소비음(消肥飮)이 비만아의 체질량지수와 비만도 감소에 미치는 영향

이동형,김덕곤,Lee, Dong-Hyung,Kim, Deog-Gon 대한한방소아과학회 2009 대한한방소아과학회지 Vol.23 No.1

Objectives The purpose of this study is to evaluate the effects of Sobieum on decrease of BMI and obesity index of obese children. Methods 66 children (33 boys, 33 girls) were involved in this study. We measured height and weight for each time their visit, and calculated BMI and obesity index. Results After medication, BMI level and obesity index were significantly reduced (p<0.001). Conclusions We speculate that Sobieum is effective in the treatment of childhood obesity, and further controlled studies are needed with clinical cases of hematological evaluation.

8-Hydroxyquinoline 誘導體에 關한 硏究 (第2報) Fe (II)-7-Nitroso-8-Hydroxyquinoline-5-Sulfonate 에 關하여

이동형,Lee, Dong-Hyung 대한화학회 1965 대한화학회지 Vol.9 No.1

The properties of Fe(II)-7-nitrose-8-hydroxyquinoline-5-sulfonate have been studied spectrophotometrically at 700$m{\mu}$, $26^{\circ}C$. The absorbance of the complex shows a maximum at pH 6.0 and good thermal stability. Excess of the ligand and the reducing agent do not interfere the formation of the complex. The composition of the complex is found to be 3:1 ligand to metal species by molar ratio and continues variation methods. Calibration curve follow Beer's law over the range of concentratiion studied. 7-Nitroso-8-hydroxyquinoline-5-sulfonate의 Fe(II)錯鹽의 性質을 700$m{\mu}$, $26^{\circ}C$에서 分光光度法으로 調査하였다. 이 錯鹽은 pH6.0에서 가장 큰 吸光度를 나타내며 熱安定度도 대단히 좋다. Ligand나 Fe(III)의 還元에 使用한 hydroxylamine이 過剩으로 存在할때 에도 錯鹽의 生成에 影響을 주지 않는다. 錯鹽의 組成을 몰比法과 連續變化法으로 調査한 結果, 金屬과 ligand의 몰比는 1:3이였다. 檢量線은 實驗한 濃度範圍內에서 Beer의 法則에 따른다.

골연령의 측정에서 Greulich-Pyle법, Tanner-Whitehouse법, 완관절 초음파 통과속도를 이용한 골연령 측정법의 비교 연구

이동형,이진용,김덕곤,Lee, Dong-Hyung,Lee, Jin-Yong,Kim, Deog-Gon 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.2

Objectives : The purpose of this study was to evaluate the correlation of 3 methods of bone age measurements. Methods : 102 children(49 boys, 53 girls) were involved in this study. We measured the height, weight and bone age based when they visited for the first time. We measured bone age using BoneAge of Sunlight Co.,Ltd. Two of the bone age measurement methods, Greulich-Pyle and Tanner-Whitehouse, were used to analyze the left dorsopalmar hand-wrist radiographs of 102 children who visited in Department of Pediatrics, O O University Oriental Hospital. This study was designed to investigate the correlation of the bone age between two methods. Results : The bone ages were related with age, height, weight and BMI according to this study(P<0.01). Each bone age assessment method had statistically significant correlation to each other(P<0.01). Conclusions : The ultrasound transonic velocity of inferior radiocarpal joint will become a sufficient diagnostic tool of bone age assessment if measurement error can be minimized by proper effort.

용적변조회전 방사선치료에서 선량전달의 중단 및 재시작에 따른 정확성 평가

이동형,배선명,곽정원,강태영,백금문,Lee, Dong Hyung,Bae, Sun Myung,Kwak, Jung Won,Kang, Tae Young,Back, Geum Mun 대한방사선치료학회 2013 대한방사선치료학회지 Vol.25 No.1

목 적: 용적변조회전 방사선치료는 겐트리 회전과 다엽콜리메이터, 선량률이 연동되어 진행되며 치료 중 선량 전달의 중단이 발생한 경우 겐트리와 다엽콜리메이터가 최초위치부터 다시 동작하여 정지된 지점부터 선량전달이 재개된다. 본 연구는 용적 변조회전 방사선치료의 치료 중단과 재 진행에 따른 선량전달의 오차를 분석하고자 하였다. 대상 및 방법: 10명의 환자를 대상으로 전산화치료계획시스템(Eclipse V10.0, Varian, USA)을 이용하여 용적변조회전 방사선 치료 계획을 수립하였다. TRILOGY (Varian, USA)의 6 MV 선속을 이용하여 계획된 선량을 이차원 배열 검출기와 CUBE (IBA dosimetry, Germany)팬텀에 조사하였다. OmniPro I'mRT system (V1.7b, IBA dosimetry, Germany)을 통해 4회에 걸쳐 일반적인 선량전달의 일관성을 평가 하고 선량 전달의 중단 또는 도어 인터락 발생으로 인해 선량 전달이 중단되고 최초지점부터 다시 시작되어 조사되는 경우와 비교하여 감마지수(Gamma index)의 변화를 분석하였다. 결 과: 선량 전달이 정상적으로 이루어진 경우에 각각의 감마 평균 신호 값의 차이는 0.1로 나타났고, 선량 전달의 중단이 발생한 경우 0.128로 나타났으며 도어 인터락의 경우 0.141로 나타났다. 각각의 경우 감마 표준편차 값의 차이는 0.071, 0.091, 0.099로 나타났고, 감마 최대값의 차이는 0.286, 0.379, 0.413으로 나타났다. Gamma pass rate (3%, 3 mm)는 허용 오차 범위를 만족하였고, T검증 결과 95% 신뢰구간에서 P-value가 0.05 미만으로 유의한 차이를 보였다. 결 론: 본 실험에서 치료 중 선량 전달의 중단 및 재시작에 관한 정확성을 평가해 본 결과 통계적으로는 차이가 있으나 임상적으로 허용 오차 범위이내로 문제가 없다는 것을 알 수 있었다. 그러나 겐트리와 다엽콜리메이터, 선량률의 연동으로 정확성이 요구되는 치료방법인 만큼 선량적인 측면에서 치료 중단에 따른 차이는 간과할 수 없다. 그러므로 갑작스러운 치료 중단 상황이 발생한 경우 추가적인 정도관리 절차를 통해 정확한 선량평가가 이루어져야 할 것으로 사료된다. Purpose: The accurate movement of gantry rotation, collimator and correct application of dose rate are very important to approach the successful performance of Volumetric Modulated Arc Therapy (VMAT), because it is tightly interlocked with a complex treatment plan. The interruption and restart of dose delivery, however, are able to occur on treatment by various factors of a treatment machine and treatment plan. If unexpected problems of a treat machine or a patient interrupt the VMAT, the movement of treatment machine for delivering the remaining dose will be restarted at the start point. In this investigation, We would like to know the effect of interruptions and restart regarding dose delivery at VMAT. Materials and Methods: Treatment plans of 10 patients who had been treated at our center were used to measure and compare the dose distribution of each VMAT after converting to a form of digital image and communications in Medicine (DICOM) with treatment planning system (Eclipse V 10.0, Varian, USA). We selected the 6 MV photon energy of Trilogy (Varian, USA) and used OmniPro I'mRT system (V 1.7b, IBA dosimetry, Germany) to analyze the data that were acquired through this measurement with two types of interruptions four times for each case. The door interlock and the beam-off were used to stop and then to restart the dose delivery of VMAT. The gamma index in OmniPro I'mRT system and T-test in Microsoft Excel 2007 were used to evaluate the result of this investigation. Results: The deviations of average gamma index in cases with door interlock, beam-off and without interruption on VMAT are 0.141, 0.128 and 0.1. The standard deviations of acquired gamma values are 0.099, 0.091, 0.071 and The maximum gamma value in each case is 0.413, 0.379, 0.286, respectively. This analysis has a 95-percent confidence level and the P-value of T-test is under 0.05. Gamma pass rate (3%, 3 mm) is acceptable in all of measurements. Conclusion: As a result, We could make sure that the interruption of this investgation are not enough to seriously affect dose delivery of VMAT by analyzing the measured data. But this investigation did not reflect all cases about interruptions and errors regarding the movement of a gantry rotation, collimator and patient So, We should continuously maintain a treatment machine and program to deliver the accurate dose when we perform the VMAT for the many kinds of cancer patients.

한방소아과에 성장치료를 주소로 내원한 환아들의 양도락 특성에 관한 연구

이동형,이진용,Lee, Dong-Hyung,Lee, Jin-Yong 대한한방소아과학회 2007 대한한방소아과학회지 Vol.21 No.3

Objectives The object of this study is to investigate the characteristics of Ryodoraku score in the Children who visited Department of Pediatrics, Hospital of Oriental Medicinewith Growth treatment as a chief complaint. Methods Subjects were 58 children who visited Department of Pediatrics, Hospital of Oriental Medicine the first time with Growth treatment as a chief complaint. We measured the height and Ryodoraku score, and we also checked bone age from some of them. This study was designed to investigate the characteristics of Ryodoraku score in children with Growth treatment as a chief complaint. Results and Conclusions The results were follows 1. The average value of Ryodoraku score in 58 children was $41.8800{\pm}13.82641$. 2. The value of H1(肺), H5(三焦), H6(大腸), H2(心包), H3(心), F4(膀胱) and F5(膽) had significant statistical differences compared to its total average. 3. The value of F3(腎) had no relationship with Mid-Parental Height(MPH) percentile. 4. The value of F1(脾), F3(腎) and total average was classified by the height percentile values when children visitedand the difference between the predicted height percentile, and it resulted as there were no relationship between those two

7-Nitroso-8-Hydroxyquinoline-5-Sulfonate 에 依한 Co (Ⅱ) 의 吸光光度定量

이동형,Lee, Dong-Hyung 대한화학회 1965 대한화학회지 Vol.9 No.2

7-Nitroso-8-hydroxyquinoline-5-sulfonate(NHQS)는 pH 4.5에서 Co(Ⅱ)와 安定한 赤色 complex를 形成하므로 이것을 利用하여 NHQS에 依한 Co(Ⅱ)의 吸光光度定量方法을 檢討하였다. 吸光度는 528$m{\mu}$, $25^{\circ}C$에서 測定하였다. Co(Ⅱ)의 濃度 0.3∼6p.p.m에서 Beer의 法則은 成立하며 complex의 分子吸光係數는 $1.1{\times}10^4$이었다. 共存이온中 Fe(Ⅱ), Fe(Ⅲ), Cu(Ⅱ), Mn(Ⅱ), Hg(Ⅰ), CN-, EDTA 等은 本定量에서 妨害가 된다. Complex의 組成을 몰比法과 連續變化法으로 檢討한 結果 NHQS와 Co(Ⅱ)의 몰比는 3:1이었다. Spectrophotometric method for the determination of Co(Ⅱ) is developed based on the fact that Co(Ⅱ) forms a stable red complex with 7-nitroso-8-hydroxyquinoline-5-sulfonate at pH 4. 5. The absorbance is measured at 528$m{\mu}$, $25^{\circ}C$. Beer's law is followed in the concentration range of 0. 3 to 6. 0 p.p.m. of Co(Ⅱ) and molar extinction coefficient of the complex was $1.1{\times}10^4$. Of the diverse ions checked, Fe(Ⅱ), Fe(Ⅲ), Cu(Ⅱ), Mn(Ⅱ), Hg(Ⅰ), CN-, EDTA interfere. The composition of the complex is found to be 3:1 ligand to metal species by mole ratio and continuous variation methods.

8-Hydroxyquinoline 誘導體에 關한 硏究 (第 1 報) 7-Nitroso-8-Hydroxyquinoline-5-Sulfonate 의 合成과 그 酸解離定數

이동형,Lee, Dong-Hyung 대한화학회 1965 대한화학회지 Vol.9 No.1

8-Hydroxyquinoline-5-sulfonic acid 를 alkali 媒質에서 $10^{\circ}C$以下로 維持하여 nitroso 化시켜 7-nitroso-8-hydroxy-quinoline-5-sulfonate (NHQS)를 合成하였으며 그 酸解離定數를 分光光度法과 pH滴定法에 依하여 測定하였다. 두 方法에 依하여 近似하게 같은 값은 얻어졌고 이것들은 8-hydorxyquinoline의 該當 pK값에 比해 작다. 8-hydroxyquinoline에 比해 NHQS의 낮은 鹽基性은 導入된 電子吸引性基들의 影響으로 생각되며 特히 nitroso 基는 ortho位의 phenol性 OH基의 酸性度의 增加에 많은 影響을 주는 것으로 생각된다. 7-Nitro-8-hydoxyquinoline-5-sulfonate (NHQS) have been synthesized from 8-hydroxyquinoline-5-sulfonic acid by nitrosation in alkaline medium at temperature below $10^{\circ}C$ and the acid dissociation constants of NHQS have been determined by spectrophotometric and potentiometric methods. Almost same values are obtained by both methods but the values are lower than the corresponding 8-hydroxyquinoline. The lower basicity of NHQS is considered as the effect of electron withdrawing groups, especially adjacent nitroso group.

8-Hydroxyquinoline 誘導體에 關한 硏究 5-Acetyl-8-Hydroxyquinoline의 酸解離定數

이동형,Lee, Dong-Hyung 대한화학회 1965 대한화학회지 Vol.9 No.1

5-Acetyl-8-hydroxyquinoline 의 酸解離定數를 $25^{\circ}C({\mu}$=0.1)에서 分光光度法과 pH滴定法에 依하여 測定하였다. 두 方法에 의하여 얻은 $pK_1$은 近似하게 一致하였으며 pK값은 8-hydroxyquinoline의 該當 pK값보다 작다. 그것은 acetyl group의 芳香族環에 대한 電子吸引性에 基因한 結果라고 생각한다. Acid dissociation constants of 5-acetyl-8-hydroxyquinoline have been determined by spectrophotometric and potentiometric methods at $25^{\circ}C$. $pK_1$, $pK_2$ values obtained by potentiometric method were 4.56, 8.20 respectively and $pK_1$ obtained by spectrophotometric method was 4.21. pK values were lower than those of 8-hydroxyquinoline. The lower basicity of 5-acetyl-8-hydroxyquinoline compared with 8-hydroxyquinoline was considered as the result of the electronic attraction of the acetyl group with aromatic ring.

감성평가 데이터베이스 구축을 위한 시스템 개발

이동형 ( Dong Hyung Lee ),임준묵 ( Joon Mook Lim ),배기웅 ( Ki Woong Bae ),고복수 ( Bok Soo Ko ),강진규 ( Jin Kyu Kang ),이정훈 ( Jeong Hoon Lee ),남경돈 ( Kyoung Don Nam ) 한국감성과학회 2000 춘계학술대회 Vol.2000 No.-

This paper deals with the construction of database system for the human sensibility evaluation.Recently, although a great deal of research efforts have been made to find out the relationships between products and emotion, the main focus of studies have been on visual and auditory sense and less on human sensibility evaluation. Therefore, we think that continuous and systematic studies on odors and the construction of database system are strongly needed in order to enhance the competitive power of products related to them.In this paper, we developed a human sensibility evaluation database system fitted with the characteristics of our country. 쏜 design procedures of database system are presented. According to these procudures, a new database system is implemented on personal computer using MS Access and Visual and is validated.

RAM 기반 신경망의 MRD 기법에 관한 연구

이동형(Dong-Hyung Lee),김성진(Seong-Jin Kim),박상무(Sang-Moo Park),이수동(Soo-Dong Lee),옥철영(Cheol-Young Ock) 한국컴퓨터정보학회 2009 韓國컴퓨터情報學會論文誌 Vol.14 No.9

다중 판별자를 가지는 RAM 기반 신경망은 단일판별자의 신경 망보다 다범주에서 더 우수한 성능 가진다. 다중 판별자를 가지는 경험유관이진신경망과 3차원 뉴로 시스템(3DNS)은 RAM 기반 이진신경망의 단점인 추가 및 반복 학습, 일반화 패턴 추출 등을 개선하였다. 다중 판별자를 사용하는 신경망의 범주 결정 방법은 MRD 기법으로, 각 판별자의 출력합들 중 최대응답 값으로 결정된다. 그러나 학습 패턴량이 증가하면 신경소자와 판별자의 메모리 포화 문제가 발생되며 이는 MRD의 변별력 저하로 전체 성능이 떨어지는 원인이 된다. 이를 해결하기 위해 기존 MRD의 성능을 향상시킬 수 있는 연구가 필요하다고 본다. 본 논문에서는 최적의 MRD 방법을 찾기 위해 사상 매칭, 누적 필터비 인형 응답 차 그리고 제안된 MRD 기법들을 이용한 최적 MRD 기법 등을 제안하였다. 제안된 MRD의 평가는 3DNS에 전처리 과정 없이 MNIST의 NIST에서 제공하는 숫자 자료를 이용하였다. 제안된 기법들은 기존 MRD보다 우수한 인식률과 입력 패턴의 변형 및 노이즈에 대하여 안정적인 결과를 보였다. A RAM-based Neural Net(RBNN) which has multi-discriminators is more effective than RBNN with a discriminator. Experience Sensitive Cumulative Neural Network and 3-D Neuro System(3DNS) that accumulate the features point improved the performance of BNN, which were enabled to train additional and repeated patterns and extract a generalized pattern. In recognition process of Neural Net with multi-discriminator, the selection of class was decided by the value of MRD which calculates the accumulated sum of each class. But they had a saturation problem of its memory cells caused by learning volume increment. Therefore, the decision of MRD has a low performance because recognition rate is decreased by saturation. In this paper, we propose the method which improve the MRD ability. The method consists of the optimum MRD and the matching ratio prototype to generalized image, the cumulative filter ratio, the gap of prototype response MRD. We experimented the performance using NIST database of NIST without preprocessor, and compared this model with 3DNS. The proposed MRD method has more performance of recognition rate and more stable system for distortion of input pattern than 3DNS.