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Intralipidos에 대한 급성독성 및 4주간 정맥 내 반복투여 독성시험
이광훈,제정환,강병철,이원우,임종희,정지윤,이병희,남정석,박재학,이영순,Li, Guang-Xun,Che, Jeong-Hwan,Kang, Byeong-Cheol,Lee, Won-Woo,Ihm, Jong-Hee,Jung, Ji-Yun,Yi, Beoung-Hi,Nam, Jeong-Seok,Park, Jae-Hak,Lee, Yong-Soon 한국독성학회 1998 Toxicological Research Vol.14 No.3
This sutdy was carried out to investigate the acute toxicity and foru-week intravenous toxicity of the intralipidos in rats and rabbits. The acute toxicity study of Intralipidos was performed in Spragur-Dawley (SD) rats. Intralipidos was administered by intravenous to maximum dose 200 ml/kg. $LD_{50}$ of intralipidos was found 139.5ml/kg and 153.8ml/kg in male female SD rats. Four-week toxicity of intralipidos using New Zealand White Rabbit and SD rats. The Rabbit and Rats were administered by intravenous seven days per week for 28 days, with dosage of 15, 6, 2 ml/kg/day and 20, 6, 2ml/kg/day, respectively. Animals treated with intralipidos did not cause any death and show any clinical signs. They did not show any significant changes of body weight, feed uptake and water consumption. They were not significantly different from the control group in urinalysis, ocular examination hematological, serum biochemical value and histopathological examination. Therefore, Intralipidos was not indicated to have any toxic effect in the Rabbits and Rats, when it was administrated by intravenous below the dosage 15ml/kg/day and 20 ml/kg/day for four weeks.
기니픽, 마우스 그리고 랫드에서 Intralipidos의 항원성
이병희,제정환,이광훈,강병철,이원우,임종희,정지윤,이영순,Yi, Beoung-Hi,Che, Jeong-Hwan,Li, Guang-Xun,Kang, Byeong-Cheol,Lee, Won-Woo,Ihm, Jong-Hee,Jung, Ji-Youn,Lee, Yong-Soon 한국독성학회 1998 Toxicological Research Vol.14 No.3
The antigenicity of intralipidos was investigated in guinea pig, mice and rats. Antigenicity tests-active systemic anaphylaxis (ASA), passive systemic anaphylaxis (PSA), passive cutaneous anaphylaxix (PCA) of this materials were performed. The results were followed: 1. After sensitizaion with YPL, YPL+intralipidos, and intralipidos, emulsified with complete Freund's adjuvant (CFA), guinea pigs didn's show any anaphylatic shock symptom in the ASA test, 2. These materials didn't show any anaphylatic shock symptom in the PSA test, 3. After sensitization with antisera of YPL, YPL+intralipidos, and intralipidos sensitized mice, blue spots were not observed on the hypodermis of back of rats in the PCA test. From the results of this investigation, the antigenicity of YPL, intralipidos was negative under the present experimental condition.
랫드에서 Alginase의 급성 및 4주간 정맥 내 반복투여 독성시험에 관한 연구
임종희,남정석,제정환,이광훈,이학모,이원우,이병희,정지윤,박재학,이영순,Ihm, Jong-Hee,Nam, Jeong-Seok,Che, Jeong-Hwan,Li, Guang-Xun,Lee, Hak-Mo,Lee, Won-Woo,Yi, Beoung-Hi,Jung, Ji-Youn,Park, Jae-Hak,Lee, Yong-Soon 한국독성학회 1998 Toxicological Research Vol.14 No.3
Alginase$Alginase^{ⓡ}$ (Arginine esterase) is one of the snake venoms which is mainly consisted of arginine esterase and acts as a thrombus -forming inhibitor/thrombus-lysin. These present studies were performed to investigate of the acute and subacute toxicity of the Alginase$Alginase^{ⓡ}$ in rats. In acute toxicity study, rats were single administered intravenously with dosages of 0.001, 0.01. 0.1, 1 and 10U/kg B.W. and examined the number of death, clinical sign, body weight and pathological change for 7days after administration of Alginase$Alginase^{ⓡ}$. At maximum dose level (10U/kg B.W.), Alginase$Alginase^{ⓡ}$ induced symptoms of shock with cyanosis and dyspnea. But these symptoms dissappeared after 30~50 minutes and we could not find any other toxic effect in rats. Therefore, $LD_{50}$ Value of Alginase was over 10U/kg B.W. in rats. In four-week intravenous toxicity study of Alginase$Alginase^{ⓡ}$, rats were administered intravenously seven days per week for 28 days, with dosages of 0, 0.0125, 0.125 and 1.25U/kg B.W./day, respectively. Alginase$Alginase^{ⓡ}$ did not caused any death and showed any clinical signs in rats. No significant Alginase$Alginase^{ⓡ}$ -related changes were found in feed uptake, water consumption, hematology, serum biochemistry, urinalysis, ocular examination, organ weight and histopathological examination. From the results, Alginase$Alginase^{ⓡ}$ seems not to have any toxic effect in rats when it were given daily intravenous injections below the dosage 1.25U/kg B.W./day for four weeks.
정지윤,이원우,임종희,남정석,제정환,이광훈,강병철,이병희,박재학,이영순,Jung, Ji-Youn,Lee, Won-Woo,Ihm, Jong-Hee,Nam, Jeong-Seok,Che, Jeong-Hwan,Li, Guang-Xun,Kang, Byeong-Cheol,Yi, Beoung-Hi,Park, Jae-Hak,Lee, Yong-Soon 한국독성학회 1998 Toxicological Research Vol.14 No.3
In order to evaluate the mutagenic potential of Intralipidos produced by Greenmate cooperation. We performed Salmonella typhimurium reversion assay, chromosomal aberration test on chinese hamster ovarian cells and in vivo micronucleus assay using mouse bone marrow cells. In the reverse mutation test using Salmonella typhimurium TA98 and TA100, Intralipidos did not increase the number of revertant at any of the concentration tested in this study. Intralipidos did not increase the number of cells having structural or numberical chromosome aberration in cytogenetic test. In mouse micronucleus test, no significant increase were observed in the occurrence of micornucleated polychromatic erythrocytes in ICR male mice intraperitoneally administered with Intralipidos. These results indicate that Intralipidos has no genetic toxicity under these experimental conditions.
A Comparative Analysis on China and ASEAN's Competition and Cooperation
LI, Guang Xun,SHIM, Ui-Sup 明知大學校 經濟硏究所 2003 경영연구 Vol.22 No.1
중국과 아세안과의 FTA(CAFTA)는 중국의 WTO가입에 대한 두려움에서 비롯되었다. 중국의 가입은 증국의 무역과 경제는 고속 성장을 할 것이다. 중국의 국제 시장점율은 높아질 것이고 FDI도 동남아에서 중국으로 이전될 것이다. 중국 대아세안 대종수출 품목은 섬유, 의류, 석유와 식량이고 수입품목은 원유, 액화가스, 정유, 식용유, 원목, 원자재 등이다 지역간 무역은 아직 소규모이지만 잠재력이 크기 때문에FTA가 체결되면 무역 창출효과와 무적 전환효과는 크게 증가될 것이다. CAFTA가 체결되면 중국의 대 아세안 수출은 55% 증가, 아세안의 대 중국 수출은 48%증가될 것이다. 한편 중국과 아세안의 GDP는 증가는 각각 0.3%, 0.9% 증가할 것이다. 현재 중국과 아세안의 무역경쟁은 치열하다. 이 논문에서는 Singapore, Malaysia, Indonesia, Thailand, Philippines 등 아세안 5개국과 중국의 현시비교우위를 분석하였다 분석결과 중국의 산업구조는 아세안과 비슷하므로 국제시장에서 중국과 아세안과의 경합은 치열하게 나타났다. 중국과 아세안과의 FTA가 실현되면 EU와 NAFT와 강력한 경제적 경쟁대상이 될 것이다. 아울러 이는 세계에서 가장 큰 대표적인 남남협력 프로젝트가 될 것이다. 이를 위한 중국의 정책 대안은 첫째, 중국의 아세안에 대한 대폭적이 양허정책이 요구되고, 둘째, 중국은 연구와 협동을 개선시켜야 하고, 넷째, 중국은 아세안과의 협력증진을 위한 많은 방안들을 강구하여야 하며, 넷째,복잡한 아세안 회원국을 감안하여 각각 상이하고 적합한 국별 협력전략을 구사하여야 하며,다섯째,중국은 아세안과 사업을 하는 중국회사들에게 정보와 상담을 제공하여야 하는 등 특별한 육성정책을 실시하여야 한다. CAFTA가 성공적으로 운영되면 이 지역의 활력이 분출될 것이고 나아가 한국과 일본의 참여도 가능할 것이라는 논리를 전개하고 있으며, EU와 NARTA에 버금가는 세계적인 강력한 FTA로 등장할 것이다.