각막 간질내 공기 주입과 평형염액 주입이 간질세포 자멸사에 미치는 영향 비교

이민정,이현주,위원량,이진학,김미금,Min Joung Lee,M,D,Hyun Ju Lee,Won Ryang Wee,M,D,Jin Hak Lee,M,D,Mee Kum Kim,M,D 대한안과학회 2007 대한안과학회지 Vol.48 No.4

Purpose: To evaluate the effects of intrastromal air injection and intrastromal balanced salt solution (BSS) injection on corneal keratocyte apoptosis. Methods: Twelve right eyes of New Zealand White rabbits were divided into an air-injected group (n=6) and a hydro-injected group (n=6). Contralateral eyes served as a control. Air or Balanced salt solution (BSS?, Alcon, USA) was injected into the deep corneal stroma at the paracentral area to propagate into nearly the entire cornea. To reduce the intraocular pressure, anterior chamber paracentesis was performed. The animals were sacrificed 4 hours (n=6) and 24 hours (n=6) after surgery. Central cornea buttons were retrieved to stain with Hematoxylin & Eosin and TUNEL (Apoptag?, Chemicon). The mean number of apoptotic keratocytes was counted in 24.67±4.04 consecutive high power field (HPF). Results: The mean number of TUNEL-positive cells at 4 hours was 12.85±7.25/HPF and 0.25±0.44/HPF in air-injected and hydro-injected eyes, respectively. It was reduced to 6.25±4.02/HPF and 0.15±0.37/HPF in air-injected and hydro-injected eyes after 24 hours. The air-injected group showed significantly more TUNEL-positive cells compared with the hydro-injected or control group until 24 hours (p=0.001, p=0.001, Mann-Whitney U test). Conclusions: Intrastromal air injection induces significant apoptosis of keratocytes suggesting some damages in the peripheral cornea when used in deep lamellar keratoplasty.

거짓비늘증후군에 동반된 단독 섬모체망막동맥폐쇄 1예

이민정,박영걸,안재균,Min Joung Lee,Yeoung Geol Park,Jae Kyoun Ahn 대한안과학회 2006 대한안과학회지 Vol.47 No.10

Purpose: To report a case of isolated cilioretinal artery occlusion associated with pseudoexfoliation syndrome. Methods: A 66-year-old female presented with acute vision loss of the right eye. Three months prior, she had been diagnosed as having pseudoexfoliation glaucoma of both eyes, and the intraocular pressure of both eyes had been well-controlled with topical medication. Results: The presenting visual acuity in her right eye was 20/100. Fundus examinations showed sectoral retinal whitening on superior macula. Fluorescein angiography revealed delayed filling of the cilioretinal artery, consistent with cilioretinal artery occlusion. No significant findings were identified by carotid doppler examination or echocardiography. After 8 weeks, retinal changes were completely resolved with improvement of her right vision to 20/25. Conclusions: Isolated cilioretinal artery occlusion may develop as an intraocular manifestation of pseudoexfoliation syndrome.

한약 단독 치료로 호전된 소양인 환자의 도한 : 후향적 증례보고 6례

이민정,이지연,황민우,Lee, Min-jung,Lee, Jiyeon,Hwang, Min-woo 사상체질의학회 2021 사상체질의학회지 Vol.33 No.3

Introduction This study is the first to report a significant improvement of Soyangin patients with persistent night sweats through herbal medicine treatment. Methods We reviewed the total of 6 Soyangin patients with moderate to severe persistent night sweats who visited the outpatient clinic. The patients received herbal medicine treatment alone for 4 to 9 weeks. We evaluated the treatment outcome using Night Sweats Degree criteria, developed by Lea and Aber(1985), every other 2 to 4 weeks. In addition, we recorded the treatment period from the first visit to symptom alleviation. Results Persistent night sweats improved significantly in all 6 Soyangin patients, and 4 out of 6 patients had better sleep quality after the treatment. It took 1 to 3 weeks until the symptom alleviated from moderate or severe to mild, and 3 to 7 weeks until the patients have no sign of night sweating. The progression of persistent night sweats and treatment period until no sign of symptom varied according to the Soyangin External and Internal disease diagnosis. Discussion The Soyangin patients having persistent night sweats treated with herbal medicines showed a significant improvement in their symptoms. This result proposes the possibility of using herbal medicine in primary care patients experiencing persistent night sweats.

아르곤레이저 치료후 재발한 중심와아래 맥락막신생혈관에 대한 광역학치료

이민정,송수정,정흠,유형곤,Min-Joung Lee,M,D,Su-Jeong Song,M,D,Hum Chung,M,D,Hyeong-Gon Yu,M,D 대한안과학회 2005 대한안과학회지 Vol.46 No.12

Purpose: To evaluate the effects of photodynamic therapy for subfoveal recurrences of juxtafoveal or extrafoveal choroidal neovascularization (CNV), previously treated with argon-laser photocoagulation. Methods: Seven eyes, previously treated with argon-laser photocoagulation for juxtafoveal or extrafoveal choroidal neovascularization, received photodynamic therapy for subfoveal recurrence. Changes in visual acuity and fluorescein angiographic findings were analyzed. Results: The average time of appearance of recurrent CNV after laser photocoagulation was 43.14±29.62 months (range, 2-77 months). After photodynamic therapy, fluorescein leakage and neovascular lesion size decreased in all patients on fluorescein angiography. Visual acuity was stabilized or improved in 5 of 7 eyes. Conclusions: Photodynamic therapy was effective in patients with subfoveal recurrences of juxtafoveal or extrafoveal choroidal neovascularization previously treated with argon-laser photocoagulation.

특허 인용 네트워크 분석

이민정,김용대,장원철,Lee, Minjung,Kim, Yongdai,Jang, Woncheol 한국통계학회 2016 응용통계연구 Vol.29 No.4

과학 기술의 발전은 사회를 급격하게 변화시켜 왔다. 특허 자료 분석은 현대 과학 기술의 흐름을 이해하고 미래 유망기술을 예측할 수 있게 한다. 본 연구에서는 기술의 동향을 파악하고자 1985년과 2012년 사이에 미국 특허청에 등록된 특허를 중심으로 특허 인용 네트워크를 분석한다. 주요 기술군을 파악하기 위해 PageRank 알고리즘 외에 다양한 중심성 지표를 이용하고, 통계적 네트워크 모형을 통해 유사한 기술들의 군집을 찾아내고자 한다. The development of technology has changed the world drastically. Patent data analysis helps to understand modern technology trends and predict prospective future technology. In this paper, we analyze the patent citation network using the USPTO data between 1985 and 2012 to identify technology trends. We use network centrality measures that include a PageRank algorithm to find core technologies and identify groups of technology with similar properties with statistical network models.

대전천 수계의 장기 모니터링 (2004$\sim$2007)에 의한 물리적, 화학적, 생물학적 평가 변수 분석

이민정,최지웅,김현맥,안광국,Lee, Min-Jung,Choi, Ji-Woong,Kim, Hyun-Mac,An, Kwang-Guk 한국하천호수학회 2009 생태와 환경 Vol.42 No.3

본 연구에서는 대전광역시를 관통하는 도심하천인 대전천의 4개 지점을 선정하여, 2004년 8월에서 2007년 10월까지 총 8차례에 걸쳐 생물학적 건강도 평가 및 물리적 서식지 평가를 실시하였고, 환경부 수질측정 망 지점자료를 이용하여 화학적 수질특성을 분석하였다. 물리적 서식지 평가 지수(QUEI)는 평균 78.2(범위: 47$\sim$124)로 "보통상태"(Fair)로 나타났다. QUEI 값은 최상류지점(S1)에서 최대치(112, "양호상태")를 보인 반면, S3에서 SS(보통$\sim$악화상태)로 가장 불량한 서식지 상태를 보였는데, 이는 심각한 하상구조의 교란, 하상도로 및 인위적활동에 의한 것으로 사료되었다. 화학적 수질변수들은 하류로 갈수록 점차 악화되는 것으로 나타나 하천주변 도심으로부터 유입되는 유기물 오염에 의한 것으로 사료되었다. 또한 TP 및 전기전도도(Conductivity)는 집중강우로 인한 희석효과가 뚜렷이 나타난 계절적 변이가 큰 것으로 나타났다. 본 연구에서는 총 5과 24종 6909개체의 어류가 채집되었고, 피라미(Zacco platypus)가 81.6%로 우점하는 것으로 나타났다. 다변수 어류 평가모델인 생물통합지수(IBI)는 평균 17(범위: 12$\sim$30)"보통상태"(C)로 나타났으며, 하류지점으로 갈수록 생태건강성이 악화되는 양상(S4: 14, "불량상태")을 보였다. 따라서 대전광역시 도심의 상가밀집지역 및 주거지역을 관통하면서 생활하수 유입 및 각종 오염원에 의한 심각한 수질저하 현상에 의한 것으로 사료되었다. We evaluated stream health, based on integrative approaches of qualitative habitat evaluation index (QHEI), chemical water quality and the index of biological integrity (IBI) using fish assemblages in Daejeon Stream during August 2004 - October 2007. The QHEI values in this study averaged 78.2 (n=28, range: 47$\sim$124), indicating "fair" condition based on the criteria of US EPA (1993). The highest value was in the headwater site (S1) that was 112 (good), whereas the value in S3, mid and downstream was SS (fair-poor) that was the lowest owing to a disturbance on the bed and an artificial bank. Concentrations of chemical parameters such as BOD, TP and conductivity increased from the upstream to the downstream due to higher inputs of organic matters and nutrients from the urban area. Conductivity and TP showed a dilution of stream water by rainwater during summer monsoon. Analysis of fish compositions showed that total number of species was 24 and Zacco platypus was predominated (82%). The mean IBI was 17 (range: 12$\sim$30) during four years and the IBI values also decreased from S1 to S4. These results indicated that ecological health was degradated distinctly as the stream goes down through the city-center. We concluded that Daejeon Stream running through the city are influenced by chemical impact such as an influx of domestic sewage as well as the quality of habitat.

112, 119 긴급신고 대응 지능화 기술 개발 동향

이민정,박현호,백명선,권은정,변성원,박영수,정의석,박혜숙,M.J. Lee,H.H. Park,M.S. Baek,E.J. Kwon,S.W. Byon,Y.S. Park,E.S. Jung,H.S. Park 한국전자통신연구원 2023 전자통신동향분석 Vol.38 No.3

Emergency numbers, such as 112 and 119, are used in many countries to connect people in need with emergency services such as police, fire, and medical assistance. We describe development directions of intelligent response technology for emergency calls. The development of this technology refers to enhancing the efficiency and effectiveness of response systems by using advanced methods such as artificial intelligence, machine learning, and big data analytics. We focus on a system that assists the receptionist of an emergency call. In the future, the recognition rate and decision-making accuracy of intelligent response technologies should be improved considering characteristics of public safety and emergency domain data. Although the current technology remains at the level of assisting a receptionist, a fully autonomous response technology is expected to emerge in the future.

확장된 뷸만-스트라웁 모형에서 신뢰도 추정 연구

이민정,고한나,최승경,이의용,Yi, Min-Jeong,Go, Han-Na,Choi, Seung-Kyoung,Lee, Eui-Yong 한국데이터정보과학회 2010 한국데이터정보과학회지 Vol.21 No.6

보험회사가 보험계약자들의 적절한 보험료를 산출하는 것은 회사나 계약자들 모두에게 중요한 문제이다. 보험료를 결정하는 방법에는 보험회사가 보유하고 있는 매뉴얼에 근거하여 계약자들마다 같은 보험료를 부과하는 방법, 보험계약자 개인이나 집단에 관한 과거 기록에 바탕을 두어 보험료를 차등하여 정하는 방법, 그리고 위 두 가지 방법을 조합하여 보험료를 산정하는 방법 등이 있다. 이중 통계적인 모형에 기반을 둔 보험료 산정 방법에는 최대 정확도 신뢰도 이론이 있고, 이에 바탕을 둔 구체적인 접근법에는 뷸만 모형과 뷸만-스트라웁 모형 등이 있다. 본 논문에서는, 뷸만-스트라웁 모형을 확장하여, 자료 수가 늘어나면서 자료 평균의 변동성이 기대한 것보다 커지는 Hewitt의 아이디어를 반영한 모형에서, 새로운 비모수적 보험료 추정법을 제안한다. 또, 제안된 추정법을 모의자료에 적용해보고, 기존의 뷸만-스트라웁 추정량과 비교해본다. When an insurer develops an insurance product, it is very critical to determine reasonable premiums, which is directly related to insurer's profits. There are three methods to determine premiums. Frist, the insurer utilizes premiums paid to the similar cases to the current one. Second, the insurer calculates premiums based on policyholder's past records. The last method is to combine the first with the second one. Based on the three methods, there are two major theories determining premiums, Limited Fluctuation Credibility Theory not based on statistical models and Greatest Accuracy Credibility Theory based on statistical models. There are well-known methods derived from Greatest Accuracy Credibility Theory, such as, Buhlmann model and Buhlmann-Straub model. In this paper, we extend the Buhlmann-Straub model to accommodate the fact that variability grows according to the number of data in practice and suggest a new non-parametric method to estimate the premiums. The suggested estimation method is also applied to the data gained from simulation and compared with the existing estimation method.

만성비염 환아의 수면의 질과 성장에 관한 임상적 연구

이민정,장규태,한윤정,Lee, Min-Jeong,Chang, Gyu-Tae,Han, Yun-Jeong 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.2

Objectives : The study was designed to find out the relationships between rhinitis, quality of sleep, growth among children with chronic rhinitis. Methods : This research was performed in 50 children from November 2007 to May 2008. We measured height, weight, body mass index of those children and asked to answer to the questionnaires that consist of nasal symptoms, period of time with rhinitis, sleep symptoms, parent's height, present illness, and medical history. We also analyzed correlations with this factors obtained from questionnaires. Results : 1. In 50 subjects, there were significant correlations between nasal obstruction, the quality of sleep, and the between quality of sleep and growth. But, there were not significant correlations between nasal symptoms and growth. 2. In 24 preschool children, frequency of waking up during sleeping and the number of snorers were higher and quality of sleeping was worse than those in the children who were attending school. And there were significant correlations between quality of sleep and nasal obstruction. An average of RH-MPH(Recent Height-Mid-Parental Height) is $-7.74{\pm}36.51(%)$ which means they aren't as tall as MPH(Mid-Parental Height). 3. In 26 school children, there were significant correlations between symptoms and period of rhinitis, quality of sleep and growth. Conclusions : Children with chronic rhinitis have low quality of sleep and low growth. But more studies are needed.

다직종 암환자 교육·상담에 대한 설문 개발과 환자 만족도 조사

이민정,금민정,김재송,김수현,손은선,이상글,송수경,최혜진,Lee, Min Jeong,Geum, Min Jung,Kim, Jae Song,Kim, Soo Hyun,Son, Eun Sun,Lee, Sang Geul,Song, Su Kyung,Choi, Hye Jin 한국임상약학회 2018 한국임상약학회지 Vol.28 No.2

Background: Presently, a multidisciplinary team of doctors, pharmacists, nurses, and dietitians provides patient education to impart information on chemotherapy. However, studies on multidisciplinary education satisfaction are inadequate. In this study, we aimed to contribute to the improvement of quality of multidisciplinary education counseling for patients with cancer by developing a satisfaction questionnaire and analyzing the satisfaction survey. Methods: A questionnaire was developed by an expert group, and the responses were recorded using the 5-point Likert scale. After conducting a pre-test, factor analysis was performed to evaluate validity. The reliability of the questionnaire was measured by Cronbach's alpha coefficient. A satisfaction survey was conducted by self-administration method. Results: Based on the results of factor analysis, factors can be divided into two parts: "overall education" and "each team member's education" (total 14 questions). The construct validity and reliability of the questionnaire are sufficiently high. Fifty-one patients took the survey between January 2, 2018 and January 20, 2018. Twenty-six (51%) patients responded that they were "very satisfied" and 22 (43.1%) patients responded that they were "satisfied". Conclusion: By developing a questionnaire on multidisciplinary education counseling for patients with cancer, it is possible to perform evaluation and research of cancer patient education. This study will contribute to the management and improvement of quality of multidisciplinary education.