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비 카세트 방식과 카세트 방식을 이용한 [<sup>68</sup>Ga]PSMA-11의 자동 합성 방법 비교
박현식,조병민,안현호,이홍진,이진형,이경재,이병철,이원우,Hyun-Sik, Park,Byeong-Min, Jo,Hyun-Ho, An,Hong-Jin, Lee,Jin-Hyeong, Lee,Gyeong-Jae, Lee,Byung-Chul, Lee,Won-Woo, Lee 대한핵의학기술학회 2022 핵의학 기술 Vol.26 No.2
Purpose [<sup>68</sup>Ga]PSMA-11 is needed the high reproducibility, excellent radiochemical yield and purity. In term of radiation safety, the radiation exposure of operator for its production also should be considered. In this work, we performed a comparative study for the fully automated synthesis of [<sup>68</sup>Ga]PSMA-11 between non-cassette type and cassette type. Materials and Methods Two different type of modules (TRACERlab FX N pro for non-cassette type and BIKBox for cassette type) were used for the automated production of [<sup>68</sup>Ga]PSMA-11. According to the previously identified elution profile, Only 2.5 ml with high radioactivity was used for the reaction. After adjusting the pH of the reaction solution with HEPES buffer solution, the precursor was added and reacted with at 95 ℃ for 15 minutes. The reaction mixture was separated and purified using a C18 light cartridge. The product was eluted with 50% EtOH/saline solution and diluted with saline. It was completed by sterilizing filter. In the non-cassette type, the aforementioned process must be prepared directly. However, in the cassette method, synthesis was possible simply by installing a kit that was already completed. Results Both total [<sup>68</sup>Ga]PSMA-11 production time were 25±3(non-cassette type) and 23±3 minutes(cassette type). The radiochemical yield of the non-cassette type(65.5±5.7%) was higher than that of the cassette type(61.6±4.8%) after sterilization filter. The non-cassette type took about 120 minutes of preparation time before synthesis due to washing of synthesizer and reagent preparation. However, since the cassette type does not require washing and reagent preparation, it took about 20 minutes to prepare before synthesis. Both type of synthesizer had a radiochemical high purity(>99%). Conclusion The non-cassette type production of [<sup>68</sup>Ga]PSMA-11 showed higher radiochemical yield and lower cost than the cassette type. However, The cassette type has an advantage in terms of preparation time, convenience, and equipment maintenance.
김강민,이병철,한인우,윤태석,Kim, Kang-Min,Lee, Byeong-Chul,Han, In-Woo,Yoon, Tae-Seog 한국천문학회 2003 天文學論叢 Vol.18 No.1
We tested the characteristics of the newly made Long Slit Spectrograph (LSS) of the BOAO which replaced the Medium Dispersion Spectrograph (MDS) in the year of 2003. Performance test results on the spectrogram shift by gravity direction variation, slit illumination function, efficiency and the precision of the radial velocity measurements show the capabilities of the LSS are much improved in every respect comparing with those of the MDS.
박성호,이국행,이병철,이명철,최익준,Park, Sung Ho,Lee, Guk Haeng,Lee, Byeong Cheol,Lee, Myung Chul,Choi, Ik Joon 대한두경부종양학회 2015 대한두경부 종양학회지 Vol.31 No.2
목적 : 국소 재발한 진행된 갑상선 유두암의 치료로 수술 후 외부방사선의 역할을 알아보고자 하였다. 대상 및 방법 : 원자력병원에서 2000년 1월부터 2012년 2월까지 사이버나이프 혹은 외부방사선 치료를 받은 수술과 방사선요오드 치료 후 국소 재발한 진행된 갑상선 유두암 환자 13 명을 대상으로 하였다. 경과관찰 기간 동안 국소 및 부위 재발이 발생환 환자는 6 명이었다. 몇몇의 위험인자를 찾기 위해서 Kaplan-Meier method와 log-rank test를 이용하여 성별, 종양단계, 방사선 치료 전 수술 횟수, 방사선요오드치료 횟수, 수술 후 잔존 암의 여부, 원격전이에 대해 단변량 분석하였다. 결과 : 방사선 치료 후 평균 추적관찰기관은 53.8개월(범위, 36 ~ 108개월)이고 그중 남자는 4 명이었다. 1년, 2년의 무진행 생존률은 각각 76.9와 53.8%였다. 단병량 분석은 성별과 잔존 암여부(p = 0.0475 and p = 0.0475, 각각)에 따라 무진행 생존률이 진행한 그룹과 진행하지 않은 그룹 사이에 유의한 차이가 있다는 것을 보여줬다. 결론 : 외부 방사선 치료 전에 잔존 암이 없었던 환자의 100%에서 국소 및 부위 재발이 일어나지 않았다. 외부방사선 치료는 수술과 방사선요오드 치료에 반응하지 않는 환자 중 수술 후 잔존 암이 없는 경우에 효과적인 치료 방법이 될 수 있다.
이동준 ( Dong Jun Lee ),이지민 ( Ji Min Lee ),금동혁 ( Dong Hyuk Kum ),박윤식 ( Youn Shik Park ),정영훈 ( Young Hun Jung ),신용철 ( Young Chul Shin ),정교철 ( Gyo Cheol Jeong ),이병철 ( Byeong Cheol Lee ),임경재 ( Kyoung Jae Li 한국물환경학회 2014 한국물환경학회지 Vol.30 No.6
Soil erosion from agricultural fields leads to various environmental problems weakening the capabilities of flood control and ecosystem in water bodies. Regarding these problems, Ministry of Environment of South-Korea prepared various structural and non-structural best management practices (BMPs) to control soil erosion. However, a lot of efforts are required to monitor and develop BMPs. Thus, modeling techniques have been developed and utilized for these issues. This study estimated the effectiveness of BMPs which are a vegetation mat with infiltration roll and Roll type vegetation channel using Soil and Water Assessment Tool(SWAT) model through the adjustment of the conservation practice factors, P factors, for Universal Soil Loss Equation which were calculated by monitoring data collected at the segment plots. Each BMP was applied to the areas with slopes ranged from 7% to 13% in the Haeanmyeon watershed. As a result of simulation, the vegetation mat with infiltration roll and Roll type vegetation channel showed 55% and 59% efficiency of soil erosion reduction, respectively. Also, Vegetation mat with infiltration roll and Roll type vegetation channel showed each 11.2% and 11.8% efficiency in reduction of sediment discharge. These roll type vegetation channel showed greater efficiency of soil erosion reduction and sediment discharge. Based on these results, if roll type vegetation channel is widely used in agricultural fields, reduction of soil erosion and sediment discharge of greater efficiency would be expected.