제점은 다양한 사용자(학습자) 수준에 따른 차별적인 교육/훈련이 이루어지지 못한다는 것이다. 본 논문에서는 학습자의 수준에 따른 교육 능력을 갖춘 새로운 교수 모델을 제안한다. 이 모델은 학습 시나리오를 비순환 방향 그래프로 표현하므로 써 교육과정의 계층적이며 순차적인 특성을 그대로 모델할 수 있다. 또한 이 교수 모델에 근거하여 각 학습자의 수준을 동적으로 평가 조절할 수 있는 학습자 모델도 제안하며 학습자와의 상호작용에 의해 학습자의 이해도를 전체 모델에 반영하는 방법이 제안된다. Multimedia systems have been widely accepted as the vehicle for computer aided instruction systems. However, most applications lack the ability to vary its instruction scenarios according to each user′s comprehension level. We propose in this paper a new instruction model capable of supporting such variations. The model represents the instruction scenario as a directed acyclic graph (DAG) which allows the modeling of hierarchical and sequential semantics of the scenario. We also propose a student model, which is based on our instruction model, where dynamic evaluation of student′s performance is possible.

관광상품의 지각된 가치가 관광만족에 미치는 영향과 한류의 조절효과

이상구 ( Sang Goo Lee ),홍재욱 ( Jae Wook Hong ) 한국문화관광학회 2012 문화관광연구 Vol.14 No.1

The primary purpose of this study was to examine the effect of perceived values of tourist products on customer satisfaction. It also aimed to demonstrate the moderating effect of Hanryu on the relationship between perceived values and customer satisfaction. Further more, this study made an effort to discover which type of Hanryu, Korean drama/movie or Korean pop music, had more influence on this relationship. First of all, perceived values had a significant effect on customer satisfaction. Specifically emotional values of tourist products had stronger influence on customer satisfaction than functional values. However, when the degree of liking Hanryu was put in as a moderating variable, functional values had greater effect on customer satisfaction than emotional values. Moreover, regardless of the type of Hanryu preferred between Korean drama/ movie and Korean pop music, functional values had greater influence on customer satisfaction than emotional values, thus partly supporting the hypothesis. Implications and limitations of this study were discussed.

창동 창업 및 문화산업단지 구조설계

이상구 ( Lee Sang Goo ),위성현 ( We Sung Hyun ) 한국복합신소재구조학회 2021 복합신소재학회논문집 Vol.12 No.1

학술발표회 초록 ( 재료 (4) ) : 침전성 탄산칼슘 결정 성장에 미치는 액상 교반속도 효과

이상구(Sang Goo Lee),최창균(Chang Kyun Choi),김우식(Woo Sik Kim) 한국화학공학회 1994 추계학술발표회 Vol.- No.-

아민기로 관능화된 Poly(glycidyl methacrylate) 다공성 입자를 활용한 수용액 중 불화수소의 제거

이상구(Sang Goo Lee),하종욱(Jong-Wook Ha),박인준(In Jun Park),이수복(Soo-Bok Lee),손은호(Eun-Ho Sohn) 한국고분자학회 2016 폴리머 Vol.40 No.4

아민 화합물로 관능화된 고분자 입자를 합성하고 이를 수용액에 포함되어 있는 불화수소의 제거에 활용하였다. 다공성의 고분자 입자는 glycidyl methacrylate와 trimethylolpropane trimethacrylate 단량체를 톨루엔과 함께 현탁중합하여 제조하였으며 ethylamine을 이용하여 관능화하였다. 불화수소 제거 효율, 흡착평형, 흡착속도 등에 관한 실험을 수행하였으며, 제조된 고분자 입자는 Qe=55 mg/g 이상의 불화수소 흡착 용량을 보였다. 제조된 고분자 입자를 사용하면 acid retardation 효과에 의해 알칼리 금속불화물과 불화수소의 혼합물 수용액으로부터 불화수소를 선택적으로 제거할 수 있어 알칼리 금속불화물의 정제 공정에 적용할 수 있음을 확인하였다. In this study, the amine-functionalized macroporous polymer microspheres are applied to the removal of HF from aqueous solution. Macroporous polymer microspheres were prepared by suspension polymerizations of glycidyl methacrylate and trimethylolpropane trimethacrylate. Toluene was used as a diluent in order to make microspheres porous. These microspheres were functionalized using ethylamine. HF removal efficiency, adsorption equilibrium, and adsorption kinetics were considered experimentally. The resulting polymeric microspheres showed a high capacity for HF removal, more than Qe = 55 mg/g. Finally, the amine-functionalized microspheres were utilized in the purification of metal fluoride via acid retardation.