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급성 및 간헐성 총담관폐쇄에서의 99mTc - DISIDA 간담도 스캔의 진단적 가치
문대혁(Dae Hyuk Moon),이명혜(Myung Hae Lee),김명환(Myung Hwan Kim),이영상(Young Sang Lee),민영일(Young Il Min) 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.2
N/A We examined patients with suspected acute or intermittent biliary obstruction using hepatobiliary scintigraphy, ultrasonography and contrast cholangiography. Of 16 patients with confirmed common bile duct obstruction, sonography and scintigraphy disagreed in 8(50%). Scintigraphy revealed partial or complete common bile duct obstruction in 13 patients (81.3%) and 6 of them had no evidence of dilated biliary trees. It is concluded that disagree, ment between sonography and scintigraphy is not rare in patients with acute or intermittent biliary obstruction and hepatobiliary scintigraphy is useful in diagnosing obstruction prior to ductal dilatation.
문대혁(Dae Hyuk Moon),이명혜(Myung Hae Lee),김명환(Myung Hwan Kim),민영일(Young Il Min),석재동(Jae Dong Suk) 대한핵의학회 1991 핵의학 분자영상 Vol.25 No.1
N/A Extracorporeal shock vave lithotripsy (ESWI.) with adjunctive oral ]itholytic therapy has proven to be a useful treatment in selected patients with gallbladder stones. To study the effect of ESWL on gillbladder dynamics, 99mTc-DISIDA hepatobiliary scintigraphy was done for 25 patients with symptomatic gallstones and 10 norrnal controls. Of these 25 patients, 15 were treated with ESWL and adjunctive oral litholytic agents (ESWL group) and 10 were treated only with oral litholytic agents (UDCA group). After overnight fast and gallbladder visualization on a routine hepatobiliary scintigra- phy with 7mCi of 99mTc-DISIDA, subjects were given fatty meal and imaged with a gamma camera interfaced to a computer (I frame/minute for i0minutes). A galibladder time-activity curve was generated and latent period (LP), ejection period (EP), ejection fraction (EF) ancl ejection rate (ER) v,ere calcutated, ESWL group were studied before, lday after and 2weeks after ESWL, and UDCA group were studied before and 2weeks after starting oral medication Mean basal EF was significantly reduced in patients but other parameters were not reduced. In ESlVL group, mean EF and mean ER at 1day after ESWL were reduced. In 3 of them, gallbladder was not visualized at all. Two weeks after ESWL, however, all parameters were recoverd to basal level. In UDCA group, all parameters were not changed significantly during medication. We can conclude that ESWL has such immediate adverse effect on gallbladder dynamics as reducing contractility ancl nonvisuaiization of gallbladder but it has no long-term effect.
Technetium - 99m Pertechnetate 갑상선 스캔에서 열결절로 나타난 갑상선암
이문호(Mun Ho Lee),문대혁(Dae Hyuk Moon),송영기(Young Kee Shong),이명혜(Myung Hae Lee),류진숙(Jin Sook Ryu) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.1
In general, hot nodules on techetium scan are regarded as benign tumors, and usually no further work up for malignancy is indicated, if they are truly autonomous. The authors experienced two cases of thyroid carcinoma presenting as hot nodule on technetium-99m pertechnetate thyroid scintigraphy. One case with papillary carcinoma, and other case with follicular carcinoma are presented in addition to a review of the literature.
이종이식된 인체대장암에서 항 태아성암항원 단세포군항체 IgG 및 F ( ab` ) 2 분절을 이용한 방사면역 검출법
고창순(Chang Soon Koh),신성해(Sung Hae Shin),문대혁(Dae Hyuk Moon),이명혜(Myung Hye Lee),이동수(Dong Soo Lee),정준기(June Key Chung),이명철(Myung Chul Lee) 대한내과학회 1991 대한내과학회지 Vol.40 No.2
N/A This study was designed to investigate whether specific monoclonal antibody against carcinoembryonic antigen (CEA-92) and F (ab`)2 fragments of CEA-92 can be used for the scintigraphic localization of human colon cancer xenograft on nude mice models. Intact CEA-92 IgG and F (ab`)2 fragments of CEA-92 were radiolabeled with Iodine-131, then injected intraperitoneally into nude mice bearing human colon cancer (SNU-C4). the scintigrams were obtained at intervals of one day. The digital computer images were also obtained to analyze quantitatively the tumor contrast and biological half life of radiolabeled antibody in tumor tissue. The paired labeling experiments, in which I-131-labeled anti-CEA antibody or it's fragments and I-125-labeled control IgG or it's fragments were injected simultaneously, were undertaken to determine the specific localization of CEA-92 IgG and F (ab`)2 fragments of CEA-92. Tumor uptake of intact CEA-92 expressed in % injected dose per gram tissue (% ID/g tissue) was 2.95 at day 2 and 1.57 at day 5 which were significantly higher than those in other tissues (p<0.05). However % injected dose in blood also showed high uptake (3.08 at day 2, 1.29 at day 5) and there was no significant difference between blood and tumor tissue. In case of F (ab`) 2 fragments, tumor uptake was 2.52 and 0.70 at day 2 and 5, respectively. In contrast to intact CEA-92, all other tissues including blood had significantly lower antibody uptakes than tumor. The antibody specific localization ratios of F (ab`) 2 fragments of CEA-92 at day 2 were ranged from 4.77 to 8.40 which were significantly higher than those at day 5 (1.89-5.15, p<0.05) and localization ratios of intact CEA-92 IgG at day 2 (1.37-2.98, p<0.01). The scintigrams clearly demonstrated selective localization of radioactivity over transplanted tumor with-out and additional image processings. With F(ab`)2 fragments, more rapid and clear tumor images were obtained. Best tumor contrast as quantitated by analyzing digital computer scans was obtained between day 4 and 5 after the antibody injection. Biologic half life of the intact CEA-92 in tumor tissue was significantly longer than that of F (ab`)2 fragments (3.89 day vs 2.19 day, p<0.005). We concluded that the monoclonal antibody CEA-92 was localized selectively and specifically in human colon carcinoma tissue and could be used in radiommunodetection in xenograft model. The F(ab`)2 fragments were found to give better and more rapid specific tumor localization than intact CEA-92.
파킨슨병에서 99mTc - HMPAO SPECT를 이용한 국소뇌혈류의 정량적 분석
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이명혜(Myung Hae Lee),노재규(Jae Kyu Roh),명호진(Ho Jin Myung),배상균(Sang Kyun Bae) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.2
N/A Regional cerebral blood flow were measured in 10 patients with Parkinson's disease and 12 normal persons using Tc-99m-HMPAO SPECT. Reconstructed images were interpreted qualitatively and were compared with those findings of CT. For the quantitative analysis, six pairs of region of interest matched with the perfusion territories of large cerebral arteries and cerebellar hemisphere were determined. From the count values, indices showing the degree of asymmetry between right and left cerebral or cerebellar hemisphere, cerebral asymmetry index (ASI) and percent index of cerebellar asymmetry (PIA), and an index showing change of each region, region to cerebellum ratio (RCR) were obtained. ASI of normal persons and patients were 0.082±0.033 and 0.108±0.062, respectively and PIA were -0.4±0.7% and -0.7±1.0%, respectively, which showed no statistically significant difference between normal persons and patients. Among 10 RCR's, those of both regions of basal ganglia and both regions of anterior cerebral artery were significantly reduced. We concluded that the most significant reduction of regional cerebral blood flow in patients with Parkinson's disease was observed in the regions of basal ganglia and in the regions of anterior cerebral artery, and the degree of change in hemispheric blood flow was similar in both hemisphere.
피부근염 - 다발성근염 환자에서 방사성 동위원소를 이용한 식도 스캔의 정량적 분석
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이명혜(Myung Hae Lee) 대한핵의학회 1989 핵의학 분자영상 Vol.23 No.2
N/A Esophageal transit of radionuclide was quantitatively analyzed in 29 patients with dermatomyositis-polymyasitis Fourteen patients (48.3%) showed retention of tracer in oropharynx. The mean value of percent retention of oropharynx was 15.5+16.6% Esophageal dysfunction was found in 19 patients (65.5%). Among thern 4 showed mild, 12 showed noderate and 3 showed severe esophageal dysfunction. Dysphagia was found in 11 patients (37.9%), which was clnsely related to percent retention of oropharynx. Quantitative analysis of esophageal transit of radionuclide seemed to be a useful technique for evatuation of dysphagia in patients with dermatomyositis-polymyositis.
간장 ( 肝臟 ) 및 담도 ( 膽道 ) : 당뇨병 환자에서의 담낭운동성에 관한 연구
민영일(Young Il Min),이성구(Sung Koo Lee),김명환(Myung Hwan Kim),임채만(Chae Man Lim),송영기(Young Kee Shong),이기업(Ki Up Lee),문대혁(Dae Hyuk Moon),이명혜(Myung Hae Lee) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.2
N/A Cholesterol gallstone is known to occur two to three times more frequently in diabetes than in normal population. Hypotheses such as hypercholesterolemia or obesity were presented to explain the higher incidence of gallstone disease in diabetes but failed to show strong cause-effect relationship. We compared the gallbladder emptying of a diabetic group who had not ever had gallstone disease with that of a control group using Tc-99m cholescintigraphy and also made assessment about several metabolic factors in diabetic group to know which one was closely related with the impaired gallbladder emptying. The results are as follows. 1) Gallbladder emptying (ejection fraction) was significantly reduced in diabetes group (72.9 +- 19.8%) compared with normal control (89.6 +-9.6%) (p<0.05). 2) Gallbladder emptying in the diabetes group with autonomic neuropathy (64.2 +- 21.6%) was impaired to a greater extent than in the diabetes without autonomic neuropathy (82.3 +- 12.3%) (p< 0.05). 3) Severe impairment of gallbladder emptying (EF < 70%) in diabetes was not related with obesity, Hb A,C level, disease duration or serum lipid level but related with the presence of autonomic neuropathy (p<0.01). In conclusion, gallbladder emptying is impaired in diabetes and such an impairment was more prominent in the diabetic patient complicated autonomic neuropathy, which may lead to bile stasis and allow for cholesterol crystal formation.