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인동덩굴로부터 분리된 Cynaroside이 Doxorubicin으로 유도된 인간 근위세뇨관 HK-2 세포의 괴사에 미치는 저해 효과
노종현,정호경,이무진,장지훈,심미옥,정자균,정다은,안병관,조현우,Nho, Jong Hyun,Jung, Ho Kyung,Lee, Mu Jin,Jang, Ji Hun,Sim, Mi Ok,Jung, Ja Kyun,Jung, Da Eun,An, Byeong Kwan,Cho, Hyun Woo 한국약용작물학회 2017 한국약용작물학회지 Vol.25 No.5
Background: Cynaroside is a flavone, a flavonoid-like compound, known by different names (luteoloside and cinaroside). It is commonly found in Lonicera japonica Thunb., Chrysanthemum moriflium, and Angelica keiskei. The process of cell death has been classified as necrosis and apoptosis. Necrosis refers to unregulated cell death induced by a chemotherapeutic agent. Doxorubicin is an anthracycline anti-cancer drug used to treat acute leukemia, cancer, and lymphoma. However, it induces nephrotoxicity including tubular damage. Therefore, we investigated the protective effect of cynaroside against doxorubicin-induced necrosis in HK-2 cells. Methods and Results: To confirm the beneficial effect of cynaroside on doxorubicin-induced necrosis, HK-2 cells, a human proximal tubule epithelial cell line were treated with $10{\mu}M$ doxorubicin and $80{\mu}M$ cynaroside. Doxorubicin treatment resulted in increased DNA fragmentation, caspase-3 activity and mitochondria hyperactivation during cell necrosis. However, pretreatment with $80{\mu}M$ cynaroside attenuated DNA fragmentation, caspase-3 activity and mitochondria hyperactivation induced by $10{\mu}M$ doxorubicin in HK-2 cells. Conclusions: These results indicated that pretreatment with cynaroside ameliorated doxorubicin-induced necrosis in HK-2 cells. Therefore, cynaroside be used as a therapeutic agent for improving doxorubicin-induced nephrotoxicity. However, further studies are required to evaluated the toxicity of cynaroside treatment in animals and to determine its protective effect against doxorubicin-induced nephrotoxicity in an animal model.
I2C 슬래이브 칩의 주소 설정을 위한 RC회로를 이용한 효과적인 아날로그-디지털 변환기 설계
이무진(Mu-Jin Lee),성광수(Kwang-Su Seong) 한국조명·전기설비학회 2012 조명·전기설비학회논문지 Vol.26 No.6
In this paper, we propose an analog-to-digital converter to set the address of a I2C slave chip. The proposed scheme converts a fixed voltage between 0 and VDD to the digital value which can be used as the address of the slave chip. The rising time and the falling time are measured with digital counter in a serially connected RC circuit, while the circuit is being charged and discharged with the voltage to be measured. The ratio of the two measured values is used to get the corresponding digital value. This scheme gives a strong point which is to be implementable all the parts except comparator using digital logic. Although the method utilizes RC circuit, it has no relation with the RC value if the quantization error is disregarded. Experimental result shows that the proposed scheme gives 32-level resolution thus it can be used to configure the address of the I2C slave chip.
어떤 다발성 외상환자가 중환자실에 오래 있게 되는가?: Injury severity score와 손상부위 수의 비교
조무진 ( Mu Jin Jo ),이성화 ( Seong Hwa Lee ),조석주 ( Seok Ju Cho ),염석란 ( Seok Ran Yeom ),한상균 ( Sang Kyoon Han ),박성욱 ( Sung Wook Park ),이대섭 ( Dae Seop Lee ) 대한외상학회 2013 大韓外傷學會誌 Vol.26 No.2
Purpose: Injury severity score (ISS), a widely used scoring system, is used to define the severity of trauma in multiple-trauma patients. Nevertheless, ISS cut-off value for predicting the outcome of multiple-trauma patients has not been confirmed. Thus, this study was performed to determine the more useful method for predicting the outcome for multiple-trauma patients: the ISS or the number of anatomical Abbreviated injury scale (AIS) injury regions. Methods: for 195 consecutive patients who a regional emergency medical center, we analyzed the ISS and the number of anatomical AIS injury region. The patients were divided into four groups based on the ISS and the number of anatomical AIS regions. We compared intensive-care-unit (ICU) admission days and hospitalization days and ICU stay ratio (ICU admission days/hospitalization days) between the four groups. Results: In the groups with an ISS more than 17, the results were not significantly different statistically the group with 2 anatomical AIS injury regions and more than 3 anatomical AIS injury regions. Also, in the group with an ISS of 17 or less, the results were the same as those for patients with an ISS more than 17 (p>0.05). Among the patients with 2 anatomical AIS injury regions, patients with an ISS more than 17 patients had more ICU admission days and a higher ICU stay ratio than patients with an ISS 17 or less. Also, Among the patients with 3 anatomical AIS injury regions, the results were the same as those for patients with 2 anatomical AIS injury regions. Conclusion: Patients with high ISS, regardless of the number of anatomical AIS injury regions had significantly longer ICU stays and higher ICU admission ratio. Thus, the ISS may be a better method than the number of anatomical AIS injury regions for predicting the outcomes for multiple-trauma patients.
고함량 폴리감마글루탐산(PGA) 청국장에 대한 칼슘 생체이용률 및 골다공증에 미치는 영향
이무진(Mu-Jin Lee),정호경(Ho-Kyung Jung),심미옥(Mi-Ok Sim),장지훈(Ji-Hun Jang),김태묵(Tae-Mook Kim),이현주(Hyun-Joo Lee),이기호(Ki-Ho Lee),안병관(Byeong-Kwan An),조정희(Jung-Hee Cho),장민철(Min-Cheol Jang),용주현(Ju-Hyun Yong),김종춘(Jo 한국식품영양과학회 2016 한국식품영양과학회지 Vol.45 No.11
본 연구는 칼슘 생체이용률 시험에 수컷 랫드를 이용하여 고함량 폴리감마글루탐산 청국장이 기존 청국장보다 칼슘의 생체이용률을 증가시키는지 알아보고자 실시하였다. 고함량 폴리감마글루탐산(PGA) 청국장 및 기존 청국장을 투여하고 0.5, 1, 2, 3, 4, 5시간에 채혈하여 칼슘 함량을 측정한 결과, 고함량 PGA 청국장이 기존 청국장보다 투여 후 3~5시간에 칼슘 흡수율이 증가할 것으로 생각한다. 골다공증 시험에 난소를 적출하여 폐경을 유도한 후 PGA 함유량이 증가한 청국장을 12주간 경구투여 하여 골다공증에 미치는 효과를 연구하고자 하였다. 혈청 검사에서 오스테오칼신은 청국장 200 mg/kg 투여군에서 OVX 대조군보다 유의성 있는 감소가 관찰되었고, 프로게스테론은 청국장 200 mg/kg투여군에서는 OVX 대조군보다 유의성 있는 증가가 관찰되어 청국장이 골다공증 개선에 효과가 있는 것으로 생각한다. 간장 조직액의 지질과산화물은 OVX 대조군보다 대조약 및 청국장 투여군에서 모두 감소 경향이 관찰되어 청국장 투여로 지질과산화물 생성을 감소시키는 것으로 기대된다. 대퇴골에 대한 조직병리학적 검사에서 대퇴골 원위부 골간단의 해면골 감소가 대조약은 OVX 대조군보다 유의성 있는 감소가 관찰되었으며, 청국장 200 mg/kg 투여군에서도 감소가 관찰되어 청국장이 해면골 감소를 억제시키는 것으로 생각한다. 이상의 결과는 고함량 PGA 청국장이 기존 청국장보다 투여 후 3~5시간에 칼슘 흡수율을 증가시킬 것으로 생각하고, 난소적출 후에 일어나는 골격 대사의 이상에도 청국장이 골 교체율 억제, 호르몬 변화, 항산화 및 해면골 감소 억제등 유익하게 나타남으로써 임상상 폐경기에 나타나는 골다공증을 어느 정도 예방시킬 수 있음을 시사하며, 폐경 후 여성의 골대사에 유익한 효과를 줄 것으로 생각한다. Various types of fermented soybean foods are consumed in various Asian countries, including China, Indonesia, Japan, Korea, and Vietnam. Cheonggukjang is a Korean whole soybean paste fermented by Bacillus subtilis and regarded as a healthy food. The objective of this study was to investigate the Ca-bioavailability and anti-osteoporotic effects of cheonggukjang (CGJ) containing high poly-gamma glutamate (PGA) contents in an animal model. Blood samples were collected from the jugular vein at 0, 0.5, 1, 2, 3, 4, and 5 h after a single oral dose in male rats. Ca-bioavailability in CGJ containing high PGA contents was approximately 3∼5 times higher than that of natural CGJ. Female rats were either sham-operated (sham; n=5) or surgically ovariectomized (OVX; five animals per group) and then administered to OVX control, raloxifene hydrochloride (RLX) 1 mg/kg/d, or CGJ containing high contents of PGA (20 and 200 mg/kg/d) for 12 weeks. Serum osteocalcin concentration was significantly lower in the CGJ 200 mg/kg/d group compared with the OVX control group. Serum progesterone concentration was significantly higher in the CGJ 200 mg/kg/d group compared with the OVX control group. Reduction grade of the trabecular bone decreased in the RLX 1 and CGJ 200 mg/kg/d group compared with that of the OVX control group. In conclusion, CGJ 200 mg/kg/d may have inhibitory effects on osteoporosis in OVX rats, and Ca-bioavailability was improved in CGJ containing high PGA contents.
스위치드 커패시터를 이용한 동작 주파수에 무관한 정전용량 터치스위치
이무진(Mu-Jin Lee),성광수(Kwang-Su Seong) 한국조명·전기설비학회 2013 조명·전기설비학회논문지 Vol.27 No.6
This paper proposes a capacitive touch switch using a switched-capacitor. The proposed method charges capacitance for measurement using the switched-capacitor until the voltage across the capacitance reaches a threshold voltage. As the proposed method uses the number of times being charged to measure the capacitance, the method has no relation with the operating frequency of the switched-capacitor. This paper also shows the quantization resolution of the proposed method is related to the capacitance in the switched-capacitor and the threshold voltage, i.e., the resolution is improved when the capacitance in the switched-capacitor is decreased and the threshold voltage is increased. Simulation result shows the method gives 31fF quantization resolution when the capacitance in the switched-capacitor is 50fF and threshold voltage is 80% of the supply voltage.
박무진,진소리,오은제,송우섭,이현석,황규현,오승주,주아라,백수인,Park, Mu-jin,Jin, So-ri,Oh, Eun-jae,Song, Woo-sub,Lee, Hyun-seok,Hwang, Kyu-hyun,Oh, Seung-ju,Ju, Ah-ra,Baek, Su-in 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.5
Objective: This study investigated the efficacy of using Nokyonggunbi-tang and other Korean medical treatments for a patient with consumptive disease and chronic fatigue. Methods: A 59-year-old female patient with fatigue, headache, dizziness, and neck pain due to consumptive disease and chronic fatigue was treated with herbal medicine (Nokyonggunbi-tang), together with acupuncture, pharmacopuncture, cupping, and chuna manual therapy, for 22 days. The treatment effects on the pain were evaluated using the scores for the Fatigue Severity Scale (FSS), European Quality of Life Five Dimensions (EQ-5d) Scale, Neck Disability Index (NDI), and Numerical Rating Scale (NRS). Results: Following treatment, the patient showed a decrease in the FSS, NDI, and NRS scores and an improvement in the EQ-5d score. Conclusions: Nokyonggunbi-tang and Korean medical treatment significantly improved fatigue symptoms in a patient with no substrate disease.
박지형,강무진,이교일,Park, Ji-Hyeong,Gang, Mu-Jin,Lee, Gyo-Il 대한기계학회 1996 大韓機械學會論文集A Vol.20 No.1
Scheduling jobs effectively under consideration of actual loads on machines is one of the most complicated tasks in production control. The complexity of the finite capacity scheduling often makes the conventional methods of industrial engineering fail. As an alternative, Knowledge-based approaches to job-shop scheduling have been evolved recently. This paper presents a blackboard- based scheduling expert system which combines knowledge-based scheduling with interactive scheduling. It is shown to be possible to generate the feasible schedule within a reasonable time. Flexible reaction management is also possible while keeping the changes in the generated schedule to the minimal and adjusting the schedule to tardy operations or working environmental changes. The system is equipped with a rule base with heuristics for handling conflicted event. A case study applying the implemented system is described.
추간판탈출증 환자에서 발생한 기능성 소화불량에 대한 한방통합치료 호전사례
오은제,박무진,송우섭,오주희,배건희,이수경,장동진,Oh, Eun-je,Park, Mu-jin,Song, Woo-sub,Oh, Joo-hee,Bae, Gun-hee,Lee, Soo-kyeong,Jang, Dong-jin 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.5
Objective: This study investigated the efficacy of using Korean medical treatments on a patient with functional dyspepsia. Methods: A 61-year-old female patient with functional dyspepsia and C/L-spine HIVD was treated with herbal medicine (Gamihyangsayukgunja-tang), acupuncture, pharmacopuncture, chuna manual therapy, and cupping therapy for 18 days. The treatment effects on the functional dyspepsia were evaluated using the Numerical Rating Scale score, Gastrointestinal Symptom Score, and Bristol Stool Scale results. Results: Following treatment, the patient showed decreases on the Numerical Rating Scale and Gastrointestinal Symptom Score and improvement on the Bristol Stool Scale. Conclusions: Korean medical treatment improved the condition of a patient with functional dyspepsia.