췌담관질환에서 담관 솔질세포검사의 유용성 - 통상도말과 $MonoPrep2^{TM}$ 액상세포검사의 전향적 비교연구 -

이동화,김미선,조영덕,천영국,최민성,김동원,진소영,Lee, Dong-Wha,Kim, Mee-Sun,Cho, Young-Deok,Cheon, Young-Koog,Choi, Min-Sung,Kim, Dong-Won,Jin, So-Young 대한세포병리학회 2006 대한세포병리학회지 Vol.17 No.1

Bile duct brush cytology has been employed as a diagnostic tool for the evaluation of pancreatic and biliary tract strictures. The specificity of this method is high however, its sensitivity is quite low. A recent study employing liquid based cytology (LBC) reported results comparable to those achieved via conventional cytology. Therefore, we have attempted to prospectively evaluate the diagnostic utility of bile duct brush cytology in pancreaticobiliary diseases. A total of 46 cases with bile duct stricture were enrolled including 11 cases of benign stricture, 29 cases of bile duct carcinoma, 3 cases of gallbladder cancer, and 3 cases of pancreatic cancer. Both conventional smear and LBC using $MonoPrep2^{TM}$ system were conducted in each case. The cytological diagnosis of each case was classed into the following categories; benign, suspicious for malignancy, and malignancy. The diagnostic accuracy of both cytologic methods was investigated. LBC evidenced a high rate of material insufficiency (13/46), which was attributed to low cellularity. The kappa index of both cytological methods was 0.508. Cytological and tissue diagnoses were correlated in 25 cases conducted from biopsy or operation. The sensitivity, specificity, positive predictive value, and negative predictive value were 41.2% (7/17), 100% (8/8), 100% (7/7), and 44.4% (10/18) in conventional smear; 58.8% (10/17), 87.5% (7/8), 90.9% (10/11), and 50.0% (7/14) in LBC; and 94.1% (16/17), 87.5% (7/8), 94.1% (16/17), and 87.5% (7/8) in any one of both cytological methods, respectively. Based on these results, the sensitivity of LBC was found to be superior to that of conventional smear and we were able to obtain higher positive predictive value upto 94.1% by simultaneously conducting both cytologic methods.

세침흡인 검체의 전자현미경 검색으로 진단된 전이성 악성 흑색종 1예

이동화,진소영,권계현,Lee, Dong-Wha,Jin, So-Young,Kwon, Kye-Hyun 대한세포병리학회 1992 대한세포병리학회지 Vol.3 No.2

Electron microscopy (EM) can provide a valuable contribution to light microscopy (LM) In the Interpretation of fine needle aspiration cytology (FNAC) specimen, especially in the diagnosis of the tumor. However, considerable care in processing the specimen is mandatory to recover the cells and avoid altering the fine structures. We experienced a case of malignant melanoma in 33-yrs-old female, diagnosed by EM study of FNAC specimen from the axillary mass, who was initially thought as disseminated carcinomatosis on LM study. The technique of EM study on FNAC specimen consisted of washing the needle and syringe in 2.5% glutaraldehyde after a rapid stain (Diff-Quik), which was used to obtain a preliminary diagnostic impression and to assure the adequacy of the EM specimen. After centrifugation in the steps of fixation and dehydration, the sediment was made into an epon block and examined. The whole processing time of EM study can be shortened within 7 or 8 hours, and results can be available within 48 to 72 hours. Our experience suggests the EM study on FNAC can be a useful diagnostic method in the diagnosis of difficult FNAC cases.

Adenoid Cystic Carcinoma of the Breast: Diagnosis by Fine Needle Aspiration Cytology

이동화,진소영,김대중,권귀향,Lee, Dong-Wha,Jin, So-Young,Kim, Dae-Joong,Kwon, Kui-Hyang The Korean Society for Cytopathology 1991 대한세포병리학회지 Vol.2 No.2

Adenoid cystic carcinoma is a rare valiant of mammary cancer with better prognosis. The diagnosis is usually made by histologic examination of biopsy specimen. Recently, we have experienced a case of adenoid cystlc carcinoma initially diagnosed by fine needle aspiration cytology which revealed distinct cytologic features in a 45-year-old woman. Pink to red globules in the tumor cell clusters on Diff-Quik staining was a very helpful finding for cytologic diagnosis. 유방의 선양낭포암종은 매우 드물며 예후는 좋다. 유방에서 이 종양이 애초에 세포학적으로 진단된 예에 관한 세계 문헌상의 보고는 없다. 최근 저자들은 45세 여성의 좌측 유방 종괴로 부터 세침 홉인 검사를 시행하여 선양 낭포성 암종을 진단하였으며, Diff-Quik 염색시 종양세포 집락 내에서 분홍 및 적색으로 염색되는 구형의 물질이 확진에 도움을 주었다.

결핵 진단의 세침 흡인 세포검사

이동화,진소영,고은석,곽정자,Lee, Dong-Wha,Jin, So-Young,Koh, Eun-Suk,Kwak, Chung-Ja 대한세포병리학회 1990 대한세포병리학회지 Vol.1 No.1

A total of 48 cases of tuberculous lesion in the lymph nodes (43 cases), lung (3 cases) and soft tissue (2 cases), was subjected to fine needle aspiration cytology (FNAC). The age of the patients ranged from 19 to 77 year-old (average 33.6 years in age) and the male to female ratio was 1 : 4. Thirty-four cases (70.8%) demonstrated distinct granulomatous reaction with or without caseation necrosis, nine cases (18.8%) showed no granulomas, but large amount of necrotic debris with numerous polymorphonuclear cells and histiocytes, and five cases (10.4%) revealed acellular material only. The overall AFB positivity in smears was 62.5%. In areas associated with granulomatous reaction and necrosis, AFB positivity was 55.8%, while it was 80.0% in cases with acellular necrotic material. There were 2 cases of parasitic infestation which could not be easily differentiated from tuberculosis based on aspiration smears only.

간과 담낭에 발생한 다발성 원발성 종양

이동화(Dong Wha Lee),조성원(Sung Won Cho),심찬섭(Chan Sup Shim),김영순(Young Soom Kim),정성환(Seong Whan Jung),문철(chul Moon) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.2

We report a case with multiple primary malignant tumor which occurred synchronously in the liver and gallbladder. A 56-year-old male was admitted because of right chest pain radiating to right shoulder. On physical examination, the liver edge was palpable 2 finger breadths below the right costal margin. The ultrasonogram showed mixed echo mass densities in right lobe of the liver and non-visualization of the gallbladder cavity. The oral cholecystogram showed non-visualization of the gallbladder and the ERCP showed suspicious irregularity of the wall of the gallbladder. Liver scan with ECT showed a cold defect on right upper anterolateral area of the liver. The abdominal CT scan revealed a small mass with slightly lower density in right upper lateral aspect of the liver. A mass was found in right lobe of the liver 5 cm apart from the gallbladder and another withish tumor mass was also found in upper part of the ga]lbladder at operative field. Microscopic findings of the these tissues were hepatocellular carcinoma in liver and adenocarcinoma of the gallbladder.

회장에 생긴 Anisakis 증

이동화(Dong Wha Lee),조성원(Sung Won Cho),심찬섭(Chan Sup Shim),문철(chul Moon),김진홍(Jin Hong Kim),이문성(Moon Sung Lee),조성우(Sung Woo Cho) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.3

Anisakiasis is infection of man by the third stage of larval nematodes of the family Anisakidae and is encountered in people who eat inadequately prepared salt-water fish or squid. Within a few hours after oral ingestion, larvae invade the wall of stomach or intestine, and develop acute gastrointestinal symptoms. The diagnosis is made by the striking feature of larva showing a thick multilayered cuticle, well developed musculature beneath the hypodermis, two Y-shaped lateral chords, and large esophagus at center. The stomach is most common invaded site, but the small intestine is relatively uncommon. So, we report a case of ileal anisakiasis complicated intestinal obstruction and briefly review the literature.

MMPI에 나타난 한의대 졸업반 학생의 성격특성에 대한 연구 (1)

이동화 ( Dong Wha Lee ),김보경 ( Bo Kyung Kim ) 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.3

Objectives: The purpose of this study was to investigate personality traits of oriental medical students in graduating class by using the Minnesota Multiphasic Personality Inventory (MMPI). Methods: The subjects of this study were 164 (male 108, female 56) oriental medical students in Busan. MMPI scores were analyzed about validity scales, clinical scales and personality disorder scales in aspects of whole student, attendant year, gender and ages. Results & Conclusions: First, The average scores of MMPI scales showed that oriental medical students in graduating class lay within the range of normal. There was no difference among attendant years, and averages of each year made little difference to whole student. The students belonged to ``defensive group`` that were doing adaptive defense relatively Second, in comparison with gender, female students got more social adaptability and less stress than male students. In comparison with ages, group of 28~42 years old tended to make up themselves with defensive attitude.

졸업논문(卒業論文) : 미국(美國)의 극동전략(極東戰略)과 한국군사전략(韓國軍事戰略)의 방향(方向)

이동화 ( Dong Wha Lee ) 국방대학교 안보문제연구소 1965 국방연구 Vol.18 No.-

대장에 발생한 임파관종

이동화(Dong Wha Lee),조성원(Sung Won Cho),심찬섭(Chan Sup Shim),김진홍(Jin Hong Kim),이문성(Moon Sung Lee),조주영(Joo Young Cho),추원석(Won Seok Chu),김익수(Ik Su Kim) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.4

Lymphangioma of the large bowel is rare benign tumor which is compo of numerous small or large thin-walled lympbatic spaces contained fibrous tissue, smooth muscle and aggregates of lymphold tissue. Lymphangiama of the large bowel has not any pathognomic signs or symptoms, and never demonstated any potential for malignant degeneration, There are three types: 1) simple eapillary lymphaegieme, 2) cavemous lymphangioma, and 3) cyetic lymphangioma. Recently, we experienced a case of cavernous lymphengioma of large intestine whieh has been revealed eharply marginiat rounded, polypoid mass with a broad base in the d ending colon by double-contrast barium enema and colonoeeopy and confirmed by surgical resection. So we report this case with brief review of literature.

불면환자의 수면의 질 척도와 한방진단시스템 병기(病機)와의 연관성 연구

이동화 ( Dong Wha Lee ),김보경 ( Bo Kyung Kim ) 대한한방신경정신과학회 2010 동의신경정신과학회지 Vol.21 No.1

Objectives: This study was to investigate the relation of Pittsburgh Sleep Quality Index(PSQI) and Diagnos system of oriental medicine(DSOM) in the Insomnia Patients. Methods: For this study, we carried out PSQI and DSOM of 92 patients with insomnia who have come to Kijang public health center and Donguei oriental hospital of Donguei university from November 2008 to October 2009. We verified the association of PSQI and DSOM using crosstabulation analysis, independent sample T-test, one-way ANOVA and correlation analysis. Results: 1. Blood-deficiency(血虛) is the most frequent pathogenic factor and frequency of nightmare has positive correlation with that factor including heart(心) in total insomnia patients. 2. Female patients have a higher percentage of chronic insomnia than male patients. 3. As patients aged, maintaining sleep gets harder, sleep time is lessening, taking hypnotics is increasing and quality of sleep gets worse. 4. There is high frequency of chronic insomnia in 40~50 years and over 60 years old. Also, the people who are over 60 years of age tend to sleepless and urinated frequently during the middle of the night. The people with the age of 20~30 years tend to take less sleeping pills and frequency of sleeping during daytime is higher than the other age groups but the quality of sleep is quite good. 5. The patient with over 6 months of chronic insomnia tend to be older in age than the patient with less than 6months. And the patient with chronic sleeping disorder has frequent pain and the quality of sleep is very poor. 6. The patient who took hypnotics tend to be older than hypnotics non-user and frequency of urination was relatively high. 7. The patient who visited oriental medical hospital were tend to be older and get difficult in maintaining sleep. And frequency of taking hypnotics and urinating during night were tend to be higher and the quality of sleep was poor compared with the patient who visited public health center. Conclusions: This study provides insights into the complicated relations of the associated symptom of insomnia with Diagnos system of oriental medicine. And especially this study showed apparent correlation between nightmare in insomnia patients and pathogenic factor of blood-deficiency and heart. Specific correlations and characteristics in this study could be connect develop of new questionaire of insomnia.