재발한 급성 괴사성 뇌병증 1례

윤종서(Jong Seo Yoon),박소현(So Hyun Park),김동언(Dong Un Kim),김영훈( Young Hoon Kim),이 진(Jin Lee),장필상(Pil Sang Jang),김진택(Jin Tack Kim),황경태(Kyung Tai Whang) 대한소아신경학회 2003 대한소아신경학회지 Vol.11 No.2

저자들은 15개월에 급성 괴사성 뇌병증을 않았던 4세 남아에서 발열 및 경한 상기도 감염의 증상 후 갑자기 의식이 나빠지고 전신발작을 일으키며 뇌 MRI상 T2 강조영상에서 고 신호 강도를 보이는, 양측 시상을 대칭적으로 침범하는 원형의 병변이 관찰되었던 재발된 급성 괴사성 뇌병증 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. A 4-year-old boy showed two episodes of encephalitis/encephalopathy involving disturbed consciousness, convulsion, and paresis associated with the elevated levels of protein and no pleocytosis of the cerebrospinal fluid. MRI studies of the brain revealed symmetrical lesions in the brain stem and thalamus at the first episode, and their sizes were regressed. The lesions were enlarged to the previous size in the second episode. These episodes were not followed by an elevation of the anti-viral antibody titer. In the second episode, intravenous methylprednisolone therapy and intravenous immunoglobulin therapy were introduced.

심박 측정을 위한 실시간 Look Around Period 변환

윤종서(Jong-Seo Yoon),이상엽(Sang-Yeob Lee),이수연(Su-Yeon Lee),이진수(Jin-Su Lee),이정환(Jeong-Whan Lee) 대한전기학회 2023 대한전기학회 학술대회 논문집 Vol.2023 No.7

어린 흰쥐의 해마 박편에서 Mg-free Medium과 4-Aminopyridine에 의해 유발된 간질양 뇌파에 대한 Lamotrigine의 효과

윤종서(Jong Seo Yoon),이인구(In Goo Lee),최병준(Byung Joon Choi),황경태(Kyung Tai Whang) 대한소아신경학회 2005 대한소아신경학회지 Vol.13 No.2

목 적 : Lamotrigine(LTG)은 최근에 개발된 항경련제 중 하나로 작용 기전에 완전히 밝혀져 있지 않으며, 실험 모델에 따라 항경련 효과를 보이는 적절한 용량 역시 결정되어 있지 않다. 이에 저자는 뇌의 발육이 미성숙한 어린 흰쥐의 해마 박편을 제작하여 Mg-free medium 뇌척수액에서 4-aminopyridine(4-AP)으로 간질양 뇌파를 유발시킨 후 이를 가장 잘 억제할 수 있는 LTG의 농도를 알아보고, 또한 이를 통한 간질양 뇌파의 억제 양상을 관찰함으로써 밝혀진 LTG의 작용 기전 외의 다른 기전의 가능성을 알아보고자 이 실험을 시행하였다. 방 법 : 생후 19-23일 사이의 Sprague-Dawley 흰쥐를 이용하여 대조군(n=12)과 실험군으로 나눈 후 실험군은 LTG 농도에 따라 400(n=9), 800(n=7), 1,000(n=8) µM 투여군으로 분류하였다. 마취 상태에서 뇌를 꺼내어 기본 뇌척수액(NaC1 125 mM; KC1 2.5 mM; NaHPO 2 mM; MgSO 1.25 mM; NaHCO 25 mM; CaC1 mM; glucose 10 mM, pH 7.3-7.4)에 담그고 vibratome으로 400µm 두께의 해마 박편을 만들었다. 대조군은 해마 박편을 Mg-free medium 뇌척수액에 옮겨 놓고 200µM 농도의 4-AP를 첨가한 1시간 후에 CA1 영역의 피라미드 층에서 뇌파를 측정하였고, 실험군은 대조군과 같은 인공 뇌척수액에 각각 400, 800, 1,000 µM의 LTG를 첨가하고 뇌파를 측정하였다. 결 과 : 1) LTG의 간질 간기 뇌파에 대한 효과 : 간질 간기 뇌파는 대조군과 LTG 투여군 모두에서 나타났다. 첫 번째 간질 간기 뇌파가 나타날 때까지의 잠복시간은 대조군에서 52.7±26.9초이었으나 LTG의 농도가 증가함에 따라 점차 길어져 800 µM군에서는 225.0±28.2초, 1,000µM군에서는 322.1±116.4초였다(P<0.05). 간질 간기 뇌파의 지속시간은 대조군에서 64.6±35.6초였으나, LTG 800µM군에서 가장 짧아 39.9±12.6초였다. 2) LTG의 간질 뇌파에 대한 효과:간질 뇌파는 대조군과 LTG 400µM군의 모든 박편에서 나타났으나, LTG의 농도가 증가하면서 발생 빈도가 줄어 800µM군에서는 57.1%, 1,000µM군에서는 12.5%에서만 나타났다. 첫 번째 간질 뇌파가 나타날 때까지의 잠복시간은 대조군에서 142.1±52.6초였으나 400 µM군에서는 304.4±84.5초, 800 µM군에서는 689.8±213.1초였다(각각 P<0.05). 그리고 1,000 µM군에서는 2,071초로 실험군 중 가장 긴 잠복시간을 보였으나 간질 뇌파가 발생한 경우가 1개의 박편 밖에 없어 통계적으로 의의를 구할 수 없었다. 간질 뇌파의 지속시간은 대조군에서 1,534.7±339.3초이었으나 LTG의 농도가 증가함에 따라 점차 짧아져 800 µM군에서는 126.5±76.1초이었고(P<0.05), 1,000 µM군에서는 42초였다. 결 론 : 어린 흰쥐의 해마 박편에서 4-AP와 Mg-free medium에 의해 유발되는 간질양 뇌파를 억제하는 LTG는 800 µM 이상의 농도일 때 가장 효과적인 항경련 효과를 가지고 있었다. 이는 LTG의 기본 약리 기전이 sodium 통로를 억제하는 것이지만 고농도에서는 potassium 통로에도 작용해 흥분성과 억제성 아미노산의 방출을 억제하고, 억제되었던 GABA의 활동을 증가시키기 때문인 것으로 생각된다. Purpose : In order to elucidate the actual mechanism and the optimal concentration of Lamotrigine(LTG) that suppresses epileptiform discharges, we observed epileptiform discharges from hippocampal slices of immature rat in 4-aminopyridine(4-AP) added Mg -free medium of artificial cerebrospinal fluid(aCSF) with various LTG concentrations. Methods : We divided 19-23 day-old Sprague-Dawley rats into 4 groups; control group(n=12) and 3 LTG group depending on the concentrations of LTG such as 400(n=9), 800(n=7), and 1,000(n=8) µM. The rats were anesthetized and their brains were taken, soaked in aCSF(NaC1 125 mM, KC1 2.5 mM, NaHPO 2 mM, MgSO 1.25 mM NaHCO 25 mM, CaC1 2 mM, Glucose 10 mM, pH 7.3-7.4). And then the brains were cut into 400 µm hippocampal slices by a vibratome. The slices of control group were soaked in 200µM 4-AP added Mg-free medium of aCSF for 1 hour, and then extracellular recordings were performed in hippocampal CA1 pyramidal region. The slices of LTG groups were soaked in the solution containing 400, 800, and 1,000µM LTG, then extracellular recordings were performed. Results : Interictal discharges were observed in all the control and the LTG groups. The latency to the first interictal discharges after 4-AP addition was 52.7±26.9 sec in control group, but was 225.0±28.2 sec in 800 µM and 322.1±116.4 sec in 1,000 µM group of LTG(P<0.05). The duration of interictal discharges was 64.6±35.6 sec in control group, but was the shortest in 800µM group of LTG at 39.3±12.6 sec. Ictal discharges were observed in all of control and 400µM group, but the frequency was decreased as the concentration of LTG increases, 57.1% in 800µM, 12.5% in 1,000 µM group. The latency to ictal discharge after 4-AP addition was 142.1±52.6 sec in control group, but increased as the concentration of LTG increases, 304.4±84.5 sec in 400 µM group and 689.8±213.1 sec in 800 µM group(P<0.05). The duration of ictal discharges was 1,534.7±339.3 sec in control group, but decreased as the concentration of LTG increases, it was 126.5±76.1 sec in 800 µM group(P <0.05) and 42 sec in 1,000 µM group. Conclusion : The antiepileptic effects of LTG were most significant when the concentration, inhibiting epileptiform discharges induced by 4-AP and Mg -free medium in hippocampal slices of immature rats, was 800uM or higher. Although the basic pharmacologic mechanism of LTG is the inhibition of sodium channel, it may also work on potassium channel at higher concentrations.

소아의 굴염에서 생리 식염수 비 세척과 충혈 제거제의 사용에 대한 전향적 무작위 개방 시험

윤종서 ( Jong Seo Yoon ),조연수 ( Yeon Soo Cho ),김민성 ( Min Sung Kim ),전윤홍 ( Yoon Hong Chun ),김현희 ( Yeon Soo Cho ),김진택 ( Jin Tack Kim ),이준성 ( Joon Sung Lee ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2010 소아알레르기 및 호흡기학회지 Vol.20 No.4

목적: 소아 굴염은 치료방법에 대해 논란이 많다. 일반적으로는 항생제를 사용하는 것이 가장 기본적인 치료로 알려져 있다. 부가적인 치료로서, 식염수로 비강을 세척하는 방법 그리고 충혈 제거제의 사용이 이루어지고 있으나, 이러한 추가적인 치료들의 효과에 대하여는 아직 명확하게 밝혀져 있지 않다. 이에 저자는 굴염의 치료에 있어서, 항생제를 기본적으로 사용하고, 이에 추가로 생리 식염수로 비강을 세척하는 방법 또는 충혈 제거제 복용, 또는 이 두 가지를 함께 추가하는 치료를 시도해서 각 치료 방법의 성과를 비교하고자 하였다. 방법: 소아 호흡기질환 클리닉에 내원한 굴염 환자를 대상으로 분석하였다. 무작위로 다음의 4가지 치료법 중 한 가지의 치료법을 적용하였다. 그룹 1은 고용량 아목시실린만 사용, 그룹 2는 고용량 아목시실린에 추가로 생리 식염수로 비강 세척을 사용, 그룹 3은 고용량 아목시실린에 추가로 충혈 제거제를 사용, 그룹 4는 고용량 아목시실린에 추가로 생리 식염수 비강 세척과 충혈 제거제를 모두 사용한 경우로 하였다. 치료에 대한 반응을 급성 및 아급성 굴염의 경우은 치료 시작 후 최소 4일 후, 만성 굴염의 경우는 치료 시작 후 최소 7일 후에 평가하였다. 결과: 4개의 치료법 간의 치료에 대한 반응을 비교했을 때, 각 그룹간에 차이가 없었다. 환자가 화농성 콧물, 코 막힘, 후비루, 굴 사진에서 특정한 소견, 그리고 아데노이드 비대증을 가지고 있는가에 따라 더 좋은 반응을 보이는 치료 방법은 없었다. 결론: 소아 굴염 환자 치료 시에 고용량 아목시실린에 추가적으로 생리 식염수 비 세척이나 충혈 제거제의 경구 사용은 환자의 증상개선에 있어서 추가적인 이득이 없었다. Purpose: The management of sinusitis in children is controversial. Antibiotic is known as the most essential management. Despite nasal irrigation and nasal decongestant have been used as adjunctive treatments of sinusitis, it is still unclear whether these are effective on sinusitis. Therefore, we used antibiotics with either nasal irrigation and an oral nasal decongestant and tried to estimate the outcome of each case. Methods: This study was conducted with sinusitis patients who visited our pediatric respiratory disease clinic. They were randomized into 4 groups: Group 1 were treated with a high dose of amoxicillin only; Group 2 were treated with nasal irrigation and a high dose of amoxicillin; Group 3 were treated with a nasal decongestant and a high dose of amoxicillin; and Group 4 were treated with nasal irrigation, a oral nasal decongestant, and a high dose of amoxicillin. Responses to treatment were estimated more than 4 days after the beginning of the therapy in acute or subacute sinusitis, and more than 7 days chronic sinusitis. Results: The responses to the treatments the 4 groups were not comparable. A favorable therapy was not found, regardless of whether a patient had suppurative rhinorrhea, nasal stuffness, typical findings of PNS plain radiograph, or adenoid hypertrophy. Conclusion: The use of nasal irrigation or a oral nasal decongestant as an additional therapy to antibiotics for the symptoms of pediatric sinusitis showed no additional effects on sinusitis. [Pediatr Allergy Respir Dis(Korea) 2010;20:232-237]

소아의 호흡기질환에서 수면다원검사의 적용

윤종서 ( Jong Seo Yoon ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1991 소아알레르기 및 호흡기학회지 Vol.1 No.2

In recent years, the field of sleep medicine for children has been significantly developing. Research has shown that polysomnography plays an important role in the diagnosis and management of children with sleep-related breathing disorders. However, evidence-based parameters have not yet been set. This article presents the current indications of polysomnography in children. Accurate diagnosis and management of children with sleep-related breathing disorders are only possible when their polysomnographic parameters and clinical findings such as medical history and physical examination are combined. (Allergy Asthma Respir Dis 2013;1:111-115)

소아의 호흡기질환에서 수면다원검사의 적용

윤종서 ( Jong Seo Yoon ) 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.2

In recent years, the field of sleep medicine for children has been significantly developing. Research has shown that polysomnography plays an important role in the diagnosis and management of children with sleep-related breathing disorders. However, evidence-based parameters have not yet been set. This article presents the current indications of polysomnography in children. Accurate diagnosis and management of children with sleep-related breathing disorders are only possible when their polysomnographic parameters and clinical findings such as medical history and physical examination are combined. (Allergy Asthma Respir Dis 2013;1:111-115)Allergy Asthma Respir Dis 2013;1:111-115)

광용적맥파를 이용한 커프리스 동맥혈압 추정에 관한 연구

문종민(Jong-Min Moon),황현진(Hyun-Jin Hwang),이상엽(Sang-Yeob Lee),이수연(Su-Yeon Lee),윤종서(Jong-seo Yoon),김경섭(Kyeong-Seop Kim),이정환(Jeong-Whan Lee) 대한전기학회 2022 정보 및 제어 심포지엄 논문집 Vol.2022 No.10

소아에서 굴곡성 기관지 내시경술을 이용한 무기폐 치료의 유용성

전윤홍 ( Yoon Hong Chun ),강성실 ( Sung Shil Kang ),방경원 ( Kyung Won Bang ),김환수 ( Hwan Soo Kim ),이의경 ( Eu Kyoung Lee ),윤종서 ( Jong Seo Yoon ),김현희 ( Hyun Hee Kim ),김진택 ( Jin Tack Kim ),이준성 ( Joon Sung Lee ) 대한소아알레르기호흡기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.3

Purpose: This study was to evaluate the effect of flexible bronchoscopy for the treatment of secondary atelectasis of children following respiratory infection. Methods: The medical records for a total of 19 cases of flexible bronchoscopy were reviewed retrospectively, which were performed for the treatment of secondary atelectasis at the Department of Pediatrics of the Catholic University of Korea Seoul St. Mary’s Hospital from April 2007 to January 2013. Results: A total of 18 patients (11 males and 7 females) were involved in the study. The range of age was 4 months to 15 years old. The causative underlying diseases were 17 cases of pneumonia, 1 case of bronchiolitis and 1 case of bronchial asthma. The most common location of atelectasis was right middle lobe and right middle lobe with left lower lobe was next. Bronchoscopy revealed inflammatory changes in 12 cases (63.2%) such as mucus plug (n=4), profuse secretion (n=4), mucosal edema (n=3), and bronchial narrowing (n=1), although 7 cases (36.8%) showed normal airway. Other additional findings were bronchomalacia, tracheomalacia, and bronchial tree abnormality. Seven out of 19 cases who received therapeutic intervention had complete or partial reexpansion of their atelectasis. Cases who occurred atelectasis within 6 weeks showed significantly higher improvement than cases occurred after 6 weeks (70% vs. 11.1%, P=0.019). Complications including seizure, fever, hypoxia, mucous bleeding, and hypotension were observed in 6 cases. Conclusion: Flexible bronchoscopy revealed to be effective and safe treatment modality in treatment of secondary atelectasis of children. Timely therapeutic intervention in pediatric patients should be considered. (Allergy Asthma Respir Dis 2013;1:274-279)

소아에서 굴곡성 기관지 내시경술을 이용한 무기폐 치료의 유용성

전윤홍 ( Yoon Hong Chun ),강성실 ( Sung Shil Kang ),방경원 ( Kyung Won Bang ),김환수 ( Hwan Soo Kim ),이의경 ( Eu Kyoung Lee ),윤종서 ( Jong Seo Yoon ),김현희 ( Hyun Hee Kim ),김진택 ( Jin Tack Kim ),이준성 ( Joon Sung Lee ) 대한소아알레르기호흡기학회 1991 소아알레르기 및 호흡기학회지 Vol.1 No.3

Purpose: This study was to evaluate the effect of flexible bronchoscopy for the treatment of secondary atelectasis of children following respiratory infection. Methods: The medical records for a total of 19 cases of flexible bronchoscopy were reviewed retrospectively, which were performed for the treatment of secondary atelectasis at the Department of Pediatrics of the Catholic University of Korea Seoul St. Mary’s Hospital from April 2007 to January 2013. Results: A total of 18 patients (11 males and 7 females) were involved in the study. The range of age was 4 months to 15 years old. The causative underlying diseases were 17 cases of pneumonia, 1 case of bronchiolitis and 1 case of bronchial asthma. The most common location of atelectasis was right middle lobe and right middle lobe with left lower lobe was next. Bronchoscopy revealed inflammatory changes in 12 cases (63.2%) such as mucus plug (n=4), profuse secretion (n=4), mucosal edema (n=3), and bronchial narrowing (n=1), although 7 cases (36.8%) showed normal airway. Other additional findings were bronchomalacia, tracheomalacia, and bronchial tree abnormality. Seven out of 19 cases who received therapeutic intervention had complete or partial reexpansion of their atelectasis. Cases who occurred atelectasis within 6 weeks showed significantly higher improvement than cases occurred after 6 weeks (70% vs. 11.1%, P=0.019). Complications including seizure, fever, hypoxia, mucous bleeding, and hypotension were observed in 6 cases. Conclusion: Flexible bronchoscopy revealed to be effective and safe treatment modality in treatment of secondary atelectasis of children. Timely therapeutic intervention in pediatric patients should be considered. (Allergy Asthma Respir Dis 2013;1:274-279)

딥러닝을 이용한 포트홀 검출 시스템

황성진,홍석우,윤종서,박희민,김현철,Hwang, Sung-jin,Hong, Seok-woo,Yoon, Jong-seo,Park, Heemin,Kim, Hyun-chul 한국반도체디스플레이기술학회 2021 반도체디스플레이기술학회지 Vol.20 No.1

The automotive industry is developing day by day. Among them, it is very important to prevent accidents while driving. However, despite the importance of developing automobile industry technology, accidents due to road defects increase every year, especially in the rainy season. To this end, we proposed a road defect detection system for road management by converging deep learning and raspberry pi, which show various possibilities. In this paper, we developed a system that visually displays through a map after analyzing the images captured by the Raspberry Pi and the route GPS. The deep learning model trained for this system achieved 96% accuracy. Through this system, it is expected to manage road defects efficiently at a low cost.