이소갑상선 19예의 신티그라피 소견

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),이찬우(Chan Woo Lee),원규장(Kyu Chang Won),윤현대(Hyun Dae Yoon),조인호(In Ho Cho),이형우(Hyoung Woo Lee),이현우(Hyun Woo Lee) 대한핵의학회 1993 핵의학 분자영상 Vol.27 No.2

N/A Abnomalities in the embryologic development and migration of the thyroid gland can result in ectopic thyroid tissue, which may occur on the midline in any position from the base of the tongue to the mediastinum. Although ectopic thyroid may be asymptomatic, local obstructive, hemorrhagic or other complication may occur. Radinuclide thyroid scan is confirmatory when the diagnosis is suspected. Hypothyroidism is common in lingual thyroid, and thyroid supplementation is generally required. In order to evaluate the features of ectopic thyroid, we investigated the scintigraphic findings, thyroid function test and clinical symptoms of 19 patients with ectopic thyroid. 1) The frequency of ectopic thyroid was about 5. 3 times more common in female than in male. Then patients were mostly below 30 years old (79%). 2) The frequency of location of ectopic thyroid were as follows: 10 cases in the tongue base, 1 case in suprahyoid, 5 cases in infrahyoid and 3 cases over 2 areas. 3) The thyroid function test was done in 16 cases of the ectopic thyroid patients. The hypothyroidism was detected in 7 cases, subclinical hypothyroidism in 4 cases and normal thyroid function in 5 cases. 4) The rate of hypothyroidism is 90% in the lingual thyroid and 33% in the others. The thyroid dysfunction was related with the location of the ectopic thyroid (p〈0.05). 5) The clinical manifestations include a mass in the tongue base, the foreignbody sensation of a throat and a swallowing difficulty in lingual thyroid. The palpable mass was the chief complaint in the others. 6) We prescribed the thyroid hormone to 10 cases with hypothyroidism. The ectope thyroid was removed in 2 cases with normal thyroid function. The rest is following up through OPD. We must consider the possibility of the ectopic thyroid and take the thyroid scan when the patient has a amass in the tongue base, the sublingual and the prelaryngeal area. Then we have to check the thyroid function and follow up when the ectopic thyroid is diagnosed, because the patient with normal thyroid function can result in the hypothyroidism. Except these, we must mind of the possibility of occurence of the cancer in the ectopic thyroid tissue.

MEN Type 2 ( Sipple ` s Syndrome ) 의 신티그램 소견

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),황기석(Kee Suk Whang),김보완(Bo Wan Kim),이인규(In Kyu Lee) 대한핵의학회 1991 핵의학 분자영상 Vol.25 No.1

Multiple endocrine neoplasia type 2 (MEN type 2, Sipple's syndrome) is a rare disorder characterized by the association of medullary carcinoma of the thyroid, parathyroid hyperplasia and can be diagonsed in early stage of the disease by meticulous screening tests of the famiiy. This case report describes the location and categorization of tumors using 99mTc-pertechnetate, I -NaI, 99mTc-pentavalent(V) DMSA, 131I -MIBG scans in two cases of MEN type 2 occurred in a 32 year old women and her 29-year old brother. In MEN type 2, we think, combined use of 99mTc-(V)-DMSA, Tc-pertechnetate and 131I -MIBG may be useful for the categorization of tumor mass lesions and planning appropriate therapy.

급성골수성백혈병의 Adriamycin 과 Ara - C 병합요법에 의한 관해유도효과

이규보 ( Kyu Bo Lee ),황기석 ( Kee Suk Whang ),이재태 ( Jae Tae Lee ),유만준 ( Man Joon Yu ) 대한내과학회 1985 대한내과학회지 Vol.28 No.4

복막투석환자에서의 개존된 Processue Vaginalis - 방사성핵종복막촬영술로 확진된 2예 -

이규보(Kyu Bo Lee),손상균(Sang Kyun Son),이재태(Jae Tae Lee),황기석(Kee Suk Whang),조동규(Dong Kyu Cho),고철우(Chul Woo Koh) 대한핵의학회 1989 핵의학 분자영상 Vol.23 No.2

Continuous ambulatory peritoneal dialysis (CAPD) is a well established method of treating end stage renal failure, and is commonly used as an alternative to hemodia]ysis. Several complications have been observed. These include catheter rnalfunction, abdominal and inguinal hernia, and peritonitis. A relatively frequent complication is swetling of externa] geniitalia, due to bowel fluid passing through a patent processus vaginalis. Special diagnostic procedures are necessary to dctermine the nature of the abnormality and to guide the surgical correction. We reported two cases of patent processus vaginalis in patient on CAPD proved by radionuclide peritonea1 scintiscan using Tc-99 m-tin colloid.

Thallium-201 을 이용한 세포막 Na+-K+ ATPase 활성도 측정 ; Rubidium-86 측정법과의 비교

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),손상균(Sang Kyun Sohn),이인규(In Kyu Lee) 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.2

N/A Purpose: Na+-K+ ATPase Activity has beem estimated by the degree of inhibition of cation transport by cardiac glycosides (ouabain) using Rb-86 as a substrate. The biological characterist- Isc of T1-201 is known to be simiIar to those of potassium as a transport substrate in the presence of glucose, insulin or phobol myristate acetate (PMA). The purpose of this study was to measure ouabain sensitive Na+-K+ ATPase activity using T1-201 and compare with that using Rb-86. Materials and Methods: Smooth muscle cells isolated from rat aorta or human placental umbilical artery were cultured, and used to measure cellular Na+-K+ ATPase activity. Na+-K+ ATPase activity was measured as a percentage decrease in cellular uptake of T1-201 or Rb-86 by ouabain under the presence of glucose, insulin or PMA in media. Results: Na+-K+ ATPase ase activity measured with T1-201, as a transport substrate, was not different from those measured with Rb-86 in rat or human smooth muscle cell preparation. Incubation with high concentration glucose resulted in about 30% decrease in enzyme activity. In contrast, insulin or PMA resulted in 50-70% or 28% increases from baseline activity, respectively. Conclusion: These results suggests that T1-201 could replace Rb-86 in measurement of ouabain sensititive Na+-K+ ATPase activity in vitro. High level of glucose concentration decreased cellular Na+-K+ ATPase activity, but insulin or PMA increased it.

K - 통로개방제가 배양심근세포와 생쥐 체내의 Thallium - 201 역동학에 미치는 영향

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),안병철(Byeong Cheol Ahn),김은지(Eun Ji Kim),손상균(Kang Kyun Sohn),하정희(Jeoung Hee Ha),김천기(Chun K . Kim) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.4

N/A Background: Potassium channel opener (K-opener) opens ATP-sensitive K+-channel located at membrane and induces potassium efflux from cytosol, resulting in intracellular hyperpolarization. Newly synthesized K-opener is currently examined for pharmacologic potency by means of rubidium release test from smooth muscle strip pre-incubated with Rb-86. Since in-vive behavior of thallium is similar to that of rubidium, we hypothesized that K-opener can alter T1-201 kinetics in vivo. Purpose: This study was prepared to investigate the effects of pinacidil (one of potent K-openers) on the T1-201 uptake and clearance in cultured myocyte, and in-vivo biodi- stribution in mice. Methods: Spontaneous contracting myocytes were prepared to imitate in-vivo condition from 20 hearts of 3-5 days old Sprague-Dawley rat and cultured for 3-5 days before use (5×105 cells/ml). Pinacidil was dissolved in 10% DMSO solution at a final concentration of 100nM or 10uM and was co-incubated with T1-201 in HBSS buffer for 20-min to evaluate its effect on cellular T1-uptake, or challenged to cell preparation pre-incubated with T1-201 for washout study. Two, 40 or 100μg of pinacidil was injected intravenously into ICR mice at 10 min after 5μCi T1-201 injection, and organ uptake and whole body retention rate were measured at different time points. Results: Co-incubation of pinacidil with T1-201 resulted in a decrease in T1-201 uptake into cultured myocyte by 1.6 to 2.5 times, depending on pinacidil concentration and activity of T1-201 used. Pinacidil enhanced T1-201 washout by 1.6-3.1 times from myocyte preparations pre-incubated with T1-201. Pinacidil treatment appears to be resulted in mild decreases in blood and liver activity in normal mice, in contrast, renal and cardiac uptake were mildly decreased in a dose dependent manner. Whole body retention ratios of T1-201 were lower at 24 hour after injection with 100μg of pinacidil than control. Conclusion: These results suggest that treatment with K-opener may affect the interpretation of T1-201myocardial images, due to decreasing thallium accumulation and enhancing washout from myocardium.

ECG Gated Blood Pool Scan을 이용한 심실벽 역행성 운동의 평가 - Cine Loop , Phase analysis , Paradox Image의 비교 -

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),황기석(Kee Suk Whang),정병천,전재은,정진홍(Jin Hong Chung),김광원(Gwang Weon Kim),채성철(Sung Chul Chae),박의현(Wee Hyun Park),이형우(Hyong Woo Lee) 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.2

N/A Sixty-four patients with paradoxical ventricular wall motion noticed both in angiocardiography or 2-dimensional echocardiography were assessed by ECG gated blood pool scan (GBPS). Endless cine loop image, phase and amplitude images and paradox image obtained by visual inspection of each cardiac beat or Fourier transformation of acquired raw data were investigated to determine the incremental value of GBPS with these processing methods for identification of paradoxical ventricular wall motion. The results were as follows:1) Paradoxical wall motions were observed on interventricular septum in 34 cases, left ventricular free wall in 26and right ventricular wall in 24. Underlying heart diseases were is chemic (23 cases) valvular(9), congenita1 heart disease (12), cardiomyopathy (5). pericardial effusion(5), post cardiac surgery(3), cor pulmonale (2), endocarditis (l) and right ventricular tumor(l). 2) Left ventricular ejection fractions of patients with paradoxical left ventricular wall motion were significantly lower than those with paradoxical septal motion (p〈0.005). 3) The sensitivity of each processing methods for detecting paradoxical wall motion was 76.9% by phase analysis, 74.6% by endless cine loop mapping and 68.4% by paradox image manipultion respectively. Paradoxial motions visualized only in phase, paradox or both images were appeared as hypokinesia or akinesia in cine loop image. 4) All events could be identified by at least one of above three processing methods, however only 34 cases (48.4%) showed the paradoxical motions in all of the three images. By these findings, we concluded that simultaneous inspection of all above three processing methods-endless cine loop, phase analysis and paradox image is necessary for accurate identification and assessment of paradoxical ventricular wall motion when performing GBPS.

당뇨병 환자의 위배출능 : 위배출시간 , 위저류율 및 Cisapride의 영향

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),정병천(Byung Chun Chung),최정일(Chung Il Choi),김보완(Bo Wan Kim),곽동석(Dong Suck Gwak),정준모(Jun Mo Chung) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.2

N/A Gastic emptying scan in diabetic patients is widely used to assess the degree of motility disturbance and the symtoms such as nausea, vomiting, bloating, abdominal pain and early gastric fullness which we can't find anatomic lesion by fiberoscopic or barium study. In order to determine the relationship among diabetic gastropathy, neropathy, retinopathy and disease duration, gastric emptying scan using Tc-99m-tin colloid labeled scramble egg in hamburger was performed in 10 healty male controls and 50 diabetic patients which were subdivided to no neuropathy, peripheral neuropathy and autonomic neuropathy groups according to the degree of diabetic neuropathy and no retinopathy, background retinopathy and proliferative retinopathy groups according to the degree of diabetic retinopathy. After medication of cisapride for 2 weeks, we observed the presence of improvement of gastric motility in diabetics. The results were as following: 1) In controls, gastric emptying time (GET1/2) was 75±13.6 min and 2 hour gastric retension rate(GRR2) was 32±11.1%. 2) In diabetics, GET/2 was prolonged more than 2 hours and GRR2 was 58±23.1%. According to degree of neuropathy, GET1/2 was prolonged more than 2 hours in all three groups and GRR2 was 54±24.1% in no neuropathy group, 57±24.3% in peripheral neuropathy group and 69±24.6% in autanomic neuropathy group. According to degree of retinopathy, GET1/2 was 110±23.4 min in no retinopathy group and prolonged more than 2 hours in other two groups and GRR2 was 45±21.6% in no retinopathy group, 71±19.7% in background retinopathy group and 73±21.5% in proliferative retinopathy group. 3) After cisapride for 2 weeks, GET1/2 and GRR2 were improved as 90±14.6 min and 40±13.8% (initial GET1/2 and GRR2 were above 2 hours and 61±15.4%). We can conclude from above findings that gastropathy in diabetic neuropathy suggesting main underlying factor in motility disorder. The degree of retinopathy and disease duration were correlated with severity of gastropathy in diabetics. From the results of gastric emptying scan, we can conclude that cisapride was useful drug for improving diabetic gastropathy and gastric emptying scan was valuable for assessing severity of diabetic gastropathy as non-invasive method.

관해된 급성 골수성 백혈병 환자에서 발생한 과립성 육종의 67Ga - citrate Scan 소견

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),황기석(Kee Suk Whang),김광원(Gwang Weon Kim),정병천(Byung Cheon Chung) 대한핵의학회 1990 핵의학 분자영상 Vol.24 No.2

N/A A case of a 39-year-old man with granulocytic sarcoma documented by positive Ga-67 scan is described and brief review of literature was performed. He was diagnosed as acute myelogenous leukemia and got complete remission with antileukemic chemotherapy for 7 months. On admission, picture of his bone marrow and peripheral blood showed remission state of leukemia. Radiologic examinations were performed for evaluation of lesions in head and chest, and findings of granulocytic sarcoma were suspected. So we got 67Ga-citrate scan and pleural biopsy for identification of causes of intractable pleural effusion and skin lesion. Myeloblastomas (or granular sarcomas) proved by pleural biopsy were correctly identified by 67Ga-citratre scan, and disease extent was clearly delineated. We believe that 67Ga-scintigraphy is very helpful in localizing and follow-up evaluation of granulocytic sarcoma.

관상동맥 질환에서의 Adenosine 부하 99mTc - MIBI 심근 스캔의 진단적 가치 : 운동 부하 99mTc - MIBI 심근 스캔과의 비교

이규보(Kyu Bo Lee),이재태(Jae Tae Lee),박의현(Wee Hyun Park),정병천(Byung Cheon Chung),최정일(Chung Il Choi),전재은(Jae Eun Jun),채성철(Sung Chull Chae),강승완(Seung Wan Kang),우언조(Eon Jo Woo) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.1

N/A Pharmacologic coronary vasodilation in conjunction with myocardial scintigraphy has become an accepted alternative to dynamic exercise testing for the diagnosis of coronary artery disease. Although dipyridamole has traditionally been used for this purpose, it causes frequent side effect, which at times can be life-threatening. Moreover, dipyridamole dose not elicit maximal coronary vasodilation in a substantial number of patients receiving the usual i.v. dose. Adenosine is an endogenously produced compound that has significant effects as a coronary vasodilator and rapid onset action and extremely short half-life ((10 seconds). The diagnostic accuracy and safety profile of adenosine Tc-99m-MIBI myocardial scintigraphy were evaluated and comparison with exercise Tc-99m-MIBI was performed. Twenty-eight subjects underwent Tc-99m-MIBI imaging after adenosine infusion and exercise Tc-99m-MIBI imaging. Adenosine was infused intravenously at a dose of 0.14 mg/kg/body weight per minute for 6 min and MIBI was injected at 3 minute. Adenosine caused an incerease in heart rate (64±12 at baseline versus 74±16 beats/min at peak effect, p〈0.001), a mild decrease in systolic and diastolic blood pressure and a slightly increase in PR interval(p; NS). Side effects were reported in 92% of patients and were mostly mild in nature and promptly resolved within 1 or 2 minutes of termination of adenosine infusion. Facial flushing (53%), chest pain (36%), mild dyspnea (39%), headache (21%), throat discomfort (21%) were frequent symptoms. ST segment depression(〉1mm) and second degree AV block in electrocardiography occured in 11% of thepatients, respectively. The overall sensitivity and specificity for individual coronary stenoses in 16 patients underwent coronary angiography were 88% and 95%, respectively. The agreement ratio of segmental perfusion between adenosine and exercise images was 92% (Kappa index=0.82). In conclusion, Tc-99m-MIBI myocardial perfusion scintigraphy with intravenous adenosine is a feasible, safe and highly accurate noninvasive technique for the detection of coronary artery disease and results are at least comparable with those of exercise Tc-99m-MIBI scintigraphy.