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지실 추출물의 전사인자 SREBP-1 활성에 의한 지질 생성 촉진
김대성(Dae Sung Kim),전병국(Byoung Kook Jeon),문연자(Yeun Ja Mun),이강태(Ghang Tai Lee),이건국(Kun Kuk Lee),우원홍(Won Hong Woo) 대한약학회 2012 약학회지 Vol.56 No.4
This study was to explore the lipogenic effect by ethanol extract of ponciri fructus (EPF) and possible molecular mechanisms in sebocyte. When SZ95 sebocyte cell line were treated with the EPF, lipid droplets were accumulated in the majority of cells. EPF increased expression of sterol regulatory element-binding protein-1 (SREBP-1) and fatty acid synthase (FAS) in the SZ95 cells. EPF augmented expression of PPAR-β and PPAR-γ but not that of PPAR-α. These results suggest that EPF induces lipogenesis in SZ95 cells through SREBP-1, PPAR-β and PPAR-γ activations.
부검으로 확진된 알쯔하이머병 1예 : An Autopsy Report
한설희,이건국,양기화,장순환 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.1
While the clinical diagnostic accuracy of probable Alzheimer′s disease (AD) is 87-96% with a diagnostic sensitivity/specificity of 0 81-0 87, the unequivocal diagnosis of AD rests on histopathological evidence at brain autopsy and/or biopsy We report here a 92-year-old woman whose clinical presentation suggested a far advanced Alzheimer′s disease Formal neuropsychological evaluations were not applicable due to severe cognitive impairments With a relatively good general physical condition she could walk with aid during her last days no focal neurological signs were noted on a detailed examination Brain MRI revealed a diffuse cortical atrophy with a marked reduction in the hippocampal volume The brain obtained weighted 780g The cerebral hemispheres examined after fixation disclosed moderately severe atrophy in prefrontal and temporal lobes on coronal section, the hippocampus was likewise severely atrophied the lateral ventricles were moderately dilated On microscope examination, there were numerous senile plaques and neurofibrillary tangles in the neocortices. hippocampus and amyglada, compatible with advanced Alzheimer′s disease In summary we report the first Korean autopsy-proven case with advanced Alzheimer′s disease.